Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

Species differences in drug transporters and implications for translating preclinical findings to humans

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Microengineered physiological biomimicry: Organs-on-Chips

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NIH Image to ImageJ: 25 years of image analysis

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How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

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Possible role of cysteine-S-conjugate β-lyase in species differences in cisplatin nephrotoxicity

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The use of controlled surface topography and flow-induced shear stress to influence renal epithelial cell function

(2011) Else M. Frohlich et al.   Integrative Biology

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions

(2010) Giuliano Ciarimboli et al.   AMERICAN JOURNAL OF PATHOLOGY

A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells

(2010) Nicholas Ferrell et al.   BIOTECHNOLOGY AND BIOENGINEERING

Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity

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Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells

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(2010) Joseph V Bonventre et al.   NATURE BIOTECHNOLOGY

Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells

(2010) Y. Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituting Organ-Level Lung Functions on a Chip

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Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters

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Renal Vulnerability to Drug Toxicity

(2009) M. A. Perazella   Clinical Journal of the American Society of Nephrology

Renal Primary Cilia Lengthen after Acute Tubular Necrosis

(2009) E. Verghese et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

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Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes

(2008) Y. Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA