Nutraceuticals in the Prevention of Viral Infections, including COVID-19, among the Pediatric Population: A Review of the Literature

NF-κB signalling as a pharmacological target in COVID-19: potential roles for IKKβ inhibitors

(2021) Mahesh Kandasamy   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Effects of Vitamin D on COVID-19 Infection and Prognosis: A Systematic Review

(2021) Hiwot Yisak et al.   Risk Management and Healthcare Policy

Adherence to the Mediterranean diet is an independent predictor of circulating vitamin D levels in normal weight and non-smoker adults: an observational cross-sectional study

(2021) Maria Dalamaga et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis

(2021) Nanyang Liu et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Dietary Antioxidants Significantly Attenuate Hyperoxia-Induced Acute Inflammatory Lung Injury by Enhancing Macrophage Function via Reducing the Accumulation of Airway HMGB1

(2020) Vivek Patel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LOW USE OF VITAMIN A IN CHILDREN HOSPITALIZED FOR MEASLES IN THE UNITED STATES

(2020) Gabrielle Z. Hester et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Vitamin A supplement after neonatal Streptococcus pneumoniae pneumonia inhibits the progression of experimental asthma by altering CD4+T cell subsets

(2020) Yonglu Tian et al.   Scientific Reports

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

(2020) Canrong Wu et al.   Acta Pharmaceutica Sinica B

Insights on the Effects of Resveratrol and Some of Its Derivatives in Cancer and Autoimmunity: A Molecule with a Dual Activity

(2020) Elena Gianchecchi et al.   Antioxidants

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

(2020) Francesca Coperchini et al.   CYTOKINE & GROWTH FACTOR REVIEWS

SARS-COV-2 infection in children and newborns: a systematic review

(2020) Ilaria Liguoro et al.   EUROPEAN JOURNAL OF PEDIATRICS

Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)

(2020) Anatoly Skalny et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study

(2020) Sourav Das et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Stilbene-based natural compounds as promising drug candidates against COVID-19

(2020) Hussain Mustatab Wahedi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Potential Role of Zinc Supplementation in Prophylaxis and Treatment of COVID-19

(2020) Amit Kumar et al.   MEDICAL HYPOTHESES

Three Novel Prevention, Diagnostic and Treatment Options for COVID-19 Urgently Necessitating Controlled Randomized Trials

(2020) Richard I. Horowitz et al.   MEDICAL HYPOTHESES

Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses

(2020) Chae Hyun Kim et al.   MOLECULES

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Infection in Children

(2020) Xiaoxia Lu et al.   NEW ENGLAND JOURNAL OF MEDICINE

15-Epi-LXA4and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation

(2020) Meriem Sekheri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of the Mediterranean Diet on 25-Hydroxyvitamin D Levels in Adults

(2020) Luigi Barrea et al.   Nutrients

25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2

(2020) Antonio D’Avolio et al.   Nutrients

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

(2020) William B. Grant et al.   Nutrients

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents

(2020) Riccardo Castagnoli et al.   JAMA Pediatrics

COVID-19 cytokine storm: the interplay between inflammation and coagulation

(2020) Ricardo J Jose et al.   Lancet Respiratory Medicine

Treatment for severe acute respiratory distress syndrome from COVID-19

(2020) Michael A Matthay et al.   Lancet Respiratory Medicine

Probiotics, Prebiotics, Synbiotics, Postbiotics, and Obesity: Current Evidence, Controversies, and Perspectives

(2020) Natalia Vallianou et al.   Current Obesity Reports

Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic

(2020) David Baud et al.   Frontiers in Public Health

Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic

(2020) Amin Gasmi et al.   CLINICAL IMMUNOLOGY

Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation

(2020) Elena Campione et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phytotherapeutics and SARS-CoV-2 infection: Potential role of bioflavonoids

(2020) Maurizio Coppola et al.   MEDICAL HYPOTHESES

Early nutritional supplementation in non-critically ill patients hospitalized for the 2019 novel coronavirus disease (COVID-19): Rationale and feasibility of a shared pragmatic protocol

(2020) Riccardo Caccialanza et al.   NUTRITION

Vitamin K deficiency and covid-19

(2020) Emanuela Anastasi et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Natural product-derived phytochemicals as potential agents against coronaviruses: A review

(2020) Janice S. Mani et al.   VIRUS RESEARCH

Intravenous high-dose vitamin C for the treatment of severe COVID-19: study protocol for a multicentre randomised controlled trial

(2020) Fang Liu et al.   BMJ Open

Probiotics and COVID-19

(2020) Eric Giannoni et al.   Lancet Gastroenterology & Hepatology

Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits

(2020) Paolo Bellavite et al.   Antioxidants

Vitamin K metabolism as the potential missing link between lung damage and thromboembolism in Coronavirus disease 2019

(2020) Rob Janssen et al.   BRITISH JOURNAL OF NUTRITION

Roles of flavonoids against coronavirus infection

(2020) Maria Russo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

“Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”

(2020) Marta Entrenas Castillo et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

(2020) Rubens Cecchini et al.   MEDICAL HYPOTHESES

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

(2020) Kelly S. Swanson et al.   Nature Reviews Gastroenterology & Hepatology

A role for quercetin in coronavirus disease 2019 (COVID‐19)

(2020) Giuseppe Derosa et al.   PHYTOTHERAPY RESEARCH

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

(2020) David Olagnier et al.   Nature Communications

Effective Immune Functions of Micronutrients against SARS-CoV-2

(2020) Kashaf Junaid et al.   Nutrients

The Role of Micronutrients in Support of the Immune Response against Viral Infections

(2020) Francesco Pecora et al.   Nutrients

A Possible Application of High Dose Vitamin C in the Prevention and Therapy for Coronavirus Infections

(2020) Ba X. Hoang et al.   Journal of Global Antimicrobial Resistance

Flattening the Risk: Pre-Exposure Prophylaxis for COVID-19

(2020) Raphael B Stricker et al.   Infection and Drug Resistance

Curcumin (a constituent of turmeric): New treatment option against COVID‐19

(2020) Fatemeh Babaei et al.   Food Science & Nutrition

Alveolar epithelial cell type II as main target of SARS-CoV-2 virus and COVID-19 development via NF-Kb pathway deregulation: A physio-pathological theory

(2020) Maurizio Carcaterra et al.   MEDICAL HYPOTHESES

Resveratrol inhibits the replication of severe acute respiratory syndrome coronavirus 2 ( SARS‐CoV ‐2) in cultured Vero cells

(2020) Minghui Yang et al.   PHYTOTHERAPY RESEARCH

Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers

(2020) Anshul Jain et al.   Scientific Reports

NF-κB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients

(2020) Ralf Kircheis et al.   Frontiers in Immunology

COVID-19 Pneumonia in Children: From Etiology to Management

(2020) Giuseppe Fabio Parisi et al.   Frontiers in Pediatrics

Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications

(2020) Mahdie Rahban et al.   Antioxidants

Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology

(2019) Daniella M. Schwartz et al.   IMMUNITY

Vitamin D protects against particles-caused lung injury through induction of autophagy in an Nrf2-dependent manner

(2019) Shasha Tao et al.   ENVIRONMENTAL TOXICOLOGY

Measles

(2019) Peter M. Strebel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lower Airway Microbiota

(2019) Giulio Pulvirenti et al.   Frontiers in Pediatrics

Saccharomyces cerevisiae Sepsis Following Probiotic Therapy in an Infant

(2019) Sanchari Chakravarty et al.   INDIAN PEDIATRICS

RvD1 ameliorates LPS-induced acute lung injury via the suppression of neutrophil infiltration by reducing CXCL2 expression and release from resident alveolar macrophages

(2019) Hua-Wei Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effects of Omega-3 Fatty Acids on Immune Cells

(2019) Saray Gutiérrez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

(2019) Dorota Skrajnowska et al.   Nutrients

Vitamin C: One compound, several uses. Advances for delivery, efficiency and stability

(2019) Amanda Costa Caritá et al.   Nanomedicine-Nanotechnology Biology and Medicine

Specialized Pro-resolving Mediators Regulate Alveolar Fluid Clearance during Acute Respiratory Distress Syndrome

(2018) Sheng-Wei Jin et al.   CHINESE MEDICAL JOURNAL

Role of Vitamin A in the Immune System

(2018) Zhiyi Huang et al.   Journal of Clinical Medicine

Effect of Vitamin D supplementation to reduce respiratory infections in children and adolescents in Vietnam: A randomized controlled trial

(2018) Mark Loeb et al.   Influenza and Other Respiratory Viruses

Beneficial effects of ascorbic acid to treat lung fibrosis induced by paraquat

(2018) Marcia Rodrigues da Silva et al.   PLoS One

Immune Function and Micronutrient Requirements Change over the Life Course

(2018) Silvia Maggini et al.   Nutrients

A Comprehensive Review of Chemistry, Sources and Bioavailability of Omega-3 Fatty Acids

(2018) Mateusz Cholewski et al.   Nutrients

Vitamin K deficiency in critical ill patients; a prospective observational study

(2018) Sofia Dahlberg et al.   JOURNAL OF CRITICAL CARE

Generation of allo-antigen-specific induced Treg stabilized by vitamin C treatment and its application for prevention of acute graft versus host disease model

(2017) Hidenori Kasahara et al.   INTERNATIONAL IMMUNOLOGY

Interventions to prevent respiratory diseases - Nutrition and the developing world

(2017) Tasneem Karim et al.   Paediatric Respiratory Reviews

Reactive oxygen species as signaling molecules in the development of lung fibrosis

(2017) Francisco J. Gonzalez-Gonzalez et al.   Translational Research

Zinc as a Gatekeeper of Immune Function

(2017) et al.   Nutrients

Vitamin C and Immune Function

(2017) Anitra Carr et al.   Nutrients

Zinc deficiency as a codeterminant for airway epithelial barrier dysfunction in an ex vivo model of COPD

(2017) Eugene Roscioli et al.   International Journal of Chronic Obstructive Pulmonary Disease

Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus

(2017) Silvia Tejada et al.   CURRENT MEDICINAL CHEMISTRY

Intracellular ascorbate tightens the endothelial permeability barrier through Epac1 and the tubulin cytoskeleton

(2016) William H. Parker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Effect of Nutritional Supplementation on Growth in Short and Lean Prepubertal Children after 1 Year of Intervention

(2016) Michal Yackobovitch-Gavan et al.   JOURNAL OF PEDIATRICS

Nutrition in Children and Adolescents

(2016) Mark R. Corkins et al.   MEDICAL CLINICS OF NORTH AMERICA

Dietary supplements and disease prevention — a global overview

(2016) Susanne Rautiainen et al.   Nature Reviews Endocrinology

Fish Oil–Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring

(2016) Hans Bisgaard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Quercetin, Inflammation and Immunity

(2016) Yao Li et al.   Nutrients

Antiviral activities of whey proteins

(2015) Tzi Bun Ng et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Vitamin D cell signalling in health and disease

(2015) Michael J. Berridge   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

(2015) Charles N. Serhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Brief Journey through the Immune System

(2015) K. M. Yatim et al.   Clinical Journal of the American Society of Nephrology

Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy

(2015) Mirelle J.A.J. Huijskens et al.   CYTOTHERAPY

Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry

(2015) Wenjiao Wu et al.   Viruses-Basel

Modulation of the Immune Response to Respiratory Viruses by Vitamin D

(2015) Claire Greiller et al.   Nutrients

A New Mechanism of Vitamin C Effects on A/FM/1/47(H1N1) Virus-Induced Pneumonia in Restraint-Stressed Mice

(2015) Ying Cai et al.   Biomed Research International

Comparative effect of fucoxanthin and vitamin C on oxidative and functional parameters of human lymphocytes

(2014) Nathalia Molina et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lactoferrin for prevention of common viral infections

(2014) Hiroyuki Wakabayashi et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Effects of Growing-Up Milk Supplemented With Prebiotics and LCPUFAs on Infections in Young Children

(2014) Pantipa Chatchatee et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Vitamin D Deficiency and Acute Lower Respiratory Infections in Children Younger Than 5 Years: Identification and Treatment

(2014) Allison Larkin et al.   Journal of Pediatric Health Care

Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages

(2014) Yuanyuan Chen et al.   MEDIATORS OF INFLAMMATION

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

(2014) Hamideh Parhiz et al.   PHYTOTHERAPY RESEARCH

Evaluating the bioactive effects of flavonoid hesperidin: A new literature data survey

(2014) Vesna Kuntic et al.   Vojnosanitetski Pregled

A dual character of flavonoids in influenza A virus replication and spread through modulating cell-autonomous immunity by MAPK signaling pathways

(2014) Wenjuan Dong et al.   Scientific Reports

Attenuation of Sepsis-Induced Organ Injury in Mice by Vitamin C

(2013) Bernard J. Fisher et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Vitamin A supplementation every 6 months with retinol in 1 million pre-school children in north India: DEVTA, a cluster-randomised trial

(2013) Shally Awasthi et al.   LANCET

Probiotics, Prebiotics and Immunomodulation of Gut Mucosal Defences: Homeostasis and Immunopathology

(2013) Holly Hardy et al.   Nutrients

Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection

(2013) Yejin Kim et al.   Immune Network

Role of Carbon Monoxide in Vascular Diseases

(2012) Ignazio Barbagallo et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Prevention of influenza in healthy children

(2012) Bruce Y Lee et al.   Expert Review of Anti-Infective Therapy

Respiratory hospitalisation of infants supplemented with docosahexaenoic acid as preterm neonates

(2012) Kerryn Atwell et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Impact of vitamin A supplementation on infant and childhood mortality

(2011) Aamer Imdad et al.   BMC PUBLIC HEALTH

A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury*

(2011) Renee D. Stapleton et al.   CRITICAL CARE MEDICINE

The effect of a 1-year multiple micronutrient or n-3 fatty acid fortified food intervention on morbidity in Indian school children

(2011) T Thomas et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury

(2011) Todd W. Rice   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory Stress Response to a High-Fat, High-Carbohydrate Meal

(2011) Husam Ghanim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prenatal Docosahexaenoic Acid Supplementation and Infant Morbidity: Randomized Controlled Trial

(2011) B. Imhoff-Kunsch et al.   PEDIATRICS

Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

(2011) Jianshe Lang et al.   PLoS One

Microbiota regulates immune defense against respiratory tract influenza A virus infection

(2011) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

(2010) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Zinc Increases Ciliary Beat Frequency in a Calcium-Dependent Manner

(2010) Bradford A. Woodworth et al.   American Journal of Rhinology & Allergy

Cellular pathways for transport and efflux of ascorbate and dehydroascorbate

(2010) Alessandro Corti et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Vitamin D: modulator of the immune system

(2010) Femke Baeke et al.   CURRENT OPINION IN PHARMACOLOGY

Vitamin a supplementation for prophylaxis or therapy in childhood pneumonia: A systematic review of randomized controlled trials

(2010) Joseph L. Mathew   INDIAN PEDIATRICS

Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Prevention and Management of Infections by Probiotics

(2010) Danielle Wolvers et al.   JOURNAL OF NUTRITION

Vitamin D controls T cell antigen receptor signaling and activation of human T cells

(2010) Marina Rode von Essen et al.   NATURE IMMUNOLOGY

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

(2010) Aartjan J. W. te Velthuis et al.   PLoS Pathogens

Glucosyl Hesperidin Prevents Influenza A Virus Replication in Vitro by Inhibition of Viral Sialidase

(2009) Repon Kumer Saha et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication

(2009) Hwa Jung Choi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Resveratrol exhibits a strong cytotoxic activity in cultured cells and has an antiviral action against polyomavirus: potential clinical use

(2009) Valerio Berardi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases

(2008) Artemis P. Simopoulos   EXPERIMENTAL BIOLOGY AND MEDICINE

Resveratrol ameliorates Serratia marcescens-induced acute pneumonia in rats

(2008) C.-C. Lu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fish Oil N-3 Polyunsaturated Fatty Acids Selectively Affect Plasma Cytokines and Decrease Illness in Thai Schoolchildren: A Randomized, Double-Blind, Placebo-Controlled Intervention Trial

(2008) Alice Thienprasert et al.   JOURNAL OF PEDIATRICS

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

(2007) Aruna Kode et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY