Review
Biochemistry & Molecular Biology
Lixin Wang, Ehsan Sadeghnezhad, Pingyin Guan, Peijie Gong
Summary: The text discusses the significance of calcium and ROS in signal transductions, as well as the role of microtubules in this process. When it comes to cold sensing, balancing the crosstalk between calcium, microtubules, and ROS poses a challenge.
Article
Biochemistry & Molecular Biology
Daniel B. Dorman, Kim T. Blackwell
Summary: Synaptic plasticity, the experience-induced change in connections between neurons, plays a crucial role in learning and memory. This study investigates how spatiotemporal synaptic input patterns produce plasticity under in vivo-like conditions. The findings reveal the robustness of plasticity to trial-to-trial variability of spike timing and derive general rules describing the control of plasticity by spatiotemporal patterns of synaptic inputs.
Article
Immunology
Tamara Sipka, Romain Peroceschi, Rahma Hassan-Abdi, Martin Gross, Felix Ellett, Christina Begon-Pescia, Catherine Gonzalez, Georges Lutfalla, Mai Nguyen-Chi
Summary: This study investigated the signaling cascade necessary for macrophage recruitment and activation after injury, using transparent zebrafish larvae as a model system. The findings suggest that inhibiting intracellular Ca-2+ release impairs macrophage recruitment and activation, while ROS is necessary for macrophage activation independently of calcium. Neutrophils were found not to be essential for macrophage recruitment and activation in this process. Additionally, Src family kinases Lyn and Yrk and NF-kappa B were identified as key regulators of macrophage activation in vivo.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Wei Sun, Xiao Chen, Yazi Mei, Xiaoliang Li, Yang Yang, Lei An
Summary: This study found that the combination of MEL and CA can cause severe cell death and disrupted energy production through the caspase-3-mediated apoptosis pathway. Additionally, the combination has inhibitory effects on neuronal activity, while the co-application of the ROS scavenger NAC can alleviate cellular apoptosis, energy metabolism dysfunction, and impairments in neuronal and synaptic function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Medicine, Research & Experimental
Robert B. Rosenblatt, Joseph A. Frank, Scott R. Burks
Summary: The study found that non-ablative pulsed focused ultrasound (pFUS) directly induces DNA damage in various tumor cell types by triggering superoxide and subsequent H2O2 formation through cytosolic calcium transients. These results support the potential clinical utility of pFUS.
Article
Neurosciences
Serene Dhawan, Philip Myers, David M. D. Bailey, Aaron D. Ostrovsky, Jan Felix Evers, Matthias Landgraf
Summary: The study reveals the role of reactive oxygen species (ROS) in regulating the size of neuronal dendritic arbors. It shows that activity-regulated ROS are transmitted between cells through NADPH oxidase and aquaporins, ultimately negatively regulating dendritic arbor size.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Ana Salome Correia, Armando Cardoso, Nuno Vale
Summary: Depression is a prevalent and debilitating disease with a complex pathophysiology. Oxidative stress plays a significant role in its onset and development, leading to processes such as inflammation and neurodegeneration. Understanding the cellular and molecular mechanisms underlying depression, including the stress response, neuroinflammation, serotonergic pathways, neurogenesis, and synaptic plasticity imbalances, is crucial for new treatment strategies and knowledge about this complex disease.
Article
Multidisciplinary Sciences
Ryota Fukaya, Marta Maglione, Stephan J. Sigrist, Takeshi Sakaba
Summary: This study suggests a potential mechanism for the cAMP-dependent increase in neurotransmission at hippocampal mossy fiber-CA3 synapses, involving an accumulation of active zone Ca2+ channels. Experimental results indicate an increase in the local Ca2+ concentration at the release site following potentiation, driven by rapid Ca2+ channel accumulation, rather than changes in intracellular Ca2+ sensitivity. Various microscopy techniques provide insights into the underlying mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Plant Sciences
Chan Liu, Weibiao Liao
Summary: Potassium ion is an essential signaling molecule in plant growth and development. It interacts with calcium, reactive oxygen species, and reactive nitrogen species to regulate plant growth, development, and abiotic stress responses.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zhiyuan Yang, Chao Bai, Peng Wang, Weidong Fu, Le Wang, Zhen Song, Xin Xi, Hanwen Wu, Guoliang Zhang, Jiahe Wu
Summary: Common sandbur, an invasive grass species, exhibits remarkable drought tolerance through the modulation of multiple metabolic pathways and other adaptations, including the accumulation of sucrose, fatty acids, and ascorbate, the shift in redox potential, the accumulation of flavonoid intermediates, and the scavenging of reactive oxygen species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Yanis Inglebert, Dominique Debanne
Summary: The importance of considering physiological levels of extracellular calcium concentration in studying functional plasticity is discussed in this study.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Salvatore Antonucci, Fabio Di Lisa, Nina Kaludercic
Summary: Mitochondrial reactive oxygen species (mROS) play a dual role in physiology, acting as second messengers while also potentially causing harm when their levels are not properly regulated. Maintaining a balance in mROS formation and elimination is crucial for normal physiological processes and preventing disease development.
Article
Neurosciences
Tobias Bock, Adrian Negrean, Steven A. Siegelbaum
Summary: Synaptic inputs targeting distal dendrites can amplify local dendritic spikes, but these spikes are often weak due to dendritic cable properties. Despite this, they are implicated in memory storage, sensory perception, and place field formation. Somatic depolarization can enhance dendritic spike propagation, leading to enhanced memory specificity and long-term synaptic plasticity in hippocampal-dependent spatial representations and learning.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Plant Sciences
Yingfeng Wang, Xiaoyan Dai, Gaoqiang Xu, Zhuoyi Dai, Peiyu Chen, Tongjin Zhang, Huifen Zhang
Summary: The study demonstrates that the Ca2+-CaM signaling pathway promotes K+ absorption by regulating ROS homeostasis and the expression of K+ uptake-related genes in plant roots under low-K+ stress.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
