Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

Sphingosine-1-Phosphate and Its Receptors: Structure, Signaling, and Influence

(2013) Hugh Rosen et al.   Annual Review of Biochemistry

Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis

(2013) Le Yang et al.   JOURNAL OF HEPATOLOGY

Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration

(2013) Michael J Kluk et al.   LABORATORY INVESTIGATION

Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism

(2013) Amanda Finley et al.   PLoS One

Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D

(2013) J. Kikuta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fingolimod Therapy for Multiple Sclerosis

(2013) Mary Willis et al.   SEMINARS IN NEUROLOGY

Molecular Basis of Sphingosine Kinase 1 Substrate Recognition and Catalysis

(2013) Zhulun Wang et al.   STRUCTURE

Sphingosine-1–Phosphate Receptor–3 Is a Novel Biomarker in Acute Lung Injury

(2012) Xiaoguang Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

Evidence for a link between histone deacetylation and Ca2+homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts

(2012) Katja Ihlefeld et al.   BIOCHEMICAL JOURNAL

Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate

(2012) Yugesh Kharel et al.   BIOCHEMICAL JOURNAL

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

(2012) Mark E. Schnute et al.   BIOCHEMICAL JOURNAL

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors

(2012) K. Alexa Orr Gandy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma

(2012) Y. Liu et al.   BLOOD

The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate

(2012) P Gergely et al.   BRITISH JOURNAL OF PHARMACOLOGY

S1PR1-STAT3 Signaling Is Crucial for Myeloid Cell Colonization at Future Metastatic Sites

(2012) Jiehui Deng et al.   CANCER CELL

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

(2012) M. Nagahashi et al.   CANCER RESEARCH

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

A Potent and Selective S1P1 Antagonist with Efficacy in Experimental Autoimmune Encephalomyelitis

(2012) Jean Quancard et al.   CHEMISTRY & BIOLOGY

Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis

(2012) T. Komiya et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Genetic elevation of Sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila

(2012) M. Pantoja et al.   DEVELOPMENT

S1P1 inhibits sprouting angiogenesis during vascular development

(2012) A. B. Shoham et al.   DEVELOPMENT

The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2

(2012) Konstantin Gaengel et al.   DEVELOPMENTAL CELL

Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development

(2012) Bongnam Jung et al.   DEVELOPMENTAL CELL

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

(2012) Suriyan Ponnusamy et al.   EMBO Molecular Medicine

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

(2012) Sahar A. Saddoughi et al.   EMBO Molecular Medicine

Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

(2012) Masayuki Nagahashi et al.   FASEB JOURNAL

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell–dependent murine model of allergic asthma

(2012) Megan M. Price et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

(2012) Shigetomo Fukuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

A Sphingosine-1-Phosphate Receptor 1-Directed Agonist Reduces Central Nervous System Inflammation in a Plasmacytoid Dendritic Cell-Dependent Manner

(2012) G. Galicia-Rosas et al.   JOURNAL OF IMMUNOLOGY

The Sjögren-Larsson Syndrome Gene Encodes a Hexadecenal Dehydrogenase of the Sphingosine 1-Phosphate Degradation Pathway

(2012) Kanae Nakahara et al.   MOLECULAR CELL

Fingolimod treatment in multiple sclerosis leads to increased macular volume

(2012) R. Nolan et al.   NEUROLOGY

Sphingosine-1-Phosphate Enhances Satellite Cell Activation in Dystrophic Muscles through a S1PR2/STAT3 Signaling Pathway

(2012) Kenneth C. Loh et al.   PLoS One

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

In Vitro and In Vivo Antagonism of a G Protein-Coupled Receptor (S1P3) with a Novel Blocking Monoclonal Antibody

(2012) Greg L. Harris et al.   PLoS One

Inhibition of Sphingosine Kinase-2 Suppresses Inflammation and Attenuates Graft Injury after Liver Transplantation in Rats

(2012) Qinlong Liu et al.   PLoS One

Characterization of Isoenzyme-Selective Inhibitors of Human Sphingosine Kinases

(2012) Peng Gao et al.   PLoS One

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R−/−) mice

(2012) Francesco Poti et al.   VASCULAR PHARMACOLOGY

The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate

(2012) Alejandra Mendoza et al.   Cell Reports

Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers

(2012) Susan Pyne et al.   Frontiers in Oncology

A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection

(2011) Ludovic Gomez et al.   BASIC RESEARCH IN CARDIOLOGY

Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate

(2011) Yugesh Kharel et al.   BIOCHEMICAL JOURNAL

SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptor

(2011) Mariangela Urbano et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules

(2011) S. Pyne et al.   CANCER RESEARCH

STAT3 Inhibition Is a Therapeutic Strategy for ABC-like Diffuse Large B-Cell Lymphoma

(2011) A. Scuto et al.   CANCER RESEARCH

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

A Phase I Clinical Trial of Safingol in Combination with Cisplatin in Advanced Solid Tumors

(2011) M. A. Dickson et al.   CLINICAL CANCER RESEARCH

Sphingosine-1-phospate receptor 4 (S1P4) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model

