Article
Biology
Lingjun Ding, Giuseppe Balsamo, Hongbiao Chen, Eduardo Blanco-Hernandez, Ioannis S. Zouridis, Robert Naumann, Patricia Preston-Ferrer, Andrea Burgalossi
Summary: Neural circuits are composed of diverse neuronal cell types, and this diversity plays a crucial role in brain function during natural behavior. In this study, the combination of juxtacellular recording, labeling, and optogenetics enabled the investigation of molecularly defined cell classes in freely moving mice, revealing the weaker spatial modulation and information transmission of Calbindin-positive CA1 pyramidal cells.
Article
Biochemistry & Molecular Biology
Laurel Watkins de Jong, Mohammadreza Mohagheghi Nejad, Euisik Yoon, Sen Cheng, Kamran Diba
Summary: Recurrent connectivity and feedback inhibition from inhibitory neurons play crucial roles in determining the dynamics and computational properties of neuronal circuits. Through optogenetic manipulations and large-scale unit recordings, paradoxical responses were observed in both CA1 and CA3 regions of the hippocampus, where subsets of cells increased firing during photoinhibition while others decreased firing during photoexcitation. These paradoxical responses were more prominent in CA3 and simulations confirmed that both CA1 and CA3 hippocampal regions exhibit inhibition-stabilized networks with strong recurrent excitation.
Article
Neurosciences
Tobias Bock, Adrian Negrean, Steven A. Siegelbaum
Summary: Synaptic inputs targeting distal dendrites can amplify local dendritic spikes, but these spikes are often weak due to dendritic cable properties. Despite this, they are implicated in memory storage, sensory perception, and place field formation. Somatic depolarization can enhance dendritic spike propagation, leading to enhanced memory specificity and long-term synaptic plasticity in hippocampal-dependent spatial representations and learning.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Pablo Vergara, Gabriela Pino, Jorge Vera, Felipe Arancibia, Magdalena Sanhueza
Summary: Prolonged changes in neural activity trigger homeostatic synaptic plasticity, allowing neuronal networks to operate within functional ranges. Deafferentation causes rapid and diverse compensations, which may contribute to understanding homeostatic or pathological events after brain injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Ying Zhang, Hai-Yan Yin, Patrizia Rubini, Peter Illes, Yong Tang
Summary: There is a dispute about whether CNS neurons possess ATP-sensitive P2X7 receptors. By genetically deleting P2X7 receptors in astrocytes and oligodendrocytes, it was found that these receptors indirectly modulate the neuronal input to neighboring neurons.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Yael Almog, Saja Fadila, Marina Brusel, Anat Mavashov, Karen Anderson, Moran Rubinstein
Summary: Dravet syndrome is a rare and severe childhood-onset epilepsy caused by mutations in the SCN1A gene. Studies on Dravet mice showed persistent reduced function in inhibitory neurons and changes in excitatory neurons during different disease stages. This suggests a complex pathophysiological mechanism with reciprocal functional changes in both excitatory and inhibitory neurons influencing the developmental trajectory of the disease.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Xuansheng Xiao, Xiaotong Wang, Ke Zhu, Lijuan Li, Ying He, Jinglan Zhang, Linying Li, Hanning Hu, Yanqiu Cui, Jianliang Zhang, Yan Zheng
Summary: BACE1 is a key enzyme involved in the production of β-amyloid, and is considered a major drug target for Alzheimer's disease. However, BACE1 inhibitors have failed in clinical trials, and may actually worsen cognitive function, suggesting that BACE1 may play a role in regulating cognition-relevant neural circuits.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Aida Maziar, Tristian N. R. H. Y. Critch, Sourav Ghosh, Vishaal Rajani, Cassandra M. Flynn, Tian Qin, Camila Reinhardt, Kwun Nok Mimi Man, Amy Lee, Johannes W. Hell, Qi Yuan
Summary: Aging is linked to cognitive decline and memory loss. In rats, aging leads to changes in neuronal excitability in the piriform cortex and hippocampus, affecting learning abilities.
Article
Neurosciences
Sebi Rolotti, Heike Blockus, Fraser T. Sparks, James B. Priestley, Attila Losonczy
Summary: The hippocampus plays a critical role in memory consolidation, particularly during sharp-wave ripple (SWR) events. This study investigated the relationship between network state and information processing in dendrites, the primary sites of synaptic input integration and plasticity. The researchers found that immobility led to increased dendritic activity, which was concentrated during SWR events. Concurrent dendritic and somatic activity during SWRs predicted increased coupling during subsequent exploration of a novel environment. Somatic-dendritic coupling and SWR recruitment also varied based on cells' tuning distance to reward location during a goal-learning task.
Article
Biochemistry & Molecular Biology
Tae-Kyeong Lee, Myoung Cheol Shin, Ji Hyeon Ahn, Dae Won Kim, Bora Kim, Hyejin Sim, Jae-Chul Lee, Jun Hwi Cho, Joon Ha Park, Young-Myeong Kim, Moo-Ho Won, Choong-Hyun Lee
Summary: This study investigated the time-dependent changes in CD200 expression in the hippocampus after transient forebrain ischemia in gerbils. The results showed that transient ischemia led to specific and selective neuronal death in the CA1 field, with CD200 expression changing over time. Interestingly, treatment with risperidone did not alter CD200 expression, indicating protection of CA1 pyramidal neurons from ischemic injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mark Rigby, Federico W. Grillo, Benjamin Compans, Guilherme Neves, Julia Gallinaro, Sophie Nashashibi, Sally Horton, Pedro M. Pereira Machado, Maria Alejandra Carbajal, Gema Vizcay-Barrena, Florian Levet, Jean-Baptiste Sibarita, Angus Kirkland, Roland A. Fleck, Claudia Clopath, Juan Burrone
Summary: Using scanning electron microscopy, researchers found that excitatory synapses in the hippocampus CA1 region do not fully adhere to the traditional definition. Over half of the excitatory synapses are multi-synaptic boutons, where a single presynaptic bouton can connect to multiple postsynaptic spines on different dendrites. The proportion of multi-synaptic boutons changes during development and with distance from the cell body. These structures exhibit less variability in synaptic properties compared to single synaptic boutons, promoting synchronous activity.
Article
Neurosciences
Christiaan F. M. Huffels, Roland E. van Dijk, Henk Karst, Frank J. Meye, Elly M. Hol, Jinte Middeldorp
Summary: The study demonstrates that blood-borne factors are sufficient to drive neurophysiological impairments in the hippocampal CA1, leading to impaired levels of long-term potentiation (LTP). These impairments are similar to those found in mouse models for AD.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Multidisciplinary Sciences
Yuichiro Hayashi, Ko Kobayakawa, Reiko Kobayakawa
Summary: Recent long-term optical imaging studies have shown that the activity levels of hippocampal neurons in familiar environments fluctuate on a daily to weekly basis. However, it is unclear whether there are any time-invariant properties in the neural representations of these cells. In this study, using miniature fluorescence microscopy, the neural activity of mouse hippocampus was measured in four different environments every 3 days. The results suggest that each cell has an inherent activity level and plays a characteristic role in the coding of space.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Ipshita Zutshi, Manuel Valero, Antonio Fernandez-Ruiz, Gyorgy Buzsaki
Summary: The extent to which neuronal spiking reflects local computation or responses to upstream inputs in circuit operations is a key problem in understanding. By performing experiments on the hippocampus, this study revealed that silencing the medial entorhinal cortex (mEC) largely abolished theta and gamma currents in CA1, while CA3 and local CA1 silencing strongly decreased firing of CA1 neurons. Despite these perturbations, the CA1 circuit was still able to support place field activity and maintain the spatial map.
