Article
Oncology
Ruozheng Wei, Yuning Zhou, Chang Li, Piotr Rychahou, Shulin Zhang, William B. Titlow, Greg Bauman, Yuanyuan Wu, Jinpeng Liu, Chi Wang, Heidi L. Weiss, B. Mark Evers, Qingding Wang
Summary: This study identifies ketogenesis as a critical regulator of the tumor microenvironment in colorectal cancer and suggests the potential for ketogenic diets as a metabolic strategy to overcome immunosuppression and prolong survival.
Article
Oncology
Hye Won Kawk, Gun-He Nam, Myeong Jin Kim, Sang-Yong Kim, Young-Min Kim
Summary: The study qualitatively evaluated beta-sitosterol in Scaphium affine ethanol extracts (SAE) through HPLC and confirmed its cytotoxicity and invasion suppression effects on colorectal cancer cells. In vivo experiments further demonstrated the anticancer properties of SAE in inducing anoikis through the EGFR/Akt pathway in HCT116 colorectal cancer cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Integrative & Complementary Medicine
Jia-Lu Zheng, Shuang-Shuang Wang, Ke-Ping Shen, Lei Chen, Xiao Peng, Jin-Fang Chen, Hong-Mei An, Bing Hu
Summary: Ursolic acid (UA) inhibits growth and induces apoptosis in RKO cells by regulating cell cycle, activating caspases, and increasing ROS levels. Furthermore, UA induces anoikis by inhibiting FAK/PI3K/AKT signaling and down-regulating EMT-related proteins.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Cell Biology
Dong Wang, Xiaohui Wang, Yujia Song, Mahan Si, Yuqi Sun, Xiaohui Liu, Shuxiang Cui, Xianjun Qu, Xinfeng Yu
Summary: This study found a significant positive correlation between CXCR7 expression and CAF activation markers in colonic tissues and transgenic mice. RNA sequencing revealed an increase in miR-146a-5p and miR-155-5p levels in CXCR7-overexpressing CRC cells and their exosomes. Furthermore, these CRC cell-derived miRNAs could be uptaken by CAFs via exosomes and promote their activation, leading to enhanced invasive capacity of CRC cells and pro-metastatic switch. The activation of CAFs by miR-146a-5p and miR-155-5p also facilitated tumor formation and lung metastasis of CRC in vivo. Therefore, these findings provide new insights into CXCR7-mediated CRC metastasis and suggest potential biomarkers and therapeutic targets for inhibiting CRC metastasis.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Meng Zhang, Ruyi Peng, Haizhou Wang, Zhenwei Yang, Hailin Zhang, Yangyang Zhang, Meng Wang, Hongling Wang, Jun Lin, Qiu Zhao, Jing Liu
Summary: This study discovered that Nanog can induce cellular dormancy in colorectal cancer cells through the FAO/ACLY-dependent pathway. This finding reveals a specific mechanism governing cellular dormancy in colorectal cancer.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Wei-Lun Hsu, Chieh-Min Wang, Chao-Ling Yao, Ssu-Ching Chen, Chung-Yi Nien, Yang-Ho Sun, Tsung-Yu Tseng, Yueh-Hsia Luo
Summary: The selenocompound SeC selectively attacks Nrf2-addicted colorectal cancer cells by reducing Nrf2 and autophagy pathway protein expression, resulting in cell death.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Siying Wang, Yuanyuan Lv, Yangyang Zhou, Jing Ling, Hui Wang, Dishui Gu, Cun Wang, Wenxin Qin, Xingling Zheng, Haojie Jin
Summary: The acidic tumor microenvironment (TME) promotes autophagy of HCC cells via the AMPK/mTOR pathway, enhancing anoikis resistance. This process is regulated by miR-3663-3p, providing new insights into HCC progression involving the acidic TME.
Article
Oncology
Taneli T. Mattila, Madhura Patankar, Juha P. Vayrynen, Kai Klintrup, Jyrki Makela, Anne Tuomisto, Pentti Nieminen, Markus J. Makinen, Tuomo J. Karttunen
Summary: Anoikis refers to apoptosis induced by the loss of contact with the extracellular matrix. We have found that it is possible to quantitatively evaluate putative anoikis resistant subpopulations in colorectal carcinoma, and the abundance of these structures in lymph node metastases is associated with prognosis.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Oncology
Teresa Catalano, Emira D'Amico, Carmelo Moscatello, Maria Carmela Di Marcantonio, Alessio Ferrone, Giuseppina Bologna, Federico Selvaggi, Paola Lanuti, Roberto Cotellese, Maria Cristina Curia, Rossano Lattanzio, Gitana Maria Aceto
Summary: The dysregulation of Wnt pathways in colorectal cancer is influenced by oxidative stress, leading to modulation of APC and beta-Catenin proteins. This study sheds light on the potential impact of oxidative distress on Wnt signaling functions in CRC and suggests avenues for developing personalized therapeutic approaches.
Article
Oncology
Xiaobing Duan, Haiwen Chen, Xiang Zhou, Pingjuan Liu, Xiao Zhang, Qian Zhu, Ling Zhong, Wanlin Zhang, Shanshan Zhang, Xinyu Zhang, Yanhong Chen, Yan Zhou, Chaopin Yang, Qisheng Feng, Yi-Xin Zeng, Miao Xu, Tong Xiang
Summary: This study reveals a mechanism by which EBV-associated epithelial malignancies escape NK-cell-mediated immune surveillance, providing a new target for improving NK-cell immunotherapy.
Review
Cell Biology
Yalan Dai, Xinyi Zhang, Yingjun Ou, Linglin Zou, Duoli Zhang, Qingfan Yang, Yi Qin, Xiuju Du, Wei Li, Zhanpeng Yuan, Zhangang Xiao, Qinglian Wen
Summary: Breast cancer has the highest global incidence among all tumor types and metastasis is a critical cause of poor prognosis. Anoikis, a form of apoptosis induced by cell detachment from the native environment, is a crucial process in tumor metastasis. Understanding the mechanisms of anoikis resistance can inform strategies for preventing and regressing metastatic breast cancer.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Pathology
Jingbing Liu, Guanzheng Lu, Can Liang, Yifan Tian, Ziyu Jiang
Summary: Colorectal cancer is a deadly malignancy and its therapeutic approaches are evolving. Anoikis, a mechanism of programmed cell death, is less studied compared to other mechanisms, but resistance to anoikis is critical for metastasis and survival. Therefore, understanding the mechanisms essential for anchorage-independent growth and metastasis is important for countering CRC progression.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Tommaso Colangelo, Annalucia Carbone, Francesco Mazzarelli, Roberto Cuttano, Elisa Dama, Teresa Nittoli, Jacopo Albanesi, Giovannina Barisciano, Nicola Forte, Orazio Palumbo, Paolo Graziano, Alessandra di Masi, Vittorio Colantuoni, Lina Sabatino, Fabrizio Bianchi, Gianluigi Mazzoccoli
Summary: The study reveals the functional role of the circadian gene Timeless (TIM) in colorectal cancer (CRC). Loss of TIM expression is associated with cancer development, metastasis, and accumulation of DNA damage. The unedited TIM-ZEB1 axis is involved in malignant phenotype acquisition in colorectal carcinogenesis, and TIM-ZEB1 expression profiling could serve as a prognostic biomarker in CRC.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Multidisciplinary Sciences
Hnin Ei Ei Khine, Gea Abigail Uy Ecoy, Sittiruk Roytrakul, Narumon Phaonakrop, Natapol Pornputtapong, Eakachai Prompetchara, Pithi Chanvorachote, Chatchai Chaotham
Summary: The study demonstrates the potential of peptide from Lentinus squarrosulus as a chemotherapeutic adjuvant for cisplatin treatment in lung cancer, showing enhanced apoptosis and inhibited colony formation in cancer cells, indicating a novel combined chemotherapy approach.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Dechen Fu, Luke Pfannenstiel, Abeba Demelash, Yee Peng Phoon, Cameron Mayell, Claudia Cabrera, Caini Liu, Junjie Zhao, Josephine Dermawan, Deepa Patil, Jennifer DeVecchio, Matthew Kalady, Andrew J. Souers, Darren C. Phillips, Xiaoxia Li, Brian Gastman
Summary: Chemotherapy-induced MCL1 translocation represents a novel resistance mechanism in colorectal cancer (CRC), especially in p53(null) CRC. Additionally, MCL1 nuclear translocation confers sensitivity to Bcl-xL inhibitors in chemotherapy-treated p53(-/-) CRC models, indicating potential therapeutic strategies for this type of cancer.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Yue Leng, Ammara Abdullah, Michael K. Wendt, Sarah Calve
Article
Oncology
Aparna Shinde, Shana D. Hardy, Dongwook Kim, Saeed Salehin Akhand, Mohit Kumar Jolly, Wen-Hung Wang, Joshua C. Anderson, Ryan B. Khodadadi, Wells S. Brown, Jason T. George, Sheng Liu, Jun Wan, Herbert Levine, Christopher D. Willey, Casey J. Krusemark, Robert L. Geahlen, Michael K. Wendt
Article
Biochemistry & Molecular Biology
Dongwook Kim, Yixing Sun, Dan Xie, Kyle E. Denton, Hao Chen, Hang Lin, Michael K. Wendt, Carol Beth Post, Casey J. Krusemark
Article
Oncology
Aparna Shinde, Juan Sebastian Paez, Sarah Libring, Kelsey Hopkins, Luis Solorio, Michael K. Wendt
Article
Oncology
Sarah Libring, Aparna Shinde, Monica K. Chanda, Maryam Nuru, Heather George, Aya M. Saleh, Ammara Abdullah, Tamara L. Kinzer-Ursem, Sarah Calve, Michael K. Wendt, Luis Solorio
Article
Biochemistry & Molecular Biology
Hao Chen, Sarah Libring, Kasi Viswanatharaju Ruddraraju, Jinmin Miao, Luis Solorio, Zhong-Yin Zhang, Michael K. Wendt
Article
Oncology
Brian H. Jun, Tianqi Guo, Sarah Libring, Monica K. Chanda, Juan Sebastian Paez, Aparna Shinde, Michael K. Wendt, Pavlos P. Vlachos, Luis Solorio
Article
Oncology
Saeed S. Akhand, Hao Chen, Stephen Connor Purdy, Zian Liu, Joshua C. Anderson, Christopher D. Willey, Michael K. Wendt
Summary: T-DM1 efficiently delivers microtubule inhibitor to HER2 overexpressing cells, while induction of EMT may promote emergence of T-DM1 resistant cells.
