Review
Biochemistry & Molecular Biology
Montse Baldan-Martin, Maria Chaparro, Javier P. Gisbert
Summary: Inflammatory bowel diseases (IBDs) are chronic and inflammatory conditions affecting the gastrointestinal tract. Despite endoscopy being the gold standard test for assessing IBD, it is invasive and uncomfortable for patients. Therefore, non-invasive biomarkers for IBD diagnosis are urgently needed. This review summarizes proteomics and metabolomics studies in animals and humans, identifying urinary biomarkers for IBD diagnosis. Large-scale multi-omics studies with collaboration between clinicians, researchers, and industry are necessary for the development of sensitive and specific diagnostic biomarkers for personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Elisabetta Lolli, Elena De Cristofaro, Irene Marafini, Edoardo Troncone, Benedetto Neri, Francesca Zorzi, Livia Biancone, Emma Calabrese, Giovanni Monteleone
Summary: Patients with long-standing and extensive/left-sided colonic inflammatory bowel diseases (IBD) have a higher risk of developing colorectal cancer. Dye-based chromoendoscopy (DCE) is recommended for surveillance and prevention of colon cancer in these patients. This study identified polypoid lesions with specific morphologic features and size greater than 7 mm as frequently dysplastic/neoplastic and, therefore, should be removed.
Article
Gastroenterology & Hepatology
Filippos Koutroumpakis, Anna Evans Phillips, Dhiraj Yadav, Jorge D. Machicado, Maaz Ahsan, Claudia Ramos Rivers, Xiaoqing Tan, Marc Schwartz, Siobhan Proksell, Elyse Johnston, Jeffrey Dueker, Jana G. Hashash, Arthur Barrie, Janet Harrison, Michael A. Dunn, Liza Konnikova, Douglas J. Hartman, Hasieb Din, Dmitriy Babichenko, Gong Tang, David G. Binion
Summary: The study identified that IgG4 subclass deficiency is common in patients with IBD and associated with markers of disease severity. Treatment with intravenous Ig replacement therapy was beneficial in patients with IgG4-deficient severe IBD. Further research is needed to understand the mechanistic role of IgG4 deficiency in this subset of severe IBD patients.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Vibeke Andersen, Tue B. Bennike, Corinna Bang, John D. Rioux, Isabelle Hebert-Milette, Toshiro Sato, Axel K. Hansen, Ole H. Nielsen
Summary: Inflammatory bowel diseases (IBD) are challenging to manage due to the diversity between patients and the lack of reliable biomarkers. Diet, gut microbiota, genetics, and patient factors are all crucial for disease occurrence and progression. Recent research has identified potential biomarkers for IBD management, but further evaluation is needed. This review provides an update on cutting-edge research in IBD to improve disease management and patient quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Reena Khanna, Christopher Ma, Vipul Jairath, Niels Vande Casteele, Guangyong Zou, Brian G. Feagan
Summary: Poor correlation between symptoms and active luminal inflammation has been established in patients with Crohn's disease and ulcerative colitis, leading to the use of endoscopic assessment. However, the current endoscopic indices used for evaluation are not completely validated and have limitations for clinical use.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Viktor Domislovic, Joachim Hog Mortensen, Majken Lindholm, Morten Asser Kaarsdal, Marko Brinar, Ana Barisic, Tina Manon-Jensen, Zeljko Krznaric
Summary: This study investigated serum biomarkers of ECM remodeling in patients with inflammatory bowel disease (IBD), and found that a combination of C4M, C3M, and PRO-C3 biomarkers may potentially serve as a biomarker to differentiate moderate to severe endoscopic disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Microbiology
Laila Aldars-Garcia, Maria Chaparro, Javier P. Gisbert
Summary: IBD is a chronic relapsing-remitting systemic disease of the gastrointestinal tract, and the gut microbiome plays a crucial role in its pathogenesis by showing reduced species richness, diversity, and temporal stability. Changes in the gut microbiome are pivotal in determining the onset of IBD, with certain microbial taxa identified as diagnostic biomarkers.
Review
Pathology
Bence Kovari, Agnes Bathori, Mark S. Friedman, Gregory Y. Lauwers
Summary: Inflammatory bowel disease is a chronic inflammatory condition of the gastrointestinal tract, and the diagnosis relies on a synthesis of clinical, endoscopic, and microscopic features. The classic morphologic features of ulcerative colitis and Crohn disease include architectural distortion, basal plasmacytosis, and expansion of the lamina propria lymphoplasmacytic infiltrate.
ADVANCES IN ANATOMIC PATHOLOGY
(2022)
Review
Pharmacology & Pharmacy
Sara Salvador-Martin, Alejandra Melgarejo-Ortuno, Luis A. Lopez-Fernandez
Summary: The use of biological drugs in pediatric inflammatory bowel disease has shown significant improvements, and predicting response to these drugs is particularly valuable in children. Clinical, biochemical, and genetic parameters can potentially predict response to biological drugs in children with IBD.
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
John Gubatan, Derek R. Holman, Christopher J. Puntasecca, Danielle Polevoi, Samuel J. S. Rubin, Stephan Rogalla
Summary: Antimicrobial peptides play crucial roles in maintaining tolerance to gut microbiota and protecting against infections in the gastrointestinal tract, and are increasingly recognized as potential biomarkers and novel therapeutic targets in the pathogenesis of inflammatory bowel disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Nutrition & Dietetics
Xue Guo, Chen Huang, Jing Xu, Haoming Xu, Le Liu, Hailan Zhao, Jiaqi Wang, Wenqi Huang, Wu Peng, Ye Chen, Yuqiang Nie, Yongjian Zhou, Youlian Zhou
Summary: Inflammatory bowel disease (IBD) is characterized by relapse and remission, making it challenging to diagnose and assess disease activity. Traditional biomarkers from plasma and stool lack specificity, while changes in gut microbiota are closely associated with IBD etiology and pathogenesis.
FRONTIERS IN NUTRITION
(2022)
Review
Nutrition & Dietetics
Vilk Janne da Silva Barros, Juliana Soares Severo, Pedro Henrique Moraes Mendes, Alda Cassia Alves da Silva, Kelly Beatriz Vieira de Oliveira, Jose Miguel Luz Parente, Murilo Moura Lima, Emidio Marques Matos Neto, Armenio Aguiar dos Santos, Moises Tolentino Bento da Silva
Summary: This review systematically evaluates the effectiveness of dietary interventions in attenuating inflammatory biomarkers in patients with inflammatory bowel diseases based on available clinical trials. It was found that some dietary interventions can reduce inflammatory markers.
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Geriatrics & Gerontology
Marco Vincenzo Lenti, Nicola Aronico, Paolo Giuffrida, Stefania Costa, Martina Costetti, Clarissa Musacchio, Luca Pastorelli, Caterina Mengoli, Federica Borrelli de Andreis, Sara Cococcia, Carmine Tinelli, Catherine Klersy, Maurizio Vecchi, Alberto Pilotto, Antonio Di Sabatino
Summary: The Multidimensional Prognostic Index (MPI) can predict mortality and is associated with a higher risk of developing diverticular disease (DD) complications in older patients. Patients with higher MPI groups have a greater likelihood of developing DD complications.
Article
Medicine, Research & Experimental
Stefano Mazza, Nicole Piazza O. Sed, Francesco Simone Conforti, Alberto Fasci, Alessandro Rimondi, Beatrice Marinoni, Valentina Casini, Chiara Ricci, Francesca Munari, Lorena Pirola, Pietro Invernizzi, Carlo Girelli, Guido Lupinacci, Luca Pastorelli, Flaminia Cavallaro, Luca Ferraris, Alice Colucci, Arnaldo Amato, Gian Eugenio Tontini, Maurizio Vecchi, Gionata Fiorino, Flavio Caprioli
Summary: A study in Italy evaluated the safety and efficacy of double-switching from originator IFX to CT-P13 and subsequently to SB2 in patients with IBD. Results showed that the double switch was associated with high continuation rates of IFX therapy and high clinical remission rates, without significant differences in safety and efficacy compared to single-switching.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Luca Elli, Pietro Soru, Leda Roncoroni, Francesca Gaia Rossi, Valeria Ferla, Luca Baldini, Nicoletta Nandi, Lucia Scaramella, Alice Scricciolo, Alessandro Rimondi, Nicola Fuscoi, Giorgio Alberto Croci, Umberto Gianelli, Lilla Crog, Marzia Barbierig, Vincenza Lombardob, Andrea Costantinoa, Valentina Vairaa, Stefano Ferrero, Gian Eugenio Tontini, Giulio Barigellettih, Sabrina Fabianoh, Luisa Doneda, Maurizio Vecchi
Summary: This study describes the clinical and histological features of a cohort of patients with refractory celiac disease (RCeD) at diagnosis, after therapy, and at lymphoma onset, as well as evaluates the rate and causes of death over a 17-year follow-up. The results show differences in clinical severity, response to therapy, and mortality between RCeD-I and RCeD-II, with atrophy extension being associated with disease severity and mortality.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Vincenzo Occhipinti, Paola Soriani, Sara Vavassori, Maria Laura Annunziata, Francesco Bagolini, Flaminia Cavallaro, Pavlos Lagoussis, Valentina Milani, Emanuele Rondonotti, Luisa Spina, Maurizio Vecchi, Luca Pastorelli, Gian Eugenio Tontini
Summary: Bowel preparation is crucial for colonoscopy completeness and lesions detection. Identification of preparation-specific risk factors for inadequate bowel preparation may lead to a personalized prescription of cleansing products to refine patients' tolerance and improve endoscopic outcomes.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Alessandro Rimondi, Andrea Sorge, Alberto Murino, Nicoletta Nandi, Lucia Scaramella, Maurizio Vecchi, Gian Eugenio Tontini, Luca Elli
Summary: This study conducted a systematic review of treatment options for Blue rubber bleb nevus syndrome (BRBNS), and found that endoscopy, surgery, and systemic drug therapy are feasible choices. Compared to endoscopy and surgery, endoscopic treatment requires more sessions to achieve complete eradication, and systemic drug therapy is favored as a second-line treatment after treatment failure or recurrence, but with more reported adverse events.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Marietta Iacucci, Tommaso Lorenzo Parigi, Rocio Del Amor, Pablo Meseguer, Giulio Mandelli, Anna Bozzola, Alina Bazarova, Pradeep Bhandari, Raf Bisschops, Silvio Danese, Gert De Hertogh, Jose G. Ferraz, Martin Goetz, Enrico Grisan, Xianyong Gui, Bu Hayee, Ralf Kiesslich, Mark Lazarey, Remo Panaccione, Adolfo Parra-Blanco, Luca Pastorelli, Timo Rath, Elin S. Royset, Gian Eugenio Tontini, Michael Vieth, Davide Zardo, Subrata Ghosh, Valery Naranjo, Vincenzo Villanacci
Summary: An artificial intelligence computer-aided diagnosis system was developed and validated to evaluate UC biopsies and predict prognosis. The system showed high accuracy and sensitivity in assessing biopsy results and predicting outcomes.
Article
Medicine, General & Internal
Olga Maria Nardone, Giovanni Marasco, Loris Riccardo Lopetuso, Giammarco Mocci, Luca Pastorelli, Carlo Petruzzellis, Franco Scaldaferri
Summary: This study investigated the use of mesalazine in the clinical practice of young gastroenterologists. The results showed that there were significant differences in the use of mesalazine between non-dedicated and IBD physicians, especially in the management of moderate-severe ulcerative colitis. It was also observed that non-IBD physicians were less likely to prescribe mesalazine for colorectal cancer chemoprevention.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Marco Vincenzo Lenti, Maria Lia Scribano, Livia Biancone, Rachele Ciccocioppo, Daniela Pugliese, Luca Pastorelli, Gionata Fiorino, Edoardo Savarino, Flavio Andrea Caprioli, Sandro Ardizzone, Massimo Claudio Fantini, Gian Eugenio Tontini, Ambrogio Orlando, Gianluca Matteo Sampietro, Giacomo Carlo Sturniolo, Giovanni Monteleone, Maurizio Vecchi, Anna Kohn, Marco Daperno, Renata D'Inca, Gino Roberto Corazza, Antonio Di Sabatino
Summary: IBD is a complex immune-mediated disorder affecting the gastrointestinal and systemic manifestations, leading to poor quality of life and negative health outcomes. A comprehensive management considering both biological and non-biological factors is necessary. The 4P medicine framework, including personalization, prediction, prevention, and participation is useful for tailoring interventions in IBD patients.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Cristina Bezzio, Marta Vernero, Stefania Costa, Alessandro Armuzzi, Gionata Fiorino, Sandro Ardizzone, Jenny Roselli, Sonia Carparelli, Ambrogio Orlando, Flavio Andrea Caprioli, Fabiana Castiglione, Chiara Vigano, Davide Ribaldone, Fabiana Zingone, Rita Monterubbianesi, Nicola Imperatore, Stefano Festa, Marco Daperno, Ludovica Scucchi, Antonio Ferronato, Luca Pastorelli, Eleonora Alimenti, Paola Balestrieri, Chiara Ricci, Maria Cappello, Carla Felice, Francesca Coppini, Patrizia Alvisi, Imma Di Luna, Viviana Gerardi, Angela Variola, Silvia Mazzuoli, Marco Vincenzo Lenti, Simone Saibeni
Summary: This study compared the characteristics and outcomes of inflammatory bowel disease (IBD) patients with SARS-CoV-2 infection between the two pandemic waves in Italy. The patients in the first wave were older, more likely to have ulcerative colitis and comorbidities, and resided more frequently in Northern Italy. The rates of negative outcomes, such as pneumonia, hospital admission, ventilatory support, and death, were significantly higher in the first wave compared to the second wave.
BMC GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Chiara Vigano, Andrea Palermo, Giacomo Mulinacci, Lorena Pirola, Alessandra Losco, Gianmichele Meucci, Simone Saibeni, Luca Pastorelli, Arnaldo Amato, Mario Gatti, Claudio Cortelezzi, Antonio Di Sabatino, Daniela Morganti, Francesca Boni, Gianalberto Grasso, Giovanni Casella, Valentina Casini, Flavio Andrea Caprioli, Maurizio Vecchi, Cristina Bezzio, Irene Bergna, Franco Radaelli, Caterina Mengoli, Sara Massironi
Summary: Disease-related malnutrition (DRM) is prevalent in inflammatory bowel disease (IBD) patients, with a rate of 23% and no significant difference between Crohn's disease and ulcerative colitis. DRM is associated with higher hospitalization rate, more frequent use of systemic steroids, lower levels of hemoglobin, albumin, prealbumin, and higher levels of C-reactive protein. Low BMI, current hospitalization, and hospitalization in the previous month are significantly associated with DRM.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Matilde Topa, Nicoletta Nandi, Lucia Scaramella, Michele Puricelli, Marco Pennazio, Reena Sidhu, David S. Sanders, Gian Eugenio Tontini, Roberto Penagini, Maurizio Vecchi, Luca Elli
Summary: This study assessed the clinical impact of videocapsule endoscopy (VCE) and double-balloon enteroscopy (DBE) in patients with indications other than suspected small bowel bleeding (OSBB), and compared them to a control group of suspected small bowel bleeding (SSBB) patients. The results showed that VCE and DBE are effective and safe in patients with indications other than suspected small bowel bleeding, similar to their role in suspected small bowel bleeding patients.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)