Gasdermins and their role in immunity and inflammation

Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation

(2019) Michael A. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly

(2019) Kaiwen W Chen et al.   EMBO JOURNAL

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization

(2019) Zhonghua Liu et al.   IMMUNITY

Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM

(2019) Michael Carty et al.   IMMUNITY

Gasdermin D Protects from Melioidosis through Pyroptosis and Direct Killing of Bacteria

(2019) Jinyong Wang et al.   JOURNAL OF IMMUNOLOGY

Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage

(2019) Jean Defourny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF2 transcriptionally induces GSDMD expression for pyroptosis

(2019) Nobuhiko Kayagaki et al.   Science Signaling

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release

(2019) Maryam Rashidi et al.   JOURNAL OF IMMUNOLOGY

Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis

(2019) Chenxuan Yang et al.   Cell Death & Disease

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

(2019) Sabrina Sofia Burgener et al.   Cell Reports

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila

(2019) Augusto V. Gonçalves et al.   PLoS Pathogens

Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

(2019) Sheng Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

(2018) Nathalia M. de Vasconcelos et al.   CELL DEATH AND DIFFERENTIATION

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

Mechanism of membrane pore formation by human gasdermin‐D

(2018) Estefania Mulvihill et al.   EMBO JOURNAL

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

(2018) Rosalie Heilig et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients

(2018) Elena Khanova et al.   HEPATOLOGY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

(2018) Monica L. Gonzalez Ramirez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

(2018) Apurva Kanneganti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice

(2018) Bing Xu et al.   JOURNAL OF HEPATOLOGY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition

(2018) Zhonghua Liu et al.   STRUCTURE

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

(2018) Hiroto Kambara et al.   Cell Reports

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

(2018) Ishita Banerjee et al.   IMMUNITY

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

(2018) Bettina L. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cryo-EM structure of the gasdermin A3 membrane pore

(2018) Jianbin Ruan et al.   NATURE

ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages

(2018) Bettina L. Lee et al.   Scientific Reports

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

(2018) Mercedes Monteleone et al.   Cell Reports

Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against Francisella novicida

(2018) Qifan Zhu et al.   JOURNAL OF IMMUNOLOGY

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice

(2018) Jianqiu Xiao et al.   PLOS BIOLOGY

Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection

(2018) Daiane M. Cerqueira et al.   PLoS Pathogens

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

(2017) Isabella Rauch et al.   IMMUNITY

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

(2017) Andrew Rhodes et al.   INTENSIVE CARE MEDICINE

Live-cell visualization of gasdermin D-driven pyroptotic cell death

(2017) Joseph K. Rathkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

(2017) Shu Zhu et al.   NATURE

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

(2017) Siyun Kuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

(2017) Katharina S. Schneider et al.   Cell Reports

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

(2016) F Martín-Sánchez et al.   CELL DEATH AND DIFFERENTIATION

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

(2016) Ine Jorgensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Access to effective antimicrobials: a worldwide challenge

(2016) Ramanan Laxminarayan et al.   LANCET

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation

(2016) Masashi Miguchi et al.   PLoS One

Loss of conservedGsdma3self-regulation causes autophagy and cell death

(2015) Peiliang Shi et al.   BIOCHEMICAL JOURNAL

Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium

(2015) Vivien I. Maltez et al.   IMMUNITY

Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+Efflux

(2015) Mausita Karmakar et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The Association ofGSDMBandORMDL3Gene Polymorphisms With Asthma: A Meta-Analysis

(2015) Chun-Ni Zhao et al.   Allergy Asthma & Immunology Research

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

(2014) Mikael E. Sellin et al.   Cell Host & Microbe

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

(2014) Kaiwen W. Chen et al.   Cell Reports

Inflammasomes and host defenses against bacterial infections

(2013) Gregory I Vladimer et al.   CURRENT OPINION IN MICROBIOLOGY

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

(2013) R. P. Dellinger et al.   INTENSIVE CARE MEDICINE

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Functional Conservation of Gsdma Cluster Genes Specifically Duplicated in the Mouse Genome

(2013) Shigekazu Tanaka et al.   G3-Genes Genomes Genetics

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness

(2012) Mi-Jin Kang et al.   HUMAN IMMUNOLOGY

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

(2012) M. Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation

(2011) Yue Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

Delineating Immune-Mediated Mechanisms Underlying Hair Follicle Destruction in the Mouse Mutant Defolliculated

(2010) Fiona Ruge et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distinctive expression and function of fourGSDMfamily genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium

(2008) Norihisa Saeki et al.   GENES CHROMOSOMES & CANCER

Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma

(2008) M S Kim et al.   ONCOGENE

Host–pathogen interactions in sepsis

(2007) Tom van der Poll et al.   LANCET INFECTIOUS DISEASES