Article
Clinical Neurology
Tommaso Guerra, Francesca Caputo, Bianca Orlando, Damiano Paolicelli, Maria Trojano, Pietro Iaffaldano
Summary: The study compared the effectiveness of natalizumab and fingolimod in achieving NEDA-3 status in RRMS patients over a four-year period. Patients treated with natalizumab were more likely to reach NEDA-3 status compared to those treated with fingolimod, indicating that natalizumab may be superior in achieving disease activity control in RRMS over an extended follow-up period.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Veronika Ticha, Zuzana Pocikova, Josef Vytlacil, Radka Stepanova
Summary: This study demonstrates the sustained effectiveness and manageable safety profile of fingolimod in patients with multiple sclerosis over a 48-month period.
Article
Immunology
Alicia Gonzalez-Martinez, Rohit Patel, Brian C. Healy, Hrishikesh Lokhande, Anu Paul, Shrishti Saxena, Mariann Polgar-Turcsanyi, Howard L. Weiner, Tanuja Chitnis
Summary: This study aimed to evaluate serum miRNAs as biomarkers of No Evidence of Disease Activity (NEDA-3) at 2 years in patients with relapsing remitting MS (RRMS) treated with fingolimod. The results showed that miR-548a-3p expression levels at 6 months after fingolimod start were associated with NEDA-3 at 2 years in MS patients. This study provides class III evidence for the use of miR-548a-3p as a biomarker of NEDA-3 in fingolimod-treated patients.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Johannes Lorscheider, Pascal Benkert, Carmen Lienert, Peter Haenni, Tobias Derfuss, Jens Kuhle, Ludwig Kappos, Oezguer Yaldizli
Summary: In a real-world setting, dimethyl fumarate and fingolimod demonstrate comparable effectiveness in reducing relapses and disability worsening in patients with RRMS. Findings from this study suggest that there is no significant difference in efficacy between the two treatment options, regardless of whether patients are treatment-naive or switching from another DMT.
JOURNAL OF NEUROLOGY
(2021)
Article
Pediatrics
Deborah L. Harris, Greg D. Gamble, Jane E. Harding
Summary: Treatment of neonatal hypoglycaemia with dextrose gel does not increase the rate of neurosensory impairment, but further assessment of visual processing and growth may be warranted.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Multidisciplinary Sciences
Tamas Biernacki, Daniel Sandi, Judit Fuvesi, Zsanett Fricska-Nagy, Tamas Zsigmond Kincses, Peter Acs, Csilla Rozsa, Eniko Dobos, Botond Cseh, Laszlo Horvath, Zsuzsanna Nagy, Attila Csanyi, Krisztina Kovacs, Tunde Csepany, Laszlo Vecsei, Krisztina Bencsik
Summary: This study conducted in Hungary demonstrates that fingolimod is effective and well-tolerated in the real-life setting for patients with relapsing-remitting multiple sclerosis, with sustained efficacy and manageable safety profile for up to 5 years.
Article
Cell Biology
Diana Ferraro, Sara De Biasi, Anna Maria Simone, Riccardo Orlandi, Milena Nasi, Francesca Vitetta, Marcello Pinti, Marco Fogliani, Stefano Meletti, Andrea Cossarizza, Patrizia Sola
Summary: The study found that the proportions of Tregs and iNKT cells in the immunoregulatory cell networks changed in patients with Multiple Sclerosis, and FTY treatment may benefit patients by increasing cells with immunomodulatory potential.
Article
Clinical Neurology
Chiara Zanetta, Massimo Filippi, Lucia Moiola
Summary: Fingolimod has been approved for the treatment of relapsing MS in both adults and children. Real-world data from Italy confirms its effectiveness in pediatric patients with active disease, supporting its use as a therapeutic strategy for pediatric MS.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Tjalf Ziemssen, Michael Lang, Stephan Schmidt, Holger Albrecht, Luisa Klotz, Judith Haas, Christoph Lassek, Stefan Lang, Veronika E. Winkelmann, Benjamin Ettle, Ulf Schulze-Topphoff
Summary: The 5-year real-world study in Germany evaluated the benefit-risk profile of fingolimod in patients with relapsing-remitting MS, showing sustained effectiveness with reduced relapse rates and stable disability status. The majority of patients continued fingolimod therapy, and adverse events were mostly non-serious and consistent with the known safety profile of the drug.
JOURNAL OF NEUROLOGY
(2022)
Review
Pharmacology & Pharmacy
Emanuela Colombo, Cinthia Farina
Summary: Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that binds to specific G protein-coupled receptors expressed in various organs. Targeting S1P receptors with modulators has shown potential in treating neurological, autoimmune, and inflammatory disorders. These modulators induce lymphopenia and may have immunological effects beyond lymphocyte trafficking inhibition. They can also cross the blood-brain barrier and target CNS resident cells expressing S1P receptors. Understanding the role of S1P signaling in neuroimmunology has important implications for therapeutic approaches in other disease areas.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Neurosciences
G. Sferruzza, F. Clarelli, E. Mascia, L. Ferre, L. Ottoboni, M. Sorosina, S. Santoro, L. Moiola, V. Martinelli, G. Comi, F. Martinelli Boneschi, M. Filippi, P. Provero, Federica Esposito
Summary: The study investigated the gene transcriptional changes induced by FTY in monocytes of multiple sclerosis patients, revealing its major impact on genes associated with cell trafficking and immune cell activation.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Claudia Fracasso, Alice Passoni, Laura Brambilla, Renato Mantegazza, Silvia Rossi, Marco Gobbi, Jacopo Lucchetti
Summary: This study developed a simple and rapid liquid chromatography-tandem mass spectrometry method for measuring the concentrations of Fingolimod and its active metabolite Fingolimod-Phosphate in human plasma. The method was accurate and precise, and can be used to evaluate the impact of drug and metabolite on inter-individual variability in clinical responses.
APPLIED SCIENCES-BASEL
(2022)
Article
Clinical Neurology
Damiano Baroncini, Angelo Ghezzi, Clara Guaschino, Lucia Moiola, Massimo Filippi, Antonio Ianniello, Carlo Pozzilli, Roberta Lanzillo, Vincenzo Brescia-Morra, Monica Margoni, Paolo Gallo, Graziella Callari, Luigi Grimaldi, Giacomo Lus, Massimiliano Calabrese, Marta Simone, Girolama Alessandra Marfia, Sarah Rasia, Daniela Cargnelutti, Giancarlo Comi, Mauro Zaffaroni
Summary: Natalizumab treatment has a long-term significant impact on disease activity in pediatric multiple sclerosis, without new safety concerns.
NEUROLOGICAL SCIENCES
(2022)
Article
Immunology
Ide Smets, Teresa Prezzemolo, Maya Imbrechts, Klara Mallants, Tania Mitera, Stephanie Humblet-Baron, Benedicte Dubois, Patrick Matthys, Adrian Liston, An Goris
Summary: The study indicates that both fingolimod and interferon-beta induce BAFF protein and mRNA expression, leading to a shift in the B cell pool towards a regulatory phenotype. Specifically, BAFF protein correlated with an increase in transitional B cells, decrease in switched B cells, and reduction in B cell-surface BAFF-R expression. However, BAFF does not directly influence the expression of immunoregulatory cytokines IL-10 and IL-35.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
A. Ciccone, G. Mathey, C. Prunis, M. Debouverie
Summary: This study aimed to investigate the immune response to COVID-19 vaccine in MS patients treated with fingolimod and explore the factors influencing the response. The results showed that 47% of the participants developed a positive serology, and age and duration of treatment were significantly related to seropositivity.
REVUE NEUROLOGIQUE
(2023)
Review
Clinical Neurology
Lyduine E. Collij, Gill Farrar, David Vallez Garcia, Ilona Bader, Mahnaz Shekari, Luigi Lorenzini, Hugh Pemberton, Daniele Altomare, Sandra Pla, Mery Loor, Pawel Markiewicz, Maqsood Yaqub, Christopher Buckley, Giovanni B. Frisoni, Agneta Nordberg, Pierre Payoux, Andrew Stephens, Rossella Gismondi, Pieter Jelle Visser, Lisa Ford, Mark Schmidt, Cindy Birck, Jean Georges, Anja Mett, Zuzana Walker, Merce Boada, Alexander Drzezga, Rik Vandenberghe, Bernard Hanseeuw, Frank Jessen, Michael Scholl, Craig Ritchie, Isadora Lopes Alves, Juan Domingo Gispert, Frederik Barkhof, AMYPAD Consortium
Summary: Amyloid Imaging to Prevent Alzheimer's Disease (AMYPAD) consortium aims to provide evidence on the clinical utility and cost-effectiveness of Positron Emission Tomography (PET) imaging in AD diagnosis and support clinical trial design. AMYPAD has contributed significantly to understanding of amyloid deposition in the brain and improving measurement methodology. Future steps include integrating and curating available clinical data for wider scientific access.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Floor C. Loonstra, Lodewijk R. J. de Ruiter, Marleen J. A. Koel-Simmelink, Menno M. Schoonheim, Eva M. M. Strijbis, Bastiaan Moraal, Frederik Barkhof, Bernard M. J. Uitdehaag, Charlotte Teunissen, Joep Killestein
Summary: This study explores the association between novel blood biomarkers (sNfL, sGFAP, and sCNTN1) and disability outcome measures and MRI volumes in people with multiple sclerosis (MS). The results indicate that sNfL and sGFAP are associated with disease progression, while sCNTN1 is not related to clinical or MRI measures.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Review
Clinical Neurology
Ariane G. Bollack, Hugh G. E. Pemberton, Lyduine E. Collij, Pawel M. Markiewicz, David M. Cash, Gill Farrar, Frederik Barkhof
Summary: This review summarizes the current design and methodologies of longitudinal PET studies, utilizing positron emission tomography to quantify amyloid and tau pathology. The intrinsic variability of AD protein load over time and technical factors contributing to PET measurement uncertainty are detailed. Suggestions for mitigating these factors, including leveraging shared information between serial scans, are provided.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Liu Shi, Jin Xu, Rebecca Green, Asger Wretlind, Jan Homann, Noel J. Buckley, Betty M. Tijms, Stephanie J. B. Vos, Christina M. Lill, Mara ten Kate, Sebastiaan Engelborghs, Kristel Sleegers, Giovanni B. Frisoni, Anders Wallin, Alberto Lleo, Julius Popp, Pablo Martinez-Lage, Johannes Streffer, Frederik Barkhof, Henrik Zetterberg, Pieter Jelle Visser, Simon Lovestone, Lars Bertram, Alejo J. Nevado-Holgado, Petroula Proitsi, Cristina Legido-Quigley
Summary: This study employed an integrative system and causal inference approach to explore molecular signatures in blood and CSF, the AT(N) framework, MCI conversion to AD, and genetic risk for AD. Using the EMIF-AD cohort, the researchers measured proteins and metabolites in blood and CSF, as well as genotyped whole-blood samples. They found associations between AT(N) framework and protein/lipid hubs, and identified Proprotein Convertase Subtilisin/Kexin Type 7 as a potential causative factor for AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Hanyi Chen, Alexandra Young, Neil P. Oxtoby, Frederik Barkhof, Daniel C. Alexander, Andre Altmann
Summary: This study examines the generalisability of data-driven Alzheimer's disease (AD) progression models using the SuStaIn algorithm. The results show consistent subtypes of atrophy in both datasets and high consistency in individuals' subtypes and stage assignments. The study also reveals associations between AD atrophy subtypes and risk factors.
Editorial Material
Clinical Neurology
Frederik Barkhof, David S. Knopman
Summary: One puzzling observation in Alzheimer's disease therapeutic trials is that treatment with anti-amyloid-beta agents does not preserve brain volume. In a recent study, Alves et al. conducted a meta-analysis and found that these agents do not slow the rate of brain volume loss. In fact, depending on the drug class, they can even accelerate loss of whole-brain and hippocampal volume and increase ventricular volume.
Article
Clinical Neurology
Javier Villacieros-Alvarez, Carmen Espejo, Georgina Arrambide, Mireia Castillo, Pere Carbonell-Mirabent, Marta Rodriguez, Luca Bollo, Joaquin Castillo, Manuel Comabella, Ingrid Galan, Luciana Midaglia, Neus Mongay-Ochoa, Carlos Nos, Jordi Rio, Breogan Rodriguez-Acevedo, Jaume Sastre-Garriga, Carmen Tur, Angela Vidal-Jordana, Andreu Vilaseca, Ana Zabalza, Cristina Auger, Alex Rovira, Xavier Montalban, Mar Tintore, Alvaro Cobo-Calvo
Summary: MOG-Ab are rare in adults with a first demyelinating event suggestive of MS. However, it is suggested to determine these antibodies in patients with ON and absence of CSF-OBs based on the results.
