Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer’s Disease

Phosphorylation of different tau sites during progression of Alzheimer’s disease

(2018) Joerg Neddens et al.   Acta Neuropathologica Communications

Identification of the Tau phosphorylation pattern that drives its aggregation

(2017) Clément Despres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease

(2016) Waltraud Mair et al.   ANALYTICAL CHEMISTRY

Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidates

(2016) Claire L. Russell et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Protein Quantification in Human Cerebrospinal Fluid by Targeted Mass Spectrometry at High Sequence Coverage Provides Insights into Its Primary Structure Heterogeneity

(2016) Nicolas R Barthélemy et al.   JOURNAL OF PROTEOME RESEARCH

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8

(2016) Thomas J. Malia et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment

(2016) Peter J. Chung et al.   Nature Communications

C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death

(2015) D. Kanmert et al.   JOURNAL OF NEUROSCIENCE

Tau imaging: early progress and future directions

(2015) Victor L Villemagne et al.   LANCET NEUROLOGY

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

(2015) Meaghan Morris et al.   NATURE NEUROSCIENCE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

(2014) Kristen E. Funk et al.   BIOCHEMICAL JOURNAL

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Technical considerations for large-scale parallel reaction monitoring analysis

(2013) Sebastien Gallien et al.   Journal of Proteomics

Extracellular Tau Levels Are Influenced by Variability in Tau That Is Associated with Tauopathies

(2012) Celeste M. Karch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Proteomic Quantification on Quadrupole-Orbitrap Mass Spectrometer

(2012) Sebastien Gallien et al.   MOLECULAR & CELLULAR PROTEOMICS

Parallel Reaction Monitoring for High Resolution and High Mass Accuracy Quantitative, Targeted Proteomics

(2012) Amelia C. Peterson et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry

(2012) Michael A Gillette et al.   NATURE METHODS

Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach

(2011) Stefani N. Thomas et al.   ACTA NEUROPATHOLOGICA

Decreased cerebrospinal fluid Aβ42correlates with brain atrophy in cognitively normal elderly

(2009) Anne M. Fagan et al.   ANNALS OF NEUROLOGY