Impact of Microbial Metabolites on Microbiota–Gut–Brain Axis in Inflammatory Bowel Disease

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

(2020) Aonghus Lavelle et al.   Nature Reviews Gastroenterology & Hepatology

Microbial imbalance in inflammatory bowel disease patients at different taxonomic levels

(2020) Mohammad Tauqeer Alam et al.   Gut Pathogens

Homeoprotein OTX1 and OTX2 involvement in rat myenteric neuron adaptation after DNBS-induced colitis

(2020) Michela Bistoletti et al.   PeerJ

Involvement of Enteric Glia in Small Intestine Neuromuscular Dysfunction of Toll-Like Receptor 4-Deficient Mice

(2020) Silvia Cerantola et al.   Cells

Microbiota-gut-brain axis and its affect inflammatory bowel disease: Pathophysiological concepts and insights for clinicians

(2020) Emanuele Sinagra et al.   World Journal of Clinical Cases

A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood

(2020) Eloisa Salvo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Co-evolution and Co-speciation of Host-Gut Bacteria Systems

(2020) Mathieu Groussin et al.   Cell Host & Microbe

Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial

(2020) Boushra Dalile et al.   NEUROPSYCHOPHARMACOLOGY

Involvement of hyaluronan in the adaptive changes of the rat small intestine neuromuscular function after ischemia/reperfusion injury

(2020) Michela Bistoletti et al.   Scientific Reports

Genetic variation in the farnesoid X-receptor predicts Crohn’s disease severity in female patients

(2020) Aze Wilson et al.   Scientific Reports

Luminal microbiota related to Crohn’s disease recurrence after surgery

(2020) Amy L. Hamilton et al.   Gut Microbes

Bile Acids: A Communication Channel in the Gut-Brain Axis

(2020) Vera F. Monteiro-Cardoso et al.   NEUROMOLECULAR MEDICINE

Variant-to-gene-mapping analyses reveal a role for the hypothalamus in genetic susceptibility to inflammatory bowel disease

(2020) Chiara Lasconi et al.   Cellular and Molecular Gastroenterology and Hepatology

The gut–brain axis in irritable bowel syndrome and inflammatory bowel disease

(2020) Angela Ancona et al.   DIGESTIVE AND LIVER DISEASE

Oxidized phospholipids affect small intestine neuromuscular transmission and serotonergic pathways in juvenile mice

(2020) Ilaria Marsilio et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Update of Probiotics in Human World: A Nonstop Source of Benefactions till the End of Time

(2020) Mohamed Zommiti et al.   Microorganisms

Anxiety But Not Depression Predicts Poor Outcomes in Inflammatory Bowel Disease

(2019) Neeraj Narula et al.   INFLAMMATORY BOWEL DISEASES

Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis

(2019) Samuel P. Costello et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice

(2019) Michela Bistoletti et al.   PLoS One

Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis

(2019) Andreina Baj et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interleukin-23 Blockers: Born to be First-line Biologic Agents in Inflammatory Bowel Disease?

(2019) Marjorie C. Argollo et al.   CURRENT PHARMACEUTICAL DESIGN

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

(2019) Jason Lloyd-Price et al.   NATURE

The role of short-chain fatty acids in microbiota–gut–brain communication

(2019) Boushra Dalile et al.   Nature Reviews Gastroenterology & Hepatology

Marine Toxins and Nociception: Potential Therapeutic Use in the Treatment of Visceral Pain Associated with Gastrointestinal Disorders

(2019) Andreina Baj et al.   Toxins

The Opposite Effects of Kynurenic Acid and Different Kynurenic Acid Analogs on Tumor Necrosis Factor-α (TNF-α) Production and Tumor Necrosis Factor-Stimulated Gene-6 (TSG-6) Expression

(2019) Yvette Mándi et al.   Frontiers in Immunology

New Approaches to Microbiome-Based Therapies

(2019) Andrea C. Wong et al.   mSystems

Inflammatory Bowel Disease: A Stressed “Gut/Feeling”

(2019) Yvonne Oligschlaeger et al.   Cells

Pain regulation by gut microbiota: molecular mechanisms and therapeutic potential

(2019) Ran Guo et al.   BRITISH JOURNAL OF ANAESTHESIA

Manipulating resident microbiota to enhance regulatory immune function to treat inflammatory bowel diseases

(2019) Yoshiyuki Mishima et al.   JOURNAL OF GASTROENTEROLOGY

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

The influence of the brain–gut axis in inflammatory bowel disease and possible implications for treatment

(2019) David J Gracie et al.   Lancet Gastroenterology & Hepatology

Antibiotic effects on gut microbiota, metabolism, and beyond

(2019) Chunlong Mu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Microbiota: a novel regulator of pain

(2019) Manon Defaye et al.   JOURNAL OF NEURAL TRANSMISSION

Effect of Enterococcus faecalis 2001 on colitis and depressive-like behavior in dextran sulfate sodium-treated mice: involvement of the brain–gut axis

(2019) Kohei Takahashi et al.   Journal of Neuroinflammation

Gut Microbiota and Obesity: A Role for Probiotics

(2019) Ludovico Abenavoli et al.   Nutrients

Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial

(2019) Selina R. Cox et al.   GASTROENTEROLOGY

Differences in Gut Microbiota in Patients With vs Without Inflammatory Bowel Diseases: A Systematic Review

(2019) Rapat Pittayanon et al.   GASTROENTEROLOGY

Stress and the brain-gut axis in functional and chronic-inflammatory gastrointestinal diseases: A transdisciplinary challenge

(2019) Alexandra Labanski et al.   PSYCHONEUROENDOCRINOLOGY

Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor

(2018) Erica E. Alexeev et al.   AMERICAN JOURNAL OF PATHOLOGY

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Oral sodium butyrate impacts brain metabolism and hippocampal neurogenesis, with limited effects on gut anatomy and function in pigs

(2018) David Val-Laillet et al.   FASEB JOURNAL

Bi-directionality of Brain–Gut Interactions in Patients With Inflammatory Bowel Disease

(2018) David J. Gracie et al.   GASTROENTEROLOGY

Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis

(2018) M Anthony Sofia et al.   INFLAMMATORY BOWEL DISEASES

Antibiotics in IBD: Still a Role in the Biological Era?

(2018) Oren Ledder et al.   INFLAMMATORY BOWEL DISEASES

A meta-analysis of the use of probiotics to alleviate depressive symptoms

(2018) Qin Xiang Ng et al.   JOURNAL OF AFFECTIVE DISORDERS

Insights into Roseburia intestinalis which alleviates experimental colitis pathology by inducing anti-inflammatory responses

(2018) Zhaohua Shen et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Abdominal Vagal Afferents Modulate the Brain Transcriptome and Behaviors Relevant to Schizophrenia

(2018) Melanie Klarer et al.   JOURNAL OF NEUROSCIENCE

Mitochondria, Oxidative Stress and the Kynurenine System, with a Focus on Ageing and Neuroprotection

(2018) Katalin Sas et al.   MOLECULES

Evidence for interplay among antibacterial-induced gut microbiota disturbance, neuro-inflammation, and anxiety in mice

(2018) Hyo-Min Jang et al.   Mucosal Immunology

Urbanization and the gut microbiota in health and inflammatory bowel disease

(2018) Tao Zuo et al.   Nature Reviews Gastroenterology & Hepatology

Prolonged restraint stressor exposure in outbred CD-1 mice impacts microbiota, colonic inflammation, and short chain fatty acids

(2018) Ross M. Maltz et al.   PLoS One

Effects of Dietary Tryptophan Supplementation in the Acetic Acid-Induced Colitis Mouse Model

(2018) shuai chen et al.   Food & Function

Manipulation of intestinal dysbiosis by a bacterial mixture ameliorates loperamide-induced constipation in rats

(2018) Y. Deng et al.   Beneficial Microbes

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

(2018) Jing Gao et al.   Frontiers in Cellular and Infection Microbiology

The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis

(2018) Bruno Bonaz et al.   Frontiers in Neuroscience

Toll-like Receptors and Inflammatory Bowel Disease

(2018) Yue Lu et al.   Frontiers in Immunology

Making Sense of … the Microbiome in Psychiatry

(2018) Thomaz F S Bastiaanssen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Probiotics in Disease Prevention and Treatment

(2018) Yuying Liu et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations

(2018) Marcel van de Wouw et al.   JOURNAL OF PHYSIOLOGY-LONDON

Rapid gastrointestinal loss of Clostridial Clusters IV and XIVa in the ICU associates with an expansion of gut pathogens

(2018) Alexandra E. Livanos et al.   PLoS One

A gut-brain neural circuit for nutrient sensory transduction

(2018) Melanie Maya Kaelberer et al.   SCIENCE

Butyrate upregulates the TLR4 expression and the phosphorylation of MAPKs and NK‑κB in colon cancer cell in�vitro

(2018) Tengfei Xiao et al.   Oncology Letters

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Rebuilding the Gut Microbiota Ecosystem

(2018) Antonella Gagliardi et al.   International Journal of Environmental Research and Public Health

The Gut Microbiota in the Pathogenesis and Therapeutics of Inflammatory Bowel Disease

(2018) Tao Zuo et al.   Frontiers in Microbiology

Indole-3-Pyruvic Acid, an Aryl Hydrocarbon Receptor Activator, Suppresses Experimental Colitis in Mice

(2018) Reiji Aoki et al.   JOURNAL OF IMMUNOLOGY

Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches

(2017) R. Balfour Sartor et al.   GASTROENTEROLOGY

Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome

(2017) Giles Major et al.   GASTROENTEROLOGY

Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases

(2017) Susanna Nikolaus et al.   GASTROENTEROLOGY

Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway

(2017) Qimeng Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Interactions between the Kynurenine and the Endocannabinoid System with Special Emphasis on Migraine

(2017) Gábor Nagy-Grócz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Butyrate restores HFD-induced adaptations in brain function and metabolism in mid-adult obese mice

(2017) I A C Arnoldussen et al.   INTERNATIONAL JOURNAL OF OBESITY

Fermentable Carbohydrates [FODMAPs] Exacerbate Functional Gastrointestinal Symptoms in Patients With Inflammatory Bowel Disease: A Randomised, Double-blind, Placebo-controlled, Cross-over, Re-challenge Trial

(2017) Selina R Cox et al.   Journal of Crohns & Colitis

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

(2017) Michele Biagioli et al.   JOURNAL OF IMMUNOLOGY

Exposure to a Social Stressor Induces Translocation of Commensal Lactobacilli to the Spleen and Priming of the Innate Immune System

(2017) William P. Lafuse et al.   JOURNAL OF IMMUNOLOGY

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial

(2017) Sudarshan Paramsothy et al.   LANCET

Gut microbiota and IBD: causation or correlation?

(2017) Josephine Ni et al.   Nature Reviews Gastroenterology & Hepatology

Kynurenine pathway metabolism and the microbiota-gut-brain axis

(2017) P.J. Kennedy et al.   NEUROPHARMACOLOGY

Tryptophan availability for kynurenine pathway metabolism across the life span: Control mechanisms and focus on aging, exercise, diet and nutritional supplements

(2017) Abdulla A-B. Badawy   NEUROPHARMACOLOGY

Kynurenine pathway metabolism and immune activation: Peripheral measurements in psychiatric and co-morbid conditions

(2017) Barbara Strasser et al.   NEUROPHARMACOLOGY

Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders

(2017) Katherine O'Farrell et al.   NEUROPHARMACOLOGY

Lactobacillus reuteriinduces gut intraepithelial CD4+CD8αα+T cells

(2017) Luisa Cervantes-Barragan et al.   SCIENCE

Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease

(2017) Natalia Pedersen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mycobacterium avium subsp. paratuberculosis and associated risk factors for inflammatory bowel disease in Iranian patients

(2017) Samin Zamani et al.   Gut Pathogens

Microbiota alteration is associated with the development of stress-induced despair behavior

(2017) Ioana A. Marin et al.   Scientific Reports

Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells

(2017) Urmi Roy et al.   Cell Reports

A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients

(2017) Andrew Brantley Hall et al.   Genome Medicine

The enteric nervous system promotes intestinal health by constraining microbiota composition

(2017) Annah S. Rolig et al.   PLOS BIOLOGY

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

(2017) Patrick Smith et al.   eLife

Functional Characterization of Novel Faecalibacterium prausnitzii Strains Isolated from Healthy Volunteers: A Step Forward in the Use of F. prausnitzii as a Next-Generation Probiotic

(2017) Rebeca Martín et al.   Frontiers in Microbiology

Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways

(2017) Valentina Caputi et al.   Frontiers in Pharmacology

The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Tract

(2017) Bruno Bonaz et al.   Frontiers in Immunology

Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism

(2017) Anna V. Golubeva et al.   EBioMedicine

Changes in hyaluronan deposition in the rat myenteric plexus after experimentally-induced colitis

(2017) Viviana Filpa et al.   Scientific Reports

Modulation of the microbiota-gut-brain axis by probiotics in a murine model of inflammatory bowel disease

(2016) Jacob R. Emge et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Memantine and Kynurenic Acid: Current Neuropharmacological Aspects

(2016) Zsófia Majláth et al.   Current Neuropharmacology

Fermentable Carbohydrate Restriction (Low FODMAP Diet) in Clinical Practice Improves Functional Gastrointestinal Symptoms in Patients with Inflammatory Bowel Disease

(2016) Alexis C. Prince et al.   INFLAMMATORY BOWEL DISEASES

Controversies Revisited

(2016) Antonina Mikocka-Walus et al.   INFLAMMATORY BOWEL DISEASES

Efficacy and safety of single fecal microbiota transplantation for Japanese patients with mild to moderately active ulcerative colitis

(2016) Atsushi Nishida et al.   JOURNAL OF GASTROENTEROLOGY

Short- and medium-chain fatty acids in energy metabolism: the cellular perspective

(2016) Peter Schönfeld et al.   JOURNAL OF LIPID RESEARCH

Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus

(2016) Alexandra K. Brooks et al.   Journal of Neuroinflammation

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

(2016) John R. Kelly et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Microbiota and neurologic diseases: potential effects of probiotics

(2016) Giulia Umbrello et al.   Journal of Translational Medicine

Increased Enterococcus faecalis infection is associated with clinically active Crohn disease

(2016) Youlian Zhou et al.   MEDICINE

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Role of glutamatergic neurotransmission in the enteric nervous system and brain-gut axis in health and disease

(2016) Viviana Filpa et al.   NEUROPHARMACOLOGY

Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes

(2016) F. Orhan et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice

(2016) Jeremy A. Goettel et al.   Cell Reports

The healthy human microbiome

(2016) Jason Lloyd-Price et al.   Genome Medicine

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Irritable bowel syndrome

(2016) Paul Enck et al.   Nature Reviews Disease Primers

Deviations in human gut microbiota: a novel diagnostic test for determining dysbiosis in patients with IBS or IBD

(2015) C. Casén et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Relationship Among Perceived Stress, Symptoms and Inflammation in Persons With Inflammatory Bowel Disease

(2015) Laura E Targownik et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A Rapid and Specific Method for the Detection of Indole in Complex Biological Samples

(2015) Charles Darkoh et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Purinergic signalling and development of the autonomic nervous system

(2015) Cristina Giaroni   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

(2015) S.M. O’Mahony et al.   BEHAVIOURAL BRAIN RESEARCH

Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions

(2015) Ashish Gurav et al.   BIOCHEMICAL JOURNAL

Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease

(2015) James D. Lewis et al.   Cell Host & Microbe

Role of indoleamine 2,3-dioxygenase in health and disease

(2015) Amanda W.S. Yeung et al.   CLINICAL SCIENCE

Stress and the Microbiota-Gut-Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome

(2015) Rachel D. Moloney et al.   CNS Neuroscience & Therapeutics

The role of IL-10 in microbiome-associated immune modulation and disease tolerance

(2015) Benoît Levast et al.   CYTOKINE

Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook

(2015) Colleen R. Kelly et al.   GASTROENTEROLOGY

Genome-wide Pathway Analysis Using Gene Expression Data of Colonic Mucosa in Patients with Inflammatory Bowel Disease

(2015) Orazio Palmieri et al.   INFLAMMATORY BOWEL DISEASES

Beneficial Effects of Probiotics, Prebiotics, Synbiotics, and Psychobiotics in Inflammatory Bowel Disease

(2015) Andrzej Wasilewski et al.   INFLAMMATORY BOWEL DISEASES

The effects of a TGR5 agonist and a dipeptidyl peptidase IV inhibitor on dextran sulfate sodium-induced colitis in mice

(2015) Taisuke Sakanaka et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The TRPV1 channel in rodents is a major target for antinociceptive effect of the probioticLactobacillus reuteriDSM 17938

(2015) Azucena Perez-Burgos et al.   JOURNAL OF PHYSIOLOGY-LONDON

The gut microbiota modulates host amino acid and glutathione metabolism in mice

(2015) A. Mardinoglu et al.   Molecular Systems Biology

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

The gut microbiome restores intrinsic and extrinsic nerve function in germ-free mice accompanied by changes in calbindin

(2015) K. A. McVey Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder

(2015) Jonathan Savitz et al.   PSYCHONEUROENDOCRINOLOGY

Role of the normal gut microbiota

(2015) Sai Manasa Jandhyala   WORLD JOURNAL OF GASTROENTEROLOGY

Differential diagnosis in inflammatory bowel disease colitis: State of the art and future perspectives

(2015) Gian Eugenio Tontini   WORLD JOURNAL OF GASTROENTEROLOGY

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Inflammatory Bowel Disease in Children and Adolescents

(2015) Michael J. Rosen et al.   JAMA Pediatrics

Stress-Induced Visceral Pain: Toward Animal Models of Irritable-Bowel Syndrome and Associated Comorbidities

(2015) Rachel D. Moloney et al.   Frontiers in Psychiatry

Antibiotics Associated With Increased Risk of New-Onset Crohn’s Disease But Not Ulcerative Colitis: A Meta-Analysis

(2014) Ryan Ungaro et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

American College of Gastroenterology Monograph on the Management of Irritable Bowel Syndrome and Chronic Idiopathic Constipation

(2014) Alexander C Ford et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

(2014) Brigitta Stockinger et al.   Annual Review of Immunology

Gut microbiota of humans, dogs and cats: current knowledge and future opportunities and challenges

(2014) Ping Deng et al.   BRITISH JOURNAL OF NUTRITION

Rethinking “Enterotypes”

(2014) Dan Knights et al.   Cell Host & Microbe

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

(2014) Aleksandar D. Kostic et al.   GASTROENTEROLOGY

Brain–Gut Microbiome Interactions and Functional Bowel Disorders

(2014) Emeran A. Mayer et al.   GASTROENTEROLOGY

Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings

(2014) Charlotte R Hedin et al.   GUT

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Fecal microbiota transplantation as therapy for inflammatory bowel disease: A systematic review and meta-analysis

(2014) Ruben J. Colman et al.   Journal of Crohns & Colitis

Sodium Butyrate Prevents Memory Impairment by Re-establishing BDNF and GDNF Expression in Experimental Pneumococcal Meningitis

(2014) Tatiana Barichello et al.   MOLECULAR NEUROBIOLOGY

Neuroplasticity and dysfunction after gastrointestinal inflammation

(2014) Stuart M. Brierley et al.   Nature Reviews Gastroenterology & Hepatology

The link between negative affect, vagal tone, and visceral sensitivity in quiescent Crohn's disease

(2014) A. Rubio et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats

(2014) S.M. O’Mahony et al.   NEUROSCIENCE

Antagonism of Ionotropic Glutamate Receptors Attenuates Chemical Ischemia-Induced Injury in Rat Primary Cultured Myenteric Ganglia

(2014) Elisa Carpanese et al.   PLoS One

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota organization is a distinct feature of proximal colorectal cancers

(2014) Christine M. Dejea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut

(2014) S. A. Joyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota and neurodevelopmental windows: implications for brain disorders

(2014) Yuliya E. Borre et al.   TRENDS IN MOLECULAR MEDICINE

Neuroanatomy of lower gastrointestinal pain disorders

(2014) Wim Vermeulen   WORLD JOURNAL OF GASTROENTEROLOGY

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

The gut microbiota in mouse models of inflammatory bowel disease

(2014) Kalliopi K. Gkouskou et al.   Frontiers in Cellular and Infection Microbiology

Colonisation byFaecalibacterium prausnitziiand maintenance of clinical remission in patients with ulcerative colitis

(2013) E. Varela et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Temporal Bacterial Community Dynamics Vary Among Ulcerative Colitis Patients After Fecal Microbiota Transplantation

(2013) Sieglinde Angelberger et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain

(2013) Siobhain M. O’ Mahony et al.   BEHAVIOURAL BRAIN RESEARCH

Pleiotropic Roles of Bile Acids in Metabolism

(2013) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Transient Flare of Ulcerative Colitis After Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection

(2013) Lauren M. De Leon et al.   Clinical Gastroenterology and Hepatology

The dynamics of gut-associated microbial communities during inflammation

(2013) Sebastian E Winter et al.   EMBO REPORTS

Role of the enteric microbiota in intestinal homeostasis and inflammation

(2013) Iurii Koboziev et al.   FREE RADICAL BIOLOGY AND MEDICINE

Toll-Like Receptor 2 Regulates Intestinal Inflammation by Controlling Integrity of the Enteric Nervous System

(2013) Paola Brun et al.   GASTROENTEROLOGY

A decrease of the butyrate-producing speciesRoseburia hominisandFaecalibacterium prausnitziidefines dysbiosis in patients with ulcerative colitis

(2013) Kathleen Machiels et al.   GUT

AIEC pathobiont instigates chronic colitis in susceptible hosts by altering microbiota composition

(2013) Benoit Chassaing et al.   GUT

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

TGR5 signalling inhibits the production of pro-inflammatory cytokines byin vitrodifferentiated inflammatory and intestinal macrophages in Crohn's disease

(2013) Kazuaki Yoneno et al.   IMMUNOLOGY

Predictors of Depression in Youth With Crohn Disease

(2013) Jeffrey G. Clark et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Microbiota is essential for social development in the mouse

(2013) L Desbonnet et al.   MOLECULAR PSYCHIATRY

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Intestinal microbiota influence the early postnatal development of the enteric nervous system

(2013) J. Collins et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Quinolinic Acid: An Endogenous Neurotoxin with Multiple Targets

(2013) Rafael Lugo-Huitrón et al.   Oxidative Medicine and Cellular Longevity

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

(2013) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis

(2013) C. L. Zindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons

(2013) Yu-Kang Mao et al.   Nature Communications

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

Psychoactive bacteria Lactobacillus rhamnosus (JB-1) elicits rapid frequency facilitation in vagal afferents

(2012) Azucena Perez-Burgos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Stress-Induced Neuroinflammation: Role of the Toll-Like Receptor-4 Pathway

(2012) Iciar Gárate et al.   BIOLOGICAL PSYCHIATRY

Indoleamine 2,3 dioxygenase in intestinal disease

(2012) Matthew A. Ciorba   CURRENT OPINION IN GASTROENTEROLOGY

The biodiversity and composition of the dominant fecal microbiota in patients with inflammatory bowel disease

(2012) Sumei Sha et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Reduced Diversity and Imbalance of Fecal Microbiota in Patients with Ulcerative Colitis

(2012) Hideyuki Nemoto et al.   DIGESTIVE DISEASES AND SCIENCES

Indoleamine 2,3-dioxygenase expression in human inflammatory bowel disease

(2012) Liping Zhou et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Revisiting concepts of visceral nociception in irritable bowel syndrome

(2012) D. Keszthelyi et al.   EUROPEAN JOURNAL OF PAIN

N-methyl-d-aspartate receptor antagonist therapy suppresses colon motility and inflammatory activation six days after the onset of experimental colitis in rats

(2012) Dániel Érces et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Brain-Gut Interactions in Inflammatory Bowel Disease

(2012) Bruno L. Bonaz et al.   GASTROENTEROLOGY

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

IL-10R Polymorphisms Are Associated with Very-early-onset Ulcerative Colitis

(2012) Christopher J. Moran et al.   INFLAMMATORY BOWEL DISEASES

Decreased abundance ofFaecalibacterium prausnitziiin the gut microbiota of Crohn's disease

(2012) Takehide Fujimoto et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Colonic epithelial response to injury requires Myd88 signaling in myeloid cells

(2012) N P Malvin et al.   Mucosal Immunology

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

(2012) Tatsuo Hashimoto et al.   NATURE

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse

(2012) K. A. McVey Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Novel, Objective, Multivariate Biomarkers Composed of Plasma Amino Acid Profiles for the Diagnosis and Assessment of Inflammatory Bowel Disease

(2012) Tadakazu Hisamatsu et al.   PLoS One

Probiotic Bacteria Regulate Intestinal Epithelial Permeability in Experimental Ileitis by a TNF-Dependent Mechanism

(2012) Daniele Corridoni et al.   PLoS One

Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats

(2012) Afifa Ait-Belgnaoui et al.   PSYCHONEUROENDOCRINOLOGY

Meta-analysis of broad-spectrum antibiotic therapy in patients with active inflammatory bowel disease

(2012) SHENG-LAN WANG et al.   Experimental and Therapeutic Medicine

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

(2012) Namiko Hoshi et al.   Nature Communications

A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome

(2012) Gerard Clarke et al.   Frontiers in Pharmacology

High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease

(2011) Alan W Walker et al.   BMC MICROBIOLOGY

Effects of Bifidobacterium infantis 35624 on Post-Inflammatory Visceral Hypersensitivity in the Rat

(2011) Anthony C. Johnson et al.   DIGESTIVE DISEASES AND SCIENCES

Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract

(2011) Ivan Monteleone et al.   GASTROENTEROLOGY

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives

(2011) M. Joossens et al.   GUT

Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis

(2011) Takeyuki Takamura et al.   IMMUNOLOGY AND CELL BIOLOGY

Invasive potential of gut mucosa-derived fusobacterium nucleatum positively correlates with IBD status of the host

(2011) Jaclyn Strauss et al.   INFLAMMATORY BOWEL DISEASES

Serum Analysis of Tryptophan Catabolism Pathway: Correlation With Crohnʼs Disease Activity

(2011) Nitin K. Gupta et al.   INFLAMMATORY BOWEL DISEASES

Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway*

(2011) Vicky De Preter et al.   INFLAMMATORY BOWEL DISEASES

Kynurenines and intestinal neurotransmission: the role of N-methyl-d-aspartate receptors

(2011) József Kaszaki et al.   JOURNAL OF NEURAL TRANSMISSION

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

(2011) Jacob S Lee et al.   NATURE IMMUNOLOGY

Different inhibitory effects of kynurenic acid and a novel kynurenic acid analogue on tumour necrosis factor-α (TNF-α) production by mononuclear cells, HMGB1 production by monocytes and HNP1-3 secretion by neutrophils

(2011) Zoltán Tiszlavicz et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication

(2011) P. Bercik et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease

(2011) Rian M. Nijmeijer et al.   PLoS One

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

(2011) Sabrina Cipriani et al.   PLoS One

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress and animal models of inflammatory bowel disease—An update on the role of the hypothalamo–pituitary–adrenal axis

(2011) S.O. Reber   PSYCHONEUROENDOCRINOLOGY

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain?

(2011) Ellen S Pierce   Gut Pathogens

Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease

(2010) J. Meregnani et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Stress at the intestinal surface: catecholamines and mucosa–bacteria interactions

(2010) Mark Lyte et al.   CELL AND TISSUE RESEARCH

A Pathobiont of the Microbiota Balances Host Colonization and Intestinal Inflammation

(2010) Janet Chow et al.   Cell Host & Microbe

Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice

(2010) Premysl Bercik et al.   GASTROENTEROLOGY

TNF  is a key mediator of the pronociceptive effects of mucosal supernatant from human ulcerative colitis on colonic DRG neurons

(2010) C. Ibeakanma et al.   GUT

Highlighting new phylogenetic specificities of Crohnʼs disease microbiota

(2010) S. Mondot et al.   INFLAMMATORY BOWEL DISEASES

Real-Time Analysis of Mucosal Flora in Patients with Inflammatory Bowel Disease in India

(2010) R. Verma et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuroinflammation in inflammatory bowel disease

(2010) Shaheen E Lakhan et al.   Journal of Neuroinflammation

Protein kinase c modulates NMDA receptors in the myenteric plexus of the guinea pig ileum during in vitro ischemia and reperfusion

(2010) C. Giaroni et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat

(2010) D. P Mckernan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Gut Microbiota in Health and Disease

(2010) Inna Sekirov et al.   PHYSIOLOGICAL REVIEWS

Psychological Stress-Induced, IDO1-Dependent Tryptophan Catabolism: Implications on Immunosuppression in Mice and Humans

(2010) Cornelia Kiank et al.   PLoS One

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis

(2010) F. J. Quintana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

(2010) L. Dethlefsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal separation as a model of brain–gut axis dysfunction

(2010) Siobhain M. O’Mahony et al.   PSYCHOPHARMACOLOGY

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Loss of vagal anti-inflammatory effect: in vivo visualization and adoptive transfer

(2009) Caitlin O'Mahony et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Involvement of Ca2+-dependent PKCs in the adaptive changes of μ-opioid pathways to sympathetic denervation in the guinea pig colon

(2009) C. Giaroni et al.   BIOCHEMICAL PHARMACOLOGY

Interferon- -triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells

(2009) B. Jurgens et al.   BLOOD

The Role of Psychological Stress in Inflammatory Bowel Disease: Quality Assessment of Methods of 18 Prospective Studies and Suggestions for Future Research

(2009) Rafael J.A. Cámara et al.   DIGESTION

Molecular diversity of Escherichia coli in the human gut: New ecological evidence supporting the role of adherent-invasive E. coli (AIEC) in Crohnʼs disease

(2009) Margarita Martinez-Medina et al.   INFLAMMATORY BOWEL DISEASES

Pain and inflammatory bowel disease

(2009) Klaus Bielefeldt et al.   INFLAMMATORY BOWEL DISEASES

Low counts of Faecalibacterium prausnitzii in colitis microbiota

(2009) H. Sokol et al.   INFLAMMATORY BOWEL DISEASES

Lactobacillus reuterienhances excitability of colonic AH neurons by inhibiting calcium-dependent potassium channel opening

(2009) Wolfgang A. Kunze et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

(2009) Akihiro Kimura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

(2009) P. Vavassori et al.   JOURNAL OF IMMUNOLOGY

Principles and clinical implications of the brain–gut–enteric microbiota axis

(2009) Sang H. Rhee et al.   Nature Reviews Gastroenterology & Hepatology

Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function

(2009) d. keszthelyi et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Psychological adjustment and autonomic disturbances in inflammatory bowel diseases and irritable bowel syndrome

(2009) Sonia Pellissier et al.   PSYCHONEUROENDOCRINOLOGY

The Manitoba IBD Cohort Study: A Population-Based Study of the Prevalence of Lifetime and 12-Month Anxiety and Mood Disorders

(2008) John R. Walker et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Protective effects of Lactobacillus reuteri and Bifidobacterium infantis in murine models for colitis do not involve the vagus nerve

(2008) Hanneke van der Kleij et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Pathophysiological Mechanisms of Stress-Induced Intestina Damage

(2008) Melanie Gareau et al.   CURRENT MOLECULAR MEDICINE

Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohnʼs disease

(2008) Ben Willing et al.   INFLAMMATORY BOWEL DISEASES

Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression

(2008) Jean-Eric Ghia et al.   JOURNAL OF CLINICAL INVESTIGATION

The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat

(2008) Lieve Desbonnet et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA