A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma
出版年份 2018 全文链接
标题
A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma
作者
关键词
-
出版物
BRITISH JOURNAL OF CANCER
Volume 118, Issue 6, Pages 793-801
出版商
Springer Nature
发表日期
2018-02-14
DOI
10.1038/bjc.2017.495
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A first-in-human phase I study of the oral Notch inhibitor, LY900009, in patients with advanced cancer
- (2016) Shubham Pant et al. EUROPEAN JOURNAL OF CANCER
- A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia
- (2015) Ivan Diaz-Padilla et al. GYNECOLOGIC ONCOLOGY
- Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors
- (2015) Ashvinikumar V. Gavai et al. ACS Medicinal Chemistry Letters
- Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933
- (2014) Sylvia M. Lee et al. CANCER
- A Phase I, Dose-Finding Study in Patients with Advanced Solid Malignancies of the Oral -Secretase Inhibitor PF-03084014
- (2014) W. A. Messersmith et al. CLINICAL CANCER RESEARCH
- A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma
- (2014) Ana De Jesus-Acosta et al. INVESTIGATIONAL NEW DRUGS
- Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer
- (2013) Shinichi Yabuuchi et al. CANCER LETTERS
- Combined inhibition of Notch and JAK/STAT is superior to monotherapies and impairs pancreatic cancer progression
- (2013) Vindhya Palagani et al. CARCINOGENESIS
- A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors
- (2013) Ivan Diaz-Padilla et al. INVESTIGATIONAL NEW DRUGS
- A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)
- (2013) Suzanne Richter et al. INVESTIGATIONAL NEW DRUGS
- Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
- (2013) Daniel D. Von Hoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- A phase II study of RO4929097 in metastatic colorectal cancer
- (2012) Jonathan R. Strosberg et al. EUROPEAN JOURNAL OF CANCER
- Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors
- (2012) Ian Krop et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors
- (2012) Anthony W. Tolcher et al. JOURNAL OF CLINICAL ONCOLOGY
- Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma
- (2012) Natalie Cook et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A novel Phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer
- (2012) John Whitehead et al. STATISTICS IN MEDICINE
- FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
- (2011) Thierry Conroy et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pharmacological Analysis of Drosophila melanogaster -Secretase with Respect to Differential Proteolysis of Notch and APP
- (2010) C. Groth et al. MOLECULAR PHARMACOLOGY
- The Notch signaling pathway: Transcriptional regulation at Notch target genes
- (2009) T. Borggrefe et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Ligand-dependent Notch Signaling Is Involved in Tumor Initiation and Tumor Maintenance in Pancreatic Cancer
- (2009) M. E. Mullendore et al. CLINICAL CANCER RESEARCH
- Inhibition of γ-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma
- (2009) Ruben Plentz et al. GASTROENTEROLOGY
- Inhibition of Notch3 enhances sensitivity to gemcitabine in pancreatic cancer through an inactivation of PI3K/Akt-dependent pathway
- (2009) Jun Yao et al. MEDICAL ONCOLOGY
- New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
- (2008) E.A. Eisenhauer et al. EUROPEAN JOURNAL OF CANCER
- Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
- (2008) S. Jones et al. SCIENCE
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