Article
Biochemistry & Molecular Biology
Aaron D. Krabill, Hao Chen, Sajjad Hussain, Chad S. Hewitt, Ryan D. Imhoff, Christine S. Muli, Chittaranjan Das, Paul J. Galardy, Michael K. Wendt, Daniel P. Flaherty
Summary: A new UCHL1 inhibitor, 34, with improved activity against UCHL1 and no activity against UCHL3 was developed, demonstrating selective inhibition against UCHL1 with no discernible off-target toxicity in cells. This molecule was used for probe studies to assess UCHL1's role in myeloma cell proliferation and small cell lung cancer cell migration behavior, making it a valuable tool for biological evaluation of UCHL1.
Article
Biochemistry & Molecular Biology
Violet A. Kiesel, Madeline P. Sheeley, Shawn S. Donkin, Michael K. Wendt, Stephen D. Hursting, Dorothy Teegarden
Summary: In this study, the differential glutamine metabolism in nonmetastatic and metastatic murine mammary cancer cells was investigated. The results showed that metastatic cells were more sensitive to changes in glutamine concentrations and had increased glutamine metabolism compared to nonmetastatic cells. Additionally, it was found that nonmetastatic cells were able to avoid nitrogen cytotoxicity through metabolic reprogramming.
Article
Biochemistry & Molecular Biology
Madeline P. Sheeley, Violet A. Kiesel, Chaylen Andolino, Nadia A. Lanman, Shawn S. Donkin, Stephen D. Hursting, Michael K. Wendt, Dorothy Teegarden
Summary: Metabolic reprogramming plays a key role in cancer progression and metastasis. In this study, the researchers investigated the effects of the bioactive metabolite of vitamin D, 1,25(OH)(2)D, on cell survival in ECM-detached conditions. They found that pretreatment with 1,25(OH)(2)D reduced cell viability in detached conditions and altered glutamine metabolism. Further analysis revealed that 1,25(OH)(2)D suppressed the expression and activity of pyruvate carboxylase (PC), a key enzyme involved in cancer cell anchorage independence. These results suggest that 1,25(OH)(2)D may suppress cancer progression by inhibiting PC and preventing anchorage independence.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Oncology
Violet A. Kiesel, Madeline P. Sheeley, Emily M. Hicks, Chaylen Andolino, Shawn S. Donkin, Michael K. Wendt, Stephen D. Hursting, Dorothy Teegarden
Summary: Regions of hypoxia in solid tumors contribute to gene expression changes and increased risk of cancer metastasis. This study found that metastatic cancer cells exhibit stronger metabolic suppression and antioxidant response to hypoxia, indicating their ability to adapt and survive in low oxygen conditions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Hao Chen, Gregory M. Cresswell, Sarah Libring, Mitchell G. Ayers, Jinmin Miao, Zhong-Yin Zhang, Luis Solorio, Timothy L. Ratliff, Michael K. Wendt
CANCER RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Elizabeth G. Porter, Alisha Dhiman, Basudev Chowdhury, Benjamin C. Carter, Hang Lin, Jane C. Stewart, Majid Kazemian, Michael K. Wendt, Emily C. Dykhuizen
Article
Oncology
Aparna Shinde, Tomasz Wilmanski, Hao Chen, Dorothy Teegardenand, Michael K. Wendt
BREAST CANCER RESEARCH
(2018)