标题
Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence
作者
关键词
-
出版物
Frontiers in Physiology
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2018-07-03
DOI
10.3389/fphys.2018.00809
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Cellular toxicity driven by high-dose vitamin C on normal and cancer stem cells
- (2018) Tae-Jun Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation
- (2018) Domenico Mastrangelo et al. BLOOD CELLS MOLECULES AND DISEASES
- Intravenous vitamin C in the supportive care of cancer patients: a review and rational approach
- (2018) E. Klimant et al. Current Oncology
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia
- (2018) Huihui Zhao et al. LEUKEMIA RESEARCH
- Vitamin C in Stem Cell Reprogramming and Cancer
- (2018) Luisa Cimmino et al. TRENDS IN CELL BIOLOGY
- Palmitoyl ascorbate and doxorubicin co-encapsulated liposome for synergistic anticancer therapy
- (2017) Yue Yang et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- New horizons in hypoxia signaling pathways
- (2017) Christopher W. Pugh et al. EXPERIMENTAL CELL RESEARCH
- Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia
- (2017) M Mingay et al. LEUKEMIA
- Ascorbate regulates haematopoietic stem cell function and leukaemogenesis
- (2017) Michalis Agathocleous et al. NATURE
- Vitamin C – A new player in regulation of the cancer epigenome
- (2017) Linn Gillberg et al. SEMINARS IN CANCER BIOLOGY
- Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells
- (2017) N Shenoy et al. Blood Cancer Journal
- Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)
- (2017) Ernestina Marianna De Francesco et al. Oncotarget
- Multiple Myeloma Tumor Cells are Selectively Killed by Pharmacologically-dosed Ascorbic Acid
- (2017) Jiliang Xia et al. EBioMedicine
- Chemical Transport Knockout for Oxidized Vitamin C, Dehydroascorbic Acid, Reveals Its Functions in vivo
- (2017) Hongbin Tu et al. EBioMedicine
- Peroxiporin Expression Is an Important Factor for Cancer Cell Susceptibility to Therapeutic H2O2: Implications for Pharmacological Ascorbate Therapy
- (2017) Dieanira Erudaitius et al. PLoS One
- Time course of changes in oxidative stress and stress-induced proteins in cardiomyocytes exposed to doxorubicin and prevention by vitamin C
- (2017) Ana Ludke et al. PLoS One
- The hypoxic tumor microenvironment: A driving force for breast cancer progression
- (2016) Gregg L. Semenza BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The epigenetic role of vitamin C in health and disease
- (2016) Vladimir Camarena et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity
- (2016) Lauren Rouleau et al. FREE RADICAL BIOLOGY AND MEDICINE
- Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice
- (2016) Elizabeth J. Campbell et al. FREE RADICAL BIOLOGY AND MEDICINE
- L-Ascorbic acid can abrogate SVCT-2-dependent cetuximab resistance mediated by mutant KRAS in human colon cancer cells
- (2016) Soo-A. Jung et al. FREE RADICAL BIOLOGY AND MEDICINE
- Genomic Classification and Prognosis in Acute Myeloid Leukemia
- (2016) Elli Papaemmanuil et al. NEW ENGLAND JOURNAL OF MEDICINE
- Expression of LPA2 is associated with poor prognosis in human breast cancer and regulates HIF-1α expression and breast cancer cell growth
- (2016) Min Li et al. ONCOLOGY REPORTS
- Vitamin C: the known and the unknown and Goldilocks
- (2016) SJ Padayatty et al. ORAL DISEASES
- Ascorbic acid in the prevention and treatment of cancer
- (2016) Ana Maria Oliveira Ferreira da Mata et al. Revista da Associacao Medica Brasileira
- Epigenetic Determinants of Cancer
- (2016) Stephen B. Baylin et al. Cold Spring Harbor Perspectives in Biology
- Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer
- (2016) Oscar Aguilera et al. Oncotarget
- Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy
- (2016) Claire M. Doskey et al. Redox Biology
- Regulation of the Epigenome by Vitamin C
- (2015) Juan I. Young et al. Annual Review of Nutrition
- Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors
- (2015) G. L. Semenza CLINICAL SCIENCE
- Treatment of Pancreatic Cancer with Pharmacological Ascorbate
- (2015) John Cieslak et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer
- (2015) John A. Cieslak et al. FREE RADICAL BIOLOGY AND MEDICINE
- Effects of High Doses of Vitamin C on Cancer Patients in Singapore
- (2015) Yuen Chuen Fong Raymond et al. INTEGRATIVE CANCER THERAPIES
- Effect of Glucose on GLUT1-Dependent Intracellular Ascorbate Accumulation and Viability of Thyroid Cancer Cells
- (2015) Paweł Jóźwiak et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
- (2015) J. Yun et al. SCIENCE
- Status of Oxidative Stress and Antioxidant Levels in Smokers with Breast Cancer from Western Nepal
- (2015) T. Nagamma et al. Asian Pacific Journal of Cancer Prevention
- High-Dose Intravenous Vitamin C Combined with Cytotoxic Chemotherapy in Patients with Advanced Cancer: A Phase I-II Clinical Trial
- (2015) L. John Hoffer et al. PLoS One
- Review of high-dose intravenous vitamin C as an anticancer agent
- (2014) Michelle K Wilson et al. Asia-Pacific Journal of Clinical Oncology
- Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer
- (2014) Margreet C.M. Vissers et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Vitamin C and survival among women with breast cancer: A Meta-analysis
- (2014) Holly R. Harris et al. EUROPEAN JOURNAL OF CANCER
- Pharmacokinetic modeling of ascorbate diffusion through normal and tumor tissue
- (2014) Caroline Kuiper et al. FREE RADICAL BIOLOGY AND MEDICINE
- Radiosensitisation by pharmacological ascorbate in glioblastoma multiforme cells, human glial cells, and HUVECs depends on their antioxidant and DNA repair capabilities and is not cancer specific
- (2014) M. Leticia Castro et al. FREE RADICAL BIOLOGY AND MEDICINE
- The active role of vitamin C in mammalian iron metabolism: Much more than just enhanced iron absorption!
- (2014) Darius J.R. Lane et al. FREE RADICAL BIOLOGY AND MEDICINE
- Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response
- (2014) Caroline Kuiper et al. FREE RADICAL BIOLOGY AND MEDICINE
- Intravenous Vitamin C and Cancer
- (2014) Heidi Fritz et al. INTEGRATIVE CANCER THERAPIES
- Nuclear HIF1A expression is strongly prognostic in sporadic but not familial male breast cancer
- (2014) Siddhartha Deb et al. MODERN PATHOLOGY
- Vitamin C Effect on Mitoxantrone-Induced Cytotoxicity in Human Breast Cancer Cell Lines
- (2014) Eliana Guerriero et al. PLoS One
- Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
- (2014) T. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy
- (2014) Y. Ma et al. Science Translational Medicine
- Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo−/−mice
- (2014) Elizabeth J. Campbell et al. Cancer Medicine
- Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer
- (2014) Caroline Kuiper et al. Frontiers in Oncology
- Vitamin C intake and breast cancer mortality in a cohort of Swedish women
- (2013) H R Harris et al. BRITISH JOURNAL OF CANCER
- Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial
- (2013) J. L. Welsh et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer
- (2013) Christopher M. Stephenson et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Interplay between the Cancer Genome and Epigenome
- (2013) Hui Shen et al. CELL
- Hypoxia-inducible factor 1α in breast cancer prognosis
- (2013) Wei Wang et al. CLINICA CHIMICA ACTA
- Breathing-in epigenetic change with vitamin C
- (2013) Asun Monfort et al. EMBO REPORTS
- Effects of Vitamin C on health: a review of evidence
- (2013) Roberto Bei Frontiers in Bioscience-Landmark
- Intestinal Dehydroascorbic Acid (DHA) Transport Mediated by the Facilitative Sugar Transporters, GLUT2 and GLUT8
- (2013) Christopher P. Corpe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine
- (2013) Emily A. Minor et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
- (2013) Peter J. Ratcliffe JOURNAL OF PHYSIOLOGY-LONDON
- Vitamin C Deficiency in a University Teaching Hospital
- (2013) Runye Gan et al. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
- TET enzymes, TDG and the dynamics of DNA demethylation
- (2013) Rahul M. Kohli et al. NATURE
- Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
- (2013) NEW ENGLAND JOURNAL OF MEDICINE
- Preclinical Demonstration of Synergistic Active Nutrients/Drug (AND) Combination as a Potential Treatment for Malignant Pleural Mesothelioma
- (2013) Viviana Volta et al. PLoS One
- (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
- (2013) J.-A. Losman et al. SCIENCE
- The Effects of High Concentrations of Vitamin C on Cancer Cells
- (2013) Seyeon Park Nutrients
- Myths, Artifacts, and Fatal Flaws: Identifying Limitations and Opportunities in Vitamin C Research
- (2013) Alexander Michels et al. Nutrients
- Ascorbic acid: Chemistry, biology and the treatment of cancer
- (2012) Juan Du et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Pharmacological concentrations of ascorbate radiosensitize glioblastoma multiforme primary cells by increasing oxidative DNA damage and inhibiting G2/M arrest
