Review
Biochemistry & Molecular Biology
Magdalena Kurnik-Lucka, Pawel Pasieka, Patrycja Laczak, Marcin Wojnarski, Michal Jurczyk, Krzysztof Gil
Summary: The dopaminergic system may play a significant role in inflammatory bowel disease, but its impact is currently underestimated. Further in-depth observational studies are needed to support this notion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Aybike Gizem Kayacan, Alper Tokay
Summary: The study found a significant relationship between chronotype and biochemical findings, nutrition intake, and gastrointestinal symptoms in patients with inflammatory bowel disease. Gender differences were observed in nutrition intake and chronotype. Chronotype is easy to determine and should be considered when evaluating nutrition and clinical status in patients with IBD.
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Irina Midenfjord, Cecilia Grinsvall, Peter Koj, Ida Carnerup, Hans Tornblom, Magnus Simren
Summary: Central sensitization was common in IBS and associated with GI symptom severity, but with stronger associations in chronic pain disorders and IBD. This suggests that other mechanisms may play a significant role in determining GI symptom severity in IBS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Nutrition & Dietetics
Catarina D. Simoes, Marta Maganinho, Ana S. Sousa
Summary: The low-FODMAP diet has shown promising results in the management of IBD, improving clinical outcomes and quality of life. However, there are concerns regarding the adequacy of the diet and its impact on the gut microbiota. Personalized and monitored nutrition interventions are important in IBD management.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Joana Franco Lacerda, Ana Catarina Lagos, Elisabete Carolino, Ana Santos Silva-Herdade, Manuel Silva, Catarina Sousa Guerreiro
Summary: The study aimed to evaluate the effect of food components on intestinal permeability and inflammatory markers in individuals with IBD. While the specific impact of food components was inconclusive, there was a trend observed in the reduction of inflammatory parameters and gastrointestinal symptom prevalence. More controlled intervention studies with diet plans including potentially beneficial food components for intestinal barrier integrity are warranted.
Review
Gastroenterology & Hepatology
William D. Chey, Laurie Keefer, Kevin Whelan, Peter R. Gibson
Summary: Irritable bowel syndrome (IBS) is a common condition that affects quality of life and costs healthcare systems billions of dollars annually. In addition to medication, behavioral techniques and dietary modifications are effective in treating IBS.
Review
Gastroenterology & Hepatology
J. Blackwell, S. Saxena, N. Jayasooriya, A. Bottle, I Petersen, M. Hotopf, C. Alexakis, R. C. Pollok
Summary: The study revealed a higher prevalence of gastrointestinal symptoms in patients diagnosed with IBD compared to the background population, potentially due to undiagnosed diseases. Patients with prior diagnoses of irritable bowel syndrome (IBS) or depression were less likely to receive timely specialist review. Enhanced pathways are needed to expedite specialist referrals and timely IBD diagnosis.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Nutrition & Dietetics
Woori Na, Yeji Lee, Hyeji Kim, Yong Sung Kim, Cheongmin Sohn
Summary: The study found that approximately 21.7% of Korean adults aged 20 to 40 had IBS, and the dietary intake and food consumption habits of these patients differed from those of non-IBS subjects. Increased intake of high-fat and high-gluten foods may lead to more IBS symptoms in Korean adults in their 20s to 40s.
Article
Multidisciplinary Sciences
Xin Gao, Yu Tang, Na Lei, Ying Luo, Pingrun Chen, Chang Liang, Shihao Duan, Yan Zhang
Summary: The study found that Chinese IBD patients have a 33.1% prevalence of symptoms of anxiety/depression, with differences between Crohn's disease and ulcerative colitis patients in terms of their impact on anxiety/depression, likely related to disease activity and surgical history.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Eileen Haring, Robert Zeiser, Petya Apostolova
Summary: Both graft-versus-host disease (GVHD) and inflammatory bowel disease (IBD) are immunologically mediated diseases of the intestine, sharing several key features in their onset and development including intestinal tissue damage and involvement of cytokines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Paulo Sergio Loubet Filho, Thais Otranto Dias, Vitoria Helena de Oliveira Teixeira Reis, Amanda Maria Tomazini Munhoz Moya, Elisvania Freitas dos Santos, Cinthia Bail Betim Cazarin
Summary: The incidence of inflammatory bowel diseases (IBD) has increased and its etiology remains unknown. Risk factors, including food intake, are associated with developing IBD. Functional foods (FF) can modulate the gut microbiota and improve the health quality of IBD patients.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nutrition & Dietetics
Wei-Qin Zhang, Ke-Yu Quan, Cui-Jiao Feng, Tao Zhang, Qiu-Wen He, Lai-Yu Kwok, Yong-Fu Chen
Summary: This study investigated the alleviation effect and mechanism of Lactobacillus gasseri G098 (G098) strain on dextran sodium sulfate (DSS)-induced colitis in mice. Results showed that G098 effectively reversed colitis-associated symptoms and prevented mortality induced by DSS. The administration of G098 improved serum cytokine balance and modulated gut microbiome, suggesting that strain treatment is a promising strategy for managing IBD.
Article
Gastroenterology & Hepatology
Berkeley N. Limketkai, Mohamed Hamideh, Rishabh Shah, Jenny S. Sauk, Nancee Jaffe
Summary: This study utilized machine learning methods to classify dietary patterns among individuals with inflammatory bowel disease with minimal bias, and evaluated the association between different diet clusters and symptoms activity.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Peter M. Irving, Krisztina B. Gecse
Summary: Therapeutic drug monitoring (TDM) is an optimization strategy in the treatment of inflammatory bowel diseases, aiming to achieve maximal treatment benefits by monitoring drug concentrations. There are variations in optimal drug concentrations based on treatment targets, disease phenotypes, inflammatory burden, and sampling timing. This review discusses the role of TDM in biologic and oral small molecule therapies, the differences between reactive and proactive TDM, and the areas where evidence is lacking. Future adaptations in TDM usage may contribute to personalized treatment for patients with IBD.
Article
Gastroenterology & Hepatology
Tim Raine, Holly Pavey, Wendi Qian, Gordon W. Moran, Sreedhar Subramanian, Lizzie Swaby, Simon P. L. Travis, Shahida Din, Peter M. Irving, James O. Lindsay, Miles Parkes, Nicholas A. Kennedy
Review
Gastroenterology & Hepatology
Sailish Honap, Susanna Meade, Ashley Spencer, Polychronis Pavlidis, Raphael P. Luber, Eduardo Calonje, Ellie Rashidghamat, Christopher B. Bunker, Fiona Lewis, Peter M. Irving
Summary: This systematic review provides a synthesis of epidemiology, clinical features, and treatment outcomes of anogenital Crohn's disease and granulomatosis. The predominant clinical features include edema, ulcers, fissures, and hypertrophic lesions, and the disease affects both adults and children similarly. Commonly prescribed treatments include antibiotics, corticosteroids, thiopurines, and anti-TNF therapy.
JOURNAL OF CROHNS & COLITIS
(2022)
Letter
Gastroenterology & Hepatology
Sailish Honap, Peter M. Irving, Mark A. Samaan
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Nutrition & Dietetics
Miranda C. E. Lomer, Bridgette Wilson, Catherine L. Wall
Summary: This study developed guidelines for the nutritional assessment and dietary management of inflammatory bowel disease (IBD) using a Delphi consensus method. The guidelines aim to improve equality of care for patients with IBD.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2023)
Article
Gastroenterology & Hepatology
Raphael P. Luber, Bianca Petri, Susanna Meade, Sailish Honap, Sebastian Zeki, Krisztina B. Gecse, Nyree Griffin, Peter M. Irving
Summary: The study showed that intestinal ultrasound (IUS) can be an effective alternative to lower gastrointestinal endoscopies (LGIEs) and magnetic resonance enterographies (MREs), with potential cost savings. There were no significant pathologies missed with IUS, and the limited pathology found in patients not suitable for IUS had limited clinical significance.
FRONTLINE GASTROENTEROLOGY
(2023)
Article
Nutrition & Dietetics
Alice C. C. Creedon, Estella S. S. Hung, Eirini Dimidi, Terri Grassby, Sarah E. E. Berry, Kevin Whelan
Summary: Almonds contain unsaturated lipids, which are beneficial for human health. The unique properties of almonds affect their particle size distribution after chewing, making it difficult for the body to fully digest the almond lipids. Commercial grinding of almonds into flour changes the particle size distribution and slightly increases the predicted bioaccessibility of lipids.
Article
Nutrition & Dietetics
Catherine L. Wall, Bridgette Wilson, Miranda C. E. Lomer
Summary: This study aimed to develop and validate an IBD-specific nutrition self-screening tool (IBD-NST) that identifies patients at nutrition risk. The final validated IBD-NST includes body mass index (BMI), weight loss and IBD-specific nutrition-focussed questions which were acceptable to patients.
FRONTIERS IN NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Bridgette Wilson, Tokuwa Kanno, Rachael Slater, Megan Rossi, Peter M. Irving, Miranda C. Lomer, Chris Probert, A. James Mason, Kevin Whelan
Summary: Baseline faecal and urine metabolites can predict response to the low FODMAP diet in patients with irritable bowel syndrome.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
James L. Alexander, Nicola J. Wyatt, Stephane Camuzeaux, Elena Chekmeneva, Beatriz Jimenez, Caroline J. Sands, Hannah Fuller, Panteleimon Takis, Tariq Ahmad, Jennifer A. Doyle, Ailsa Hart, Peter M. Irving, Nicholas A. Kennedy, Charlie W. Lees, James O. Lindsay, Rebecca E. McIntyre, Miles Parkes, Natalie J. Prescott, Tim Raine, Jack Satsangi, Richard Alexander Speight, Luke Jostins-Dean, Nick Powell, Julian R. Marchesi, Christopher J. Stewart, Christopher A. Lamb
Article
Nutrition & Dietetics
Eirini Dimidi, Katerina Belogianni, Kevin Whelan, Miranda C. E. Lomer
Summary: This study aimed to evaluate the effectiveness of a low FODMAP diet app. The results showed that using the app during FODMAP restriction can significantly reduce gut symptoms and help users detect dietary triggers for long-term self-management.
Article
Gastroenterology & Hepatology
Sailish Honap, Peter M. Irving, Mark A. Samaan
Summary: This study reveals that despite clinical practices appearing to align with international guidelines, a significant minority of healthcare providers remain deterred by safety concerns.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Eirini Dimidi, Alastair James McArthur, Rachel White, Kevin Whelan, Miranda C. E. Lomer
Summary: This study evaluated different education delivery methods of the low FODMAP diet in patients with disorders of gut-brain interaction (DGBI), and found that dietitian-led consultations had the highest level of clinical effectiveness, followed by the app, while the booklet group had the lowest effectiveness.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Multidisciplinary Sciences
Molly S. George, Jenifer Sanchez, Christina Rollings, David Fear, Peter Irving, Linda V. Sinclair, Anna Schurich
Summary: Long-term T cell dysregulation following COVID-19 disease is associated with disease severity and long-covid symptoms. Alterations in cellular origin and protein content of extracellular vesicles (EV) during COVID-19 convalescence are linked to initial disease severity. EV derived from convalescent donors can affect the function and metabolic rewiring of CD4 and CD8 T cells, with immune-suppressive properties observed in mild cases.