Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

Export of sphingosine-1-phosphate and cancer progression

(2014) Kazuaki Takabe et al.   JOURNAL OF LIPID RESEARCH

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Genetic Deletion of Mst1 Alters T Cell Function and Protects against Autoimmunity

(2014) Konstantin V. Salojin et al.   PLoS One

Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss

(2014) Jing Chen et al.   PLoS Genetics

Molecular and physiological functions of sphingosine 1-phosphate transporters

(2013) Tsuyoshi Nishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

(2012) Masayuki Nagahashi et al.   FASEB JOURNAL

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell–dependent murine model of allergic asthma

(2012) Megan M. Price et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

(2012) Shigetomo Fukuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of Sphingosine-1-Phosphate Transporter Spns2 in Immune System Function

(2012) A. Nijnik et al.   JOURNAL OF IMMUNOLOGY

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate

(2012) Alejandra Mendoza et al.   Cell Reports

The Sphingosine 1-Phosphate Transporter, SPNS2, Functions as a Transporter of the Phosphorylated Form of the Immunomodulating Agent FTY720

(2010) Yu Hisano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Sphingosine Kinase 1 Deficiency Significantly Decreases Synovial Inflammation and Joint Erosions in Murine TNF- -Induced Arthritis

(2010) D. A. Baker et al.   JOURNAL OF IMMUNOLOGY

Requirement for Class II Phosphoinositide 3-Kinase C2  in Maintenance of Glomerular Structure and Function

(2010) D. P. Harris et al.   MOLECULAR AND CELLULAR BIOLOGY

The Solute Carrier Families Have a Remarkably Long Evolutionary History with the Majority of the Human Families Present before Divergence of Bilaterian Species

(2010) P. J. Hoglund et al.   MOLECULAR BIOLOGY AND EVOLUTION

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness

(2009) Rainer V. Haberberger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Incomplete Inhibition of Sphingosine 1-Phosphate Lyase Modulates Immune System Function yet Prevents Early Lethality and Non-Lymphoid Lesions

(2009) Peter Vogel et al.   PLoS One

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

The Spinster Homolog, Two of Hearts, Is Required for Sphingosine 1-Phosphate Signaling in Zebrafish

(2008) Nick Osborne et al.   CURRENT BIOLOGY

A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis

(2008) Ashley J. Snider et al.   FASEB JOURNAL

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE

Ocular Albinism and Hypopigmentation Defects in Slc24a5—I— Mice

(2008) P. Vogel et al.   VETERINARY PATHOLOGY