Article
Nutrition & Dietetics
Umair Shabbir, Akanksha Tyagi, Hun Ju Ham, Fazle Elahi, Deog-Hwan Oh
Summary: This study found that black soybean fermented with P. acidilactici has the ability to inhibit inflammation and cholinesterase enzymes. Increased antioxidant capacity, anthocyanins, phenolics, flavonoids, and GABA content were observed in the fermented samples. A total of 38 bioactive components were identified using the UHPLC-ESI-QTOF-MS/MS technique. These findings suggest that fermentation of black soybean with P. acidilactici is a promising approach for the development of functional foods to inhibit/prevent AD and other neurodegenerative diseases.
FRONTIERS IN NUTRITION
(2022)
Review
Food Science & Technology
David Fonseca Hernandez, Eugenia Lugo Cervantes, Diego A. Luna-Vital, Luis Mojica
Summary: Food contains bioactive compounds with diverse biological activities, used in the cosmetic industry for nutricosmetic and cosmeceutical products aimed at reducing skin aging and inflammation. Phytochemicals from fruits, vegetables, herbs, and plants are being utilized for their anti-aging potential. These compounds have antioxidant and biological properties that modulate molecular markers involved in the aging process.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Cell Biology
Nida Ajmal, Maislin C. Bogart, Palwasha Khan, Ibiagbani M. Max-Harry, Craig S. Nunemaker
Summary: Type 1 diabetes is an autoimmune disorder that damages beta cells and causes insulin loss and hyperglycemia. Currently, there are no treatment options to halt the progression of the disease, but emerging non-immunomodulator drugs show promise in restoring beta cells and suppressing the autoimmune response.
Review
Food Science & Technology
Chongde Sun, Yilong Liu, Liuhuan Zhan, Gina R. Rayat, Jianbo Xiao, Huamin Jiang, Xian Li, Kunsong Chen
Summary: Consumption of fruits with natural antioxidants may have positive effects on preventing and treating diabetes, helping to lower blood glucose levels. Bioactive compounds in various fruits, such as phenolic compounds, polysaccharides, and vitamin C, have been found to exhibit anti-diabetic activities.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huan Chen, Ying Li, Jinrui Wang, Tingting Zheng, Chenyang Wu, Mengyao Cui, Yifan Feng, Hanyi Ye, Zhengqi Dong, Yunjie Dang
Summary: The pathogenesis of ulcerative colitis (UC) is closely related to inflammation, oxidative stress, and gut microbiota imbalance. This study explored the antioxidant activity and underlying mechanisms of various plant polyphenols, such as gallic acid, proanthocyanidin, ellagic acid, and tannic acid. The results showed that polyphenols with more phenolic hydroxyl groups exhibited stronger antioxidant activity. Moreover, these polyphenols effectively ameliorated UC symptoms and pathological progression in mice by reducing inflammatory cytokine levels, repairing the intestinal barrier, and regulating the intestinal microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Haiwen Li, Reza Rafie, Zhidong Xu, Rafat A. Siddiqui
Summary: The study showed that ginger has the highest phenolic content and anti-oxidation properties when harvested at an early stage, with a gradual decrease as it matures. Baby ginger extract demonstrated inhibitory effects on lipid accumulation and triglyceride content, and promoted glucose uptake.
FOOD SCIENCE & NUTRITION
(2022)
Article
Medicine, General & Internal
Jun Watanabe, Kazuhiko Kotani, Alejandro Gugliucci
Summary: This study conducted a meta-analysis on the relationship between oxidative stress and paraoxonase 1 (PON1) in chronic kidney disease (CKD). The results showed that CKD patients had lower PON1 activity compared to healthy controls. Further studies are needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Atena Mansouri, Zeljko Reiner, Massimiliano Ruscica, Eugenia Tedeschi-Reiner, Shabnam Radbakhsh, Mariam Bagheri Ekta, Amirhossein Sahebkar
Summary: This review discusses the antioxidant effects of statins achieved by modulating the Nrf2/HO-1 pathway and their potential role in different organs and diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Oke-Oghene Philomena Akpoveso, Emeka Emmanuel Ubah, Gideon Obasanmi
Summary: The global prevalence of diabetes is increasing due to urbanization and an aging population, leading to an increase in diabetic vascular complications. There is a need for safe and effective alternative therapies, with natural products like polyphenols showing potential. Polyphenols can reduce oxidative stress and hyperglycemia, preventing diabetic complications. This review summarizes the effects of polyphenols on endogenous antioxidant systems and discusses therapeutic strategies for diabetic vascular complications.
Article
Nutrition & Dietetics
Jose-Luis Rodriguez, Paola Berrios, Zoyla-Mirella Clavo, Manuel Marin-Bravo, Luis Inostroza-Ruiz, Mariella Ramos-Gonzalez, Miguel Quispe-Solano, Maria S. Fernandez-Alfonso, Olga Palomino, Luis Goya
Summary: It is proposed that oxidative stress is a pathogenic mechanism for cytotoxicity and cardiovascular and neuronal diseases. This study evaluated the antioxidant and cytoprotective capacity of Desmodium tortuosum (D. tortuosum) extract in cell lines subjected to oxidative stress induced by t-BOOH. The results showed that D. tortuosum extract was able to reduce the oxidative and cytotoxic effects induced by t-BOOH, possibly due to its high content of phenolic compounds.
Article
Biochemistry & Molecular Biology
Magdalena Wojciak, Aleksandra Ziemlewska, Martyna Zagorska-Dziok, Zofia Niziol-Lukaszewska, Dariusz Szczepanek, Tomasz Oniszczuk, Ireneusz Sowa
Summary: This study aimed to evaluate the antioxidant, anti-inflammatory, and protective effects of Sambucus nigra fruit extract and its ferment obtained through fermentation with kombucha tea fungus. The chemical composition of fermented and non-fermented extracts was compared using HPLC/ESI-MS chromatographic method. The antioxidant activity of the samples was assessed using DPPH and ABTS assays. The results showed that the extract and the ferment possess antioxidant properties and promote cell proliferation in both fibroblast and keratinocyte skin cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Kirinde Gedara Isuru Sandanuwan Kirindage, Ilekuttige Priyan Shanura Fernando, Arachchige Maheshika Kumari Jayasinghe, Eui-Jeong Han, Mawalle Kankanamge Hasitha Madhawa Dias, Kyung-Pil Kang, Sung-Ig Moon, Tai-Sun Shin, Ayeong Ma, Ginnae Ahn
Summary: The present study identified phenolic compounds in Moringa oleifera hot water extract (MOH) and evaluated its antioxidant activity on H2O2-induced oxidative stress in Vero cells. Results showed that MOH exhibited strong radical scavenging and antioxidant properties, reduced ROS generation, increased cell viability, suppressed mitochondrial depolarization and apoptosis, and activated the Nrf2/HO-1 signaling pathway.
Review
Biochemistry & Molecular Biology
Raquel da Ana, Joel Fonseca, Jacek Karczewski, Amelia M. Silva, Aleksandra Zielinska, Eliana B. Souto
Summary: Ocular drug administration is a challenging topic in the pharmaceutical field due to the complexity of the eye structure and its physiology. Lipid nanoparticles show great potential as an alternative for ocular drug delivery, increasing bioavailability, compliance, and achieving sustained drug release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Giusy Rita Caponio, Miriam Cofano, Tamara Lippolis, Isabella Gigante, Valentina De Nunzio, Graziana Difonzo, Mirella Noviello, Luigi Tarricone, Giuseppe Gambacorta, Gianluigi Giannelli, Maria De Angelis, Maria Notarnicola
Summary: This study investigates the effects of grape pomace extract on colon cancer cells, showing its anti-proliferative and apoptosis-inducing effects. Phenolic compounds were found to be the main active ingredients, and the extract digested with simulated gastrointestinal digestion could potentially be used as a dietary ingredient with health benefits for colon cancer cell proliferation.
Article
Multidisciplinary Sciences
Serene Hilary, Ozaz Mohamed, Carine Platat, Muhammad A. Qureshi, Jaleel Kizhakkayil, Fatima Al-Meqbaali, Frank C. Howarth
Summary: This study investigated the differences in health outcomes associated with ferulic acid (FA) supplementation in animals before and after streptozotocin (STZ) treatment for diabetes. The results showed that FA supplementation did not affect glucose and lipid profile, but it reduced lipid and protein oxidative damage in the heart, liver, and pancreas, and increased glutathione levels in the pancreas. However, FA supplementation was not sufficient to improve metabolic markers of diabetes.
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)