ANNALS OF NEUROLOGY
(2023)
Article
Medical Laboratory Technology
David Wilson, Dandan Chan, Lei Chang, Robert Mathis, Inge Verberk, Xavier Montalban, Manuel Comabella, Nicolas Fissolo, Bibi Bielekova, Ruturaj Masvekar, Tanuja Chitnis, Tjalf Ziemssen, Katja Akguen, Kaj Blennow, Henrik Zetterberg, Wolfgang Brueck, Gavin Giovannoni, Sharmilee Gnanapavan, Stefan Bittner, Frauke Zipp, Giancarlo Comi, Roberto Furlan, Sylvain Lehmann, Simon Thebault, Mark Freedman, Amit Bar-Or, Marty Kramer, Markus Otto, Steffen Halbgebauer, Kevin Hrusovsky, Tatiana Plavina, Michael Khalil, Fredrik Piehl, Heinz Wiendl, Ludwig Kappos, Aleksandra Maceski, Eline Willemse, David Leppert, Charlotte Teunissen, Jens Kuhle
Summary: A fully automated digital immunoassay for measuring neurofilament light chain (NfL) in serum has been developed and validated across multiple centers. This assay shows high sensitivity, reproducibility, and automation, making it suitable for clinical use in assessing and monitoring axonal injury.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Clinical Neurology
Amit Bar-Or, Anne H. Cross, Anthony L. Cunningham, Yann Hyvert, Andrea Seitzinger, Hans Guehring, Elise E. Drouin, Nektaria Alexandri, Davorka Tomic, Xavier Montalban
Summary: A post hoc analysis showed that Evobrutinib, an investigational drug for patients with relapsing multiple sclerosis (RMS), has an impact on immune responses. The results suggest that the drug acts as an immunomodulator, inhibiting aberrant immune cell responses while maintaining responsiveness to foreign and recall antigens.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Multidisciplinary Sciences
Adil Harroud, Pernilla J. Stridh, Jacob H. McCauley, Janna Saarela, Aletta M. R. van den Bosch, Hendrik Engelenburg, Ashley Beecham, Lars Alfredsson, Katayoun Alikhani, Lilyana Amezcua, Till F. M. Andlauer, Maria Ban, Lisa Barcellos, Nadia Barizzone, Tone Berge, Achim Berthele, Stefan Bittner, Steffan Bos, Farren B. S. Briggs, Stacy Caillier, Peter Calabresi, Domenico Caputo, David Carmona-Burgos, Paola Cavalla, Elisabeth Celius, Gabriel Cerono, Angel Chinea, Tanuja Chitnis, Ferdinando Clarelli, Manuel Comabella, Giancarlo Comi, Chris Cotsapas, Bruce C. A. Cree, Sandra D'Alfonso, Efthimios Dardiotis, Philip De Jager, Silvia Delgado, Benedicte Dubois, Sinah Engel, Federica Esposito, Marzena Fabis-Pedrini, Massimo Filippi, Kathryn Fitzgerald, Christiane Gasperi, Lissette Gomez, Refujia Gomez, Georgios Hadjigeorgiou, Joerg Hamann, Friederike Held, Roland Henry, Jan Hillert, Jesse Huang, Inge Huitinga, Talat Islam, Noriko Isobe, Maja Jagodic, Allan L. Kermode, Michael Khalil, Trevor Kilpatrick, Ioanna Konidari, Karim Kreft, Jeannette Lechner-Scott, Maurizio Leone, Felix Luessi, Sunny Malhotra, Ali Manouchehrinia, Clara Manrique, Filippo Martinelli-Boneschi, Andrea Martinez, Viviana Martinez-Maldonado, Elisabetta Mascia, Luanne Metz, Luciana Midaglia, Xavier Montalban, Jorge Oksenberg, Tomas Olsson, Annette Oturai, Kimmo Paakkonen, Grant P. Parnell, Nikolaos Patsopoulos, Margaret Pericak-Vance, Fredrik Piehl, Justin Rubio, Adam Santaniello, Silvia Santoro, Catherine Schaefer, Finn Sellebjerg, Hengameh Shams, Klementy Shchetynsky, Claudia Silva, Vasileios Siokas, Helle Sondergaard, Melissa Sorosina, Bruce Taylor, Marijne Vandebergh, Elena Vasileiou, Domizia Vecchio, Margarete Voortman, Howard Weiner, Dennis Wever, V. Wee Yong, David Hafler, Graeme Stewart, Alastair Compston, Frauke Zipp, Hanne Harbo, Bernhard Hemmer, An Goris, Joost Smolders, Stephen Hauser, Ingrid Kockum, Stephen Sawcer, Sergio Baranzini, Ingileif Jonsdottir, Yolanda Blanco, Sara Llufriu, Lohith Madireddy, Albert Saiz, Pablo Villoslada, Kari Stefansson, Hanne F. Harbo, Bernhard Hemmer, An Goris, Ingrid Kockum, Stephen J. Sawcer, Sergio E. Baranzini
Summary: Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system (CNS) and results in significant neurodegeneration. A genome-wide association study identified a significant association between the rs10191329 polymorphism in the DYSF-ZNF638 locus and MS severity. This polymorphism was also associated with earlier need for a walking aid and increased brain pathology. Another polymorphism in the DNM3-PIGC locus showed suggestive association with MS, and there was significant heritability enrichment in CNS tissues. Mendelian randomization analyses suggested a potential protective effect of higher educational attainment in MS.
Review
Cell Biology
Sunny Malhotra, Mari Carmen Martin Miras, Agustin Pappolla, Xavier Montalban, Manuel Comabella
Summary: Liquid biopsy is a non-invasive method for studying early-stage biomarkers. It involves extracting and analyzing non-solid biological tissues without invasive procedures to determine disease prognosis. Liquid biopsy components, such as extracellular vesicles, microRNAs, and circulating tumor cells, have shown potential as valuable biomarkers in various neurological conditions. This review provides an overview of liquid biopsy and discusses its applications, future directions, and potential limitations.
Review
Clinical Neurology
Ralf Gold, Michael Barnett, Andrew Chan, Huiyu Feng, Kazuo Fujihara, Gavin Giovannoni, Xavier Montalban, Fu-Dong Shi, Mar Tintore, Qun Xue, Chunsheng Yang, Hongyu Zhou
Summary: Dimethyl fumarate (DMF) is a widely used oral disease-modifying therapy for multiple sclerosis (MS) with proven efficacy and safety. Existing data on DMF are primarily derived from populations outside of Asia. However, recent approval for use in China suggests its relevance to the Chinese population as well.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Clinical Neurology
Sara Sanchez-Velasco, Luciana Midaglia, Angela Vidal-Jordana, Felix Castillo, Rosalia Horno, Elena Carreras, Berta Serrano, Montserrat Bosch, Antonia Agusti, Xavier Montalban, Mar Tintore
Summary: Multiple sclerosis primarily affects women of childbearing age, making the pregnancy and postpartum period a topic of interest due to its impact on disease course and treatment considerations. This study reviews the safety of disease-modifying drugs during breastfeeding, including their transfer into breast milk and potential adverse effects on the infant. Interferon beta and glatiramer acetate are considered safe options during breastfeeding, while other drugs are not recommended. However, recent research suggests that some of these drugs may be used safely during this period.
REVISTA DE NEUROLOGIA
(2023)
Meeting Abstract
Clinical Neurology
Carmen Tur, Zhaonan Sun, Daniel Bradley, Cynthia Grossman, Xavier Montalban, Alex Rovira, Mar Tintore, Nolan Campbell, Elizabeth Fisher
Meeting Abstract
Clinical Neurology
Marianna Cortese, Xiaojing Peng, Kjetil Bjornevik, Clary B. Clish, Gilles Edan, Mark Freedman, Hans-Peter Hartung, Xavier Montalban, Rupert Sandbrink, Ernst-Wilhelm Radue, Frederik Barkhof, Eva-Maria Wicklein, Ludwig Kappos, Kassandra Munger, Alberto Ascherio