Article
Neurosciences
Hadas E. Sloin, Amir Levi, Shirly Someck, Lidor Spivak, Eran Stark
Summary: Single hippocampal cells can encode the spatial position of an animal through phase rolling, a faster and distinct form of phase change compared to phase precession. Place fields exhibiting phase rolling are larger in size than nonrolling fields.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Daniel C. Moreira-Lobo, Jader S. Cruz, Flavia R. Silva, Fabiola M. Ribeiro, Christopher Kushmerick, Fernando A. Oliveira
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2017)
Article
Neurosciences
Matthew P. Schroeder, Craig Weiss, Daniel Procissi, Lei Wang, John F. Disterhoft
Article
Neurosciences
Annielle Mendes Brito da Silva, Laiz Costa Silva-Goncalves, Fernando Augusto Oliveira, Manoel Arcisio-Miranda
MOLECULAR NEUROBIOLOGY
(2018)
Article
Biology
Xiao-Wen Yu, Daniel M. Curlik, M. Matthew Oh, Jerry C. P. Yin, John F. Disterhoft
Article
Behavioral Sciences
Timothy F. Musial, Elizabeth Molina-Campos, Linda A. Bean, Natividad Ybarra, Ronen Borenstein, Matthew L. Russo, Eric W. Buss, Daniel Justus, Krystina M. Neuman, Gelique D. Ayala, Sheila A. Mullen, Yuliya Voskobiynyk, Christopher T. Tulisiak, Jasmine A. Fels, Nicola J. Corbett, Gabriel Carballo, Colette D. Kennedy, Jelena Popovic, Josefina Ramos-Franco, Michael Fill, Melissa R. Pergande, Jeffrey A. Borgia, Grant T. Corbett, Kalipada Pahan, Ye Han, Dane M. Chetkovich, Robert J. Vassar, Richard W. Byrne, M. Matthew Oh, Travis R. Stoub, Stefan Remy, John F. Disterhoft, Daniel A. Nicholson
NEUROBIOLOGY OF LEARNING AND MEMORY
(2018)
Review
Geriatrics & Gerontology
Matthew R. Holahan, Niko Tzakis, Fernando A. Oliveira
FRONTIERS IN AGING NEUROSCIENCE
(2019)
Review
Neurosciences
Vitor S. Alves, Helio S. Alves-Silva, Diego J. B. Orts, Luisa Ribeiro-Silva, Manoel Arcisio-Miranda, Fernando A. Oliveira
Article
Behavioral Sciences
M. Matthew Oh, John F. Disterhoft
NEUROBIOLOGY OF LEARNING AND MEMORY
(2020)
Article
Neurosciences
Vitor S. Alves, Manoel Arcisio-Miranda, Daniel C. Carrettiero, Fernando A. Oliveira
Article
Biology
Carmen Lin, Venus N. Sherathiya, M. Matthew Oh, John F. Disterhoft
Correction
Microbiology
Mateus B. Casaro, Andrew M. Thomas, Eduardo Mendes, Claudio Fukumori, Willian R. Ribeiro, Fernando A. Oliveira, Amanda R. Crisma, Gilson M. Murata, Bruna Bizzarro, Anderson Sa-Nunes, Joao C. Setubal, Marcia P. A. Mayer, Flaviano S. Martins, Angelica T. Vieira, Ana T. F. B. Antiorio, Wothan Tavares-de-Lima, Niels O. S. Camara, Rui Curi, Emmanuel Dias-Neto, Caroline M. Ferreira
Article
Microbiology
Mateus B. Casaro, Andrew M. Thomas, Eduardo Mendes, Claudio Fukumori, Willian R. Ribeiro, Fernando A. Oliveira, Amanda R. Crisma, Gilson M. Murata, Bruna Bizzarro, Anderson Sa-Nunes, Joao C. Setubal, Marcia P. A. Mayer, Flaviano S. Martins, Angelica T. Vieira, Ana T. F. B. Antiorio, Wothan Tavares-de-Lima, Niels O. S. Camara, Rui Curi, Emmanuel Dias-Neto, Caroline M. Ferreira
Summary: The study found that probiotics can affect the diversity of gut microbiota in mice, and the abundance of different bacterial genera is also influenced by probiotics. Probiotics have a certain regulatory effect on airway inflammation, with acetate-producing probiotics having a positive impact on allergic inflammation.
Article
Biology
Miguel Antonio Xavier de Lima, Marcus Vinicius C. Baldo, Fernando A. Oliveira, Newton Sabino Canteras
Summary: This study reveals the important role of the anterior cingulate area (ACA) in the acquisition and expression of contextual fear in mice.
Article
Multidisciplinary Sciences
Leila F. Coelho, Mateus B. Casaro, Willian R. Ribeiro, Eduardo Mendes, Gilson Murata, Patricia Xander, Adriana Lino-dos-Santos-Franco, Fernando A. Oliveira, Caroline M. Ferreira
Summary: This study investigates the influence of a high-sugar diet on allergic contact dermatitis (ACD) in mice. The results suggest that a high-sugar diet may increase liver cholesterol and triglyceride levels, worsen dermatitis symptoms, and cause an increase in skin epithelial thickness.
Article
Behavioral Sciences
Xiao-Wen Yu, M. Matthew Oh, John F. Disterhoft
BEHAVIOURAL BRAIN RESEARCH
(2017)
