Development of Antiretroviral Drug Resistance

Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance

(2012) Hong-Tao Xu et al.   Retrovirology

Cost-effectiveness of new WHO recommendations for prevention of mother-to-child transmission of HIV in a resource-limited setting

(2011) Maunank Shah et al.   AIDS

Global trends in molecular epidemiology of HIV-1 during 2000–2007

(2011) Joris Hemelaar et al.   AIDS

Detection of Low-Level K65R Variants in Nucleoside Reverse Transcriptase Inhibitor–Naive Chronic and Acute HIV-1 Subtype C Infections

(2011) Jin-fen Li et al.   JOURNAL OF INFECTIOUS DISEASES

Subtype diversity associated with the development of HIV-1 resistance to integrase inhibitors

(2011) Bluma G. Brenner et al.   JOURNAL OF MEDICAL VIROLOGY

Triple-Antiretroviral Prophylaxis to Prevent Mother-To-Child HIV Transmission through Breastfeeding—The Kisumu Breastfeeding Study, Kenya: A Clinical Trial

(2011) Timothy K. Thomas et al.   PLOS MEDICINE

HIV-1 Drug Resistance Emergence among Breastfeeding Infants Born to HIV-Infected Mothers during a Single-Arm Trial of Triple-Antiretroviral Prophylaxis for Prevention of Mother-To-Child Transmission: A Secondary Analysis

(2011) Clement Zeh et al.   PLOS MEDICINE

Expanding access to HAART: a cost-effective approach for treating and preventing HIV

(2010) Karissa M Johnston et al.   AIDS

Effect on transmission of HIV-1 resistance of timing of implementation of viral load monitoring to determine switches from first to second-line antiretroviral regimens in resource-limited settings

(2010) Andrew N Phillips et al.   AIDS

Analysis of RT Sequences of Subtype C HIV-Type 1 Isolates from Indian Patients at Failure of a First-Line Treatment According to Clinical and/or Immunological WHO Guidelines

(2010) Alaka Deshpande et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Differences in HIV Type 1 RNA Plasma Load Profile of Closely Related Cocirculating Ethiopian Subtype C Strains: C and C′

(2010) Workenesh Ayele et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Tenofovir (TDF)-Selected or Abacavir (ABC)-Selected Low-Frequency HIV Type 1 Subpopulations During Failure with Persistent Viremia as Detected by Ultradeep Pyrosequencing

(2010) Richard T. D'Aquila et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV-1 Protease Codon 36 Polymorphisms and Differential Development of Resistance to Nelfinavir, Lopinavir, and Atazanavir in Different HIV-1 Subtypes

(2010) I. Lisovsky et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hot Spots of Integrase Genotypic Changes Leading to HIV-2 Resistance to Raltegravir

(2010) Charlotte Charpentier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Distinct Mutation Pathways of Non-Subtype B HIV-1 during In Vitro Resistance Selection with Nonnucleoside Reverse Transcriptase Inhibitors

(2010) M.-T. Lai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Understanding the HIV-1 protease nelfinavir resistance mutation D30N in subtypes B and C through molecular dynamics simulations

(2010) Rosemberg O. Soares et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study

(2010) Julio SG Montaner et al.   LANCET

Tracking a century of global expansion and evolution of HIV to drive understanding and to combat disease

(2010) Denis M Tebit et al.   LANCET INFECTIOUS DISEASES

Nucleic Acid Template and the Risk of a PCR-Induced HIV-1 Drug Resistance Mutation

(2010) Vici Varghese et al.   PLoS One

The public health approach to identify antiretroviral therapy failure: high-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapy

(2009) Mina C Hosseinipour et al.   AIDS

The HIV-1 integrase genotype strongly predicts raltegravir susceptibility but not viral fitness of primary virus isolates

(2009) Maria José Buzón et al.   AIDS

Modulation of K65R Selection by Zidovudine Inclusion: Analysis of HIV Resistance Selection in Subjects with Virologic Failure Receiving Once-Daily Abacavir/Lamivudine/Zidovudine and Tenofovir DF (Study COL40263)

(2009) Lisa Ross et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Primary Antiretroviral Drug Resistance among HIV Type 1-Infected Individuals in Brazil

(2009) Eduardo Sprinz et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Antiretroviral Drug-Resistant Mutations at Baseline and at Time of Failure of Antiretroviral Therapy in HIV Type 1-Coinfected TB Patients

(2009) Lakshmi Rajesh et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Longitudinal Analysis of Raltegravir Susceptibility and Integrase Replication Capacity of Human Immunodeficiency Virus Type 1 during Virologic Failure

(2009) S. Fransen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiretroviral Drug Resistance in Human Immunodeficiency Virus Type 2

(2009) M. L. Ntemgwa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Emergence of Multiclass Drug–Resistance in HIV‐2 in Antiretroviral‐Treated Individuals in Senegal: Implications for HIV‐2 Treatment in Resouce‐Limited West Africa

(2009) Geoffrey S. Gottlieb et al.   CLINICAL INFECTIOUS DISEASES

Signature Nucleotide Polymorphisms at Positions 64 and 65 in Reverse Transcriptase Favor the Selection of the K65R Resistance Mutation in HIV‐1 Subtype C

(2009) Cédric F. Invernizzi et al.   JOURNAL OF INFECTIOUS DISEASES

Prevalence of the K65R resistance reverse transcriptase mutation in different HIV-1 subtypes in Israel

(2009) Dan Turner et al.   JOURNAL OF MEDICAL VIROLOGY

Loss of Raltegravir Susceptibility by Human Immunodeficiency Virus Type 1 Is Conferred via Multiple Nonoverlapping Genetic Pathways

(2009) S. Fransen et al.   JOURNAL OF VIROLOGY

Selective-Advantage Profile of Human Immunodeficiency Virus Type 1 Integrase Mutants Explains In Vivo Evolution of Raltegravir Resistance Genotypes

(2009) R. Quercia et al.   JOURNAL OF VIROLOGY

Diagnosis of antiretroviral therapy failure in Malawi: poor performance of clinical and immunological WHO criteria

(2009) Joep J.G. van Oosterhout et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Five-year follow up of genotypic resistance patterns in HIV-1 subtype C infected patients in Botswana after failure of thymidine analogue-based regimens

(2009) Florence Doualla-Bell et al.   Journal of the International AIDS Society

Silent mutations are selected in HIV-1 reverse transcriptase and affect enzymatic efficiency

(2008) P Richard Harrigan et al.   AIDS

Rapid accumulation of nonnucleoside reverse transcriptase inhibitor-associated resistance: evidence of transmitted resistance in rural South Africa

(2008) Roos E Barth et al.   AIDS

HIV Type 1 Subtype C Drug Resistance among Pediatric and Adult South African Patients Failing Antiretroviral Therapy

(2008) Visva Pillay et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro

(2008) I. Malet et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prevalence of HIV‐1 Drug Resistance after Failure of a First Highly Active Antiretroviral Therapy Regimen in KwaZulu Natal, South Africa

(2008) Vincent C. Marconi et al.   CLINICAL INFECTIOUS DISEASES

Factors Associated with the Emergence of K65R in Patients with HIV‐1 Infection Treated with Combination Antiretroviral Therapy Containing Tenofovir

(2008) Viktor von Wyl et al.   CLINICAL INFECTIOUS DISEASES

Increase of Non-B Subtypes and Recombinants Among Newly Diagnosed HIV-1 Native Spaniards and Immigrants in Spain

(2008) Africa Holguin et al.   CURRENT HIV RESEARCH

Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy*

(2008) C Charpentier et al.   HIV MEDICINE

Genotypic resistance profiles in antiretroviral-naive HIV-1 infections before and after initiation of first-line HAART: impact of polymorphism on resistance to therapy

(2008) Chonlaphat Sukasem et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

HIV Drug Resistance Pattern Among HAART-Exposed Patients With Suboptimal Virological Response in Ouagadougou, Burkina Faso

(2008) Denis M Tebit et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

High rate of early virological failure with the once-daily tenofovir/lamivudine/nevirapine combination in naive HIV-1-infected patients

(2008) D. Rey et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Template Usage Is Responsible for the Preferential Acquisition of the K65R Reverse Transcriptase Mutation in Subtype C Variants of Human Immunodeficiency Virus Type 1

(2008) D. Coutsinos et al.   JOURNAL OF VIROLOGY