标题
Gamma Secretase Inhibitors in Cancer: A Current Perspective on Clinical Performance
作者
关键词
-
出版物
ONCOLOGIST
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2020-12-07
DOI
10.1002/onco.13627
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs
- (2020) Hye Yeon Choi et al. Nature Communications
- Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells
- (2019) Christian B. Lessard et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma
- (2018) Natalie Cook et al. BRITISH JOURNAL OF CANCER
- Dynamic Ligand Discrimination in the Notch Signaling Pathway
- (2018) Nagarajan Nandagopal et al. CELL
- A multi-arm phase I dose escalating study of an oral NOTCH inhibitor BMS-986115 in patients with advanced solid tumours
- (2018) Kyaw L. Aung et al. INVESTIGATIONAL NEW DRUGS
- Notch1 is a prognostic factor that is distinctly activated in the classical and proneural subtype of glioblastoma and that promotes glioma cell survival via the NF-κB(p65) pathway
- (2018) Long Hai et al. Cell Death & Disease
- Regulation of CD8+ T Cells and Antitumor Immunity by Notch Signaling
- (2018) Shin-ichi Tsukumo et al. Frontiers in Immunology
- Notch Signaling as a Regulator of the Tumor Immune Response: To Target or Not To Target?
- (2018) Mahnaz Janghorban et al. Frontiers in Immunology
- Notch Signaling in the Tumor Microenvironment
- (2018) Olivier Meurette et al. CANCER CELL
- The Many Substrates of Presenilin/γ-Secretase
- (2018) Annakaisa Haapasalo et al. JOURNAL OF ALZHEIMERS DISEASE
- Gamma-secretase-dependent signaling of receptor tyrosine kinases
- (2018) Johannes A.M. Merilahti et al. ONCOGENE
- Synergistic antitumor effect of a γ-secretase inhibitor PF-03084014 and sorafenib in hepatocellular carcinoma
- (2018) Xuran Yang et al. Oncotarget
- Gamma secretase inhibitors: a patent review (2013 - 2015)
- (2017) Kai Gu et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis)
- (2017) Shivaani Kummar et al. JOURNAL OF CLINICAL ONCOLOGY
- Biology and Treatment of Aggressive Fibromatosis or Desmoid Tumor
- (2017) Keith M. Skubitz MAYO CLINIC PROCEEDINGS
- Gamma secretase inhibitor impairs epithelial-to-mesenchymal transition induced by TGF-β in ovarian tumor cell lines
- (2017) M.C. Pazos et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma
- (2017) Katherine M. Morgan et al. MOLECULAR CANCER THERAPEUTICS
- Practice Bulletin Number 179
- (2017) OBSTETRICS AND GYNECOLOGY
- Notch Signaling in Development, Tissue Homeostasis, and Disease
- (2017) Chris Siebel et al. PHYSIOLOGICAL REVIEWS
- HES1 Promotes Colorectal Cancer Cell Resistance To 5-Fu by Inducing Of EMT and ABC Transporter Proteins
- (2017) Lei Sun et al. Journal of Cancer
- Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling
- (2016) D. Peng et al. CANCER RESEARCH
- Notch and TGFβ form a positive regulatory loop and regulate EMT in epithelial ovarian cancer cells
- (2016) Jiesi Zhou et al. CELLULAR SIGNALLING
- Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial
- (2016) R. Xu et al. CLINICAL CANCER RESEARCH
- A first-in-human phase I study of the oral Notch inhibitor, LY900009, in patients with advanced cancer
- (2016) Shubham Pant et al. EUROPEAN JOURNAL OF CANCER
- Sequential combination therapy of ovarian cancer with cisplatin and γ-secretase inhibitor MK-0752
- (2016) XiuXiu Chen et al. GYNECOLOGIC ONCOLOGY
- Inhibition of Notch and HIF enhances the antitumor effect of radiation in Notch expressing lung cancer
- (2016) Yasuyuki Ikezawa et al. International Journal of Clinical Oncology
- Phase I study of RO4929097 with bevacizumab in patients with recurrent malignant glioma
- (2016) Edward Pan et al. JOURNAL OF NEURO-ONCOLOGY
- Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer
- (2016) Tanya Stoyanova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer
- (2016) Pasquale Sansone et al. Nature Communications
- Phase I study of the gamma secretase inhibitor PF-03084014 in combination with docetaxel in patients with advanced triple-negative breast cancer
- (2016) Marzia A. Locatelli et al. Oncotarget
- Targeting theNotch pathway: A potential therapeutic approach for desmoid tumors
- (2015) Hui Shang et al. CANCER
- Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study
- (2015) Lindsey M. Hoffman et al. CHILDS NERVOUS SYSTEM
- Targeting Notch signaling by γ-secretase inhibitor I enhances the cytotoxic effect of 5-FU in gastric cancer
- (2015) Hyun-Woo Lee et al. CLINICAL & EXPERIMENTAL METASTASIS
- HES1 promotes metastasis and predicts poor survival in patients with colorectal cancer
- (2015) Ruixue Yuan et al. CLINICAL & EXPERIMENTAL METASTASIS
- A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors
- (2015) E. G. Chiorean et al. CLINICAL CANCER RESEARCH
- Notch Pathway Inhibition Using PF-03084014, a -Secretase Inhibitor (GSI), Enhances the Antitumor Effect of Docetaxel in Prostate Cancer
- (2015) D. Cui et al. CLINICAL CANCER RESEARCH
- A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia
- (2015) Ivan Diaz-Padilla et al. GYNECOLOGIC ONCOLOGY
- Increased Notch1 Expression Is Associated With Poor Overall Survival in Patients With Ovarian Cancer
- (2015) Ahmed Numan Alniaimi et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- γ Secretase Inhibitor BMS-708163 Reverses Resistance to EGFR Inhibitor via the PI3K/Akt Pathway in Lung Cancer
- (2015) Mian Xie et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- The Role of Notch Receptors in Transcriptional Regulation
- (2015) Hongfang Wang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Control of peripheral tolerance by regulatory T cell–intrinsic Notch signaling
- (2015) Louis-Marie Charbonnier et al. NATURE IMMUNOLOGY
- Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors
- (2015) Ashvinikumar V. Gavai et al. ACS Medicinal Chemistry Letters
- Gastric tumor-initiating CD44+ cells and epithelial-mesenchymal transition are inhibited by γ-secretase inhibitor DAPT
- (2015) LU-CHUN LI et al. Oncology Letters
- Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis
- (2015) Xun Yuan et al. Scientific Reports
- Nuclear Notch3 Expression is Associated with Tumor Recurrence in Patients with Stage II and III Colorectal Cancer
- (2014) Tsuyoshi Ozawa et al. ANNALS OF SURGICAL ONCOLOGY
- A parallel-arm phase I trial of the humanised anti-IGF-1R antibody dalotuzumab in combination with the AKT inhibitor MK-2206, the mTOR inhibitor ridaforolimus, or the NOTCH inhibitor MK-0752, in patients with advanced solid tumours
- (2014) I Brana et al. BRITISH JOURNAL OF CANCER
- Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933
- (2014) Sylvia M. Lee et al. CANCER
- A Phase I, Dose-Finding Study in Patients with Advanced Solid Malignancies of the Oral -Secretase Inhibitor PF-03084014
- (2014) W. A. Messersmith et al. CLINICAL CANCER RESEARCH
- Pretreatment with the γ-secretase inhibitor DAPT sensitizes drug-resistant ovarian cancer cells to cisplatin by downregulation of Notch signaling
- (2014) MINGYI WANG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma
- (2014) Ana De Jesus-Acosta et al. INVESTIGATIONAL NEW DRUGS
- A multicenter phase 1 study of γ -secretase inhibitor RO4929097 in combination with capecitabine in refractory solid tumors
- (2014) Noelle K. LoConte et al. INVESTIGATIONAL NEW DRUGS
- Inhibition of the Jagged/Notch pathway inhibits retinoblastoma cell proliferation via suppressing the PI3K/Akt, Src, p38MAPK and Wnt/β-catenin signaling pathways
- (2014) WEI XIAO et al. Molecular Medicine Reports
- Three-dimensional structure of human γ-secretase
- (2014) Peilong Lu et al. NATURE
- Oncogenic roles of EMT-inducing transcription factors
- (2014) Alain Puisieux et al. NATURE CELL BIOLOGY
- Rescue of Notch-1 Signaling in Antigen-Specific CD8+ T Cells Overcomes Tumor-Induced T-cell Suppression and Enhances Immunotherapy in Cancer
- (2014) R. A. Sierra et al. Cancer Immunology Research
- γ-Secretase inhibitors and modulators
- (2013) Todd E. Golde et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients
- (2013) P A Candy et al. BRITISH JOURNAL OF CANCER
- Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a γ-secretase inhibitor, in a preclinical colorectal explant model
- (2013) J J Arcaroli et al. BRITISH JOURNAL OF CANCER
- A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)
- (2013) S Sahebjam et al. BRITISH JOURNAL OF CANCER
- Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1
- (2013) Jia Lu et al. CANCER CELL
- Deadly crosstalk: Notch signaling at the intersection of EMT and cancer stem cells
- (2013) Ingrid Espinoza et al. CANCER LETTERS
- Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer
- (2013) Shinichi Yabuuchi et al. CANCER LETTERS
- Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors
- (2013) A. F. Schott et al. CLINICAL CANCER RESEARCH
- Notch3 induces epithelial–mesenchymal transition and attenuates carboplatin-induced apoptosis in ovarian cancer cells
- (2013) Nidhi Gupta et al. GYNECOLOGIC ONCOLOGY
- A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors
- (2013) Ivan Diaz-Padilla et al. INVESTIGATIONAL NEW DRUGS
- A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)
- (2013) Suzanne Richter et al. INVESTIGATIONAL NEW DRUGS
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- A High Notch Pathway Activation Predicts Response to γ Secretase Inhibitors in Proneural Subtype of Glioma Tumor-Initiating Cells
- (2013) Norihiko Saito et al. STEM CELLS
- Synergistic Effect of the γ-Secretase Inhibitor PF-03084014 and Docetaxel in Breast Cancer Models
- (2013) Cathy C. Zhang et al. Stem Cells Translational Medicine
- Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease
- (2012) Vladimir Coric et al. ARCHIVES OF NEUROLOGY
- γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer
- (2012) H Mizugaki et al. BRITISH JOURNAL OF CANCER
- Cisplatin Selects for Multidrug-Resistant CD133+ Cells in Lung Adenocarcinoma by Activating Notch Signaling
- (2012) Y.-P. Liu et al. CANCER RESEARCH
- A phase II study of RO4929097 in metastatic colorectal cancer
- (2012) Jonathan R. Strosberg et al. EUROPEAN JOURNAL OF CANCER
- Notch signaling mediates TGF-β1-induced epithelial–mesenchymal transition through the induction of Snai1
- (2012) Yosuke Matsuno et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors
- (2012) Ian Krop et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors
- (2012) Anthony W. Tolcher et al. JOURNAL OF CLINICAL ONCOLOGY
- Differential Effects between -Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice
- (2012) Y. Mitani et al. JOURNAL OF NEUROSCIENCE
- Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway
- (2012) He Wang et al. MODERN PATHOLOGY
- The Gamma Secretase Inhibitor MRK-003 Attenuates Pancreatic Cancer Growth in Preclinical Models
- (2012) M. Mizuma et al. MOLECULAR CANCER THERAPEUTICS
- Non-canonical Notch signaling: emerging role and mechanism
- (2012) Peter Andersen et al. TRENDS IN CELL BIOLOGY
- What the halted phase III γ-secretase inhibitor trial may (or may not) be telling us
- (2011) Nina F. Schor ANNALS OF NEUROLOGY
- Notch1 and Notch2 have opposite prognostic effects on patients with colorectal cancer
- (2011) D. Chu et al. ANNALS OF ONCOLOGY
- Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells
- (2011) Yi-Yang Hu et al. BMC CANCER
- Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells
- (2011) T. S. Zhu et al. CANCER RESEARCH
- γ-Secretase inhibitor, DAPT inhibits self-renewal and stemness maintenance of ovarian cancer stem-like cells in vitro
- (2011) Li-yu Jiang et al. Chinese Journal of Cancer Research
- Phase I Trial of MK-0752 in Children With Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study
- (2011) Maryam Fouladi et al. JOURNAL OF CLINICAL ONCOLOGY
- MRK003, a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma
- (2011) V Ramakrishnan et al. LEUKEMIA
- High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ-secretase inhibitor, RO4929097
- (2011) Wei He et al. Molecular Oncology
- Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer
- (2011) M Kondratyev et al. ONCOGENE
- The Novel Gamma Secretase Inhibitor RO4929097 Reduces the Tumor Initiating Potential of Melanoma
- (2011) Chanh Huynh et al. PLoS One
- Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters
- (2011) M Saxena et al. Cell Death & Disease
- Gamma-secretase inhibitor enhances the cytotoxic effect of bortezomib in multiple myeloma
- (2011) Feng Chen et al. CELLULAR ONCOLOGY
- Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease
- (2010) Bart De Strooper et al. Annual Review of Cell and Developmental Biology
- Downregulation of Notch Pathway by a -Secretase Inhibitor Attenuates AKT/Mammalian Target of Rapamycin Signaling and Glucose Uptake in an ERBB2 Transgenic Breast Cancer Model
- (2010) C. L. Efferson et al. CANCER RESEARCH
- Acute -Secretase Inhibition of Nonhuman Primate CNS Shifts Amyloid Precursor Protein (APP) Metabolism from Amyloid- Production to Alternative APP Fragments without Amyloid- Rebound
- (2010) J. J. Cook et al. JOURNAL OF NEUROSCIENCE
- Evaluation of Selective -Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design
- (2010) P. Wei et al. MOLECULAR CANCER THERAPEUTICS
- Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells
- (2010) M. Mazzone et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor
- (2010) Kevin W. Gillman et al. ACS Medicinal Chemistry Letters
- Alzheimer’s disease and Notch signaling
- (2009) Ha-Na Woo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells
- (2009) S. S. Rao et al. CANCER RESEARCH
- Preclinical Profile of a Potent -Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties
- (2009) L. Luistro et al. CANCER RESEARCH
- -Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity
- (2009) R. D. Meng et al. CANCER RESEARCH
- z-Leucinyl-Leucinyl-Norleucinal Induces Apoptosis of Human Glioblastoma Tumor-Initiating Cells by Proteasome Inhibition and Mitotic Arrest Response
- (2009) M. Monticone et al. MOLECULAR CANCER RESEARCH
- Emerging role of Notch in stem cells and cancer
- (2008) Zhiwei Wang et al. CANCER LETTERS
- Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors
- (2008) S. Zhang et al. CANCER RESEARCH
- Substrate specificity of γ-secretase and other intramembrane proteases
- (2008) A. J. Beel et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The many facets of Notch ligands
- (2008) B D'Souza et al. ONCOGENE
- Control of the Reversibility of Cellular Quiescence by the Transcriptional Repressor HES1
- (2008) L. Sang et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started