标题
Biased agonism at chemokine receptors
作者
关键词
Biased agonism, G protein-coupled receptors, Chemokine System
出版物
CELLULAR SIGNALLING
Volume 78, Issue -, Pages 109862
出版商
Elsevier BV
发表日期
2020-11-27
DOI
10.1016/j.cellsig.2020.109862
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Clinical significance of chemokine receptor antagonists
- (2020) Miao Miao et al. Expert Opinion on Drug Metabolism & Toxicology
- Differential activity and selectivity of N‐terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors
- (2020) Agnieszka Jaracz‐Ros et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity
- (2020) Tony Ngo et al. PLOS BIOLOGY
- CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4
- (2020) Christoph Matti et al. JOURNAL OF LEUKOCYTE BIOLOGY
- The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides
- (2020) Max Meyrath et al. Nature Communications
- Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20
- (2020) David Jonathan Wasilko et al. Nature Communications
- Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations
- (2019) Laura M. Wingler et al. CELL
- CCR9 Expressing T Helper and T Follicular Helper Cells Exhibit Site-Specific Identities During Inflammatory Disease
- (2019) Ilaria Cosorich et al. Frontiers in Immunology
- ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin
- (2019) Friederike Saaber et al. Cell Reports
- Mogamulizumab: a new tool for management of cutaneous T-cell lymphoma
- (2019) Thomas A Ollila et al. OncoTargets and Therapy
- Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1
- (2019) Sanchez et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- CXCR5+CD8+ T cells are a distinct functional subset with an antitumor activity
- (2019) Fuliang Chu et al. LEUKEMIA
- CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis
- (2019) Frank Blanco-Pérez et al. Scientific Reports
- CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond
- (2019) Marcelo G. Kazanietz et al. Frontiers in Endocrinology
- Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7
- (2019) Kathrin Jaeger et al. CELL
- CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways
- (2019) Alexander N. Wein et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms
- (2019) Eshan Ghosh et al. Cell Reports
- Pathogen Evasion of Chemokine Response Through Suppression of CXCL10
- (2019) Alejandro L. Antonia et al. Frontiers in Cellular and Infection Microbiology
- 5234KAND567, the first selective small molecule CX3CR1 antagonist in clinical development, mediates anti-inflammatory cardioprotective effects in rodent models of atherosclerosis and myocardial infarction
- (2019) S Abdelmoaty et al. EUROPEAN HEART JOURNAL
- Clinical use, efficacy, and durability of maraviroc for antiretroviral therapy in routine care: A European survey
- (2019) Andrea De Luca et al. PLoS One
- Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma
- (2019) Satyamaheshwar Peddibhotla et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Inhibition of CX 3 CR1 reduces cell motility and viability in pancreatic adenocarcinoma epithelial cells
- (2018) Matthew C. Stout et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3
- (2018) Martyna Szpakowska et al. BRITISH JOURNAL OF PHARMACOLOGY
- G protein-coupled receptor kinases: Past, present and future
- (2018) Konstantin E. Komolov et al. CELLULAR SIGNALLING
- Chemokine Signaling in Allergic Contact Dermatitis
- (2018) Jeffrey S. Smith et al. Dermatitis
- A guide to chemokines and their receptors
- (2018) Catherine E. Hughes et al. FEBS Journal
- Novel peptide nanoparticle–biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness
- (2018) Milica Grozdanovic et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Characterization of a chimeric chemokine as a specific ligand for ACKR3
- (2018) Rafet Ameti et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Balixafortide plus eribulin in HER2-negative metastatic breast cancer: a phase 1, single-arm, dose-escalation trial
- (2018) Sonia Pernas et al. LANCET ONCOLOGY
- Molecular Mechanisms of Biased and Probe-Dependent Signaling at CXC-Motif Chemokine Receptor CXCR3 Induced by Negative Allosteric Modulators
- (2018) Regine Brox et al. MOLECULAR PHARMACOLOGY
- Biased signalling: from simple switches to allosteric microprocessors
- (2018) Jeffrey S. Smith et al. NATURE REVIEWS DRUG DISCOVERY
- Intracellular Receptor Modulation: Novel Approach to Target GPCRs
- (2018) Natalia V. Ortiz Zacarías et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation
- (2018) Qiong Wu et al. Cell Death & Disease
- Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands
- (2018) Mieke Metzemaekers et al. Frontiers in Immunology
- The Phosphorylation of CCR6 on Distinct Ser/Thr Residues in the Carboxyl Terminus Differentially Regulates Biological Function
- (2018) Mei-Yi Lu et al. Frontiers in Immunology
- Tissue-specific Role of CX3CR1 Expressing Immune Cells and Their Relationships with Human Disease
- (2018) Myoungsoo Lee et al. Immune Network
- Effect of the CXCR2 antagonist danirixin on symptoms and health status in COPD
- (2018) Aili L. Lazaar et al. EUROPEAN RESPIRATORY JOURNAL
- Mutational analysis of CCL20 reveals flexibility of N-terminal amino acid composition and length
- (2018) Sarah J. Riutta et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation
- (2018) Jeffrey S. Smith et al. Science Signaling
- G protein subtype–specific signaling bias in a series of CCR5 chemokine analogs
- (2018) Emily Lorenzen et al. Science Signaling
- Biased antagonism of CXCR4 avoids antagonist tolerance
- (2018) Ben Hitchinson et al. Science Signaling
- β-Arrestin Based Receptor Signaling Paradigms: Potential Therapeutic Targets for Complex Age-Related Disorders
- (2018) Jaana van Gastel et al. Frontiers in Pharmacology
- Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3–mediated chemokine scavenging
- (2017) Nicolas Montpas et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Danirixin: A Reversible and Selective Antagonist of the CXC Chemokine Receptor 2
- (2017) Jakob Busch-Petersen et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers—results of a dose escalation trial
- (2017) Darja Karpova et al. Journal of Translational Medicine
- G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of β -Arrestin
- (2017) Jiansong Luo et al. MOLECULAR PHARMACOLOGY
- C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways
- (2017) Jeffrey S. Smith et al. MOLECULAR PHARMACOLOGY
- Trends in GPCR drug discovery: new agents, targets and indications
- (2017) Alexander S. Hauser et al. NATURE REVIEWS DRUG DISCOVERY
- Protein engineering of the chemokine CCL20 prevents psoriasiform dermatitis in an IL-23–dependent murine model
- (2017) A. E. Getschman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CCR8+FOXp3+Tregcells as master drivers of immune regulation
- (2017) Yiftah Barsheshet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis
- (2017) Thomas J. Cahill et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation
- (2017) Joshua J. Ziarek et al. Science Signaling
- Structural basis of ligand interaction with atypical chemokine receptor 3
- (2017) Martin Gustavsson et al. Nature Communications
- Targeting CCR2 with its antagonist suppresses viability, motility and invasion by downregulating MMP-9 expression in non-small cell lung cancer cells
- (2017) Jun An et al. Oncotarget
- ACKR3 expression on diffuse large B cell lymphoma is required for tumor spreading and tissue infiltration
- (2017) Viola Puddinu et al. Oncotarget
- Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation
- (2017) Joshua J. Ziarek et al. Science Signaling
- Chemokines and Chemokine Receptors: Accomplices for Human Immunodeficiency Virus Infection and Latency
- (2017) Zhuo Wang et al. Frontiers in Immunology
- A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy
- (2017) Ilze Bot et al. Scientific Reports
- Ligand activation induces different conformational changes in CXCR3 receptor isoforms as evidenced by plasmon waveguide resonance (PWR)
- (2017) K. Boyé et al. Scientific Reports
- A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma
- (2017) Yang Zhang et al. Scientific Reports
- New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model
- (2016) Andrew B. Kleist et al. BIOCHEMICAL PHARMACOLOGY
- N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity
- (2016) Asitha Abeywardane et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors
- (2016) Jeffrey S. Smith et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery and Characterization of Biased Allosteric Agonists of the Chemokine Receptor CXCR3
- (2016) Lampros Milanos et al. JOURNAL OF MEDICINAL CHEMISTRY
- Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells
- (2016) F. Shen et al. MOLECULAR CANCER RESEARCH
- Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists
- (2016) Yi Zheng et al. NATURE
- Intracellular allosteric antagonism of the CCR9 receptor
- (2016) Christine Oswald et al. NATURE
- Design, synthesis, and biological evaluation of CXCR4 ligands
- (2016) Christine E. Mona et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Distinct cortical and striatal actions of a β-arrestin–biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties
- (2016) Nikhil M. Urs et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response
- (2016) Raffaella Bonecchi et al. Frontiers in Immunology
- Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis
- (2016) Tomokazu Ohta et al. Scientific Reports
- Randomised clinical trial: vercirnon, an oral CCR9 antagonist, vs. placebo as induction therapy in active Crohn's disease
- (2015) B. G. Feagan et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- CXCR2 Antagonist MK-7123. A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease
- (2015) Stephen I. Rennard et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction
- (2015) Wan-Tseng Hsu et al. CELL TRANSPLANTATION
- Ligand-Biased and Probe-Dependent Modulation of Chemokine Receptor CXCR3 Signaling by Negative Allosteric Modulators
- (2015) Viachaslau Bernat et al. ChemMedChem
- Preclinical discovery and development of maraviroc for the treatment of HIV
- (2015) Nevena Veljkovic et al. Expert Opinion on Drug Discovery
- CXCL12-CXCR7 axis is important for tumor endothelial cell angiogenic property
- (2015) Kenji Yamada et al. INTERNATIONAL JOURNAL OF CANCER
- Biased Signaling at Chemokine Receptors
- (2015) Jenny Corbisier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GRK2 Targeted Knock-down Results in Spontaneous Hypertension, and Altered Vascular GPCR Signaling
- (2015) Elena Tutunea-Fatan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets
- (2015) Nathan Karin et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Development of Novel CXC Chemokine Receptor 7 (CXCR7) Ligands: Selectivity Switch from CXCR4 Antagonists with a Cyclic Pentapeptide Scaffold
- (2015) Shinya Oishi et al. JOURNAL OF MEDICINAL CHEMISTRY
- CCR9 Antagonists in the Treatment of Ulcerative Colitis
- (2015) Pirow Bekker et al. MEDIATORS OF INFLAMMATION
- Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor
- (2015) J. S. Burg et al. SCIENCE
- Emerging Functional Divergence of β-Arrestin Isoforms in GPCR Function
- (2015) Ashish Srivastava et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The Chemokine System in Innate Immunity
- (2015) Caroline L. Sokol et al. Cold Spring Harbor Perspectives in Biology
- Discovery and Characterization of an Endogenous CXCR4 Antagonist
- (2015) Onofrio Zirafi et al. Cell Reports
- The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756) − a selective CXCR2 antagonist − in healthy adult subjects
- (2015) Bruce E. Miller et al. BMC Pharmacology & Toxicology
- Potent Anti-HIV Chemokine Analogs Direct Post-Endocytic Sorting of CCR5
- (2015) Claudia Bönsch et al. PLoS One
- Chemokines in Atherosclerosis
- (2014) Alma Zernecke et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Design and synthesis of novel small molecule CCR2 antagonists: Evaluation of 4-aminopiperidine derivatives
- (2014) M. Vilums et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists
- (2014) Laura Ajram et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis
- (2014) Yaniv Zohar et al. JOURNAL OF CLINICAL INVESTIGATION
- Arrestin 3 Mediates Endocytosis of CCR7 following Ligation of CCL19 but Not CCL21
- (2014) M. A. Byers et al. JOURNAL OF IMMUNOLOGY
- Distinct Conformations of the Chemokine Receptor CCR4 with Implications for Its Targeting in Allergy
- (2014) J. M. Viney et al. JOURNAL OF IMMUNOLOGY
- Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2
- (2014) Dean Y. Maeda et al. JOURNAL OF MEDICINAL CHEMISTRY
- Met-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection
- (2014) Ying Huang et al. Journal of Neuroinflammation
- Chemokine Receptor CCR8 Is Required for Lipopolysaccharide-Triggered Cytokine Production in Mouse Peritoneal Macrophages
- (2014) Tomoyuki Oshio et al. PLoS One
- Bias in chemokine receptor signalling
- (2014) Annelien J.M. Zweemer et al. TRENDS IN IMMUNOLOGY
- Biased and G Protein-Independent Signaling of Chemokine Receptors
- (2014) Anne Steen et al. Frontiers in Immunology
- A synthetic bivalent ligand of CXCR4 inhibits HIV infection
- (2013) Yan Xu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Allosteric peptide regulators of chemokine receptors CXCR4 and CXCR7
- (2013) Anna Ehrlich et al. BIOCHEMICAL PHARMACOLOGY
- The structural role of receptor tyrosine sulfation in chemokine recognition
- (2013) Justin P Ludeman et al. BRITISH JOURNAL OF PHARMACOLOGY
- Modulation of Circadian Glucocorticoid Oscillation via Adrenal Opioid-CXCR7 Signaling Alters Emotional Behavior
- (2013) Yuichi Ikeda et al. CELL
- Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial
- (2013) H. Neighbour et al. CLINICAL AND EXPERIMENTAL ALLERGY
- Vercirnonfor the treatment of Crohn's disease
- (2013) Kristen O Arseneau et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- CCL17/thymus and activation-regulated chemokine induces calcitonin gene–related peptide in human airway epithelial cells through CCR4
- (2013) Kandace Bonner et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors
- (2013) Sudarshan Rajagopal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hierarchical Organization of Multi-Site Phosphorylation at the CXCR4 C Terminus
- (2013) Wiebke Mueller et al. PLoS One
- Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein
- (2013) J. Quoyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CCR6/CCL20 Chemokine Expression Profile in Distinct Colorectal Malignancies
- (2013) V. O. Frick et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- -Arrestin-Dependent Activation of the Cofilin Pathway Is Required for the Scavenging Activity of the Atypical Chemokine Receptor D6
- (2013) E. M. Borroni et al. Science Signaling
- Physiology and Pharmacology of Plerixafor
- (2013) Simon P. Fricker TRANSFUSION MEDICINE AND HEMOTHERAPY
- Discovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists
- (2013) Valarie M. Truax et al. ACS Medicinal Chemistry Letters
- Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial
- (2012) Paul P Tak et al. ANNALS OF THE RHEUMATIC DISEASES
- Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate with Gi-protein pathway activation
- (2012) Anne O. Watts et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection
- (2012) Chung-Her Jenh et al. BMC IMMUNOLOGY
- Molecular requirements for inhibition of the chemokine receptor CCR8 - probe-dependent allosteric interactions
- (2012) PC Rummel et al. BRITISH JOURNAL OF PHARMACOLOGY
- Chemokine Signaling Directs Trunk Lymphatic Network Formation along the Preexisting Blood Vasculature
- (2012) Young Ryun Cha et al. DEVELOPMENTAL CELL
- Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists
- (2012) Maikel Wijtmans et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The Chemokine Receptors CXCR1 and CXCR2 Couple to Distinct G Protein-Coupled Receptor Kinases To Mediate and Regulate Leukocyte Functions
- (2012) S. K. Raghuwanshi et al. JOURNAL OF IMMUNOLOGY
- Development of a Unique Small Molecule Modulator of CXCR4
- (2012) Zhongxing Liang et al. PLoS One
- A Systemically-Administered Small Molecule Antagonist of CCR9 Acts as a Tissue-Selective Inhibitor of Lymphocyte Trafficking
- (2012) Noah J. Tubo et al. PLoS One
- G protein-coupled receptor modulation with pepducins: moving closer to the clinic
- (2011) Patricia Dimond et al. Annals of the New York Academy of Sciences
- Reparixin, an Inhibitor of CXCR1 and CXCR2 Receptor Activation, Attenuates Blood Pressure and Hypertension-Related Mediators Expression in Spontaneously Hypertensive Rats
- (2011) Hye Young Kim et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Targeting CXCR4 with cell-penetrating pepducins in lymphoma and lymphocytic leukemia
- (2011) K. O'Callaghan et al. BLOOD
- Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies
- (2011) Christian Doll et al. BRITISH JOURNAL OF PHARMACOLOGY
- Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitor
- (2011) R Bertini et al. BRITISH JOURNAL OF PHARMACOLOGY
- Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2
- (2011) PC Jensen et al. BRITISH JOURNAL OF PHARMACOLOGY
- Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3
- (2011) DJ Scholten et al. BRITISH JOURNAL OF PHARMACOLOGY
- Pharmacological modulation of chemokine receptor function
- (2011) DJ Scholten et al. BRITISH JOURNAL OF PHARMACOLOGY
- Pharmacokinetic and Pharmacodynamic Evaluation of the Novel CCR1 Antagonist CCX354 in Healthy Human Subjects: Implications for Selection of Clinical Dose
- (2011) D J Dairaghi et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- CXCR3 in T cell function
- (2011) Joanna R. Groom et al. EXPERIMENTAL CELL RESEARCH
- CXCR7/CXCR4 Heterodimer Constitutively Recruits β-Arrestin to Enhance Cell Migration
- (2011) Fabien M. Décaillot et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The chemokine system and cancer
- (2011) Frances R Balkwill JOURNAL OF PATHOLOGY
- The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells
- (2011) Brian A Zabel et al. Molecular Cancer
- CXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration
- (2011) Yanling Wang et al. NEURON
- Targeting chemokine receptors in chronic inflammatory diseases: An extensive review
- (2011) Pim J. Koelink et al. PHARMACOLOGY & THERAPEUTICS
- Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways
- (2011) L. J. Drury et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GRK2-Dependent S1PR1 Desensitization Is Required for Lymphocytes to Overcome Their Attraction to Blood
- (2011) T. I. Arnon et al. SCIENCE
- Distinct Phosphorylation Sites on the 2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of -Arrestin
- (2011) K. N. Nobles et al. Science Signaling
- Agonists for the Chemokine Receptor CXCR4
- (2011) Marilou Lefrançois et al. ACS Medicinal Chemistry Letters
- CCR5 blockade in rheumatoid arthritis: a randomised, double-blind, placebo-controlled clinical trial
- (2010) A. W. R. van Kuijk et al. ANNALS OF THE RHEUMATIC DISEASES
- CCR1 Antagonists: What Have We Learned From Clinical Trials
- (2010) Ronald P. Gladue et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19
- (2010) Mirjam R. Britschgi et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Effect of posttranslational processing on the in vitro and in vivo activity of chemokines
- (2010) Anneleen Mortier et al. EXPERIMENTAL CELL RESEARCH
- Site-specific Phosphorylation of CXCR4 Is Dynamically Regulated by Multiple Kinases and Results in Differential Modulation of CXCR4 Signaling
- (2010) John M. Busillo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differential G-protein-coupled Receptor Phosphorylation Provides Evidence for a Signaling Bar Code
- (2010) Adrian J. Butcher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Peptidomimetic CXCR4 Antagonist TC14012 Recruits β-Arrestin to CXCR7
- (2010) Stéphanie Gravel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synthesis and Structure−Activity Relationships of Azamacrocyclic C-X-C Chemokine Receptor 4 Antagonists: Analogues Containing a Single Azamacrocyclic Ring are Potent Inhibitors of T-Cell Tropic (X4) HIV-1 Replication
- (2010) Gary J. Bridger et al. JOURNAL OF MEDICINAL CHEMISTRY
- Dipyrimidine Amines: A Novel Class of Chemokine Receptor Type 4 Antagonists with High Specificity
- (2010) Aizhi Zhu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Novel Small Molecule Orally Bioavailable C−X−C Chemokine Receptor 4 Antagonists That Are Potent Inhibitors of T-Tropic (X4) HIV-1 Replication
- (2010) Renato T. Skerlj et al. JOURNAL OF MEDICINAL CHEMISTRY
- Characterization of CCX282-B, an Orally Bioavailable Antagonist of the CCR9 Chemokine Receptor, for Treatment of Inflammatory Bowel Disease
