Article
Biochemistry & Molecular Biology
Anju Krishnan Anitha, Pratibha Narayanan, Neethu Ajayakumar, Krishnankutty Chandrika Sivakumar, Kesavakurup Santhosh Kumar
Summary: This study designed and generated peptide ligands targeting CCR5, which showed significant CCR5 specificity and did not mediate migration of responsive cells.
JOURNAL OF BIOCHEMISTRY
(2022)
Article
Immunology
Kai Kammers, Athena Chen, Daniel R. Monaco, Sarah E. Hudelson, Wendy Grant-McAuley, Richard D. Moore, Galit Alter, Steven G. Deeks, Charles S. Morrison, Leigh A. Eller, Joel N. Blankson, Oliver Laeyendecker, Ingo Ruczinski, Susan H. Eshleman, H. Benjamin Larman
Summary: Low HIV viral load is linked to delayed disease progression and reduced transmission, with HIV controllers able to suppress viral load without treatment. The study used the VirScan antibody profiling system to compare antibody reactivity in different HIV groups. Results showed that controllers had higher antibody reactivity to certain peptides compared to non-controllers who were virally suppressed on ART.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Matthew Weichseldorfer, Yutaka Tagaya, Marvin Reitz, Anthony L. DeVico, Olga S. Latinovic
Summary: This study aims to understand the different conformations of CCR5 involved in HIV entry and identify the specific CCR5 populations that are best targeted to inhibit HIV-1 entry. Through quantification and visualization, it was found that a decreased surface presence of certain CCR5 subpopulations after infection represents a highly relevant target for future antiviral therapy strategies. The findings will contribute to the development of inhibitors to block CCR5 usage by HIV-1 and inform future HIV-1 vaccine design.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Makoto Nakakido, Naoki Tanaka, Ayako Shimojo, Nobuhiro Miyamae, Kouhei Tsumoto
Summary: Respiratory infectious diseases pose a serious global threat, and novel antiviral materials are in high demand. In this study, a new platform was constructed to evaluate antiviral activity of surface coating materials using the M13 bacteriophage and phagemid system. The experimental system developed in this study provides rapid and effective screening, which can be applied to the development of novel antiviral materials.
Article
Immunology
Thauane Silva, Jairo R. Temerozo, Gabriele do Vale, Andre C. Ferreira, Vinicius Cardoso Soares, Suelen Silva Gomes Dias, Gabriela Sardella, Dumith Chequer Bou-Habib, Marilda Siqueira, Thiago Moreno L. Souza, Milene Miranda
Summary: This study found that ligands of the CCR5 receptor can inhibit IAV replication by significantly increasing SAMHD1 levels during the course of IAV infection, providing a new perspective on combating viral replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Radheshyam Jena, Sukriti Vishwas, Rajan Kumar, Jaskiran Kaur, Rubiya Khursheed, Monica Gulati, Thakur Gurjeet Singh, B. Meenashi Vanathi, Aftab Alam, Bimlesh Kumar, M. V. N. L. Chaitanya, Saurabh Gupta, Poonam Negi, Narendra Kumar Pandey, Shvetank Bhatt, Gaurav Gupta, Dinesh Kumar Chellappan, Brian G. Oliver, Kamal Dua, Sachin Kumar Singh
Summary: Advances in biotechnology have led to the development of novel approaches for improving human health, particularly in the treatment of life-threatening diseases such as HIV infection, cancer, and neurodegenerative diseases. While current antiretroviral drugs show promise in treating HIV, they are unable to completely cure the disease due to the complexity of HIV pathogenesis and limitations in drug properties. Researchers are exploring alternative treatment strategies, including the use of CRISPR/Cas9 gene editing, and investigating the potential benefits of gene modification in the treatment of HIV.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Laura Franz, Jesko Koehnke
Summary: This study demonstrates a Sortase A-based approach for modifying peptides with enzymes from unrelated pathways, leading to the synthesis of a new-to-nature, hybrid ribosomal natural product in a one-pot reaction.
CHEMICAL COMMUNICATIONS
(2021)
Review
Microbiology
Su Jin Jo, Jun Kwon, Sang Guen Kim, Seung-Jun Lee
Summary: Bacterial infections have become a global threat, and bacteriophages are gaining attention as promising alternatives due to their distinctive attributes and genetic modification abilities. Phage engineering can enhance diagnostics, drug delivery, and therapy, and holds promise in transforming precision medicine, addressing antibiotic resistance, and advancing diverse applications.
Article
Immunology
Bashar Alkhatib, Mary Jabari, Shymaa Bilasy, Husni Abdul-Rahman, Kamal Sandhu, Stephen Lai, Ghalib Alkhatib
Summary: We analyzed a case of a same-gender couple where one partner had HIV while the other partner was HIV-negative. The HIV-negative partner had a mutation in their CCR5 gene, known as CCR5 Delta 32, and a C20S missense mutation. Their cells showed resistance to HIV infection and had no response to a specific chemokine. Although CCR5-specific RNA was present in the HIV-negative partner's cells, CCR5 protein was not detectable. The combination of CCR5 Delta 32 and C20S mutations impaired CCR5 function and conferred resistance to HIV-1.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biotechnology & Applied Microbiology
Tatjana Cornu, Claudio Mussolino, Matthias C. Mueller, Claudia Wehr, Winfried Kern, Toni Cathomen
Summary: The progress in antiretroviral therapy has reduced mortality and improved the quality of life for individuals infected with HIV, but challenges such as drug resistance, treatment-associated toxicity, adherence, and lifelong therapy remain. While an HIV vaccine remains elusive, innovative cell and gene therapies offer new possibilities for treating HIV infection.
HUMAN GENE THERAPY
(2021)
Article
Engineering, Environmental
Ruonan Sun, Pingfeng Yu, Pengxiao Zuo, Dino Villagran, Jacques Mathieu, Pedro J. J. Alvarez
Summary: This study explores the use of engineered bacteriophage M13 to enhance biofilm affinity and precise delivery of polyvalent phages in water distribution systems. The modified M13 shows higher affinity and effectiveness in delivering polyvalent phages to biofilms, resulting in reduced bacterial biomass, biofilm surface coverage, and biofilm regrowth.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Sandra Oloketuyi, Robert Bernedo, Andreas Christmann, Justyna Borkowska, Giulia Cazzaniga, Horst Wilhelm Schuchmann, Joanna Niedziolka-Joensson, Katarzyna Szot-Karpinska, Harald Kolmar, Ario de Marco
Summary: C-reactive protein (CRP) is an inflammation biomarker that should be accurately quantified during infections and healing processes. Nanobodies show promise as alternatives to conventional antibodies in immunodiagnostics, with the ability to achieve higher binder density on capture surfaces. By comparing two different selection strategies, researchers were able to isolate anti-CRP nanobodies with low nanomolar affinity, suitable for use in ELISA and immunoprecipitation assays. One of the nanobodies was fused to SpyTag and used in an electrochemical biosensor to detect CRP with high sensitivity.
Article
Biophysics
Olga I. Guliy, Stella S. Evstigneeva, Lev A. Dykman
Summary: Antibody phage display is a useful technique for producing antibodies to specific antigens, replacing the traditional hybrid-oma technology. It simplifies the process by manipulating DNA and bacteria, shortening the time and reducing the cost of antibody production. Antibodies prepared through phage display can be used as selective receptors in biosensors.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Biochemical Research Methods
Rui Wang, Hui-Da Li, Ying Cao, Zi-Yi Wang, Ting Yang, Jian-Hua Wang
Summary: Viruses, specifically M13 phage, are being utilized in biosensing and biomedicine due to their versatility, specific reactivities, and responsiveness to genetic modifications. M13 phages can be engineered and modified to create a multifunctional analysis platform, with different functional regions performing their tasks without interference. The unique filamentous morphology and flexibility of M13 phages enhance target affinity and signal amplification in analytical applications.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mengmeng Zheng, Jianmin Gao
Summary: Peptides, as a therapeutic modality between small molecules and antibodies, are gaining attention for their ability to combine the benefits of both. This study presents a novel phage library that incorporates two distinct designer groups, allowing the screening of peptides with diverse and non-natural functional motifs. The modification of phage-displayed peptides through sequential chemical reactions resulted in the discovery of potent peptide inhibitors against TEV protease.
ACS CHEMICAL BIOLOGY
(2023)
Article
Immunology
Makoto Miyara, Melissa Saichi, Delphine Sterlin, Francois Anna, Stephane Marot, Alexis Mathian, Mo Atif, Paul Quentric, Audrey Mohr, Laetitia Claer, Christophe Parizot, Karim Dorgham, Hans Yssel, Jehane Fadlallah, Thibaut Chazal, Julien Haroche, Charles-Edouard Luyt, Julien Mayaux, Alexandra Beurton, Neila Benameur, David Boutolleau, Sonia Burrel, Sophia de Alba, Sasi Mudumba, Rick Hockett, Cary Gunn, Pierre Charneau, Vincent Calvez, Anne-Genevieve Marcelin, Alain Combes, Alexandre Demoule, Zahir Amoura, Guy Gorochov
Summary: It was found that most COVID-19 patients developed IgG antibodies against SARS-CoV-2, as well as IgG antibodies against beta-HCoV. However, pre-existing immunity to HCoV does not provide cross-protection against COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Makoto Miyara, Florence Tubach, Valerie Pourcher, Capucine Morelot-Panzini, Julie Pernet, Julien Haroche, Said Lebbah, Elise Morawiec, Guy Gorochov, Eric Caumes, Pierre Hausfater, Alain Combes, Thomas Similowski, Zahir Amoura
Summary: This study investigated the smoking status of COVID-19 patients and found a lower smoking rate among patients compared to the general population in France.
FRONTIERS IN MEDICINE
(2022)
Letter
Biochemistry & Molecular Biology
Diana Molino, Christine Durier, Anne Radenne, Corinne Desaint, Jacques Ropers, Soizic Courcier, Louis Victorien Vieillard, Claire Rekacewicz, Beatrice Parfait, Victor Appay, Frederic Batteux, Emmanuel Barillot, Michel Cogne, Behazine Combadiere, Christiane S. Eberhardt, Guy Gorochov, Philippe Hupe, Laetitia Ninove, Stephane Paul, Isabelle Pellegrin, Sylvie van der Werf, Maeva Lefebvre, Elisabeth Botelho-Nevers, Inmaculada Ortega-Perez, Marie Jaspard, Samba Sow, Jean Daniel Lelievre, Xavier de Lamballerie, Marie Paule Kieny, Eric Tartour, Odile Launay
Editorial Material
Pharmacology & Pharmacy
Guy Gorochov, Stephan von Gunten
Article
Multidisciplinary Sciences
Jeremy Manry, Paul Bastard, Adrian Gervais, Tom Le Voyer, Jeremie Rosain, Quentin Philippot, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Shohei Eto, Marina Garcia-Prat, Lucy Bizien, Alba Parra-Martinez, Rui Yang, Liis Haljasmagi, Melanie Migaud, Karita Sarekannu, Julia Maslovskaja, Nicolas de Prost, Yacine Tandjaoui-Lambiotte, Charles-Edouard Luyt, Blanca Amador-Borrero, Alexandre Gaudet, Julien Poissy, Pascal Morel, Pascale Richard, Fabrice Cognasse, Jesus Troya, Sophie Trouillet-Assant, Alexandre Belot, Kahina Saker, Pierre Garcon, Jacques G. Riviere, Jean-Christophe Lagier, Stephanie Gentile, Lindsey B. Rosen, Elana Shaw, Tomohiro Morio, Junko Tanaka, David Dalmau, Pierre-Louis Tharaux, Damien Sene, Alain Stepanian, Bruno Megarbane, Vasiliki Triantafyllia, Arnaud Fekkar, James R. Heath, Jose Luis Franco, Juan-Manuel Anaya, Jordi Sole-Violan, Luisa Imberti, Andrea Biondi, Paolo Bonfanti, Riccardo Castagnoli, Ottavia M. Delmonte, Yu Zhang, Andrew L. Snow, Steven M. Holland, Catherine M. Biggs, Marcela Moncada-Velez, Andres Augusto Arias, Lazaro Lorenzo, Soraya Boucherit, Dany Anglicheau, Anna M. Planas, Filomeen Haerynck, Sotirija Duvlis, Tayfun Ozcelik, Sevgi Keles, Ahmed A. Bousfiha, Jalila El Bakkouri, Carolina Ramirez-Santana, Stephane Paul, Qiang Pan-Hammarstrom, Lennart Hammarstrom, Annabelle Dupont, Alina Kurolap, Christine N. Metz, Alessandro Aiuti, Giorgio Casari, Vito Lampasona, Fabio Ciceri, Lucila A. Barreiros, Elena Dominguez-Garrido, Mateus Vidigal, Mayana Zatz, Diederik van de Beek, Sabina Sahanic, Ivan Tancevski, Yurii Stepanovskyy, Oksana Boyarchuk, Yoko Nukui, Miyuki Tsumura, Loreto Vidaur, Stuart G. Tangye, Sonia Burrel, Darragh Duffy, Lluis Quintana-Murci, Adam Klocperk, Nelli Y. Kann, Anna Shcherbina, Yu-Lung Lau, Daniel Leung, Matthieu Coulongeat, Julien Marlet, Rutger Koning, Luis Felipe Reyes, Angelique Chauvineau-Grenier, Fabienne Venet, Guillaume Monneret, Michel C. Nussenzweig, Romain Arrestier, Idris Boudhabhay, Hagit Baris-Feldman, David Hagin, Joost Wauters, Isabelle Meyts, Adam H. Dyer, Sean Kennelly, Nollaig M. Bourkeh, Rabih Halwan, Fatemeh Saheb Sharif-Askar, Karim Dorgham, Jerome Sallette, Souad Mehlal Sedkaoui, Suzan AlKhater, Raul Rigo-Bonnin, Francisco Morandeira, Lucie Roussel, Donald C. Vinh, Christian Erikstrup, Antonio Condino-Neto, Carolina Prando, Anastasiia Bondarenko, Andras N. Spaan, Laurent Gilardin, Jacques Fellay, Stanislas Lyonnet, Kaya Bilguvar, Richard P. Lifton, Shrikant Mane, Mark S. Anderson, Bertrand Boisson, Vivien Beziat, Shen-Ying Zhang, Evangelos Andreakos, Olivier Hermine, Aurora Pujol, Part Peterson, Trine H. Mogensen, Lee Rowen, James Mond, Stephanie Debette, Xavier de Lamballerie, Charles Burdet, Lila Bouadma, Marie Zins, Pere Soler-Palacin, Roger Colobran, Guy Gorochov, Xavier Solanich, Sophie Susen, Javier Martinez-Picado, Didier Raoult, Marc Vasse, Peter K. Gregersen, Lorenzo Piemonti, Carlos Rodriguez-Gallego, Luigi D Notarangelo, Helen C. Su, Kai Kisand, Satoshi Okada, Anne Puel, Emmanuelle Jouanguy, Charles M. Rice, Pierre Tiberghien, Qian Zhang, Jean-Laurent Casanova, Laurent Abel, Aurelie Cobat
Summary: This study investigates the impact of autoimmunity on COVID-19-related deaths and finds that individuals carrying autoantibodies neutralizing type I interferons are at higher risk of death, with the risk decreasing with age.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Jean-Eudes Fahrner, Imran Lahmar, Anne-Gaelle Goubet, Yacine Haddad, Agathe Carrier, Marine Mazzenga, Damien Drubay, Carolina Alves Costa Silva, Eric de Sousa, Cassandra Thelemaque, Clea Melenotte, Agathe Dubuisson, Arthur Geraud, Gladys Ferrere, Roxanne Birebent, Camille Bigenwald, Marion Picard, Luigi Cerbone, Joana R. Lerias, Ariane Laparra, Alice Bernard-Tessier, Benoit Kloeckner, Marianne Gazzano, Francois-Xavier Danlos, Safae Terrisse, Eugenie Pizzato, Caroline Flament, Pierre Ly, Eric Tartour, Nadine Benhamouda, Lydia Meziani, Abdelhakim Ahmed-Belkacem, Makoto Miyara, Guy Gorochov, Fabrice Barlesi, Alexandre Trubert, Benjamin Ungar, Yeriel Estrada, Caroline Pradon, Emmanuelle Gallois, Fanny Pommeret, Emeline Colomba, Pernelle Lavaud, Marc Deloger, Nathalie Droin, Eric Deutsch, Bertrand Gachot, Jean-Philippe Spano, Mansouria Merad, Florian Scotte, Aurelien Marabelle, Frank Griscelli, Jean-Yves Blay, Jean-Charles Soria, Miriam Merad, Fabrice Andre, Juliette Villemonteix, Mathieu F. Chevalier, Sophie Caillat-Zucman, Florence Fenollar, Emma Guttman-Yassky, Odile Launay, Guido Kroemer, Bernard La Scola, Markus Maeurer, Lisa Derosa, Laurence Zitvogel
Summary: This study investigates the polarity and specificity of memory T cells against SARS-CoV-2 viral lysates and peptides to determine factors associated with protection against COVID-19. The research reveals a potential imbalance in cytokine release and a specific T cell deficit that may contribute to susceptibility to COVID-19. Current vaccines show variable efficacy in triggering immune responses, suggesting the need for next-generation vaccines to address viral variants.
Article
Immunology
Amelie Guihot, Isabelle Plu, Cathia Soulie, Alice Rousseau, Cecilia Nakid-Cordero, Karim Dorgham, Christophe Parizot, Elena Litvinova, Julien Mayaux, Isabelle Malet, Paul Quentric, Behazine Combadiere, Christophe Combadiere, Olivia Bonduelle, Lucille Adam, Pierre Rosenbaum, Alexandra Beurton, Patrice Hemon, Patrice Debre, Vincent Vieillard, Brigitte Autran, Danielle Seilhean, Frederic Charlotte, Anne-Genevieve Marcelin, Guy Gorochov, Charles-Edouard Luyt
Summary: The immunopathological pulmonary mechanisms leading to Coronavirus Disease (COVID-19)-related death in adults are still poorly understood. This study found that despite strong antiviral CD4 T cell-specific responses migrating to the lung, disease severity still occurs, suggesting a potential pathogenic role for perivascular memory CD4 T cells in fatal COVID-19 pneumonia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Alexis Mathian, Paul Breillat, Karim Dorgham, Paul Bastard, Caroline Charre, Raphael Lhote, Paul Quentric, Quentin Moyon, Alice-Andree Mariaggi, Suzanne Mouries-Martin, Clara Mellot, Francois Anna, Julien Haroche, Fleur Cohen-Aubart, Delphine Sterlin, Noel Zahr, Adrian Gervais, Tom Le Voyer, Lucy Bizien, Quentin Amiot, Micheline Pha, Miguel Hie, Francois Chasset, Hans Yssel, Makoto Miyara, Pierre Charneau, Pascale Ghillani-Dalbin, Jean-Laurent Casanova, Flore Rozenberg, Zahir Amoura, Guy Gorochov
Summary: This study finds that neutralizing and non-neutralizing autoantibodies against type-I interferons (IFNs-I) are present in patients with systemic lupus erythematosus (SLE). Neutralizing anti-IFN-alpha antibodies are associated with reduced IFN-alpha levels and a decreased likelihood of developing active disease, but they increase the risk of herpes zoster and severe COVID-19 pneumonia. Severe COVID-19 pneumonia in SLE patients is mainly associated with combined neutralization of different IFNs-I.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Petra Barhoum, Marc Pineton de Chambrun, Karim Dorgham, Mathieu Kerneis, Sonia Burrel, Paul Quentric, Christophe Parizot, Juliette Chommeloux, Nicolas Brechot, Quentin Moyon, Guillaume Lebreton, Samia Boussouar, Matthieu Schmidt, Hans Yssel, Lucie Lefevre, Makoto Miyara, Jean-Luc Charuel, Stephane Marot, Anne-Genevieve Marcelin, Charles-Edouard Luyt, Pascal Leprince, Zahir Amoura, Gilles Montalescot, Alban Redheuil, Alain Combes, Guy Gorochov, Guillaume Hekimian
Summary: This study compares the characteristics and clinical outcomes of patients with fulminant COVID-19-related myocarditis who meet or do not meet the MIS-A criteria. The results show that these two groups of patients have different presentations, prognosis, and immunological profiles.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Correction
Biochemistry & Molecular Biology
A. Magnani, M. Semeraro, F. Adam, C. Booth, L. Dupre, E. C. Morris, A. Gabrion, C. Roudaut, D. Borgel, A. Toubert, E. Clave, C. Abdo, G. Gorochov, R. Petermann, M. Guiot, M. Miyara, D. Moshous, E. Magrin, A. Denis, F. Suarez, C. Lagresle, A. M. Roche, J. Everett, A. Trinquand, M. Guisset, J. Xu Bayford, S. Hacein-Bey-Abina, A. Kauskot, R. Elfeky, C. Rivat, S. Abbas, H. B. Gaspar, E. Macintyre, C. Picard, F. D. Bushman, A. Galy, A. Fischer, E. Six, A. J. Thrasher, M. Cavazzana
Article
Multidisciplinary Sciences
Guillaume Voiriot, Karim Dorgham, Guillaume Bachelot, Anne Fajac, Laurence Morand-Joubert, Christophe Parizot, Grigorios Gerotziafas, Dominique Farabos, Germain Trugnan, Thibaut Eguether, Clarisse Blayau, Michel Djibre, Alexandre Elabbadi, Aude Gibelin, Vincent Labbe, Antoine Parrot, Matthieu Turpin, Jacques Cadranel, Guy Gorochov, Muriel Fartoukh, Antonin Lamaziere
Summary: In this study, the immune-inflammatory biomarker signature in bronchoalveolar and blood samples of critically ill COVID-19 patients was identified and found to be associated with a poor 28-day outcome.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Immunology
Alexandre Bolze, Trine H. Mogensen, Shen-Ying Zhang, Laurent Abel, Evangelos Andreakos, Lisa M. Arkin, Alessandro Borghesi, Petter Brodin, David Hagin, Giuseppe Novelli, Satoshi Okada, Jonny Peter, Laurent Renia, Karine Severe, Pierre Tiberghien, Donald C. Vinh, Elizabeth T. Cirulli, Jean-Laurent Casanova, Elena W. Y. Hsieh
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Letter
Dermatology
Oceane Landon-Cardinal, Perrine Guillaume-Jugnot, Segolene Toquet, Nabiha Sbeih, Aude Rigolet, Nicolas Champtiaux, Karim Dorgham, Guy Gorochov, Alain Meyer, Celine Anquetil, Stephane Barete, Olivier Benveniste, Yves Allenbach
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Immunology
Sandra Weller, Delphine Sterlin, Tatiana Fadeev, Eva Coignard, Alba Verge de los Aires, Clara Goetz, Remi Fritzen, Mathilde Bahuaud, Frederic Batteux, Guy Gorochov, Jean-Claude Weill, Claude-Agnes Reynaud
Summary: By sequencing the antibodies produced by B cells in humans vaccinated with Pneumovax, it was found that marginal zone (MZ) B cells play a significant role in T-independent (TI) immune responses. The study also showed that immunoglobulin M (IgM) components were already diversifying and amplifying before vaccination. These clones could be traced back mainly to MZ B cells, along with clonally related IgA+ and IgG+CD27+ B cells. Recombinant monoclonal antibodies derived from these large B cell clones were able to recognize various bacterial species in the gut, indicating the involvement of MZ and switched B cells in TI responses and their cross-reactivity with pneumococcus through somatic hypermutation.
SCIENCE IMMUNOLOGY
(2023)
Article
Immunology
Paul Bastard, Sara Vazquez, Jamin Liu, Matthew T. Laurie, Chung Yu Wang, Adrian Gervais, Tom Le Voyer, Lucy Bizien, Colin Zamecnik, Quentin Philippot, Jeremie Rosain, Emilie Catherinot, Andrew Willmore, Anthea M. Mitchell, Rebecca Bair, Pierre Garcon, Heather Kenney, Arnaud Fekkar, Maria Salagianni, Garyphallia Poulakou, Eleni Siouti, Sabina Sahanic, Ivan Tancevski, Gunter Weiss, Laurenz Nagl, Jeremy Manry, Sotirija Duvlis, Daniel Arroyo-Sanchez, Estela Paz Artal, Luis Rubio, Cristiano Perani, Michela Bezzi, Alessandra Sottini, Virginia Quaresima, Lucie Roussel, Donald C. Vinh, Luis Felipe Reyes, Margaux Garzaro, Nevin Hatipoglu, David Boutboul, Yacine Tandjaoui-Lambiotte, Alessandro Borghesi, Anna Aliberti, Irene Cassaniti, Fabienne Venet, Guillaume Monneret, Rabih Halwani, Narjes Saheb Sharif-Askari, Jeffrey Danielson, Sonia Burrel, Caroline Morbieu, Yurii Stepanovskyy, Anastasia Bondarenko, Alla Volokha, Oksana Boyarchuk, Alenka Gagro, Mathilde Neuville, Benedicte Neven, Sevgi Keles, Romain Hernu, Antonin Bal, Antonio Novelli, Giuseppe Novelli, Kahina Saker, Oana Ailioaie, Arnau Antoli, Eric Jeziorski, Gemma Rocamora-Blanch, Carla Teixeira, Clarisse Delaunay, Marine Lhuillier, Paul Le Turnier, Yu Zhang, Matthieu Mahevas, Qiang Pan-Hammarstrom, Hassan Abolhassani, Thierry Bompoil, Karim Dorgham, French Covid Study Group, Guy Gorochov, Cedric Laouenan, Carlos Rodriguez-Gallego, Lisa F. P. Ng, Laurent Renia, Aurora Pujol, Alexandre Belot, Francois Raffi, Luis M. Allende, Javier Martinez-Picado, Tayfun Ozcelik, Sevgi Keles, Luisa Imberti, Luigi D. Notarangelo, Jesus Troya, Xavier Solanich, Shen-Ying Zhang, Anne Pue, Michael R. Wilson, Sophie Trouillet-Assants, Laurent Abe, Emmanuelle Jouanguy, Chun Jimmie Ye, Aurelie Cobat, Leslie M. Thompson, Evangelos Andreakos, Qian Zhang, Mark S. Anderson, Jean-Laurent Casanova, Joseph L. DeRisi
Summary: The presence of autoantibodies neutralizing type I interferons may contribute to breakthrough cases of hypoxemic COVID-19 pneumonia in vaccinated individuals. This highlights the vulnerability of this particular population.
SCIENCE IMMUNOLOGY
(2022)