(2011) Tobias Schulze et al.   FASEB JOURNAL

The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice

(2011) Gema Tarrasón et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lipid phosphate phosphatase 3 enables efficient thymic egress

(2011) Béatrice Bréart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Amelioration of Collagen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory Activities

(2011) Y. Fujii et al.   JOURNAL OF IMMUNOLOGY

Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer

(2011) J. W. Antoon et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

(2011) N. Takasugi et al.   JOURNAL OF NEUROSCIENCE

The Selective Sphingosine 1-Phosphate Receptor 1 Agonist Ponesimod Protects against Lymphocyte-Mediated Tissue Inflammation

(2011) L. Piali et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes

(2011) Alaa S. Awad et al.   KIDNEY INTERNATIONAL

Unknown

(2011) Constance Finney et al.   MOLECULAR MEDICINE

A Sphingosine Kinase Form 2 Knockout Sensitizes Mouse Myocardium to Ischemia/Reoxygenation Injury and Diminishes Responsiveness to Ischemic Preconditioning

(2011) Donald A. Vessey et al.   Oxidative Medicine and Cellular Longevity

Therapeutic Effects of Novel Sphingosine-1-Phosphate Receptor Agonist W-061 in Murine DSS Colitis

(2011) Yasuaki Sanada et al.   PLoS One

Prevention of GVHD and graft rejection by a new S1P receptor agonist, W-061, in rat small bowel transplantation

(2011) Jinghai Song et al.   TRANSPLANT IMMUNOLOGY

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Translational aspects of sphingosine 1-phosphate biology

(2011) Susan Pyne et al.   TRENDS IN MOLECULAR MEDICINE

Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist

(2011) Takahide Nishi et al.   ACS Medicinal Chemistry Letters

S1P4 Receptor Mediates S1P-Induced Vasoconstriction in Normotensive and Hypertensive Rat Lungs

(2011) Hiroki Ota et al.   Pulmonary Circulation

High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients

(2010) Carol Watson et al.   AMERICAN JOURNAL OF PATHOLOGY

Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis

(2010) Athanasia Skoura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT+ Cancers

(2010) K. G. Roberts et al.   CANCER RESEARCH

Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase

(2010) Alexander A. Chumanevich et al.   CARCINOGENESIS

Design and Synthesis of Selective and Potent Orally Active S1P5 Agonists

(2010) Henri Mattes et al.   ChemMedChem

Antiestrogenic Effects of the Novel Sphingosine Kinase-2 Inhibitor ABC294640

(2010) James W. Antoon et al.   ENDOCRINOLOGY

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ERBB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells

(2010) Jaclyn S. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate Lyase Deficiency Produces a Pro-inflammatory Response While Impairing Neutrophil Trafficking

(2010) Maria L. Allende et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

(2010) Masaru Ishii et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic Sphingosine Kinase 1 Deficiency Significantly Decreases Synovial Inflammation and Joint Erosions in Murine TNF- -Induced Arthritis

(2010) D. A. Baker et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

(2010) Jeffrey T. Bagdanoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

2-Imino-thiazolidin-4-one Derivatives as Potent, Orally Active S1P1Receptor Agonists

(2010) Martin H. Bolli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

(2010) K. J. French et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

An update on sphingosine-1-phosphate and other sphingolipid mediators

(2010) Henrik Fyrst et al.   Nature Chemical Biology

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

(2010) Heehyoung Lee et al.   NATURE MEDICINE

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Function of Sphingosine-1-Phosphate Lyase, a Key Enzyme of Sphingolipid Metabolism

(2010) Florence Bourquin et al.   STRUCTURE

Targeting the correct HDAC(s) to treat cognitive disorders

(2010) André Fischer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase

(2010) Leo R. Fitzpatrick et al.   INFLAMMOPHARMACOLOGY

Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn’s disease

(2010) Lynn W. Maines et al.   INFLAMMOPHARMACOLOGY

Differential Effects of Sphingosine 1–Phosphate Receptors on Airway and Vascular Barrier Function in the Murine Lung

(2009) Saad Sammani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Export and functions of sphingosine-1-phosphate

(2009) Roger H. Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts

(2009) D. Kapitonov et al.   CANCER RESEARCH

T-bet–dependent S1P5expression in NK cells promotes egress from lymph nodes and bone marrow

(2009) Craig N. Jenne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AUY954, a selective S1P1 modulator, prevents experimental autoimmune neuritis

(2009) Zhi-Yuan Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

(2009) Masaru Ishii et al.   NATURE

A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection

(2009) D. Marsolais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

(2008) S. W. Paugh et al.   BLOOD

Role for sphingosine kinase 1 in colon carcinogenesis

(2008) Toshihiko Kawamori et al.   FASEB JOURNAL

Increased survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1-phosphate receptor agonist

(2008) Scott E. Wenderfer et al.   KIDNEY INTERNATIONAL

Full Pharmacological Efficacy of a Novel S1P1 Agonist That Does Not Require S1P-Like Headgroup Interactions

(2008) P. J. Gonzalez-Cabrera et al.   MOLECULAR PHARMACOLOGY

Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation

(2008) Frank Niessen et al.   NATURE

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE