Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

Regulation of Autophagy by Sphingolipids

(2012) Carmen Bedia et al.   Anti-Cancer Agents in Medicinal Chemistry

Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate

(2012) Yugesh Kharel et al.   BIOCHEMICAL JOURNAL

Shaping the landscape: Metabolic regulation of S1P gradients

(2012) Ana Olivera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Sphingosine 1-Phosphate Receptor Signaling Regulates Proper Embryonic Vascular Patterning

(2012) Karen Mendelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

(2012) Shigetomo Fukuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingosine Kinase 1 Deficiency Exacerbates LPS-Induced Neuroinflammation

(2012) Natalia M. Grin’kina et al.   PLoS One

Regulation of Mammalian Physiology, Development, and Disease by the Sphingosine 1-Phosphate and Lysophosphatidic Acid Receptors

(2011) Victoria A. Blaho et al.   CHEMICAL REVIEWS

Development of small-molecule inhibitors of sphingosine-1-phosphate signaling

(2011) Yvette Edmonds et al.   PHARMACOLOGY & THERAPEUTICS

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

Kdo2-Lipid A, a TLR4-specific Agonist, Inducesde NovoSphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy

(2010) Kacee Sims et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice

(2010) Ana Olivera et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Sphingosine Kinase-1 (SphK-1) Regulates Mycobacterium smegmatis Infection in Macrophages

(2010) Hridayesh Prakash et al.   PLoS One

Stopping Sepsis by Targeting Sphingosine Kinase 1

(2010) L. A. J. O'Neill   Science Translational Medicine

Differential regulation of sphingosine kinases 1 and 2 in lung injury

(2009) Raj Wadgaonkar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Safingol (l-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway

(2009) Jesse Coward et al.   Autophagy

Ceramide-induced autophagy: To junk or to protect cells?

(2009) Sophie Pattingre et al.   Autophagy

Natural Sphingadienes Inhibit Akt-Dependent Signaling and Prevent Intestinal Tumorigenesis

(2009) H. Fyrst et al.   CANCER RESEARCH

Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation

(2009) S. Colie et al.   CANCER RESEARCH

Inhibitory Role of Sphingosine 1-Phosphate Receptor 2 in Macrophage Recruitment during Inflammation

(2009) J. Michaud et al.   JOURNAL OF IMMUNOLOGY

Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia

(2009) D. Nayak et al.   NEUROSCIENCE

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation

(2008) Frank Niessen et al.   NATURE

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE