Article
Gastroenterology & Hepatology
Emily P. Vonderhaar, Nicholas S. Barnekow, Donna McAllister, Laura McOlash, Mahmoud Abu Eid, Matthew J. Riese, Vera L. Tarakanova, Bryon D. Johnson, Michael B. Dwinell
Summary: STING agonists can promote T-cell infiltration, counteract immune suppression, and generate systemic anti-tumor inflammation in locally treated and distant tumors.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Alvaro de Mingo Pulido, Kay Hanggi, Daiana P. Celias, Alycia Gardner, Jie Li, Bruna Batista-Bittencourt, Eslam Mohamed, Jimena Trillo-Tinoco, Olabisi Osunmakinde, Reymi Pena, Alexis Onimus, Tsuneyasu Kaisho, Johanna Kaufmann, Kristen McEachern, Hatem Soliman, Vincent C. Luca, Paulo C. Rodriguez, Xiaoqing Yu, Brian Ruffell
Summary: Blockade of the inhibitory receptor TIM-3 has shown efficacy in clinical trials of cancer immunotherapy, specifically in enhancing antitumor immunity in mammary carcinomas by increasing CXCL9 expression by cDC1 cells. This increased expression required type I interferons and extracellular DNA, with DNA uptake and efficacy of TIM-3 blockade being dependent on HMGB1 and galectin-9-induced cell surface clustering of TIM-3, suggesting a potential mechanism for TIM-3 immunotherapy.
Review
Immunology
Qijun Lu, Yukun Chen, Jianwen Li, Feng Zhu, Zhan Zheng
Summary: The cGAS-STING pathway and autophagy are interconnected and may influence cancer progression. Understanding their relationship and interactions in cancer immunity is crucial for developing effective treatments.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kohsuke Tsuchiya
Summary: Pyroptosis is a regulated form of cell death, executed by Gasdermines (GSDMs) that form pores in the plasma membrane leading to cell lysis. Pyroptotic cells release pro-inflammatory molecules, eliciting inflammation and immune responses. Recent studies have advanced our understanding of pyroptosis mechanisms and roles, which may aid in the development of cancer immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Cunguo Chen, Murong Hu, Yunyun Cao, Binbin Zhu, Jiashe Chen, Yashi Li, Junyi Shao, Sen Zhou, Pengfei Shan, Chen Zheng, Zhongyu Li, Zhiming Li
Summary: In this study, a combined immunotherapy strategy was developed based on immune agonists and photothermal therapy, which can effectively improve the biological efficacy of immunotherapy, transform the immunosuppressive tumor microenvironment into an immunogenic and tumoricidal microenvironment, and completely kill tumor cells.
Article
Immunology
Yunyun Guo, Fei Jiang, Lingli Kong, Haifeng Wu, Honghai Zhang, Xiaorong Chen, Jian Zhao, Baoshan Cai, Yanqi Li, Chunhong Ma, Fan Yi, Lei Zhang, Bingyu Liu, Yi Zheng, Lingqiang Zhang, Chengjiang Gao
Summary: STING is a critical adaptor protein for innate antiviral and antitumor immunity, regulated by protein ubiquitination, with OTUD5 identified as a key deubiquitinase that interacts with STING to maintain its stability. Knockout of OTUD5 resulted in impaired immune responses and increased susceptibility to viral infection and tumor development.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Oncology
Noor Shakfa, Deyang Li, Sarah Nersesian, Juliette Wilson-Sanchez, Madhuri Koti
Summary: Ovarian cancer, particularly high-grade serous ovarian carcinoma, is resistant to conventional therapies. Studies have shown that tumors with DNA damage repair gene deficiency and chromosomal instability have increased immune cell infiltration and expression of immune-related genes. However, most ovarian cancer patients have not responded to immunomodulatory treatments due to the lack of understanding of the mechanisms underlying immune infiltration.
BRITISH JOURNAL OF CANCER
(2022)
Review
Medicine, Research & Experimental
Huashan Du, Tianmin Xu, Manhua Cui
Summary: Recent studies have revealed that the cGAS-STING pathway plays a crucial role in antitumor immunity, promoting senescence and apoptosis of cancer cells while enhancing the protective effects of cytotoxic T cells and natural killer cells. Combining the cGAS-STING signaling pathway with other therapeutic methods offers a new perspective for overcoming obstacles in its application.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Mohammad Alshebremi, Suzanne L. Tomchuck, Jay T. Myers, Daniel T. Kingsley, Saada Eid, Muta Abiff, Melissa Bonner, Shahrazad T. Saab, Sung Hee Choi, Alex Yee-Chen Huang
Summary: The tumor cell-intrinsic STING pathway plays a crucial role in the effectiveness of cryoablation, and the expression of STING-related signaling components may serve as a potential therapy response biomarker.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Qiushi Tang, Shuo Yang, Guangpeng He, Hongyu Zheng, Sheng Zhang, Jiaxing Liu, Shibo Wei, Qing Fan, Xueqiang Peng, Xinyu Li, Dewei Zhang, Liang Yang, Hangyu Li
Summary: Tumor-derived exosomes (TDEs) play a critical role in regulating the immune microenvironment of tumors and have the ability to suppress immune responses, thus impacting the effectiveness of cancer therapy. By delivering suppressive factors to immune cells, TDEs directly or indirectly influence immune cell function and antitumor activities. TDE-based therapy is emerging as a promising strategy for inhibiting tumor progression and enhancing antitumor immunity.
Review
Cell Biology
Jun Li, Samuel F. Bakhoum
Summary: In this review, the recent advances in the cGAS-STING field are discussed, with a focus on its crosstalk with other signaling pathways in the tumor microenvironment (TME). A more detailed understanding of the roles of cGAS-STING signaling in the TME will facilitate the design of more precise cancer treatment strategies.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Article
Oncology
Si-Yu Wu, Yi Xiao, Jin-Li Wei, Xiao-En Xu, Xi Jin, Xin Hu, Da-Qiang Li, Yi-Zhou Jiang, Zhi-Ming Shao
Summary: This study identified two distinct microenvironment phenotypes, 'inflamed' and 'non-inflamed', within the classic basal-like subtype of TNBC, and revealed that MYC amplification and overexpression led to the formation of the non-inflamed TIME. Combination therapy with a DNA methyltransferase inhibitor and immunotherapy reversed T cell exhaustion and improved T cell function, resulting in potent antitumor activity in MYC-overexpressing TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Qinghao Zhou, Yu Zhou, Taiyuan Li, Zhishen Ge
Summary: STING agonists have shown promise in cancer immunotherapy, but the limitations of small molecule agonists and physiological barriers for in vivo activation hinder their therapeutic efficacy. Drug delivery systems are crucial for enhancing STING activation efficiency in targeting tissues.
MACROMOLECULAR BIOSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Hongyong Huang, Yanmin Weng, Wen Tian, Xian Lin, Jian Chen, Lianxiang Luo
Summary: This review provides an overview of the mechanisms of pyroptosis, the relationship between the gasdermin family and pyroptosis, and the interplay between pyroptosis and anti-tumor immunity. Additionally, the potential implications of pyroptosis in cancer immunotherapy are discussed, along with future research possibilities and a novel approach to tumor treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiaohui Si, Lu Xiao, Christine E. Brown, Dongrui Wang
Summary: This review provides an overview of the development of in vitro and in vivo models for evaluating CAR T cell function, and discusses how these models can provide information for the preclinical assessment of CAR T cell therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Fangchao Liu, Yanhua Zhang, Janelle Schafer, Guangzhao Mao, Harry G. Goshgarian
JOURNAL OF SPINAL CORD MEDICINE
(2019)
Correction
Nanoscience & Nanotechnology
Brittany Haynes, Yanhua Zhang, Fangchao Liu, Jing Li, Sarah Petit, Hend Kothayer, Xun Bao, Andrew D. Westwell, Guangzhao Mao, Malathy P. V. Shekhar
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2019)
Article
Immunology
Michael H. Zhang, Emily M. Slaby, Georgina Stephanie, Chunsong Yu, Darcy M. Watts, Haipeng Liu, Gregory L. Szeto
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Materials Science, Multidisciplinary
Xuecheng Yu, Mohamed Kilani, Abdurrafay Siddiqui, Guangzhao Mao
ADVANCED MATERIALS TECHNOLOGIES
(2020)
Article
Oncology
Branislava Janic, Stephen L. Brown, Ryan Neff, Fangchao Liu, Guangzhao Mao, Yalei Chen, Latoya Jackson, Indrin J. Chetty, Benjamin Movsas, Ning Wen
Summary: Gold nanoparticles have shown to enhance the efficacy of cancer radiotherapy by localizing radiation energy in tumors, leading to improved cell death. The size of nanoparticles plays a role in this enhancement, with different sizes affecting intracellular targeting and immunological responses.
CANCER BIOLOGY & THERAPY
(2021)
Article
Pathology
Ashapurna Sarma, Ambikai Gajan, Seongho Kim, Katherine Gurdziel, Guangzhao Mao, Pratima Nangia-Makker, Malathy P. V. Shekhar
Summary: Canonical Wnt signaling plays a critical role in melanocyte lineage commitment and melanoma development. RAD6B, a ubiquitin-conjugating enzyme involved in translesion DNA synthesis, enhances beta-catenin stability/activity through a proteasome-insensitive polyubiquitination process. Targeting RAD6B through genetic knockout or selective small-molecule inhibition has been shown to inhibit melanoma cell proliferation and reduce metastasis, suggesting a potential novel strategy for treating melanomas with dysregulated canonical Wnt signaling.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Immunology
Meng Li, Arata Itoh, Jingchao Xi, Chunsong Yu, Yuehong Wu, William M. Ridgway, Haipeng Liu
Summary: Efforts to restore immune tolerance to self-antigens without global immune suppression in autoimmune disorders have largely failed. However, modifying peptides with lipophilic compounds significantly enhances antigen presentation and induces immune tolerance, showing promise for the treatment of autoimmune diseases.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Xin Geng, Shuwei Li, Lalani Mawella-Vithanage, Tao Ma, Mohamed Kilani, Bingwen Wang, Lu Ma, Chathuranga C. Hewa-Rahinduwage, Alina Shafikova, Eranda Nikolla, Guangzhao Mao, Stephanie L. Brock, Liang Zhang, Long Luo
Summary: The study introduces a novel bimetallic PbCdSe quantum dot gel sensor with high sensitivity and fast response for detecting NO2 gas. By employing the strategy of atomically dispersed metal ions, the sensor achieves an optimal combination of response and recovery, leading to high performance in NO2 detection.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Chunsong Yu, Myunggi An, Meng Li, Charles Manke, Haipeng Liu
Summary: The molecular structure of amphiphiles, including lipids and PEG spacers, has a profound effect on the stability of membrane-anchored amphiphiles on cell surfaces under mechanical stress. This underscores the importance of molecular design in ensuring the dynamic stability of these molecules.
Article
Nanoscience & Nanotechnology
Yifang Wang, Mohannad Mayyas, Jiong Yang, Mohammad B. Ghasemian, Jianbo Tang, Maedehsadat Mousavi, Jialuo Han, Mostak Ahmed, Mahroo Baharfar, Guangzhao Mao, Yin Yao, Dorna Esrafilzadeh, David Cortie, Kourosh Kalantar-Zadeh
Summary: The method presented in the study utilizes liquid metal-based technology to achieve room temperature deposition and patterning of MoO2, providing a new way of fabrication. Through laser writing technique, electrically conductive MoO2 patterns can be obtained on desired substrates. The electrical conductivity and plasmonic properties of MoO2 are analyzed and demonstrated.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Md Musfizur Hassan, Malsha Hettiarachchi, Mohamed Kilani, Xiaohua Gao, Abdulghani Sankari, Cyrille Boyer, Guangzhao Mao
Summary: Respiratory dysfunction is a major cause of death in SCI patients. By utilizing neural tracing proteins to bypass the blood-brain barrier and target respiratory motoneurons in the spinal cord and brainstem, this study introduces a novel approach to deliver drugs with reduced side effects and improved efficacy for treating SCI-related respiratory issues.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Tomasz Adamus, Chia-Yang Hung, Chunsong Yu, Elaine Kang, Mohamed Hammad, Linda Flores, Sergey Nechaev, Qifang Zhang, Joanna Marie Gonzaga, Kokilah Muthaiyah, Piotr Swiderski, Karen S. Aboody, Marcin Kortylewski
Summary: Neural stem cells (NSCs) can effectively transport antisense oligonucleotides (ASOs) targeting STAT3 protein to glioma microenvironment. NSC-derived exosomes loaded with CpG-STAT3ASO stimulate immune activity and inhibit tumor growth.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Meeting Abstract
Oncology
Branislava Janic, Stephen Brown, Ryan Neff, Fangchao Liu, Kevin Bobbitt, Guangzhao Mao, Indrin Chetty, Benjamin Movsas, Ning Wen
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Meeting Abstract
Oncology
B. Janic, R. Neff, S. L. Brown, F. Liu, G. Mao, I. J. Chetty, B. Movsas, N. Wen
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Article
Electrochemistry
Disni Gunasekera, Mohamed Kilani, Xuecheng Yu, Qianjin Chen, Guangzhao Mao, Long Luo
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2019)
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.