Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research

Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform

(2020) Shiny Amala Priya Rajan et al.   Acta Biomaterialia

Towards chamber specific heart-on-a-chip for drug testing applications

(2020) Yimu Zhao et al.   ADVANCED DRUG DELIVERY REVIEWS

Heart-on-a-chip Model with Integrated Extra- and Intra-cellular Bioelectronics for Monitoring Cardiac Electrophysiology under Acute Hypoxia

(2020) Haitao Liu et al.   NANO LETTERS

Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine

(2020) Elaheh Karbassi et al.   Nature Reviews Cardiology

Calcium Handling Defects and Cardiac Arrhythmia Syndromes

(2020) Kornél Kistamás et al.   Frontiers in Pharmacology

PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells

(2020) Yanping Liu et al.   Aging-US

The cell surface marker CD36 selectively identifies matured, mitochondria-rich hPSC-cardiomyocytes

(2020) Ellen Ngar-Yun Poon et al.   CELL RESEARCH

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

(2020) Elisa Giacomelli et al.   Cell Stem Cell

Cardiomyocyte Maturation

(2020) Yuxuan Guo et al.   CIRCULATION RESEARCH

Strain-Dependent Variability of Early Discovery Small Molecule Pharmacokinetics in Mice: Does Strain Matter?

(2020) John T Barr et al.   DRUG METABOLISM AND DISPOSITION

Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Can Be Improved by Lowering Accumulation of Fatty Acid Oxidation Intermediates

(2020) Suzan J. G. Knottnerus et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A cardiomyocyte show of force: A fluorescent alpha-actinin reporter line sheds light on human cardiomyocyte contractility versus substrate stiffness

(2020) Marcelo C. Ribeiro et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A high-content, in vitro cardiac fibrosis assay for high-throughput, phenotypic identification of compounds with anti-fibrotic activity

(2020) G. Palano et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Stem Cell–Derived Cardiomyocytes and Beta-Adrenergic Receptor Blockade in Duchenne Muscular Dystrophy Cardiomyopathy

(2020) Forum Kamdar et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Efficient Drug Screening and Nephrotoxicity Assessment on Co-culture Microfluidic Kidney Chip

(2020) Lei Yin et al.   Scientific Reports

Vascularized cardiac tissue construction with orientation by layer-by-layer method and 3D printer

(2020) Yoshinari Tsukamoto et al.   Scientific Reports

Muscle and cardiac therapeutic strategies for Duchenne muscular dystrophy: past, present, and future

(2020) Agnieszka Łoboda et al.   Pharmacological Reports

Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes

(2020) Dries A.M. Feyen et al.   Cell Reports

Perspective on human pluripotent stem cell‐derived cardiomyocytes in heart disease modeling and repair

(2020) Qiang Li et al.   Stem Cells Translational Medicine

Optical Interrogation of Sympathetic Neuronal Effects on Macroscopic Cardiomyocyte Network Dynamics

(2020) Rebecca-Ann B. Burton et al.   iScience

Microfluidic organ-on-a-chip models of human liver tissue

(2020) Ehsanollah Moradi et al.   Acta Biomaterialia

Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes

(2020) Yvonne Sleiman et al.   EBioMedicine

Single-cell RNA-seq and optical electrophysiology of human induced pluripotent stem cell-derived cardiomyocytes reveal discordance between cardiac subtype-associated gene expression patterns and electrophysiological phenotypes

(2019) Sherri M. Biendarra-Tiegs et al.   STEM CELLS AND DEVELOPMENT

SarcTrack: An Adaptable Software Tool for Efficient Large-Scale Analysis of Sarcomere Function in hiPSC-Cardiomyocytes

(2019) Christopher N Toepfer et al.   CIRCULATION RESEARCH

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling

(2019) Yimu Zhao et al.   CELL

Personalized medicine in cardio-oncology: the role of induced pluripotent stem cell

(2019) Nazish Sayed et al.   CARDIOVASCULAR RESEARCH

Oxygen Management at the Microscale: A Functional Biochip Material with Long-Lasting and Tunable Oxygen Scavenging Properties for Cell Culture Applications

(2019) Drago Sticker et al.   ACS Applied Materials & Interfaces

Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications

(2019) Idit Goldfracht et al.   Acta Biomaterialia

User-Friendly and Parallelized Generation of Human Induced Pluripotent Stem Cell-Derived Microtissues in a Centrifugal Heart-on-a-Chip

(2019) Oliver Schneider et al.   TISSUE ENGINEERING PART A

Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes

(2019) Sanam Shafaattalab et al.   Stem Cell Reports

Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation

(2019) Wesley LaBarge et al.   PLoS One

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

(2019) Tae-Eun Park et al.   Nature Communications

Transcriptomic analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Cardiomyocyte Maturation Compared to 2D Culture

(2019) Mariana A. Branco et al.   Scientific Reports

Bioprinting Approaches to Engineering Vascularized 3D Cardiac Tissues

(2019) Nazan Puluca et al.   Current Cardiology Reports

Brain-on-a-chip: A history of development and future perspective

(2019) Seokyoung Bang et al.   Biomicrofluidics

Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes Exhibit Adult Cardiomyocyte-Like Energy Metabolism Phenotypes

(2019) Yuichi Horikoshi et al.   Cells

A heart-on-a-chip platform for online monitoring of contractile behavior via digital image processing and piezoelectric sensing technique

(2019) Mutsuhito Sakamiya et al.   MEDICAL ENGINEERING & PHYSICS

Reproducing human and cross-species drug toxicities using a Liver-Chip

(2019) Kyung-Jin Jang et al.   Science Translational Medicine

Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

(2019) Berend J. van Meer et al.   Nature Communications

Engineered Liver-on-a-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review

(2019) Deng et al.   Micromachines

Engineering of Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Using Substrates with Multiscale Topography

(2018) Parisa P. S. S. Abadi et al.   ADVANCED FUNCTIONAL MATERIALS

Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL/6 models of bronchopulmonary dysplasia

(2018) Qian Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Can non-clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium

(2018) Eunjung Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Kidney-on-a-Chip: A New Technology for Predicting Drug Efficacy, Interactions, and Drug-induced Nephrotoxicity

(2018) Jeonghwan Lee et al.   CURRENT DRUG METABOLISM

Electrical dysfunctions in human-induced pluripotent stem cell-derived cardiomyocytes from a patient with an arrhythmogenic right ventricular cardiomyopathy

(2018) Ibrahim El-Battrawy et al.   EUROPACE

Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?

(2018) Jonathan P Stack et al.   EUROPEAN HEART JOURNAL

Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues

(2018) Andrea Leonard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Human brain organoid-on-a-chip to model prenatal nicotine exposure

(2018) Yaqing Wang et al.   LAB ON A CHIP

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

The immature electrophysiological phenotype of iPSC-CMs still hampers in vitro drug screening: Special focus on I K1

(2018) Birgit Goversen et al.   PHARMACOLOGY & THERAPEUTICS

Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease

(2018) Harsha D. Devalla et al.   Science Translational Medicine

Functional video-based analysis of 3D cardiac structures generated from human embryonic stem cells

(2018) Scarlett Nitsch et al.   Stem Cell Research

Pancreatic Effects of a Bruton’s Tyrosine Kinase Small-molecule Inhibitor in Rats Are Strain-dependent

(2018) Manoj Bhaskaran et al.   TOXICOLOGIC PATHOLOGY

Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin—Integration and Visualization of Multi-Omics Data

(2018) Gustav Holmgren et al.   TOXICOLOGICAL SCIENCES

Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study

(2018) Daniel Millard et al.   TOXICOLOGICAL SCIENCES

Assessment of hepatic metabolism-dependent nephrotoxicity on an organs-on-a-chip microdevice

(2018) Zhongyu Li et al.   TOXICOLOGY IN VITRO

Polypyrrole-chitosan conductive biomaterial synchronizes cardiomyocyte contraction and improves myocardial electrical impulse propagation

(2018) Zhi Cui et al.   Theranostics

Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

(2018) David A Knowles et al.   eLife

Conductive silk–polypyrrole composite scaffolds with bioinspired nanotopographic cues for cardiac tissue engineering

(2018) Jonathan H. Tsui et al.   Journal of Materials Chemistry B

International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

(2018) Ksenia Blinova et al.   Cell Reports

Development of torsadogenic risk assessment using human induced pluripotent stem cell-derived cardiomyocytes: Japan iPS Cardiac Safety Assessment (JiCSA) update

(2018) Yasunari Kanda et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium

(2018) Marta Lemme et al.   Stem Cell Reports

Development of a Human iPSC Cardiomyocyte-Based Scoring System for Cardiac Hazard Identification in Early Drug Safety De-risking

(2018) Ivan Kopljar et al.   Stem Cell Reports

Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes

(2018) Ivana Acimovic et al.   Journal of Clinical Medicine

A cardiac patch from aligned microvessel and cardiomyocyte patches

(2017) Jeremy A. Schaefer et al.   Journal of Tissue Engineering and Regenerative Medicine

Evaluation system for arrhythmogenic potential of drugs using human-induced pluripotent stem cell-derived cardiomyocytes and gene expression analysis

(2017) Arisa Higa et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Simultaneous electrical recording of cardiac electrophysiology and contraction on chip

(2017) Fang Qian et al.   LAB ON A CHIP

Cardiac microphysiological devices with flexible thin-film sensors for higher-throughput drug screening

(2017) Johan U. Lind et al.   LAB ON A CHIP

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities

(2017) Ben M. Maoz et al.   LAB ON A CHIP

Differentiation of cardiomyocytes and generation of human engineered heart tissue

(2017) Kaja Breckwoldt et al.   Nature Protocols

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells

(2017) Arun Sharma et al.   Science Translational Medicine

Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling

(2017) Oscar J. Abilez et al.   STEM CELLS

Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells

(2017) Patrick A. Schweizer et al.   Stem Cell Research & Therapy

Current Strategies and Challenges for Purification of Cardiomyocytes Derived from Human Pluripotent Stem Cells

(2017) Kiwon Ban et al.   Theranostics

Drugs and life-threatening ventricular arrhythmia risk: results from the DARE study cohort

(2017) Abigail L Coughtrie et al.   BMJ Open

Assessment of extracellular field potential and Ca2+ transient signals for early QT/pro-arrhythmia detection using human induced pluripotent stem cell-derived cardiomyocytes

(2017) Najah Abi-Gerges et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Anisotropic microfibrous scaffolds enhance the organization and function of cardiomyocytes derived from induced pluripotent stem cells

(2017) Maureen Wanjare et al.   Biomaterials Science

Novel Two-Step Classifier for Torsades de Pointes Risk Stratification from Direct Features

(2017) Jaimit Parikh et al.   Frontiers in Pharmacology

Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes

(2017) Tadahiro Shinozawa et al.   Stem Cell Reports

CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice

(2017) Yu Zhang et al.   Science Advances

MUSCLEMOTION

(2017) Luca Sala et al.   CIRCULATION RESEARCH

Biomaterial-Free Three-Dimensional Bioprinting of Cardiac Tissue using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes

(2017) Chin Siang Ong et al.   Scientific Reports

hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen

(2017) André Monteiro da Rocha et al.   Scientific Reports

From Molecular Mechanisms to Clinical Management of Antineoplastic Drug-Induced Cardiovascular Toxicity: A Translational Overview

(2017) Carlo Gabriele Tocchetti et al.   ANTIOXIDANTS & REDOX SIGNALING

Nanotopography-Induced Structural Anisotropy and Sarcomere Development in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells

(2016) Daniel Carson et al.   ACS Applied Materials & Interfaces

PNIPAAm-based biohybrid injectable hydrogel for cardiac tissue engineering

(2016) Ali Navaei et al.   Acta Biomaterialia

Development of vascularized iPSC derived 3D-cardiomyocyte tissues by filtration Layer-by-Layer technique and their application for pharmaceutical assays

(2016) Yuto Amano et al.   Acta Biomaterialia

Human engineered heart tissue as a model system for drug testing

(2016) Alexandra Eder et al.   ADVANCED DRUG DELIVERY REVIEWS

Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform

(2016) Chris Denning et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

(2016) Yu Shrike Zhang et al.   BIOMATERIALS

A microfluidic optical platform for real-time monitoring of pH and oxygen in microfluidic bioreactors and organ-on-chip devices

(2016) Seyed Ali Mousavi Shaegh et al.   Biomicrofluidics

Atomic force microscopy combined with human pluripotent stem cell derived cardiomyocytes for biomechanical sensing

(2016) Martin Pesl et al.   BIOSENSORS & BIOELECTRONICS

Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac TissueClinical Perspective

(2016) Jia-Ling Ruan et al.   CIRCULATION

Cardio-Oncology

(2016) Carrie G. Lenneman et al.   CIRCULATION RESEARCH

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues

(2016) Anna Marsano et al.   LAB ON A CHIP

Human induced pluripotent stem cell-derived fiber-shaped cardiac tissue on a chip

(2016) Y. Morimoto et al.   LAB ON A CHIP

Micropost arrays for measuring stem cell-derived cardiomyocyte contractility

(2016) Kevin M. Beussman et al.   METHODS

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker

(2016) Stephanie I Protze et al.   NATURE BIOTECHNOLOGY

Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

(2016) Paul W Burridge et al.   NATURE MEDICINE

Validating the pharmacogenomics of chemotherapy-induced cardiotoxicity: What is missing?

(2016) Tarek Magdy et al.   PHARMACOLOGY & THERAPEUTICS

Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2016) Ashley H. Fong et al.   TISSUE ENGINEERING PART A

The Use of Ratiometric Fluorescence Measurements of the Voltage Sensitive Dye Di-4-ANEPPS to Examine Action Potential Characteristics and Drug Effects on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2016) M. P. Hortigon-Vinagre et al.   TOXICOLOGICAL SCIENCES

Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening

(2016) Martijn J. Wilmer et al.   TRENDS IN BIOTECHNOLOGY

Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes

(2016) George Eng et al.   Nature Communications

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

(2016) Thomas Colatsky et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Laminar ventricular myocardium on a microelectrode array-based chip

(2016) Ville J. Kujala et al.   Journal of Materials Chemistry B

Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers

(2016) Junjun Li et al.   Stem Cells International

Electrical Stimulation Promotes Cardiac Differentiation of Human Induced Pluripotent Stem Cells

(2016) Damián Hernández et al.   Stem Cells International

Early drug development: assessment of proarrhythmic risk and cardiovascular safety

(2016) Robert M. Lester et al.   Expert Review of Clinical Pharmacology

Human Engineered Heart Tissue: Analysis of Contractile Force

(2016) Ingra Mannhardt et al.   Stem Cell Reports

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

Conductive interpenetrating networks of polypyrrole and polycaprolactone encourage electrophysiological development of cardiac cells

(2015) Benjamin S. Spearman et al.   Acta Biomaterialia

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment

(2015) Umesh Chaudhari et al.   ARCHIVES OF TOXICOLOGY

Dynamics of Cell Generation and Turnover in the Human Heart

(2015) Olaf Bergmann et al.   CELL

Revisiting Cardiac Cellular CompositionNovelty and Significance

(2015) Alexander R. Pinto et al.   CIRCULATION RESEARCH

Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology

(2015) H. D. Devalla et al.   EMBO Molecular Medicine

Modeling structural and functional deficiencies ofRBM20familial dilated cardiomyopathy using human induced pluripotent stem cells

(2015) Saranya P. Wyles et al.   HUMAN MOLECULAR GENETICS

Stem cell derived in vivo-like human cardiac bodies in a microfluidic device for toxicity testing by beating frequency imaging

(2015) Gunnar Bergström et al.   LAB ON A CHIP

Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes

(2015) Kavitha T. Kuppusamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

Engineering Adolescence

(2014) Xiulan Yang et al.   CIRCULATION RESEARCH

Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil

(2014) L Johannesen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Measuring the Contractile Forces of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes With Arrays of Microposts

(2014) Marita L. Rodriguez et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

Chemically defined generation of human cardiomyocytes

(2014) Paul W Burridge et al.   NATURE METHODS

Three-Dimensional Extracellular Matrix Scaffolds by Microfluidic Fabrication for Long-Term Spontaneously Contracted Cardiomyocyte Culture

(2014) Jeng-Chun Mei et al.   TISSUE ENGINEERING PART A

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes

(2013) Donghui Zhang et al.   BIOMATERIALS

Screening Drug-Induced Arrhythmia Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays

(2013) E. G. Navarrete et al.   CIRCULATION

Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity

(2013) Ping Liang et al.   CIRCULATION

Ultrastructural Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Long-Term Culture

(2013) Tsukasa Kamakura et al.   CIRCULATION JOURNAL

Modeling of Arrhythmogenic Right Ventricular Cardiomyopathy With Human Induced Pluripotent Stem Cells

(2013) Oren Caspi et al.   Circulation-Cardiovascular Genetics

Educational Paper: Decreasing the burden of cardiovascular disease in childhood cancer survivors: An update for the pediatrician

(2013) Rejane F. Dillenburg et al.   EUROPEAN JOURNAL OF PEDIATRICS

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs

(2013) Changsung Kim et al.   NATURE

Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes

(2013) Sara S Nunes et al.   NATURE METHODS

Bioengineered 3D Human Kidney Tissue, a Platform for the Determination of Nephrotoxicity

(2013) Teresa M. DesRochers et al.   PLoS One

Exon Skipping and Gene Transfer Restore Dystrophin Expression in Human Induced Pluripotent Stem Cells-Cardiomyocytes Harboring DMD Mutations

(2013) Emily Dick et al.   STEM CELLS AND DEVELOPMENT

In-vitro perfusion of engineered heart tissue through endothelialized channels

(2013) Ingra Vollert et al.   TISSUE ENGINEERING PART A

3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies

(2013) Patrina Gunness et al.   TOXICOLOGICAL SCIENCES

CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia

(2013) E Di Pasquale et al.   Cell Death & Disease

Comparison of Biocompatibility and Adsorption Properties of Different Plastics for Advanced Microfluidic Cell and Tissue Culture Models

(2012) Paul M. van Midwoud et al.   ANALYTICAL CHEMISTRY

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip

(2012) Leila Choucha-Snouber et al.   BIOTECHNOLOGY AND BIOENGINEERING

In vitro 3D human small intestinal villous model for drug permeability determination

(2012) Jiajie Yu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Shugo Tohyama et al.   Cell Stem Cell

Animal Models of Heart Failure

(2012) Steven R. Houser et al.   CIRCULATION RESEARCH

Optical Imaging of Voltage and Calcium in Cardiac Cells & Tissues

(2012) Todd J. Herron et al.   CIRCULATION RESEARCH

Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells to Cardiomyocytes

(2012) Christine L. Mummery et al.   CIRCULATION RESEARCH

Modeling of Catecholaminergic Polymorphic Ventricular Tachycardia With Patient-Specific Human-Induced Pluripotent Stem Cells

(2012) Ilanit Itzhaki et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

(2012) Xiaojun Lian et al.   Nature Protocols

Atomic Force Mechanobiology of Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Jianwei Liu et al.   PLoS One

Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy

(2012) N. Sun et al.   Science Translational Medicine

Muscle on a chip: In vitro contractility assays for smooth and striated muscle

(2012) Anna Grosberg et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture

(2011) Nathaniel L. Tulloch et al.   CIRCULATION RESEARCH

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

(2011) Christian B. Jung et al.   EMBO Molecular Medicine

Reversible alteration of calcium dynamics in cardiomyocytes during acute hypoxia transient in a microfluidic platform

(2011) S. Martewicz et al.   Integrative Biology

SCN5A Mutations Associate With Arrhythmic Dilated Cardiomyopathy and Commonly Localize to the Voltage-Sensing Mechanism

(2011) William P. McNair et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

A Universal System for Highly Efficient Cardiac Differentiation of Human Induced Pluripotent Stem Cells That Eliminates Interline Variability

(2011) Paul W. Burridge et al.   PLoS One

Integrated Proteomic and Transcriptomic Investigation of the Acetaminophen Toxicity in Liver Microfluidic Biochip

(2011) Jean Matthieu Prot et al.   PLoS One

Biohybrid thin films for measuring contractility in engineered cardiovascular muscle

(2010) Patrick W. Alford et al.   BIOMATERIALS

Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome

(2010) Alessandra Moretti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes

(2009) Tomofumi Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nongenetic method for purifying stem cell–derived cardiomyocytes

(2009) Fumiyuki Hattori et al.   NATURE METHODS

Electrical stimulation systems for cardiac tissue engineering

(2009) Nina Tandon et al.   Nature Protocols