RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers

On the Pathogenesis of Alzheimer's Disease: The MAM Hypothesis

(2017) Estela Area-Gomez et al.   FASEB JOURNAL

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

(2017) Ting Yang et al.   JOURNAL OF NEUROSCIENCE

Neuronal Ryanodine Receptors in Development and Aging

(2017) Nawaf Abu-Omar et al.   MOLECULAR NEUROBIOLOGY

Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of Aβ-Oligomers

(2016) Pedro Lobos et al.   NEURAL PLASTICITY

Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum Ca2+ content in primary hippocampal neurons

(2015) Tatiana Adasme et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Ins and Outs of Mitochondrial Calcium

(2015) T. Finkel et al.   CIRCULATION RESEARCH

Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

(2015) Ildete Luísa Ferreira et al.   NEUROBIOLOGY OF AGING

N-Acetyl Cysteine in the Treatment of Obsessive Compulsive and Related Disorders: A Systematic Review

(2015) Georgina Oliver et al.   Clinical Psychopharmacology and Neuroscience

Contribution of Ca2+ Release Channels to Hippocampal Synaptic Plasticity and Spatial Memory: Potential Redox Modulation

(2014) Andrea C. Paula-Lima et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuroprotection Induced by N-acetylcysteine and Selenium Against Traumatic Brain Injury-Induced Apoptosis and Calcium Entry in Hippocampus of Rat

(2014) Mustafa Nazıroğlu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons

(2014) Carol D. SanMartín et al.   Frontiers in Molecular Neuroscience

Minocycline plus N-acetylcysteine synergize to modulate inflammation and prevent cognitive and memory deficits in a rat model of mild traumatic brain injury

(2013) Margalit Haber et al.   EXPERIMENTAL NEUROLOGY

Calcium regulation of neural rhythms, memory and Alzheimer's disease

(2013) Michael J. Berridge   JOURNAL OF PHYSIOLOGY-LONDON

Can the Calcium Hypothesis Explain Synaptic Loss in Alzheimer's Disease?

(2013) Elena Popugaeva et al.   Neurodegenerative Diseases

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methods for Detection of Mitochondrial and Cellular Reactive Oxygen Species

(2012) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Sub-lethal levels of amyloid β-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons

(2012) C. D. SanMartín et al.   BIOMETALS

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

(2012) Michael H. Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amyloid-β Oligomers Induce Differential Gene Expression in Adult Human Brain Slices

(2012) Adriano Sebollela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation

(2012) Dagmar Schlenzig et al.   JOURNAL OF NEUROCHEMISTRY

The Antioxidant N-Acetylcysteine Prevents the Mitochondrial Fragmentation Induced by Soluble Amyloid-F Peptide Oligomers

(2012) C.D. SanMartin et al.   Neurodegenerative Diseases

Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic β-cells using ratiometric fluorescent proteins: confounding effects of pH with HyPer but not roGFP1

(2011) Leticia P. Roma et al.   BIOCHEMICAL JOURNAL

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

(2011) Vincent T. Marchesi   FASEB JOURNAL

Amyloid  -Induced Impairments in Hippocampal Synaptic Plasticity Are Rescued by Decreasing Mitochondrial Superoxide

(2011) T. Ma et al.   JOURNAL OF NEUROSCIENCE

N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: Relevance to schizophrenia and bipolar disorder

(2011) Olivia M. Dean et al.   NEUROSCIENCE LETTERS

Glutathione Restores the Mechanism of Synaptic Plasticity in Aged Mice to That of the Adult

(2011) Julie M. Robillard et al.   PLoS One

Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation

(2011) T. Adasme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: Insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive

(2011) Renã A. S. Robinson et al.   PROTEOMICS

Oxidative stress caused by mitochondrial calcium overload

(2010) Tsung-I Peng et al.   Annals of the New York Academy of Sciences

Amyloid β-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF

(2010) Andrea C. Paula-Lima et al.   ANTIOXIDANTS & REDOX SIGNALING

High-Frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-Mediated Ca2+ Release and Generates Hydrogen Peroxide, Which Jointly Stimulate NF-κB Activity

(2010) Denise Riquelme et al.   ANTIOXIDANTS & REDOX SIGNALING

Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: Toward therapeutic modulation of mild cognitive impairment

(2010) Quanzhen Huang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mitochondrial Glutathione, a Key Survival Antioxidant

(2009) Montserrat Marí et al.   ANTIOXIDANTS & REDOX SIGNALING

The cell-type specificity of mitochondrial dynamics

(2009) Andrey V. Kuznetsov et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Dynamin-Like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer's Disease Patients

(2008) Xinglong Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling

(2008) A SPAT et al.   CELL CALCIUM

Ischemia Enhances Activation by Ca2+ and Redox Modification of Ryanodine Receptor Channels from Rat Brain Cortex

(2008) R. Bull et al.   JOURNAL OF NEUROSCIENCE

Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes

(2008) N. Galeotti et al.   LEARNING & MEMORY

Mitochondrial fragmentation in neurodegeneration

(2008) Andrew B. Knott et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs

(2008) Sara Sanz-Blasco et al.   PLoS One

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA