Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation

Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity

(2017) Jutamas Suwanpradid et al.   JOURNAL OF IMMUNOLOGY

The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors

(2016) Jeffrey S. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

(2016) Tarsis F. Brust et al.   Science Signaling

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

(2016) Tarsis F. Brust et al.   Science Signaling

Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

(2015) Ignacio Moraga et al.   CELL

“Chemokine receptors as therapeutic targets: Why aren’t there more drugs?”

(2015) Roberto Solari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis

(2014) Yaniv Zohar et al.   JOURNAL OF CLINICAL INVESTIGATION

Multicenter Phase II Study of Mogamulizumab (KW-0761), a Defucosylated Anti-CC Chemokine Receptor 4 Antibody, in Patients With Relapsed Peripheral T-Cell Lymphoma and Cutaneous T-Cell Lymphoma

(2014) Michinori Ogura et al.   JOURNAL OF CLINICAL ONCOLOGY

Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers

(2014) David G. Soergel et al.   PAIN

CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo

(2014) M. Rashighi et al.   Science Translational Medicine

The β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium

(2013) Michelle M. Monasky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

(2013) Sudarshan Rajagopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

(2013) J. Quoyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical Subtleties in Small-Molecule Modulation of Peptide Receptor Function: The Case of CXCR3 Biaryl-Type Ligands

(2012) Maikel Wijtmans et al.   JOURNAL OF MEDICINAL CHEMISTRY

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

(2012) Asuka Inoue et al.   NATURE METHODS

 -Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway

(2012) H. L. Nichols et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3

(2011) DJ Scholten et al.   BRITISH JOURNAL OF PHARMACOLOGY

CXCR3 ligands: redundant, collaborative and antagonistic functions

(2011) Joanna R Groom et al.   IMMUNOLOGY AND CELL BIOLOGY

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

(2011) L. J. Drury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Arrestins Scaffold Cofilin with Chronophin to Direct Localized Actin Filament Severing and Membrane Protrusions Downstream of Protease-activated Receptor-2

(2010) Maria Zoudilova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An arrestin-dependent multi-kinase signaling complex mediates MIP-1β/CCL4 signaling and chemotaxis of primary human macrophages

(2009) Ricky Cheung et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance

(2009) Bing Luan et al.   NATURE

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

(2009) D. A. Zidar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCR4 dimerization and  -arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome

(2008) B. Lagane et al.   BLOOD

A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

(2008) Jean-Martin Beaulieu et al.   CELL

CXCR3 Antagonist NBI-74330 Attenuates Atherosclerotic Plaque Formation in LDL Receptor–Deficient Mice

(2007) Eva J.A. van Wanrooij et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY