Article
Biochemistry & Molecular Biology
Yue Wu, Zhongting Zhao, Naidi Yang, Chenqi Xin, Zheng Li, Jiajia Xu, Bo Ma, Kah-Leong Lim, Lin Li, Qiong Wu, Changmin Yu, Chengwu Zhang
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the midbrain. Oxidative stress is believed to be the main cause of PD, and antioxidants have shown potential for its treatment. The study investigated the effects of vitamin B12 (VB12) supplementation in cellular and animal models of PD, and found that VB12 reduced reactive oxygen species (ROS) generation, improved motor dysfunction, and protected against mitochondrial dysfunction and dopaminergic neuron loss. These findings suggest that vitamin supplementation may be a safer and more feasible approach for PD intervention compared to chemical drug treatment.
Article
Nutrition & Dietetics
Antonia Pignolo, Sergio Mastrilli, Chiara Davi, Valentina Arnao, Paolo Aridon, Felipe Augusto dos Santos Mendes, Cesare Gagliardo, Marco D'Amelio
Summary: Vitamin D plays a crucial role in bone metabolism, calcium and phosphorous homeostasis, as well as brain development and neuroprotection. Patients with Parkinson's disease often have a high frequency of vitamin D deficiency, which may be related to disease severity and progression. However, the evidence regarding the use of vitamin D supplementation to reduce symptoms and disability in patients with Parkinson's disease is limited. Further clinical studies are needed to confirm the potential benefits and risks of vitamin D supplementation in this population.
Article
Biochemistry & Molecular Biology
Andy Wai Kan Yeung, Nikolay T. Tzvetkov, Maya G. Georgieva, Iliyan V. Ognyanov, Karolina Kordos, Artur Jozwik, Toni Kuhl, George Perry, Maria Cristina Petralia, Emanuela Mazzon, Atanas G. Atanasov
Summary: This research analyzed the literature on neurodegenerative diseases associated with ROS, identifying the US as the major contributor, the 21st century as the main publication time, and China, South Korea, and India as emerging major contributors. The study primarily focused on diseases such as AD, PD, and ALS, with future research directions emphasizing mitochondrial dysfunction, autophagy, and nuclear factor 2 related factor 2.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Jung Sun Park, Taeyeon Kim, Dohoon Kim, Young-IL Jeong
Summary: This study aimed to fabricate ROS-sensitive nanoparticles for Alzheimer's disease treatment, demonstrating their efficient brain targeting and significant suppression of NMDAR1 protein expression while alleviating cellular oxidative stress. The nanoparticles showed rapid memantine release in response to H2O2 and were able to mitigate H2O2-induced NMDAR1 upregulation, indicating their potential application in Alzheimer's disease therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Bosong Zhang, Yufang Zhao, Kai Guo, Hui Tian, Cao Wang, Ruiqi Wang, Yue Chen, Xiongbiao Chen, Hongxia Zheng, Bingxin Gao, Jieyi Shen, Weiming Tian
Summary: Prevention and early intervention are crucial in treating Alzheimer's disease (AD). This study investigates the use of nanoparticles composed of resveratrol and oligomeric proanthocyanidin grafted with hyaluronic acid to address the issue of ROS accumulation in early AD. The results demonstrate that these nanoparticles are effective in scavenging ROS, reducing brain inflammation, and improving cognitive function in AD mice.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Neurosciences
Michela Barichella, Federica Garri, Serena Caronni, Carlotta Bolliri, Luciano Zocchi, Maria Carmela Macchione, Valentina Ferri, Daniela Calandrella, Gianni Pezzoli
Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor symptoms and various non-motor symptoms. Recent research has suggested a potential correlation between vitamin D and Parkinson's disease, although the mechanisms and efficacy are still unclear.
Article
Neurosciences
Samanta Mazzetti, Michela Barichella, Federica Giampietro, Angelica Giana, Alessandra M. Calogero, Alida Amadeo, Nicola Palazzi, Alessandro Comincini, Giorgio Giaccone, Manuela Bramerio, Serena Caronni, Viviana Cereda, Emanuele Cereda, Graziella Cappelletti, Chiara Rolando, Gianni Pezzoli
Summary: This study found a specific subpopulation of astrocytes in the brains of Parkinson's disease (PD) patients, which can protect neurons by sequestering alpha-Synuclein oligomers and are associated with Lewy body negative neurons. These findings suggest the potential neuroprotective role of the vitamin D pathway in neurodegenerative diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Yu-Jung Cheng, Chieh-Hsin Lin, Hsien-Yuan Lane
Summary: Recent studies have shown the association of d-amino acids, especially d-serine, with brain and neurological disorders, affecting neurotransmission and learning and memory functions through NMDARs modulation. Aberrant levels of d-amino acids and gene polymorphisms related to d-amino acid metabolism are linked to neurodegenerative brain conditions. The roles of d-amino acids and pLG72 in schizophrenia and Alzheimer's disease, as well as their diagnostic and therapeutic value, are reviewed in this study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lixin Wang, Ehsan Sadeghnezhad, Pingyin Guan, Peijie Gong
Summary: The text discusses the significance of calcium and ROS in signal transductions, as well as the role of microtubules in this process. When it comes to cold sensing, balancing the crosstalk between calcium, microtubules, and ROS poses a challenge.
Article
Biochemistry & Molecular Biology
Hironori Mizutani, Yoshifumi Sato, Masaya Yamazaki, Tatsuya Yoshizawa, Yukio Ando, Mitsuharu Ueda, Kazuya Yamagata
Summary: This study found that the expression of SIRT7 is increased in the brain of Alzheimer's disease patients. Treatment with A beta(42) increased the expression of NOX4, leading to the production of reactive oxygen species (ROS) and apoptosis. Knockdown of SIRT7 inhibited A beta(42)-induced ROS production and apoptosis by suppressing the upregulation of NOX4. These findings suggest that inhibiting SIRT7 may be beneficial in the pathogenesis of AD by regulating ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Eleonora Dzoljic, Marija Saric Matutinovic, Oliver Stojkovic, Jelena Velickovic, Neda Milinkovic, Vladimir Kostic, Svetlana Ignjatovic
Summary: The findings of this study confirm a significant relationship between hypovitaminosis D and Parkinson's disease. The study demonstrates a higher prevalence of vitamin D deficiency in Parkinson's disease patients and its potential to predict the onset and progression of the disease.
Review
Pharmacology & Pharmacy
Tapan Behl, Arpita Arora, Rajeev K. Singla, Aayush Sehgal, Hafiz A. Makeen, Mohammed Albratty, Abdulkarim M. Meraya, Asim Najmi, Simona Gabriela Bungau
Summary: Parkinson's disease is a common neurological disorder in older adults, and vitamin D plays a crucial role in its pathogenesis. Lower serum concentrations of vitamin D are associated with the disease. Supplementation with vitamin D can slow down symptom progression, improve cognition, and reduce the risk of fractures.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Samir Kumar Beura, Rishika Dhapola, Abhishek Ramachandra Panigrahi, Pooja Yadav, Dibbanti Harikrishna Reddy, Sunil Kumar Singh
Summary: Alzheimer's disease, a common neurodegenerative disorder, is associated with platelet hyperactivity and ROS generation, which may contribute to disease progression.
Article
Neurosciences
Yan Peng, Li Zhang, Fanlin Zhou, Yangyang Wang, Xiong Zhang, Jianing Fan, Shijie Li, Xiaoju Li, Yu Li
Summary: This study reveals that impaired glucose uptake in Alzheimer's disease is caused by the decreased expression of GLUT1. Scavenging ROS with NAC and activating Akt with SC79 can restore glucose uptake.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Arif Andra, Shoko Tanigawa, Tomohiro Bito, Atsushi Ishihara, Fumio Watanabe, Yukinori Yabuta
Summary: The study showed that B-12 deficiency accelerates Aβ-related paralysis in C. elegans models, while AsA-2G can rescue this paralysis phenotype. However, AsA-2G has no effect on the aggregation of Aβ peptides.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)