Thioredoxin activity confers resistance against oxidative stress in tumor-infiltrating NK cells

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Thioredoxin-1 improves the immuno-metabolic phenotype of anti-tumor T cells

(2019) Paramita Chakraborty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients

(2019) Joseph Cursons et al.   Cancer Immunology Research

Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance

(2019) Xiaohu Zheng et al.   NATURE IMMUNOLOGY

Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells

(2019) Trine B. Levring et al.   Scientific Reports

Natural Killer Cell Therapy: A New Treatment Paradigm for Solid Tumors

(2019) Sooyeon Oh et al.   Cancers

CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment

(2019) Shi Yong Neo et al.   JOURNAL OF CLINICAL INVESTIGATION

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Nitric Oxide Production by Myeloid-Derived Suppressor Cells Plays a Role in Impairing Fc Receptor–Mediated Natural Killer Cell Function

(2018) Andrew Stiff et al.   CLINICAL CANCER RESEARCH

CD56bright NK cells exhibit potent antitumor responses following IL-15 priming

(2017) Julia A. Wagner, Maximillian Rosario, Rizwan Romee, Melissa M. Berrien-Elliott, Stephanie E. Schneider, Jeffrey W. Leong, Ryan P. Sullivan, Brea A. Jewell, Michelle Becker-Hapak, Timothy Schappe, Sara Abdel-Latif, Aaron R. Ireland, Devika Jaishankar, Justin A. King, Ravi Vij, Dennis Clement, Jodie Goodridge, Karl-Johan Malmberg, Hing C. Wong, Todd A. Fehniger   JOURNAL OF CLINICAL INVESTIGATION

Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity

(2017) E Liu et al.   LEUKEMIA

Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches

(2017) Alessandra Leone et al.   Oxidative Medicine and Cellular Longevity

mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors

(2017) Clare F. Malone et al.   Cancer Discovery

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

(2017) Scott Gettinger et al.   Cancer Discovery

Role of NOX2-Derived Reactive Oxygen Species in NK Cell–Mediated Control of Murine Melanoma Metastasis

(2017) Ebru Aydin et al.   Cancer Immunology Research

IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells

(2016) Y. Mao et al.   BLOOD

IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function

(2016) D. A. Vallera et al.   CLINICAL CANCER RESEARCH

Reactive oxygen species induced by therapeutic CD20 antibodies inhibit natural killer cell-mediated antibody-dependent cellular cytotoxicity against primary CLL cells

(2016) Olle Werlenius et al.   Oncotarget

IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas

(2016) Peter S. Kim et al.   Oncotarget

Phenotypically distinct helper NK cells are required for gp96-mediated anti-tumor immunity

(2016) Abigail L. Sedlacek et al.   Scientific Reports

Trx1/TrxR1 system regulates post-selected DP thymocytes survival by modulating ASK1-JNK/p38 MAPK activities

(2015) Rong Jin et al.   IMMUNOLOGY AND CELL BIOLOGY

Enduring and Emerging Challenges of Informed Consent

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein

(2014) V. Bachanova et al.   BLOOD

Cigarette Smoking and Variations in Systemic Immune and Inflammation Markers

(2014) Meredith S. Shiels et al.   JNCI-Journal of the National Cancer Institute

IL-18-Primed Helper NK Cells Collaborate with Dendritic Cells to Promote Recruitment of Effector CD8+ T Cells to the Tumor Microenvironment

(2013) J. L. Wong et al.   CANCER RESEARCH

Natural killer cells regulate diverse T cell responses

(2013) Sarah Q. Crome et al.   TRENDS IN IMMUNOLOGY

anota: analysis of differential translation in genome-wide studies

(2011) O. Larsson et al.   BIOINFORMATICS

T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules

(2011) Navtej Kaur et al.   CYTOKINE

Structure, Function, and Mechanism of Thioredoxin Proteins

(2010) Jean-Francois Collet et al.   ANTIOXIDANTS & REDOX SIGNALING

Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress

(2010) D. Mougiakakos et al.   BLOOD

Chronic Cigarette Smoke Exposure Primes NK Cell Activation in a Mouse Model of Chronic Obstructive Pulmonary Disease

(2010) G. T. Motz et al.   JOURNAL OF IMMUNOLOGY

Intracellular Shuttling and Mitochondrial Function of Thioredoxin-interacting Protein

(2009) Geetu Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exposure to cigarette smoke suppresses IL-15 generation and its regulatory NK cell functions in poly I:C-augmented human PBMCs

(2009) M. Firoz Mian et al.   MOLECULAR IMMUNOLOGY

Identification of human thioredoxin as a novel IFN-gamma-induced factor: Mechanism of induction and its role in cytokine production

(2008) Seol-Hee Kim et al.   BMC IMMUNOLOGY

The thiol redox state of lymphoid organs is modified by immunization: Role of different immune cell populations

(2008) Patrizia Castellani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natural killer cell recognition of missing self

(2008) Klas Kärre   NATURE IMMUNOLOGY

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY