Cadmium and molybdenum co-induce pyroptosis via ROS/PTEN/PI3K/AKT axis in duck renal tubular epithelial cells

Molecular hydrogen regulates PTEN‐AKT‐mTOR signaling via ROS to alleviate peritoneal dialysis‐related peritoneal fibrosis

(2020) Hongtao Lu et al.   FASEB JOURNAL

Combination of Ruthenium Complex and Doxorubicin Synergistically Inhibits Cancer Cell Growth by Down-Regulating PI3K/AKT Signaling Pathway

(2020) Ke Lin et al.   Frontiers in Oncology

Astragalus polysaccharides alleviates LPS‐induced inflammation via the NF‐κB/MAPK signaling pathway

(2020) Na Dong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypothermia protects neurons against ischemia/reperfusion-induced pyroptosis via m6A-mediated activation of PTEN and the PI3K/Akt/GSK-3β signaling pathway

(2020) Meng-Yuan Diao et al.   BRAIN RESEARCH BULLETIN

Quercetin alleviates Cadmium-induced autophagy inhibition via TFEB-dependent lysosomal restoration in primary proximal tubular cells

(2020) Yuan Zhao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Health Risk Assessment of Potentially Toxic Trace and Elements in Vegetables Grown Under the Impact of Kajaran Mining Complex

(2019) Davit Pipoyan et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Accumulation, ecological-health risks assessment, and source apportionment of heavy metals in paddy soils: A case study in Hanzhong, Shaanxi, China

(2019) Ran Xiao et al.   ENVIRONMENTAL POLLUTION

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

MCC950 closes the active conformation of NLRP3 to an inactive state

(2019) Ana Tapia-Abellán et al.   Nature Chemical Biology

Inhibition of Caspase-1-dependent pyroptosis attenuates copper-induced apoptosis in chicken hepatocytes

(2019) Jianzhao Liao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome

(2019) Lingbin Sun et al.   Cell Death & Disease

Concentration, Source, and Total Health Risks of Cadmium in Multiple Media in Densely Populated Areas, China

(2019) Kui Cai et al.   International Journal of Environmental Research and Public Health

Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

(2019) Lidija Milkovic et al.   Cells

Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production

(2019) Ruifen Kang et al.   ENVIRONMENTAL POLLUTION

Gasdermins and their role in immunity and inflammation

(2019) Pontus Orning et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molybdenum and Cadmium co-induced the levels of autophagy-related genes via adenosine 5′-monophosphate-activated protein kinase/mammalian target of rapamycin signaling pathway in Shaoxing Duck (Anas platyrhyncha) kidney

(2019) Jionghan Zhuang et al.   POULTRY SCIENCE

Apolipoprotein M and sphingosine-1-phosphate complex alleviates TNF-α-induced endothelial cell injury and inflammation through PI3K/AKT signaling pathway

(2019) Yang Liu et al.   BMC Cardiovascular Disorders

Melatonin ameliorates ochratoxin A-induced oxidative stress and apoptosis in porcine oocytes

(2019) Mei Lan et al.   ENVIRONMENTAL POLLUTION

17β-estradiol at low concentrations attenuates the efficacy of tamoxifen in breast cancer therapy

(2019) Zhixiang Xu et al.   ENVIRONMENTAL POLLUTION

Liver-derived exosome-laden lncRNA MT1DP aggravates cadmium-induced nephrotoxicity

(2019) Ming Gao et al.   ENVIRONMENTAL POLLUTION

Molybdenum and cadmium co-induce oxidative stress and apoptosis through mitochondria-mediated pathway in duck renal tubular epithelial cells

(2019) Chang Wang et al.   JOURNAL OF HAZARDOUS MATERIALS

Avermectin inhibits neutrophil extracellular traps release by activating PTEN demethylation to negatively regulate the PI3K-ERK pathway and reducing respiratory burst in carp

