Article
Optics
Xuanling Li, Zhaowu Chen, Yinmei Li, Hanci Liang, Haowei Wang, Ming Li
Summary: The study demonstrated that transfection of miR-92b-3p significantly increased invasiveness and membrane fluidity of SHP77 cells. By using optical tweezers and a newly developed physical model, the research laid the groundwork for a better understanding of cancer cell invasion and membrane mechanical characteristics.
Article
Biotechnology & Applied Microbiology
Caimei Wang, Yiyuan Wang, Congrong Liu, Xiaoyu Meng, Zhongxia Hang
Summary: This study reveals the important role of KNTC1 in the development of cervical cancer and identifies the mechanism by which KNTC1 promotes cervical cancer through MMP9 and MMP2-mediated reduction in tumor cell invasion and migration abilities.
Article
Oncology
Weiwei Chen, Daguang Ni, Hailin Zhang, Xia Li, Youqin Jiang, Jixiang Wu, Yan Gu, Mingcheng Gao, Woda Shi, Jianxiang Song, Wenyu Shi
Summary: Aberrant ubiquitin modifications caused by an imbalance in the activities of ubiquitinases and de-ubiquitinases are important mechanisms underlying non-small cell lung cancer (NSCLC) progression. The deubiquitinating enzyme USP15 plays a key role in NSCLC tumorigenesis and is a potential therapeutic target. Knocking down USP15 expression in NSCLC cells leads to suppressed cell proliferation, reduced migration and invasion abilities, and decreased tumor size in animal models. USP15 knockdown also inhibits the expression of MMP3 and MMP9, and high levels of USP15 and MMP3 are associated with poor prognosis in NSCLC.
Article
Cardiac & Cardiovascular Systems
Shane P. Smith, Adam J. Bograd, Gal Levy, Shu-Ching Chang, Alex S. Farivar, Ralph W. Aye, Brian E. Louie, Eric Vallieres
Summary: This study investigated the impact of resection extent on overall survival and recurrence patterns in lung cancer patients with tumors invading across the fissure. Results showed that parenchymal-sparing resections can reduce immediate surgical morbidity, do not increase the cumulative incidence of recurrence, and have no significant difference in overall survival compared to maximal resections.
ANNALS OF THORACIC SURGERY
(2021)
Article
Multidisciplinary Sciences
Eunsun Ko, Dasom Kim, Dong Wha Min, Seung-Hae Kwon, Ji-Yun Lee
Summary: Nrf2 is a important regulator of antioxidant and anti-inflammatory enzymes, interacting with Keap1 to affect the transcription of cytoprotective enzymes. The Nrf2/Keap1 pathway may impact cell motility through dysregulation of the RhoA-ROCK1 signaling pathway in non-small cell lung cancer cells.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Atsushi Kagimoto, Yasuhiro Tsutani, Yoshihisa Shimada, Takahiro Mimae, Yoshihiro Miyata, Hiroyuki Ito, Haruhiko Nakayama, Norihiko Ikeda, Morihito Okada
Summary: Segmentectomy is feasible for clinically early-stage NSCLC, regardless of the presence of LY, V, PL, or lymph node metastasis.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Food Science & Technology
Haiyan Zheng, Yu Pei, Yuan-Lin He, Yi Liu, Minqi Chen, Pengzhi Hong, Chunxia Zhou, Zhong-Ji Qian
Summary: Sulfated polysaccharides from red algae have antitumor activities. In this study, it was found that the sulfated polysaccharide from Gelidium crinale can inhibit the migration and invasion of human fibrosarcoma cells and suppress the expression and activity of MMP-9 by regulating NF-kappa B, MAPK, and mTOR/PI3K/Akt signaling pathways. This suggests that GNP may serve as an MMP-9 inhibitor for preventing tumor metastasis.
Article
Medicine, General & Internal
Ki-Eun Hwang, Hyo-Jin Kim, In-Sol Song, Chul Park, Jae Wan Jung, Sim Park, Seon-Hee Oh, Young-Suk Kim, Hak-Ryul Kim
Summary: Salinomycin (Sal) inhibits TGF-beta 1-induced EMT by downregulating MMP-2 and MMP-9 through the AMPK/SIRT pathway, thereby blocking lung cancer cell migration and invasion.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Food Science & Technology
Shuai Hao, Fannian Li, Yuanpu Liu, Qi Yang, Qiancheng Li, Wenjing Zhang, Chengtao Wang
Summary: The study found that phycocyanin can inhibit the viability of non-small cell lung cancer cells by activating autophagy and AMPK signaling pathway. Therefore, targeting autophagy could be a promising approach to improve the treatment of NSCLC.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell Biology
Changhui Li, Jiaqi Zhang, Xiaohua Yang, Cheng Hu, Tianqing Chu, Runbo Zhong, Yinchen Shen, Fang Hu, Feng Pan, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Hai Zhang, Wei Nie, Baohui Han, Xueyan Zhang
Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Yitong Xu, Chenglong Wang, Xizi Jiang, Yao Zhang, Hongbo Su, Jun Jiang, Hongjiu Ren, Xueshan Qiu
Summary: KLHL38 plays a promoting role in non-small cell lung cancer, enhancing cell proliferation, migration, and invasion through activating the Akt signaling pathway, and is closely associated with the malignancy of tumors.
CELL DEATH & DISEASE
(2021)
Article
Veterinary Sciences
Florentina Daraban Bocaneti, Gennaro Altamura, Annunziata Corteggio, Oana Irina Tanase, Mihaela Anca Dascalu, Sorin Aurelian Pasca, Ozana Hritcu, Mihai Mares, Giuseppe Borzacchiello
Summary: This study conducted immunohistochemical and biochemical analysis on MMPs and TIMPs in BPV-2 positive bovine cutaneous fibropapillomas, revealing their significant role in tumor development and their unbalanced expression in tumor samples.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Medicine, Research & Experimental
Huimin Shi, Renyu Kong, Xu Miao, Lingshan Gou, Xin Yin, Yuning Ding, Xiliang Cao, Qingyong Meng, Maosheng Gu, Feng Suo
Summary: Reduced levels of PPP1R3G may contribute to the progression of pre-eclampsia by suppressing trophoblast invasion and migration and targeting the Akt/MMP-9 signaling pathway.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Chung-Yuan Lee, Yung-Chuan Ho, Chiao-Wen Lin, Min-Chieh Hsin, Po-Hui Wang, Ya-Cheng Tang, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Xiao-Wei Zhang, Lin Li, Wen-Qian Hu, Ming-Ning Hu, Yan Tao, Hui Hu, Xiao-Kang Miao, Wen-Le Yang, Qiong Zhu, Ling-Yun Mou
Summary: This study reveals that G protein-coupled receptor neurokinin-1 (NK1R) is significantly upregulated in lung cancer samples and is associated with advanced clinical stages and poor prognosis. NK1R co-expresses with epidermal growth factor receptor (EGFR) and interacts with it in tumor cells. Activation of NK1R promotes lung cancer cell proliferation and migration through EGFR signaling pathways. Inhibition of NK1R suppresses cell proliferation and migration, and knockdown of NK1R slows down tumor growth. The presence of a selective NK1R antagonist enhances the sensitivity of lung cancer cells to specific drugs.
CELL DEATH & DISEASE
(2022)