The Structure and Function of Paraoxonase-1 and Its Comparison to Paraoxonase-2 and -3

Molecular mechanism whereby paraoxonase‐2 regulates coagulation activation through endothelial tissue factor in rat haemorrhagic shock model

(2020) Jian‐Hua Xu et al.   International Wound Journal

Serum PON1 as a biomarker for the estimation of microvascular invasion in hepatocellular carcinoma

(2020) Guang-Yu Ding et al.   Annals of Translational Medicine

The inhibition Effects of Some Sulfonamides on Human Serum Paraoxonase-1 (hPON1)

(2019) Yeliz Demir et al.   Pharmacological Reports

Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway

(2019) Dawoud Sulaiman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The behaviour of some antihypertension drugs on human serum paraoxonase‐1: an important protector enzyme against atherosclerosis

(2019) Yeliz Demir   JOURNAL OF PHARMACY AND PHARMACOLOGY

Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases

(2019) Kenta Mizoi et al.   XENOBIOTICA

Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies

(2019) Mesut Işık et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Differential effects of selective serotonin reuptake inhibitors on paraoxonase-1 enzyme activity: An in vitro study

(2019) Yeliz Demir et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition

(2019) Moshe Ben-David et al.   MOLECULAR BIOLOGY AND EVOLUTION

Paraoxonase 2 prevents the development of heart failure

(2018) Wei Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Serum Endocan Levels are Associated With Paraoxonase 1 Concentration in Patients With Chronic Kidney Disease

(2018) Elisabeth Samouilidou et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer

(2018) Asokan Devarajan et al.   Cell Death & Disease

Some indazoles reduced the activity of human serum paraoxonase 1, an antioxidant enzyme: in vitro inhibition and molecular modeling studies

(2018) Zuhal Alım et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Identification of biologically active δ-lactone eicosanoids as paraoxonase substrates

(2018) John F. Teiber et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Paraoxonase 3 is involved in the multi-drug resistance of esophageal cancer

(2018) Dabing Huang et al.   Cancer Cell International

Regulation of the epithelial Na+channel by paraoxonase-2

(2017) Shujie Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport

(2017) Arvindhan Nagarajan et al.   MOLECULAR CELL

The role of paraoxonase in cancer

(2017) Tiziana Bacchetti et al.   SEMINARS IN CANCER BIOLOGY

Engineering Soluble Human Paraoxonase 2 for Quorum Quenching

(2016) Xin Cathy Li et al.   ACS Chemical Biology

Paraoxonases-1, -2 and -3: What are their functions?

(2016) Clement E. Furlong et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Paraoxonase 3 inhibits cell proliferation and serves as a prognostic predictor in hepatocellular carcinoma

(2016) Jie Cai et al.   Oncotarget

Theoretical study of the hydrolysis mechanism of dihydrocoumarin catalyzed by serum paraoxonase 1 (PON1): different roles of Glu53 and His115 for catalysis

(2016) Beibei Lin et al.   RSC Advances

Paraoxonase-1 and Early-Life Environmental Exposures

(2016) Judit Marsillach et al.   Annals of Global Health

Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein Interaction

(2015) Xiaodong Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalytic Stimulation by Restrained Active-Site Floppiness—The Case of High Density Lipoprotein-Bound Serum Paraoxonase-1

(2015) Moshe Ben-David et al.   JOURNAL OF MOLECULAR BIOLOGY

An Engineered Version of Human PON2 Opens the Way to Understand the Role of Its Post-Translational Modifications in Modulating Catalytic Activity

(2015) Luigi Mandrich et al.   PLoS One

Exploring the aryl esterase catalysis of paraoxonase-1 through solvent kinetic isotope effects and phosphonate-based isosteric analogues of the tetrahedral reaction intermediate

(2014) Aljoša Bavec et al.   BIOCHIMIE

Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane

(2014) Henning Hagmann et al.   FASEB JOURNAL

Temperature dependence of binding and catalysis for human serum arylesterase/paraoxonase

(2013) Jean Debord et al.   BIOCHIMIE

Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression

(2013) G. Giordano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

(2013) Ying Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

Catalytic Metal Ion Rearrangements Underline Promiscuity and Evolvability of a Metalloenzyme

(2013) Moshe Ben-David et al.   JOURNAL OF MOLECULAR BIOLOGY

Paraoxonase 1 and homocysteine metabolism

(2012) Joanna Perła-Kaján et al.   AMINO ACIDS

PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death

(2012) E-M Schweikert et al.   CELL DEATH AND DIFFERENTIATION

Catalytic Versatility and Backups in Enzyme Active Sites: The Case of Serum Paraoxonase 1

(2012) Moshe Ben-David et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanistic insights into the hydrolysis of organophosphorus compounds by paraoxonase-1: exploring the limits of substrate tolerance in a promiscuous enzyme

(2012) Sivaramakrishnan Muthukrishnan et al.   JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease

(2011) Anna Rull et al.   ATHEROSCLEROSIS

Serum paraoxonase-3 concentration is associated with the severity of hepatic impairment in patients with chronic liver disease

(2011) Anabel García-Heredia et al.   CLINICAL BIOCHEMISTRY

Directed evolution of hydrolases for prevention of G-type nerve agent intoxication

(2011) Rinkoo D Gupta et al.   Nature Chemical Biology

Paraoxonase 2 Deficiency Alters Mitochondrial Function and Exacerbates the Development of Atherosclerosis

(2010) Asokan Devarajan et al.   ANTIOXIDANTS & REDOX SIGNALING

Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: The hunt goes on

(2010) Lucio G. Costa et al.   BIOCHEMICAL PHARMACOLOGY

Lactonases with oragnophosphatase activity: Structural and evolutionary perspectives

(2010) Dragomir I. Draganov   CHEMICO-BIOLOGICAL INTERACTIONS

One Enzyme, Two Functions

(2010) Sebastian Altenhöfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum paraoxonase 1 activity status in patients with liver disorders

(2010) Mungli Prakash et al.   Saudi Journal of Gastroenterology

Dramatic Differences in Organophosphorus Hydrolase Activity between Human and Chimeric Recombinant Mammalian Paraoxonase-1 Enzymes

(2009) Tamara C. Otto et al.   BIOCHEMISTRY

A Common Mutation in Paraoxonase-2 Results in Impaired Lactonase Activity

(2009) David A. Stoltz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycoproteomics Analysis of Human Liver Tissue by Combination of Multiple Enzyme Digestion and Hydrazide Chemistry

(2009) Rui Chen et al.   JOURNAL OF PROTEOME RESEARCH

Paraoxonase2 C311S polymorphism and low levels of HDL contribute to a higher mortality risk after acute myocardial infarction in elderly patients

(2009) Francesca Marchegiani et al.   MOLECULAR GENETICS AND METABOLISM

Immunohistochemical analysis of paraoxonases-1, 2, and 3 expression in normal mouse tissues

(2008) Judit Marsillach et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dominant Role of Paraoxonases in Inactivation of the Pseudomonas aeruginosa Quorum-Sensing Signal N-(3-Oxododecanoyl)-L-Homoserine Lactone

(2008) J. F. Teiber et al.   INFECTION AND IMMUNITY

Homocysteine Levels, Paraoxonase 1 (PON1) Activity, and Cardiovascular Risk

(2008) Eddie Vos   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning

(2008) R. C. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA