MCC950 closes the active conformation of NLRP3 to an inactive state

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

Ion homeostasis and ion channels in NLRP3 inflammasome activation and regulation

(2018) Iva Hafner-Bratkovič et al.   CURRENT OPINION IN IMMUNOLOGY

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

(2018) Iva Hafner-Bratkovič et al.   Nature Communications

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease

(2017) Mattia Cocco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lytic cell death induced by melittin bypasses pyroptosis but induces NLRP3 inflammasome activation and IL-1β release

(2017) Fátima Martín-Sánchez et al.   Cell Death & Disease

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

(2016) F Martín-Sánchez et al.   CELL DEATH AND DIFFERENTIATION

Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

(2016) Michael J. Primiano et al.   JOURNAL OF IMMUNOLOGY

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Brief Report: Late-Onset Cryopyrin-Associated Periodic Syndrome Due to Myeloid-Restricted Somatic NLRP3 Mosaicism

(2016) Anna Mensa-Vilaro et al.   Arthritis & Rheumatology

Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process

(2016) Carlos de Torre-Minguela et al.   Scientific Reports

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling

(2015) Vincent Compan et al.   JOURNAL OF IMMUNOLOGY

A Novel Flow Cytometric Method To Assess Inflammasome Formation

(2014) David P. Sester et al.   JOURNAL OF IMMUNOLOGY

NLRP3 and IL-1βin macrophages as critical regulators of metabolic diseases

(2013) A. F. McGettrick et al.   DIABETES OBESITY & METABOLISM

Mechanisms of Sterile Inflammation

(2013) Anna Rubartelli et al.   Frontiers in Immunology

High-Throughput parallel blind Virtual Screening using BINDSURF

(2012) Irene Sánchez-Linares et al.   BMC BIOINFORMATICS

Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

(2012) Vincent Compan et al.   IMMUNITY

The Inflammasome in Atherosclerosis and Type 2 Diabetes

(2011) S. L. Masters et al.   Science Translational Medicine

The Inflammasomes

(2010) Kate Schroder et al.   CELL