Neutralizing antibodies to HIV-1 induced by immunization

On HIV diversity

(2012) Thumbi Ndung’u et al.   AIDS

Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization

(2012) Laura E. McCoy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein

(2012) Florian Klein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Magnitude and Breadth of the Neutralizing Antibody Response in the RV144 and Vax003 HIV-1 Vaccine Efficacy Trials

(2012) D. C. Montefiori et al.   JOURNAL OF INFECTIOUS DISEASES

Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-Infected Donor: Implications for Vaccine Design

(2012) Mattia Bonsignori et al.   JOURNAL OF VIROLOGY

The Development of CD4 Binding Site Antibodies during HIV-1 Infection

(2012) R. M. Lynch et al.   JOURNAL OF VIROLOGY

HIV-1 Neutralization Coverage Is Improved by Combining Monoclonal Antibodies That Target Independent Epitopes

(2012) N. A. Doria-Rose et al.   JOURNAL OF VIROLOGY

A Nonfucosylated Variant of the anti-HIV-1 Monoclonal Antibody b12 Has Enhanced Fc RIIIa-Mediated Antiviral Activity In Vitro but Does Not Improve Protection against Mucosal SHIV Challenge in Macaques

(2012) B. Moldt et al.   JOURNAL OF VIROLOGY

PGV04, an HIV-1 gp120 CD4 Binding Site Antibody, Is Broad and Potent in Neutralization but Does Not Induce Conformational Changes Characteristic of CD4

(2012) Emilia Falkowska et al.   JOURNAL OF VIROLOGY

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

(2012) Dan H. Barouch et al.   NATURE

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

(2012) Jinghe Huang et al.   NATURE

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

(2012) Florian Klein et al.   NATURE

Lessons learned from HIV-1 vaccine trials: new priorities and directions

(2012) Andrew J McMichael et al.   NATURE IMMUNOLOGY

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Llama Antibody Fragments Recognizing Various Epitopes of the CD4bs Neutralize a Broad Range of HIV-1 Subtypes A, B and C

(2012) Nika Strokappe et al.   PLoS One

Mixed Adjuvant Formulations Reveal a New Combination That Elicit Antibody Response Comparable to Freund's Adjuvants

(2012) Rachel P. J. Lai et al.   PLoS One

HIV-1 envelope trimer elicits more potent neutralizing antibody responses than monomeric gp120

(2012) James M. Kovacs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120

(2012) Anthony P. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses

(2012) D. R. Burton et al.   SCIENCE

Prime boost vaccination approaches with different conjugates of a new HIV-1 gp41 epitope encompassing the membrane proximal external region induce neutralizing antibodies in mice

(2012) Mingkui Zhou et al.   VACCINE

The changing face of HIV vaccine research

(2012) Peter D Kwong et al.   Journal of the International AIDS Society

How Can HIV-Type-1-Env Immunogenicity Be Improved to Facilitate Antibody-Based Vaccine Development?

(2011) Per Johan Klasse et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Llama Antibody Fragments Have Good Potential for Application as HIV Type 1 Topical Microbicides

(2011) Andrea Gorlani et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

New Paradigms for HIV/AIDS Vaccine Development

(2011) Louis J. Picker et al.   Annual Review of Medicine

Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies

(2011) Laurent Verkoczy et al.   CURRENT OPINION IN IMMUNOLOGY

The V1V2 Domain and an N-Linked Glycosylation Site in the V3 Loop of the HIV-1 Envelope Glycoprotein Modulate Neutralization Sensitivity to the Human Broadly Neutralizing Antibody 2G12

(2011) A. Chaillon et al.   JOURNAL OF VIROLOGY

Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01

(2011) Y. Li et al.   JOURNAL OF VIROLOGY

The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection

(2011) E. S. Gray et al.   JOURNAL OF VIROLOGY

Sequential Immunization with a Subtype B HIV-1 Envelope Quasispecies Partially Mimics the In Vivo Development of Neutralizing Antibodies

(2011) D. C. Malherbe et al.   JOURNAL OF VIROLOGY

The gp41 epitope, QARVLAVERY, is highly conserved and a potent inducer of IgA that neutralizes HIV-1 and inhibits viral transcytosis

(2011) S Jain et al.   Mucosal Immunology

A sweet cleft in HIV's armour

(2011) Quentin J. Sattentau   NATURE

Antibody-based protection against HIV infection by vectored immunoprophylaxis

(2011) Alejandro B. Balazs et al.   NATURE

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

(2011) Jason S. McLellan et al.   NATURE

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

Prospects for an HIV vaccine: leading B cells down the right path

(2011) Susan Moir et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Anti-HIV-1 V3 Loop Antibody Fully Protects Cross-Clade and Elicits T-Cell Immunity in Macaques Mucosally Challenged with an R5 Clade C SHIV

(2011) Jennifer D. Watkins et al.   PLoS One

Induction of Antibodies in Rhesus Macaques That Recognize a Fusion-Intermediate Conformation of HIV-1 gp41

(2011) S. Moses Dennison et al.   PLoS One

Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design

(2011) R. Diskin et al.   SCIENCE

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

(2011) J. F. Scheid et al.   SCIENCE

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

(2011) R. Pejchal et al.   SCIENCE

A combination HIV vaccine based on Tat and Env proteins was immunogenic and protected macaques from mucosal SHIV challenge in a pilot study

(2011) Flavia Ferrantelli et al.   VACCINE

Prime–boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: Efficacy against repeated mucosal R5 clade C SHIV challenges

(2011) Samir K. Lakhashe et al.   VACCINE

An engineered mutant of HIV-1 gp120 formulated with adjuvant Quil A promotes elicitation of antibody responses overlapping the CD4-binding site

(2011) Fatima K. Ahmed et al.   VACCINE

“Rational Vaccine Design” for HIV Should Take into Account the Adaptive Potential of Polyreactive Antibodies

(2011) Jordan D. Dimitrov et al.   PLoS Pathogens

Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies

(2011) Ben-Jiang Ma et al.   PLoS Pathogens

Neutralizing Antibodies and Control of HIV: Moves and Countermoves

(2011) Ann J. Hessell et al.   Current HIV/AIDS Reports

Rational antibody-based HIV-1 vaccine design: current approaches and future directions

(2010) Laura M Walker et al.   CURRENT OPINION IN IMMUNOLOGY

Structure-based Vaccine Design in HIV: Blind Men and the Elephant?

(2010) Robert Pejchal et al.   CURRENT PHARMACEUTICAL DESIGN

Induction of Immunity to Human Immunodeficiency Virus Type-1 by Vaccination

(2010) M. Juliana McElrath et al.   IMMUNITY

Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates

(2010) Christopher Sundling et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Magnitude and Breadth of a Nonprotective Neutralizing Antibody Response in an Efficacy Trial of a Candidate HIV‐1 gp120 Vaccine

(2010) Peter Gilbert et al.   JOURNAL OF INFECTIOUS DISEASES

Antibody-Mediated Protection against Mucosal Simian-Human Immunodeficiency Virus Challenge of Macaques Immunized with Alphavirus Replicon Particles and Boosted with Trimeric Envelope Glycoprotein in MF59 Adjuvant

(2010) S. W. Barnett et al.   JOURNAL OF VIROLOGY

Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals

(2010) Davide Corti et al.   PLoS One

Profiles of Human Serum Antibody Responses Elicited by Three Leading HIV Vaccines Focusing on the Induction of Env-Specific Antibodies

(2010) Michael Vaine et al.   PLoS One

sCD4-17b bifunctional protein: Extremely broad and potent neutralization of HIV-1 Env pseudotyped viruses from genetically diverse primary isolates

(2010) Laurel A Lagenaur et al.   Retrovirology

A Boost for HIV Vaccine Design

(2010) D. R. Burton et al.   SCIENCE

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Recombinant varicella vaccines induce neutralizing antibodies and cellular immune responses to SIV and reduce viral loads in immunized rhesus macaques

(2010) V. Traina-Dorge et al.   VACCINE

Poxvirus vector-based HIV vaccines

(2010) Giuseppe Pantaleo et al.   Current Opinion in HIV and AIDS

Novel adenovirus vector-based vaccines for HIV-1

(2010) Dan H Barouch   Current Opinion in HIV and AIDS

Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope

(2009) Susan W Barnett et al.   AIDS

Toward Effective HIV Vaccination

(2009) Yasuhiro Nishiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of Novel CD4 Binding-Defective HIV-1 Envelope Glycoprotein Immunogens on Neutralizing Antibody and T-Cell Responses in Nonhuman Primates

(2009) I. Douagi et al.   JOURNAL OF VIROLOGY

Broad Neutralization of Human Immunodeficiency Virus Type 1 (HIV-1) Elicited from Human Rhinoviruses That Display the HIV-1 gp41 ELDKWA Epitope

(2009) G. F. Arnold et al.   JOURNAL OF VIROLOGY

Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm

(2009) M. D. Simek et al.   JOURNAL OF VIROLOGY

HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4+ cell infection: an IgA gene and functional analysis

(2009) D Tudor et al.   Mucosal Immunology

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

(2009) Johannes F. Scheid et al.   NATURE

Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys

(2009) Philip R Johnson et al.   NATURE MEDICINE

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of HIV membrane in neutralization by two broadly neutralizing antibodies

(2009) S. M. Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Long-term vaccine protection from AIDS and clearance of viral DNA following SHIV89.6P challenge

(2009) John Schell et al.   VACCINE

Immunogenicity of HIV-1 envelope glycoprotein oligomers

(2009) Mattias NE Forsell et al.   Current Opinion in HIV and AIDS

Fc receptor-mediated antiviral antibodies

(2009) Donald N Forthal et al.   Current Opinion in HIV and AIDS

Broadly Neutralizing Human Anti-HIV Antibody 2G12 Is Effective in Protection against Mucosal SHIV Challenge Even at Low Serum Neutralizing Titers

(2009) Ann J. Hessell et al.   PLoS Pathogens

Vaccines: Correlates of Vaccine‐Induced Immunity

(2008) Stanley A. Plotkin   CLINICAL INFECTIOUS DISEASES

Human Immunodeficiency Virus Type 1 Env Trimer Immunization of Macaques and Impact of Priming with Viral Vector or Stabilized Core Protein

(2008) A. Morner et al.   JOURNAL OF VIROLOGY

Llama Antibody Fragments with Cross-Subtype Human Immunodeficiency Virus Type 1 (HIV-1)-Neutralizing Properties and High Affinity for HIV-1 gp120

(2008) A. Forsman et al.   JOURNAL OF VIROLOGY

Profiling the Specificity of Neutralizing Antibodies in a Large Panel of Plasmas from Patients Chronically Infected with Human Immunodeficiency Virus Type 1 Subtypes B and C

(2008) J. M. Binley et al.   JOURNAL OF VIROLOGY

An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions

(2008) J. G. Joyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Humoral immunity to HIV-1: neutralisation and antibody effector functions

(2008) Suzanne Willey et al.   TRENDS IN MICROBIOLOGY

Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challenge

(2008) Willy M.J.M. Bogers et al.   VIROLOGY

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics

(2008) Josh D. Nelson et al.   VIROLOGY

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

(2007) Thomas Tiller et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Structure of Antibody F425-B4e8 in Complex with a V3 Peptide Reveals a New Binding Mode for HIV-1 Neutralization

(2007) Christian H. Bell et al.   JOURNAL OF MOLECULAR BIOLOGY