标题
Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death
作者
关键词
-
出版物
Frontiers in Oncology
Volume 10, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2020-05-07
DOI
10.3389/fonc.2020.00723
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Resibufogenin inhibited colorectal cancer cell growth and tumorigenesis through triggering ferroptosis and ROS production mediated by GPX4 inactivation
- (2020) Lian‐Dong Shen et al. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
- Cysteine depletion induces pancreatic tumor ferroptosis in mice
- (2020) Michael A. Badgley et al. SCIENCE
- A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity
- (2019) Jennifer Yinuo Cao et al. Cell Reports
- Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion
- (2019) Isaac S. Harris et al. Cell Metabolism
- The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival
- (2019) Joseph A. Combs et al. Cancers
- Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses
- (2019) Boutaina Daher et al. CANCER RESEARCH
- Novel analogs of sulfasalazine as system x c − antiporter inhibitors: Insights from the molecular modeling studies
- (2019) Dhavalkumar Patel et al. DRUG DEVELOPMENT RESEARCH
- Molecular mechanisms of ferroptosis and its role in cancer therapy
- (2019) Tao Xu et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy
- (2019) Huanhuan Lv et al. Oxidative Medicine and Cellular Longevity
- Glutaminolysis‐related genes determine sensitivity to xCT‐targeted therapy in head and neck squamous cell carcinoma
- (2019) Shogo Okazaki et al. CANCER SCIENCE
- Recent Progress in Ferroptosis Inducers for Cancer Therapy
- (2019) Chen Liang et al. ADVANCED MATERIALS
- Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma
- (2019) Ning Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation
- (2019) Jiajun Zhu et al. Cell Metabolism
- Nutrient regulation of mTORC1 at a glance
- (2019) Kendall J. Condon et al. JOURNAL OF CELL SCIENCE
- FSP1 is a glutathione-independent ferroptosis suppressor
- (2019) Sebastian Doll et al. NATURE
- The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
- (2019) Kirill Bersuker et al. NATURE
- Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance
- (2019) Nan Liu et al. BRITISH JOURNAL OF CANCER
- Mammalian Sulfur Amino Acid Metabolism: A Nexus Between Redox Regulation, Nutrition, Epigenetics, and Detoxification
- (2018) María A. Pajares et al. ANTIOXIDANTS & REDOX SIGNALING
- miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma
- (2018) Meiying Luo et al. CELL DEATH AND DIFFERENTIATION
- The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)
- (2018) Yann Cormerais et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glutathione metabolism in cancer progression and treatment resistance
- (2018) Ankita Bansal et al. JOURNAL OF CELL BIOLOGY
- xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression
- (2018) Xiangming Ji et al. ONCOGENE
- Amino acid transporters revisited: New views in health and disease
- (2018) Palanivel Kandasamy et al. TRENDS IN BIOCHEMICAL SCIENCES
- xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction
- (2018) Lara Cobler et al. Oncotarget
- Glutathione: subcellular distribution and membrane transport
- (2018) Julian Oestreicher et al. Biochemistry and Cell Biology
- Cystinuria: genetic aspects, mouse models, and a new approach to therapy
- (2018) Amrik Sahota et al. Urolithiasis
- Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
- (2017) Matthew J. Hangauer et al. NATURE
- CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway
- (2017) Meng-Shian Chen et al. Oncotarget
- The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code
- (2017) Milica Vučetić et al. Frontiers in Oncology
- A simple isotopic labeling method to study cysteine oxidation in Alzheimer’s disease: oxidized cysteine-selective dimethylation (OxcysDML)
- (2016) Liqing Gu et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth
- (2016) Y. Cormerais et al. CANCER RESEARCH
- Emerging roles for lipids in non-apoptotic cell death
- (2016) L Magtanong et al. CELL DEATH AND DIFFERENTIATION
- ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
- (2016) Sebastian Doll et al. Nature Chemical Biology
- Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
- (2016) Shira L Cramer et al. NATURE MEDICINE
- Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis
- (2016) Xinlei Yu et al. Scientific Reports
- MRP1 and its role in anticancer drug resistance
- (2015) Jamie F. Lu et al. DRUG METABOLISM REVIEWS
- Cysteine is not a substrate but a specific modulator of human ASCT2 (SLC1A5) transporter
- (2015) Mariafrancesca Scalise et al. FEBS LETTERS
- Cystathionase mediates senescence evasion in melanocytes and melanoma cells
- (2013) C Leikam et al. ONCOGENE
- Nutrient transporters: the Achilles’ heel of anabolism
- (2013) Alison N. McCracken et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain
- (2012) Si-Eun Yoo et al. FREE RADICAL BIOLOGY AND MEDICINE
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond
- (2011) Marcus Conrad et al. AMINO ACIDS
- CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth
- (2011) Takatsugu Ishimoto et al. CANCER CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Free Radical Lipid Peroxidation: Mechanisms and Analysis
- (2011) Huiyong Yin et al. CHEMICAL REVIEWS
- The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
- (2010) Jiangbin Ye et al. EMBO JOURNAL
- Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines
- (2008) Adrián M. Ramos et al. BIOCHEMICAL PHARMACOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started