- (2012) Patries M. Herst et al. FREE RADICAL BIOLOGY AND MEDICINE
- Inhibitors of hydroperoxide metabolism enhance ascorbate-induced cytotoxicity
- (2012) K. E. Olney et al. FREE RADICAL RESEARCH
- Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin C-deficient mice
- (2012) JOHN CHA et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
- (2012) Lambert Busque et al. NATURE GENETICS
- Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer
- (2012) Daniel A. Monti et al. PLoS One
- Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA
- (2012) S. Volinia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vitamin C: A Concentration-Function Approach Yields Pharmacology and Therapeutic Discoveries
- (2012) Mark Levine et al. Advances in Nutrition
- Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy
- (2011) Ping Chen et al. ANTI-CANCER DRUGS
- Intracellular ATP levels determine cell death fate of cancer cells exposed to both standard and redox chemotherapeutic agents
- (2011) Julien Verrax et al. BIOCHEMICAL PHARMACOLOGY
- Vitamin C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells
- (2011) Sung-Ho An et al. BMB Reports
- The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C
- (2011) James M May BRITISH JOURNAL OF PHARMACOLOGY
- Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary parenteral glutathione in preclinical cancer models
- (2011) Ping Chen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer
- (2011) Michael Graham Espey et al. FREE RADICAL BIOLOGY AND MEDICINE
- Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains
- (2011) Benjamin P Berman et al. NATURE GENETICS
- HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
- (2011) H Zhang et al. ONCOGENE
- Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
- (2011) Y.-F. He et al. SCIENCE
- In vitro screening of synergistic ascorbate–drug combinations for the treatment of malignant mesothelioma
- (2011) Simona Martinotti et al. TOXICOLOGY IN VITRO
- Dietary ascorbate intake affects steady state tissue concentrations in vitamin C–deficient mice: tissue deficiency after suboptimal intake and superior bioavailability from a food source (kiwifruit)
- (2010) Margreet CM Vissers et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs
- (2010) Anja Frömberg et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Low Ascorbate Levels Are Associated with Increased Hypoxia-Inducible Factor-1 Activity and an Aggressive Tumor Phenotype in Endometrial Cancer
- (2010) C. Kuiper et al. CANCER RESEARCH
- Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer
- (2010) J. Du et al. CLINICAL CANCER RESEARCH
- Vitamin C Modulates Doxorubicin-Induced Cardiotoxicity by Reducing P53 and Map Kinase Activation
- (2010) Ana Ludke et al. FREE RADICAL BIOLOGY AND MEDICINE
- Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects
- (2010) Sebastian J. Padayatty et al. PLoS One
- Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications
- (2009) Dan Cao et al. BMC CANCER
- Vitamin C: update on physiology and pharmacology
- (2009) J Mandl et al. BRITISH JOURNAL OF PHARMACOLOGY
- HIF-1: upstream and downstream of cancer metabolism
- (2009) Gregg L Semenza CURRENT OPINION IN GENETICS & DEVELOPMENT
- Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2
- (2009) Fiona E. Harrison et al. FREE RADICAL BIOLOGY AND MEDICINE
- Ascorbic acid inhibits antitumor activity of bortezomib in vivo
- (2009) G Perrone et al. LEUKEMIA
- Oxalic acid excretion after intravenous ascorbic acid administration
- (2009) Line Robitaille et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Metabolic origin of hypovitaminosis C in acutely hospitalized patients
- (2009) Rebecca Evans-Olders et al. NUTRITION
- Oxidant/Antioxidant Status, Lipids and Hormonal Profile in Overweight Women with Breast Cancer
- (2009) Naima Badid et al. PATHOLOGY & ONCOLOGY RESEARCH
- Antiproliferative Effect of Ascorbic Acid Is Associated with the Inhibition of Genes Necessary to Cell Cycle Progression
- (2009) Sophie Belin et al. PLoS One
- Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
- (2009) M. Tahiliani et al. SCIENCE
- Phase I clinical trial of i.v. ascorbic acid in advanced malignancy
- (2008) L. J. Hoffer et al. ANNALS OF ONCOLOGY
- Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice
- (2008) Q. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metal Ions-Stimulated Iron Oxidation in Hydroxylases Facilitates Stabilization of HIF-1α Protein
- (2008) Monika Kaczmarek et al. TOXICOLOGICAL SCIENCES
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