The Role of Notch Receptors in Transcriptional Regulation

Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia

(2014) Thomas Trimarchi et al.   CELL

Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes

(2014) Jill M. Dowen et al.   CELL

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

(2014) K. Durinck et al.   HAEMATOLOGICA

Cyclin C is a haploinsufficient tumour suppressor

(2014) Na Li et al.   NATURE CELL BIOLOGY

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

(2014) Daniel Herranz et al.   NATURE MEDICINE

The Tumor Suppressor Ikaros Shapes the Repertoire of Notch Target Genes in T Cells

(2014) A.-S. Geimer Le Lay et al.   Science Signaling

Discovery of Biomarkers Predictive of GSI Response in Triple-Negative Breast Cancer and Adenoid Cystic Carcinoma

(2014) A. Stoeck et al.   Cancer Discovery

RBPJ, the Major Transcriptional Effector of Notch Signaling, Remains Associated with Chromatin throughout Mitosis, Suggesting a Role in Mitotic Bookmarking

(2014) Robert J. Lake et al.   PLoS Genetics

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme

(2013) A. Terriente-Felix et al.   DEVELOPMENT

Dynamic binding of RBPJ is determined by Notch signaling status

(2013) D. Castel et al.   GENES & DEVELOPMENT

Whole exome sequencing of adenoid cystic carcinoma

(2013) Philip J. Stephens et al.   JOURNAL OF CLINICAL INVESTIGATION

The Human Papillomavirus Type 8 E6 Protein Interferes with NOTCH Activation during Keratinocyte Differentiation

(2013) J. M. Meyers et al.   JOURNAL OF VIROLOGY

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

(2013) S. C. J. Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

(2013) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Function of the CSL-KyoT2 Corepressor Complex: A Negative Regulator of Notch Signaling

(2013) Kelly J. Collins et al.   STRUCTURE

NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function

(2012) Ahmad Yatim et al.   MOLECULAR CELL

Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling

(2012) N Brimer et al.   ONCOGENE

Cutaneous  -human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling

(2012) M. J. A. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The double-edged sword of Notch signaling in cancer

(2012) Andrew P. South et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Ubiquitination of Notch1 is regulated by MAML1-mediated p300 acetylation of Notch1

(2011) Anita E. Popko-Scibor et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency

(2011) R David Hawkins et al.   CELL RESEARCH

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Functional antagonism between histone H3K4 demethylases in vivo

(2011) L. Di Stefano et al.   GENES & DEVELOPMENT

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

(2011) Hind Medyouf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development

(2011) Peter Mulligan et al.   MOLECULAR CELL

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

(2011) Virginia Guarani et al.   NATURE

CTCF-mediated functional chromatin interactome in pluripotent cells

(2011) Lusy Handoko et al.   NATURE GENETICS

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

(2011) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL

(2010) R. Jeannet et al.   BLOOD

Notch dimerization is required for leukemogenesis and T-cell development

(2010) H. Liu et al.   GENES & DEVELOPMENT

Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex

(2010) R. Liefke et al.   GENES & DEVELOPMENT

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

(2010) Kelly L Arnett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

The Notch signaling pathway: Transcriptional regulation at Notch target genes

(2009) T. Borggrefe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Notch Signaling in Leukemia

(2008) Jon C. Aster et al.   Annual Review of Pathology-Mechanisms of Disease

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling

(2008) K. Hori et al.   GENES & DEVELOPMENT

Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains

(2008) S. Cuddapah et al.   GENOME RESEARCH