(2019) Shufang Zheng et al.   JOURNAL OF HAZARDOUS MATERIALS

NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling

(2019) Xueliang Chen et al.   Cell Death & Disease

Preparation of thiol-functionalized activated carbon from sewage sludge with coal blending for heavy metal removal from contaminated water

(2018) Juan Li et al.   ENVIRONMENTAL POLLUTION

A multi-medium chain modeling approach to estimate the cumulative effects of cadmium pollution on human health

(2018) Xingmei Liu et al.   ENVIRONMENTAL POLLUTION

Cadmium exposure and early renal effects in the children and adults living in a tungsten-molybdenum mining areas of South China

(2018) Xiangfen Cui et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Contamination of soils by potentially toxic elements in the impact zone of tungsten‑molybdenum ore mine in the Baikal region: A survey and risk assessment

(2018) Ivan Timofeev et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

(2018) Xianxian Wu et al.   Cell Death & Disease

Metabolomics analysis reveals potential mechanisms of tolerance to excess molybdenum in soybean seedlings

(2018) Shoujun Xu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

DHA attenuates hepatic ischemia reperfusion injury by inhibiting pyroptosis and activating PI3K/Akt pathway

(2018) Ziyi Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages

(2018) Bettina L. Lee et al.   Scientific Reports

Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice

(2018) Yunxia Fan et al.   Frontiers in Cellular Neuroscience

Metals in the Scheldt estuary: From environmental concentrations to bioaccumulation

(2017) Evy Van Ael et al.   ENVIRONMENTAL POLLUTION

Blood cell responses and metallothionein in the liver, kidney and muscles of bullfrog tadpoles, Lithobates catesbeianus , following exposure to different metals

(2017) C.S. Carvalho et al.   ENVIRONMENTAL POLLUTION

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Overexpression of Circular RNA ciRS-7 Abrogates the Tumor Suppressive Effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway

(2017) Haiyan Pan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction

(2017) Yi Zhang et al.   Cell Death & Disease

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

(2017) Katharina S. Schneider et al.   Cell Reports

Toxic Heavy Metal and Metalloid Accumulation in Crop Plants and Foods

(2016) Stephan Clemens et al.   Annual Review of Plant Biology

Alterations in trace element levels and mRNA expression of Hsps and inflammatory cytokines in livers of duck exposed to molybdenum or/and cadmium

(2016) Huabin Cao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment

(2016) Xiangyang Wu et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts

(2016) Eun-Mi Noh et al.   Oxidative Medicine and Cellular Longevity

Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells

(2016) Haiyan Chen et al.   TOXICOLOGY LETTERS

Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway

(2016) Sai-Qi Wang et al.   Oncotarget

The Co-induced Effects of Molybdenum and Cadmium on Antioxidants and Heat Shock Proteins in Duck Kidneys

(2015) Bing Xia et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Characteristics of concentration–inhibition curves of individual chemicals and applicability of the concentration addition model for mixture toxicity prediction

(2015) Na Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Cadmium Transporters in the Kidney and Cadmium-Induced Nephrotoxicity

(2015) Hong Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis

(2014) J Xu et al.   CELL DEATH AND DIFFERENTIATION

Interleukin-1β in innate inflammation, autophagy and immunity

(2013) Leo A.B. Joosten et al.   SEMINARS IN IMMUNOLOGY

Effects of molybdenum on sperm quality and testis oxidative stress

(2013) Xiao-Wei Zhai et al.   Systems Biology in Reproductive Medicine

CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia/reperfusion injury: Involving activation of PI3K/Akt signaling

(2012) Zhijuan Cao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Plant science: the key to preventing slow cadmium poisoning

(2012) Stephan Clemens et al.   TRENDS IN PLANT SCIENCE

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells

(2011) Qiong Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Molybdenum cofactors, enzymes and pathways

(2009) Günter Schwarz et al.   NATURE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Effects of high dietary molybdenum in rabbits

(2008) András Bersényi et al.   ACTA VETERINARIA HUNGARICA