- (2010) M. J. Walters et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Different Effects of the Different Natural CC Chemokine Receptor 2b Ligands on -Arrestin Recruitment, G i Signaling, and Receptor Internalization
- (2010) Y. A. Berchiche et al. MOLECULAR PHARMACOLOGY
- Teaching old receptors new tricks: biasing seven-transmembrane receptors
- (2010) Sudarshan Rajagopal et al. NATURE REVIEWS DRUG DISCOVERY
- Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells
- (2010) B. Tchernychev et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
- (2010) B. Wu et al. SCIENCE
- Intravitreal poly(l-lactide) microparticles sustain retinal and choroidal delivery of TG-0054, a hydrophilic drug intended for neovascular diseases
- (2010) Namdev B. Shelke et al. Drug Delivery and Translational Research
- Blockade of X4-Tropic HIV-1 Cellular Entry by GSK812397, a Potent Noncompetitive CXCR4 Receptor Antagonist
- (2009) S. Jenkinson et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- MLN3897 plus methotrexate in patients with rheumatoid arthritis: Safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study
- (2009) Clarissa E. Vergunst et al. ARTHRITIS AND RHEUMATISM
- Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2
- (2009) Niu Shin et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The AMD3100 story: The path to the discovery of a stem cell mobilizer (Mozobil)
- (2009) Erik De Clercq BIOCHEMICAL PHARMACOLOGY
- CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling
- (2009) A. Levoye et al. BLOOD
- Vicriviroc: a CCR5 antagonist for treatment-experienced patients with HIV-1 infection
- (2009) Tim Kümmerle et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- CXCR4 chemokine receptor antagonists: perspectives in SCLC
- (2009) Jan A Burger et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- The chemokine CCL20 and its receptor CCR6 in human malignancy with focus on colorectal cancer
- (2009) Pirus Ghadjar et al. INTERNATIONAL JOURNAL OF CANCER
- RecognitionVersusAdaptive Up-regulation and Degradation of CC Chemokines by the Chemokine Decoy Receptor D6 Are Determined by Their N-terminal Sequence
- (2009) Benedetta Savino et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist
- (2009) T. Wisniewski et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Elucidation of CXCR7-Mediated Signaling Events and Inhibition of CXCR4-Mediated Tumor Cell Transendothelial Migration by CXCR7 Ligands
- (2009) B. A. Zabel et al. JOURNAL OF IMMUNOLOGY
- Differential Activation and Regulation of CXCR1 and CXCR2 by CXCL8 Monomer and Dimer
- (2009) M. W. Nasser et al. JOURNAL OF IMMUNOLOGY
- AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties
- (2009) I. Kalatskaya et al. MOLECULAR PHARMACOLOGY
- -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7
- (2009) S. Rajagopal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
- (2009) D. A. Zidar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CXCR4 dimerization and -arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome
- (2008) B. Lagane et al. BLOOD
- Translating an Antagonist of Chemokine Receptor CXCR4: From Bench to Bedside
- (2008) D. Wong et al. CLINICAL CANCER RESEARCH
- Maraviroc: A CCR5-receptor antagonist for the treatment of HIV-1 infection
- (2008) Sharon S. Lieberman-Blum et al. CLINICAL THERAPEUTICS
- Constitutive CXCL12 Expression Induces Anoikis in Colorectal Carcinoma Cells
- (2008) Michael K. Wendt et al. GASTROENTEROLOGY
- Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis
- (2008) C. Otero et al. JOURNAL OF CELL SCIENCE
- The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice
- (2008) Allisson Freire Bento et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Orally Bioavailable Isothioureas Block Function of the Chemokine Receptor CXCR4 In Vitro and In Vivo
- (2008) Gebhard Thoma et al. JOURNAL OF MEDICINAL CHEMISTRY
- Highly potent, fully recombinant anti-HIV chemokines: Reengineering a low-cost microbicide
- (2008) H. Gaertner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12
- (2008) C. T. Veldkamp et al. Science Signaling
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