期刊
CANCER CELL INTERNATIONAL
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12935-018-0657-1
关键词
Esophageal cancer; Multi-drug resistance; Methylation; PON3
类别
资金
- Special Subsidy for Central Guidance of China [2017070503B041]
- Anhui Provincial science and technology key projects [1501041142]
- Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy [1606c08236]
- Key research and development plan of Anhui Province [1704a0802148]
BackgroundDrug resistance prevents the effective treatment of cancers. DNA methylation has been found to participate in the development of cancer drug resistance.MethodsWe performed the wound-healing and invasion assays to test the effect of the paraoxonase gene PON3 on esophageal cancer (EC) cells. In addition, in vivo EC-derived tumor xenografts in nude mice were generated to test the effect of PON3 on the chemoresistance of EC cells.ResultsWe found that PON3 is hypermethylated in drug-resistant EC cell line K150, which in-return down-regulates its expression. The following experiments by the forced changes of PON3 level in vitro and in vivo demonstrated that the PON3 expression negatively correlates with drug resistance in EC cells. Further wound-healing and invasion assays showed that PON3 suppresses the migration and invasion of EC cells.ConclusionOur data established that PON3 is associated with the EC drug resistance, which may serve as a biomarker for the potential therapeutic treatment of EC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据