Notch1 is a prognostic factor that is distinctly activated in the classical and proneural subtype of glioblastoma and that promotes glioma cell survival via the NF-κB(p65) pathway
出版年份 2018 全文链接
标题
Notch1 is a prognostic factor that is distinctly activated in the classical and proneural subtype of glioblastoma and that promotes glioma cell survival via the NF-κB(p65) pathway
作者
关键词
-
出版物
Cell Death & Disease
Volume 9, Issue 2, Pages -
出版商
Springer Nature
发表日期
2018-02-06
DOI
10.1038/s41419-017-0119-z
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The role of miR-451 in the switching between proliferation and migration in malignant glioma cells: AMPK signaling, mTOR modulation and Rac1 activation required
- (2017) Kai Zhao et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- The challenge of targeting cancer stem cells to halt metastasis
- (2017) Alice Agliano et al. SEMINARS IN CANCER BIOLOGY
- Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth
- (2016) Baoli Hu et al. CELL
- Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial
- (2016) R. Xu et al. CLINICAL CANCER RESEARCH
- Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment
- (2016) Keisuke Katsushima et al. Nature Communications
- Notch signaling: An emerging therapeutic target for cancer treatment
- (2015) Xun Yuan et al. CANCER LETTERS
- Cancer stem cells in glioblastoma
- (2015) Justin D. Lathia et al. GENES & DEVELOPMENT
- Nuclear factor-κB in glioblastoma: insights into regulators and targeted therapy
- (2015) Kirk E. Cahill et al. NEURO-ONCOLOGY
- Synergistic association of Notch and NFκB signaling and role of Notch signaling in modulating epithelial to mesenchymal transition in colorectal adenocarcinoma
- (2014) Natarajan Gopalakrishnan et al. BIOCHIMIE
- The Cyclin-like Protein Spy1 Regulates Growth and Division Characteristics of the CD133+ Population in Human Glioma
- (2014) Dorota Lubanska et al. CANCER CELL
- Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy
- (2014) K. Yan et al. GENES & DEVELOPMENT
- Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
- (2014) A. P. Patel et al. SCIENCE
- Notch1 Stimulation Induces a Vascularization Switch With Pericyte-Like Cell Differentiation of Glioblastoma Stem Cells
- (2014) Pierre-Olivier Guichet et al. STEM CELLS
- NF- B, an Active Player in Human Cancers
- (2014) Y. Xia et al. Cancer Immunology Research
- EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme
- (2013) Bryan W. Day et al. CANCER CELL
- Constitutive Activation of Signal Transducer and Activator of Transcription 3 (STAT3) and Nuclear Factor κB Signaling in Glioblastoma Cancer Stem Cells Regulates the Notch Pathway
- (2013) Jo Meagan Garner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differential patterns of NOTCH1-4 receptor expression are markers of glioma cell differentiation
- (2013) P. Dell'Albani et al. NEURO-ONCOLOGY
- A High Notch Pathway Activation Predicts Response to γ Secretase Inhibitors in Proneural Subtype of Glioma Tumor-Initiating Cells
- (2013) Norihiko Saito et al. STEM CELLS
- An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma
- (2013) Esther Rheinbay et al. Cell Reports
- Interferon regulatory factor 7 regulates glioma stem cells via interleukin-6 and Notch signalling
- (2012) X. Jin et al. BRAIN
- Emerging insights into the molecular and cellular basis of glioblastoma
- (2012) G. P. Dunn et al. GENES & DEVELOPMENT
- Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors
- (2012) Ian Krop et al. JOURNAL OF CLINICAL ONCOLOGY
- Dll4-Fc, an Inhibitor of Dll4-Notch Signaling, Suppresses Liver Metastasis of Small Cell Lung Cancer Cells through the Downregulation of the NF- B Activity
- (2012) T. Kuramoto et al. MOLECULAR CANCER THERAPEUTICS
- Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells
- (2011) T. S. Zhu et al. CANCER RESEARCH
- Heterogeneity Maintenance in Glioblastoma: A Social Network
- (2011) R. Bonavia et al. CANCER RESEARCH
- Notch1 promotes glioma cell migration and invasion by stimulating β-catenin and NF-κB signaling via AKT activation
- (2011) Xiaohua Zhang et al. CANCER SCIENCE
- Notch1 Expression, Which Is Related to p65 Status, Is an Independent Predictor of Prognosis in Colorectal Cancer
- (2011) D. Chu et al. CLINICAL CANCER RESEARCH
- Phase I Trial of MK-0752 in Children With Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study
- (2011) Maryam Fouladi et al. JOURNAL OF CLINICAL ONCOLOGY
- Notch1 is an independent prognostic factor for patients with glioma
- (2011) Jiang Li et al. JOURNAL OF SURGICAL ONCOLOGY
- Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
- (2010) Roel G.W. Verhaak et al. CANCER CELL
- Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
- (2010) Lucia Ricci-Vitiani et al. NATURE
- Glioblastoma stem-like cells give rise to tumour endothelium
- (2010) Rong Wang et al. NATURE
- Inhibition of Notch Signaling in Glioblastoma Targets Cancer Stem Cells via an Endothelial Cell Intermediate
- (2010) Koos E. Hovinga et al. STEM CELLS
- Turning Cancer Stem Cells Inside Out: An Exploration of Glioma Stem Cell Signaling Pathways
- (2009) Zhizhong Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
- (2009) Roger Stupp et al. LANCET ONCOLOGY
- Notch-1 regulates transcription of the epidermal growth factor receptor through p53
- (2008) Benjamin W. Purow et al. CARCINOGENESIS
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- (2008) Roger McLendon et al. NATURE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started