标题
Ca2+ Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer’s Disease
作者
关键词
-
出版物
Cells
Volume 9, Issue 12, Pages 2655
出版商
MDPI AG
发表日期
2020-12-11
DOI
10.3390/cells9122655
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mitochondrial localization of NCXs: Balancing calcium and energy homeostasis
- (2020) Simona Magi et al. CELL CALCIUM
- NCX and EAAT transporters in ischemia: At the crossroad between glutamate metabolism and cell survival
- (2020) Silvia Piccirillo et al. CELL CALCIUM
- Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer’s Disease Pathology
- (2020) Sean Schrank et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death
- (2020) Song Han et al. Cells
- Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase
- (2020) Noemi Esteras et al. FEBS Journal
- Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer’s Disease
- (2020) Md. Sahab Uddin et al. MOLECULAR NEUROBIOLOGY
- Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances
- (2020) Wenzhang Wang et al. Molecular Neurodegeneration
- NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models
- (2020) Swagata Ghatak et al. MOLECULAR PSYCHIATRY
- Intranasal administration of dantrolene increased brain concentration and duration
- (2020) Jintao Wang et al. PLoS One
- Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease
- (2020) Maria Calvo-Rodriguez et al. Nature Communications
- NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model
- (2020) Simona Magi et al. CELL CALCIUM
- Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability
- (2020) Fabio Bertan et al. CELL DEATH AND DIFFERENTIATION
- Complexin Suppresses Spontaneous Exocytosis by Capturing the Membrane-Proximal Regions of VAMP2 and SNAP25
- (2020) Jörg Malsam et al. Cell Reports
- Memory and Learning Deficits Are Associated With Ca2+ Dyshomeostasis in Normal Aging
- (2020) Arkady Uryash et al. Frontiers in Aging Neuroscience
- Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants
- (2020) Jing Yan et al. SCIENCE
- Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation
- (2020) Jinjing Yao et al. Cell Reports
- Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer’s disease
- (2019) Shreaya Chakroborty et al. Molecular Neurodegeneration
- Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer’s disease
- (2019) Sunil S Adav et al. Molecular Brain
- Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate
- (2019) Yang He et al. Nature Communications
- Synaptopodin deficiency ameliorates symptoms in the 3xTg mouse model of Alzheimer's disease
- (2019) Etay Aloni et al. JOURNAL OF NEUROSCIENCE
- Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors
- (2019) Zoë P. Van Acker et al. Molecular Neurodegeneration
- Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer’s Disease
- (2019) Saranya Canchi et al. Cell Reports
- Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
- (2019) Pooja Jadiya et al. Nature Communications
- Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls
- (2019) Swagata Ghatak et al. eLife
- Calcium Signaling Deficits in Glia and Autophagic Pathways Contributing to Neurodegenerative Disease
- (2018) Sarah Mustaly-Kalimi et al. ANTIOXIDANTS & REDOX SIGNALING
- A new target for Alzheimer’s disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice
- (2018) Katherine Krajnak et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The role of mitochondria in stem cell fate and aging
- (2018) Hongbo Zhang et al. DEVELOPMENT
- Religious Orders Study and Rush Memory and Aging Project
- (2018) David A. Bennett et al. JOURNAL OF ALZHEIMERS DISEASE
- Early Presymptomatic Changes in the Proteome of Mitochondria-Associated Membrane in the APP/PS1 Mouse Model of Alzheimer’s Disease
- (2018) Katalin Völgyi et al. MOLECULAR NEUROBIOLOGY
- Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex
- (2018) Sirui Jiang et al. Molecular Neurodegeneration
- A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease
- (2018) Sara Mostafavi et al. NATURE NEUROSCIENCE
- Intracellular Ca2+stores control in vivo neuronal hyperactivity in a mouse model of Alzheimer’s disease
- (2018) Chommanad Lerdkrai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease
- (2018) Estela Area-Gomez et al. Cell Death & Disease
- Presenilin mutations deregulate mitochondrial Ca2+ homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans
- (2018) Shaarika Sarasija et al. eLife
- Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease
- (2018) Eleanor K. Pickett et al. ACTA NEUROPATHOLOGICA
- Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial
- (2018) Brian Lawlor et al. PLOS MEDICINE
- The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease
- (2018) Minghui Wang et al. Scientific Data
- A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research
- (2018) Philip L. De Jager et al. Scientific Data
- Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling
- (2018) William J. Foster et al. Science Signaling
- The vicious circle of hypometabolism in neurodegenerative diseases: Ways and mechanisms of metabolic correction
- (2017) Yuri Zilberter et al. JOURNAL OF NEUROSCIENCE RESEARCH
- First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288
- (2017) Kelvin W Gee et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain
- (2017) Michal Arbel-Ornath et al. Molecular Neurodegeneration
- Interactions of Mitochondria/Metabolism and Calcium Regulation in Alzheimer’s Disease: A Calcinist Point of View
- (2017) Gary E. Gibson et al. NEUROCHEMICAL RESEARCH
- Activity-Dependent Exocytosis of Lysosomes Regulates the Structural Plasticity of Dendritic Spines
- (2017) Zahid Padamsey et al. NEURON
- BACE inhibition-dependent repair of Alzheimer’s pathophysiology
- (2017) Aylin D. Keskin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Contacts between the endoplasmic reticulum and other membranes in neurons
- (2017) Yumei Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms
- (2017) Jesse S. Kerr et al. TRENDS IN NEUROSCIENCES
- Tau association with synaptic vesicles causes presynaptic dysfunction
- (2017) Lujia Zhou et al. Nature Communications
- RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers
- (2017) Carol D. SanMartín et al. Frontiers in Molecular Neuroscience
- Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer’s Disease-Associated Presenilin 1 Mutation
- (2017) Patricia Martín-Maestro et al. Frontiers in Molecular Neuroscience
- The current agonists and positive allosteric modulators of α 7 nAChR for CNS indications in clinical trials
- (2017) Taoyi Yang et al. Acta Pharmaceutica Sinica B
- Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer’s disease
- (2016) Alfredo Ramos-Miguel et al. ACTA NEUROPATHOLOGICA
- The crucial impact of lysosomes in aging and longevity
- (2016) Didac Carmona-Gutierrez et al. AGEING RESEARCH REVIEWS
- Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease
- (2016) Daniel J. Colacurcio et al. AGEING RESEARCH REVIEWS
- Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B
- (2016) Si Ming Man et al. Autophagy
- Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis
- (2016) Dah Ihm Kim et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Accelerating Medicines Partnership: Alzheimer’s Disease (AMP-AD) Knowledge Portal Aids Alzheimer’s Drug Discovery through Open Data Sharing
- (2016) Richard J. Hodes et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Peroxiredoxin 5 prevents amyloid-beta oligomer-induced neuronal cell death by inhibiting ERK–Drp1-mediated mitochondrial fragmentation
- (2016) Bokyung Kim et al. FREE RADICAL BIOLOGY AND MEDICINE
- Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes
- (2016) Dolores Del Prete et al. JOURNAL OF ALZHEIMERS DISEASE
- Soluble Amyloid-β42 Stimulates Glutamate Release through Activation of the α7 Nicotinic Acetylcholine Receptor
- (2016) Kevin N. Hascup et al. JOURNAL OF ALZHEIMERS DISEASE
- α7-nAChR agonist enhances neural plasticity in the hippocampus via a GABAergic circuit
- (2016) Matthew Townsend et al. JOURNAL OF NEUROPHYSIOLOGY
- Regulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters
- (2016) Trine Lisberg Toft-Bertelsen et al. MOLECULAR BIOLOGY OF THE CELL
- The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model
- (2016) M Cissé et al. MOLECULAR PSYCHIATRY
- Calcium, Reactive Oxygen Species, and Synaptic Plasticity
- (2016) Cecilia Hidalgo et al. PHYSIOLOGY
- Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling
- (2016) Yaling Yin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry
- (2016) Benjamin Chun-Kit Tong et al. Science Signaling
- Deciphering the Molecular Signals of PINK1/Parkin Mitophagy
- (2016) Thanh N. Nguyen et al. TRENDS IN CELL BIOLOGY
- Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry
- (2016) Benjamin Chun-Kit Tong et al. Science Signaling
- Lysosomal Physiology
- (2015) Haoxing Xu et al. Annual Review of Physiology
- Oxidative stress in Alzheimer disease and mild cognitive impairment: evidence from human data provided by redox proteomics
- (2015) Aaron M. Swomley et al. ARCHIVES OF TOXICOLOGY
- Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression
- (2015) Willem Huijbers et al. BRAIN
- Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Encenicline, a Selective α7 Nicotinic Receptor Partial Agonist, in Single Ascending-dose and Bioavailability Studies
- (2015) Ann J. Barbier et al. CLINICAL THERAPEUTICS
- PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease
- (2015) Patricia Martín-Maestro et al. HUMAN MOLECULAR GENETICS
- The Na+/H+Exchanger NHE6 Modulates Endosomal pH to Control Processing of Amyloid Precursor Protein in a Cell Culture Model of Alzheimer Disease
- (2015) Hari Prasad et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca2+release from the endoplasmic reticulum
- (2015) María Guerra-Álvarez et al. JOURNAL OF NEUROCHEMISTRY
- Nitric Oxide Signaling Is Recruited As a Compensatory Mechanism for Sustaining Synaptic Plasticity in Alzheimer's Disease Mice
- (2015) S. Chakroborty et al. JOURNAL OF NEUROSCIENCE
- Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease
- (2015) H. Zhang et al. JOURNAL OF NEUROSCIENCE
- Proteomics of the Synapse – A Quantitative Approach to Neuronal Plasticity
- (2015) Daniela C. Dieterich et al. MOLECULAR & CELLULAR PROTEOMICS
- Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB
- (2015) Diego L. Medina et al. NATURE CELL BIOLOGY
- Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification
- (2015) Caroline Mauvezin et al. Nature Communications
- Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
- (2015) Ju-Hyun Lee et al. Cell Reports
- A Voltage-Gated Calcium Channel Regulates Lysosomal Fusion with Endosomes and Autophagosomes and Is Required for Neuronal Homeostasis
- (2015) Xuejun Tian et al. PLOS BIOLOGY
- Association of Brain DNA Methylation inSORL1,ABCA7,HLA-DRB5,SLC24A4, andBIN1With Pathological Diagnosis of Alzheimer Disease
- (2015) Lei Yu et al. JAMA Neurology
- Safety and clinical effects of EVP-6124 in subjects with Alzheimer's disease currently or previously receiving an acetylcholinesterase inhibitor medication
- (2014) William James Deardorff et al. Expert Review of Neurotherapeutics
- Presynaptic 7 Nicotinic Acetylcholine Receptors Enhance Hippocampal Mossy Fiber Glutamatergic Transmission via PKA Activation
- (2014) Q. Cheng et al. JOURNAL OF NEUROSCIENCE
- The voltage-gated sodium channel TPC1 confers endolysosomal excitability
- (2014) Chunlei Cang et al. Nature Chemical Biology
- Mitochondrial dynamics and inheritance during cell division, development and disease
- (2014) Prashant Mishra et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- α7 Nicotinic Receptor Agonist Enhances Cognition in Aged 3xTg-AD Mice with Robust Plaques and Tangles
- (2013) Rodrigo Medeiros et al. AMERICAN JOURNAL OF PATHOLOGY
- Restoring long-term potentiation impaired by amyloid-beta oligomers: Comparison of an acetylcholinesterase inhibitior and selective neuronal nicotinic receptor agonists
- (2013) Katja S. Kroker et al. BRAIN RESEARCH BULLETIN
- The Role of Calcium Stores in Apoptosis and Autophagy
- (2013) S. S. Smaili et al. CURRENT MOLECULAR MEDICINE
- Phase II Crossover Trial of Varenicline in Mild-to-Moderate Alzheimer's Disease
- (2013) Seong Yoon Kim et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Reduced SNAP-25 alters short-term plasticity at developing glutamatergic synapses
- (2013) Flavia Antonucci et al. EMBO REPORTS
- Presenilins regulate the cellular activity of ryanodine receptors differentially through isotype-specific N-terminal cysteines
- (2013) Andrew J. Payne et al. EXPERIMENTAL NEUROLOGY
- Altered Calcium Metabolism in Aging CA1 Hippocampal Pyramidal Neurons
- (2013) M. M. Oh et al. JOURNAL OF NEUROSCIENCE
- Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits
- (2013) Tao Ma et al. NATURE NEUROSCIENCE
- Beta amyloid peptide plaques fail to alter evoked neuronal calcium signals in APP/PS1 Alzheimer's disease mice
- (2013) Clark A. Briggs et al. NEUROBIOLOGY OF AGING
- Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models
- (2013) L. Hedskog et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons
- (2013) B. Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
- (2013) M. Talantova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitophagy: mechanisms, pathophysiological roles, and analysis
- (2012) Wen-Xing Ding et al. BIOLOGICAL CHEMISTRY
- Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: Implications for lysosomal function
- (2012) Kara M Neely Kayala et al. BRAIN RESEARCH
- Mitochondrial Ca2+ signals in autophagy
- (2012) César Cárdenas et al. CELL CALCIUM
- Upregulated function of mitochondria-associated ER membranes in Alzheimer disease
- (2012) Estela Area-Gomez et al. EMBO JOURNAL
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
- (2012) Katrijn Coen et al. JOURNAL OF CELL BIOLOGY
- Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease
- (2012) K. Shahpasand et al. JOURNAL OF NEUROSCIENCE
- Early Presynaptic and Postsynaptic Calcium Signaling Abnormalities Mask Underlying Synaptic Depression in Presymptomatic Alzheimer's Disease Mice
- (2012) S. Chakroborty et al. JOURNAL OF NEUROSCIENCE
- A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2
- (2012) X. Zhang et al. JOURNAL OF NEUROSCIENCE
- Ryanodine Receptor Blockade Reduces Amyloid- Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease
- (2012) B. Oules et al. JOURNAL OF NEUROSCIENCE
- Mitochondria-associated ER membranes in Alzheimer disease
- (2012) Eric A. Schon et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
- (2012) Manuel Torres et al. Molecular Neurodegeneration
- Endoplasmic reticulum–mitochondria contacts: function of the junction
- (2012) Ashley A. Rowland et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
- (2012) Zu-Hang Sheng et al. NATURE REVIEWS NEUROSCIENCE
- Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice
- (2012) Jun Peng et al. NEUROSCIENCE LETTERS
- Stress management at the ER: Regulators of ER stress-induced apoptosis
- (2012) Adrienne M. Gorman et al. PHARMACOLOGY & THERAPEUTICS
- Stabilizing ER Ca2+ Channel Function as an Early Preventative Strategy for Alzheimer’s Disease
- (2012) Shreaya Chakroborty et al. PLoS One
- Critical role of soluble amyloid- for early hippocampal hyperactivity in a mouse model of Alzheimer's disease
- (2012) M. A. Busche et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cognitive reserve, presynaptic proteins and dementia in the elderly
- (2012) W G Honer et al. Translational Psychiatry
- Primary lysosomal dysfunction causes cargo-specific deficits of axonal transport leading to Alzheimer-like neuritic dystrophy
- (2011) SooYeon Lee et al. Autophagy
- Microautophagy: lesser-known self-eating
- (2011) Wen-wen Li et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug
- (2011) P. F. Copenhaver et al. Disease Models & Mechanisms
- Activation of α7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Aß-mediated inhibition of LTP in the rat hippocampus
- (2011) Tomas Ondrejcak et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy
- (2011) S. Lee et al. JOURNAL OF NEUROSCIENCE
- Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease
- (2011) Angela M. Bruno et al. NEUROBIOLOGY OF AGING
- Amyloid β-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF
- (2010) Andrea C. Paula-Lima et al. ANTIOXIDANTS & REDOX SIGNALING
- Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
- (2010) Dun-Sheng Yang et al. BRAIN
- Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of α7 nicotinic receptors and internalization of NMDA receptors
- (2010) H Shen et al. BRITISH JOURNAL OF PHARMACOLOGY
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
- (2010) Ju-Hyun Lee et al. CELL
- Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer’s disease
- (2010) Eduardo Cumbo et al. EPILEPSY & BEHAVIOR
- NMDA-Mediated Ca2+ Influx Drives Aberrant Ryanodine Receptor Activation in Dendrites of Young Alzheimer's Disease Mice
- (2010) I. Goussakov et al. JOURNAL OF NEUROSCIENCE
- Making memories last: the synaptic tagging and capture hypothesis
- (2010) Roger L. Redondo et al. NATURE REVIEWS NEUROSCIENCE
- The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus
- (2009) Jeroen J.M. Hoozemans et al. AMERICAN JOURNAL OF PATHOLOGY
- Synaptotagmins in Neurodegeneration
- (2009) Gordana Glavan et al. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
- The Common Inhalational Anesthetic Isoflurane Induces Apoptosis via Activation of Inositol 1,4,5-Trisphosphate Receptors
- (2009) Huafeng Wei et al. ANESTHESIOLOGY
- Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy
- (2009) Koji Okamoto et al. DEVELOPMENTAL CELL
- Functional Distribution of Nicotinic Receptors in CA3 Region of the Hippocampus
- (2009) Michael Grybko et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Enhanced Calcium Buffering in F344 Rat Cholinergic Basal Forebrain Neurons Is Associated With Age-Related Cognitive Impairment
- (2009) David Murchison et al. JOURNAL OF NEUROPHYSIOLOGY
- Picomolar Amyloid- Positively Modulates Synaptic Plasticity and Memory in Hippocampus
- (2009) D. Puzzo et al. JOURNAL OF NEUROSCIENCE
- Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice
- (2009) S. Chakroborty et al. JOURNAL OF NEUROSCIENCE
- NAADP mobilizes calcium from acidic organelles through two-pore channels
- (2009) Peter J. Calcraft et al. NATURE
- Presenilins are essential for regulating neurotransmitter release
- (2009) Chen Zhang et al. NATURE
- Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
- (2009) Paul Saftig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Aging-related changes in calcium-binding proteins in rat perirhinal cortex
- (2009) James R. Moyer et al. NEUROBIOLOGY OF AGING
- Oligomeric amyloid associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
- (2009) R. M. Koffie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Gene Network Regulating Lysosomal Biogenesis and Function
- (2009) Marco Sardiello et al. SCIENCE
- Lysosomes co-localize with ryanodine receptor subtype 3 to form a trigger zone for calcium signalling by NAADP in rat pulmonary arterial smooth muscle
- (2008) Nicholas P. Kinnear et al. CELL CALCIUM
- Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications
- (2008) Elliott J Mufson et al. Expert Review of Neurotherapeutics
- SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production
- (2008) Kim N. Green et al. JOURNAL OF CELL BIOLOGY
- Increased intraneuronal resting [Ca2+] in adult Alzheimer’s disease mice
- (2008) José R. Lopez et al. JOURNAL OF NEUROCHEMISTRY
- Action Potential-Independent and Nicotinic Receptor-Mediated Concerted Release of Multiple Quanta at Hippocampal CA3-Mossy Fiber Synapses
- (2008) G. Sharma et al. JOURNAL OF NEUROSCIENCE
- Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating
- (2008) King-Ho Cheung et al. NEURON
- Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks
- (2008) Kishore V. Kuchibhotla et al. NEURON
- Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease
- (2008) M. A. Busche et al. SCIENCE
- Improvement in behavioural symptoms in patients with moderate to severe Alzheimer's disease by memantine: a pooled data analysis
- (2007) S. Gauthier et al. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
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