Oxidative Stress in the Tumor Microenvironment and Its Relevance to Cancer Immunotherapy

Non-steroidal anti-inflammatory drugs induce immunogenic cell death in suppressing colorectal tumorigenesis

(2021) Rochelle Fletcher et al.   ONCOGENE

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy

(2020) Hongzhang Deng et al.   NANO LETTERS

High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model

(2020) Rebecca A. Luchtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-dose vitamin C enhances cancer immunotherapy

(2020) Alessandro Magrì et al.   Science Translational Medicine

Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function

(2020) Henry Kurniawan et al.   Cell Metabolism

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Integrated molecular signalling involving mitochondrial dysfunction and alteration of cell metabolism during antitumoral properties of tyrosine kinase inhibitors in cancer

(2020) María A. Rodríguez-Hernández et al.   Redox Biology

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death

(2020) Boutaina Daher et al.   Frontiers in Oncology

The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy

(2020) Yuechen Zhao et al.   OncoTargets and Therapy

Thioredoxin activity confers resistance against oxidative stress in tumor-infiltrating NK cells

(2020) Ying Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy

(2020) Weimin Wang et al.   MOLECULAR CELL

xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling

(2020) Jinyun Liu et al.   MOLECULAR THERAPY

Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death

(2020) Hongzhang Deng et al.   Nature Communications

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

Engineering Prodrug Nanomedicine for Cancer Immunotherapy

(2020) Bin Yang et al.   Advanced Science

Extracellular Neuroglobin as a Stress-Induced Factor Activating Pre-Adaptation Mechanisms against Oxidative Stress and Chemotherapy-Induced Cell Death in Breast Cancer

(2020) Marco Fiocchetti et al.   Cancers

Effective ferroptotic small-cell lung cancer cell death from SLC7A11 inhibition by sulforaphane

(2020) Yuko Iida et al.   Oncology Letters

Oxidative Stress-Inducing Anticancer Therapies: Taking a Closer Look at Their Immunomodulating Effects

(2020) Jinthe Van Loenhout et al.   Antioxidants

Prostaglandin E2 and Cancer: Insight into Tumor Progression and Immunity

(2020) Federica Finetti et al.   Biology-Basel

Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma

(2019) Niraj Shenoy et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Specific Reactive Oxygen Species Accelerators Improve Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies

(2019) Hyeon Joo Yoo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity

(2019) Michael D. Arensman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 in cancers: A double‐edged sword

(2019) Shijia Wu et al.   Cancer Medicine

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

(2019) Clotilde Wiel et al.   CELL

Neuroglobin: A Novel Player in the Oxidative Stress Response of Cancer Cells

(2019) Marco Fiocchetti et al.   Oxidative Medicine and Cellular Longevity

Survival of the fittest: how myeloid-derived suppressor cells survive in the inhospitable tumor microenvironment

(2019) Suzanne Ostrand-Rosenberg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2019) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

A ROS-responsive polymeric prodrug nanosystem with self-amplified drug release for PSMA (−) prostate cancer specific therapy

(2019) Yifan Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Immunotherapy with Monoclonal Antibodies in Lung Cancer of Mice: Oxidative Stress and Other Biological Events

(2019) Jun Tang et al.   Cancers

Neuroglobin as key mediator in the 17β-estradiol-induced antioxidant cell response to oxidative stress

(2019) Virginia Solar Fernandez et al.   ANTIOXIDANTS & REDOX SIGNALING

The Role of Nrf2 Activity in Cancer Development and Progression

(2019) Alina-Andreea Zimta et al.   Cancers

Iron homeostasis and oxidative stress: An intimate relationship

(2019) Dimitrios Galaris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Harnessing altered oxidative metabolism in cancer by augmented prooxidant therapy

(2019) Malgorzata Firczuk et al.   CANCER LETTERS

How the redox state regulates immunity

(2019) Lisa Mullen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Understanding of ROS-Inducing Strategy in Anticancer Therapy

(2019) Su Ji Kim et al.   Oxidative Medicine and Cellular Longevity

Celecoxib inhibits mitochondrial O 2 consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway

(2018) Rhys Pritchard et al.   BIOCHEMICAL PHARMACOLOGY

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner

(2018) Matthew J. Scheffel et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

(2018) Tsadik Habtetsion et al.   Cell Metabolism

Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma

(2018) Masaki Nagane et al.   PLoS One

Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism

(2018) Davide G. Franchina et al.   TRENDS IN IMMUNOLOGY

The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells

(2018) Mami Sato et al.   Scientific Reports

OxInflammation: From Subclinical Condition to Pathological Biomarker

(2018) Giuseppe Valacchi et al.   Frontiers in Physiology

Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence

(2018) Margreet C. M. Vissers et al.   Frontiers in Physiology

ROS-responsive drug delivery systems for biomedical applications

(2018) Wenhui Tao et al.   Asian Journal of Pharmaceutical Sciences

Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer

(2018) Nikos Koundouros et al.   Frontiers in Oncology

ROS-Responsive N-Alkylaminoferrocenes for Cancer-Cell-Specific Targeting of Mitochondria

(2018) Viktor Reshetnikov et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly

(2018) Niraj Shenoy et al.   CANCER CELL

Discovery and Optimization of Novel Hydrogen Peroxide Activated Aromatic Nitrogen Mustard Derivatives as Highly Potent Anticancer Agents

(2018) WENBING CHEN et al.   JOURNAL OF MEDICINAL CHEMISTRY

xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction

(2018) Lara Cobler et al.   Oncotarget

A catalogue of somatic NRF2 gain-of-function mutations in cancer

(2018) Michael John Kerins et al.   Scientific Reports

Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

(2018) Kim Ohl et al.   Frontiers in Immunology

Reactive oxygen species and cancer paradox: To promote or to suppress?

(2017) Sehamuddin Galadari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutathione Primes T Cell Metabolism for Inflammation

(2017) Tak W. Mak et al.   IMMUNITY

Regulation of redox balance in cancer and T cells

(2017) Hyewon Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROS-modulated therapeutic approaches in cancer treatment

(2017) Muhammad Hassan Raza et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Reactive Oxygen Species-Mediated Mechanisms of Action of Targeted Cancer Therapy

(2017) Hanna-Riikka Teppo et al.   Oxidative Medicine and Cellular Longevity

ROS in Cancer: The Burning Question

(2017) Iok In Christine Chio et al.   TRENDS IN MOLECULAR MEDICINE

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

(2017) David S. Liu et al.   Nature Communications

Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells

(2017) N Shenoy et al.   Blood Cancer Journal

Efficacy of Adoptive T-cell Therapy Is Improved by Treatment with the Antioxidant N-Acetyl Cysteine, Which Limits Activation-Induced T-cell Death

(2016) M. J. Scheffel et al.   CANCER RESEARCH

Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer

(2016) Weimin Wang et al.   CELL

Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

(2016) Gregg L Semenza   EMBO JOURNAL

Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins

(2016) Ivan Verrastro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epidermal growth factor-induced hydrogen peroxide production is mediated by dual oxidase 1

(2016) Gábor Sirokmány et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs

(2016) Zhenke Wen et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2

(2016) Daniel W. Beury et al.   JOURNAL OF IMMUNOLOGY

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

(2016) Shira L Cramer et al.   NATURE MEDICINE

Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment

(2016) Xinfeng Chen et al.   Oxidative Medicine and Cellular Longevity

Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance

(2016) In-geun Ryoo et al.   Oxidative Medicine and Cellular Longevity

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

NF-κB in cancer therapy

(2015) Feng Li et al.   ARCHIVES OF TOXICOLOGY

Activity of aminoferrocene-based prodrugs against prostate cancer

(2015) Margot Schikora et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?

(2015) Maria Peiris-Pagès et al.   Cell Metabolism

Norepinephrine-induced myeloid-derived suppressor cells block T-cell responsesviageneration of reactive oxygen species

(2015) Yufeng Liu et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Coexpressed Catalase Protects Chimeric Antigen Receptor–Redirected T Cells as well as Bystander Cells from Oxidative Stress–Induced Loss of Antitumor Activity

(2015) Maarten A. Ligtenberg et al.   JOURNAL OF IMMUNOLOGY

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species

(2015) Sheng-Xiong Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10

(2015) Nan Li et al.   Oncotarget

New insights into the use of currently available non-steroidal anti-inflammatory drugs

(2015) Brune et al.   Journal of Pain Research

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

Promoting Thiol Expression Increases the Durability of Antitumor T-cell Functions

(2014) P. Kesarwani et al.   CANCER RESEARCH

Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

(2014) M Ogrunc et al.   CELL DEATH AND DIFFERENTIATION

The Cellular Redox Environment Alters Antigen Presentation

(2014) Jonathan A. Trujillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive Oxygen Species (ROS) Inducible DNA Cross-Linking Agents and Their Effect on Cancer Cells and Normal Lymphocytes

(2014) Wenbing Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Promise and Perils of Antioxidants for Cancer Patients

(2014) Navdeep S. Chandel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity

(2014) N Li et al.   ONCOGENE

High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy

(2014) Y. Ma et al.   Science Translational Medicine

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

Targeting Immune Suppression with PDE5 Inhibition in End-Stage Multiple Myeloma

(2014) K. A. Noonan et al.   Cancer Immunology Research

The Involvement of Endoplasmic Reticulum Stress in the Suppression of Colorectal Tumorigenesis by Tolfenamic Acid

(2013) X. Zhang et al.   Cancer Prevention Research

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

Crosstalk between ER stress and immunogenic cell death

(2013) Oliver Kepp et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Indomethacin Sensitizes TRAIL-Resistant Melanoma Cells to TRAIL-Induced Apoptosis through ROS-Mediated Upregulation of Death Receptor 5 and Downregulation of Survivin

(2013) Anfernee Kai-Wing Tse et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sulindac Selectively Inhibits Colon Tumor Cell Growth by Activating the cGMP/PKG Pathway to Suppress Wnt/ -Catenin Signaling

(2013) N. Li et al.   MOLECULAR CANCER THERAPEUTICS

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Epigenetic reprogramming governs EcSOD expression during human mammary epithelial cell differentiation, tumorigenesis and metastasis

(2013) M L Teoh-Fitzgerald et al.   ONCOGENE

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

(2013) N. Iida et al.   SCIENCE

Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells

(2012) Wei-Hsin Chiu et al.   BIOCHEMICAL PHARMACOLOGY

Ascorbic acid: Chemistry, biology and the treatment of cancer

(2012) Juan Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Molecular Pathways: Tumor-Infiltrating Myeloid Cells and Reactive Oxygen Species in Regulation of Tumor Microenvironment

(2012) T. Lu et al.   CLINICAL CANCER RESEARCH

Non-steroidal anti-inflammatory drugs, tumour immunity and immunotherapy

(2012) Muzammal Hussain et al.   PHARMACOLOGICAL RESEARCH

Implications of Altered Glutathione Metabolism in Aspirin-Induced Oxidative Stress and Mitochondrial Dysfunction in HepG2 Cells

(2012) Haider Raza et al.   PLoS One

Inhibition of PDE5 by Sulindac Sulfide Selectively Induces Apoptosis and Attenuates Oncogenic Wnt/ -Catenin-Mediated Transcription in Human Breast Tumor Cells

(2011) H. N. Tinsley et al.   Cancer Prevention Research

Acetylsalicylic acid-induced oxidative stress, cell cycle arrest, apoptosis and mitochondrial dysfunction in human hepatoma HepG2 cells

(2011) Haider Raza et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Vitamin E and the Risk of Prostate Cancer

(2011) Eric A. Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Aminoferrocene-Based Prodrugs Activated by Reactive Oxygen Species

(2011) Helen Hagen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hydrogen Peroxide Inducible DNA Cross-Linking Agents: Targeted Anticancer Prodrugs

(2011) Yunyan Kuang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulation of reactive oxygen species generation in cell signaling

(2011) Yun Soo Bae et al.   MOLECULES AND CELLS

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Celecoxib induces cell apoptosis coupled with up-regulation of the expression of VEGF by a mechanism involving ER stress in human colorectal cancer cells

(2011) Ying Zhang   ONCOLOGY REPORTS

Ncf1 (p47phox) Is Essential for Direct Regulatory T Cell Mediated Suppression of CD4+ Effector T Cells

(2011) Olga Efimova et al.   PLoS One

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

(2011) A. T. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress

(2010) D. Mougiakakos et al.   BLOOD

Cancer cell killing via ROS: To increase or decrease, that is the question

(2010) Jie Wang et al.   CANCER BIOLOGY & THERAPY

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Regulatory T Cells Interfere with Glutathione Metabolism in Dendritic Cells and T Cells

(2010) Zhonghua Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species

(2010) Marina D. Kraaij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox-control of matrix metalloproteinase-1: A critical link between free radicals, matrix remodeling and degenerative disease

(2010) Supriya Kar et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects

(2009) Julien Verrax et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

(2009) C. A. Corzo et al.   JOURNAL OF IMMUNOLOGY

Oxidative stress can alter the antigenicity of immunodominant peptides

(2009) Daniela Weiskopf et al.   JOURNAL OF LEUKOCYTE BIOLOGY

iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells

(2009) Sara De Boo et al.   Molecular Cancer

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Sulindac Enhances the Killing of Cancer Cells Exposed to Oxidative Stress

(2009) Maria Marchetti et al.   PLoS One

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2

(2008) Marcelo G. Binker et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased levels of superoxide and H2O2mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation

(2008) Nùkhet Aykin-Burns et al.   BIOCHEMICAL JOURNAL

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells

(2008) A. R. Mantegazza et al.   BLOOD

Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress-induced cell death

(2008) D. Mougiakakos et al.   BLOOD

Reactive oxygen species in tumor metastasis

(2008) Makiya Nishikawa   CANCER LETTERS

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

(2008) Masuko Ushio-Fukai et al.   CANCER LETTERS

Mechanisms of ROS modulated cell survival during carcinogenesis

(2008) J.S. Clerkin et al.   CANCER LETTERS

Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells

(2008) Aki Ogura et al.   CANCER LETTERS

The Thioredoxin System Mediates Redox-Induced Cell Death in Human Colon Cancer Cells: Implications for the Mechanism of Action of Anticancer Agents

(2008) Y. Sun et al.   CANCER RESEARCH

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

(2008) Hirotaka Kazama et al.   IMMUNITY

The xc− cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases

(2008) Maisie Lo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression

(2008) D Komatsu et al.   ONCOGENE

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Chemoprevention Through Dietary Antioxidants: Progress and Promise

(2007) Naghma Khan et al.   ANTIOXIDANTS & REDOX SIGNALING