Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases
出版年份 2020 全文链接
标题
Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases
作者
关键词
Humanin, Cell survival, Cytoprotection, Apoptosis, Infertility, Mitochondria-derived peptide, Diabetes mellitus, Cancer, Oxidative stress, BCL-2
出版物
LIFE SCIENCES
Volume 264, Issue -, Pages 118679
出版商
Elsevier BV
发表日期
2020-10-30
DOI
10.1016/j.lfs.2020.118679
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway
- (2020) ChangHyuk Kwon et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hippocampal Deficits in Amyloid-β-Related Rodent Models of Alzheimer’s Disease
- (2020) Yukti Vyas et al. Frontiers in Neuroscience
- A Delicate Balance - The BCL-2 Family and its Role in Apoptosis, Oncogenesis, and Cancer Therapeutics
- (2019) Tristan Knight et al. BIOCHEMICAL PHARMACOLOGY
- Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment
- (2019) Farasat Zaman et al. FASEB JOURNAL
- Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
- (2019) Rumani Singh et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Humanin levels in human seminal plasma and spermatozoa are related to sperm quality
- (2019) M. Rao et al. Andrology
- BCL-2 family isoforms in apoptosis and cancer
- (2019) Chloe F. A. Warren et al. Cell Death & Disease
- Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease
- (2019) Raluca Ştefănescu et al. MOLECULES
- ASSOCIATION OF HUMANIN A NOVEL MITOCHONDRIAL PROTEIN WITH HUMAN HEART FAILURE: AN ASSESSMENT OF MORTALITY AND CLINICAL BIOMARKERS
- (2019) Sati Patel et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Apoptosis: A mammalian cell bioprocessing perspective
- (2019) Antonio L. Grilo et al. BIOTECHNOLOGY ADVANCES
- Pinus halepensis essential oil attenuates the toxic Alzheimer’s amyloid beta (1-42)-induced memory impairment and oxidative stress in the rat hippocampus
- (2019) Paula Alexandra Postu et al. BIOMEDICINE & PHARMACOTHERAPY
- Mitochondrial peptides—appropriate options for therapeutic exploitation
- (2019) Lucia-Doina Popov CELL AND TISSUE RESEARCH
- The humanin analogue (HNG) prevents temozolomide-induced male germ cell apoptosis and other adverse effects in severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma
- (2019) Yue Jia et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Pharmacological preconditioning with phosphodiestrase inhibitor: an answer to stem cell survival against ischemic injury through JAK/STAT signaling
- (2019) Manju Yadav et al. HEART FAILURE REVIEWS
- Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment
- (2019) Hemal H. Mehta et al. Metabolomics
- Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway
- (2019) Hui Zhao et al. NEUROSCIENCE
- Oxidation destabilizes toxic amyloid beta peptide aggregation
- (2019) J. Razzokov et al. Scientific Reports
- Humanin, a Mitochondrial-Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal Neurons
- (2019) Sandra Cristina Zárate et al. Frontiers in Aging Neuroscience
- Mitochondrial-Derived Peptides Are Down Regulated in Diabetes Subjects
- (2019) Manjunath Ramanjaneya et al. Frontiers in Endocrinology
- The role of mitochondria-derived peptides in cardiovascular disease: Recent updates
- (2019) Yingxi Yang et al. BIOMEDICINE & PHARMACOTHERAPY
- BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis
- (2019) Kai Huang et al. CELL RESEARCH
- Mitochondrial Peptide Humanin Protects Silver Nanoparticles-Induced Neurotoxicity in Human Neuroblastoma Cancer Cells (SH-SY5Y)
- (2019) Gurunathan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events
- (2019) Isabel Gonçalves et al. STROKE
- BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins
- (2019) Tudor Moldoveanu et al. Cold Spring Harbor Perspectives in Biology
- BAX and BAK become killers without a BH3 trigger
- (2019) Jerry M. Adams CELL RESEARCH
- Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization
- (2019) Daniel L. Morris et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses
- (2019) Neil Murphy et al. GASTROENTEROLOGY
- Catestatin in defense of oxidative-stress-induced apoptosis: A novel mechanism by activating the beta2 adrenergic receptor and PKB/Akt pathway in ischemic-reperfused myocardium
- (2019) Song-Yun Chu et al. PEPTIDES
- Chronic Treatment With the Mitochondrial Peptide Humanin Prevents Age-related Myocardial Fibrosis in mice
- (2018) Qing Qin et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors
- (2018) María Florencia Gottardo et al. APOPTOSIS
- Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells
- (2018) Qingqing Qin et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Comparison of serum concentrations of humanin in women with and without gestational diabetes mellitus
- (2018) Yuhang Ma et al. GYNECOLOGICAL ENDOCRINOLOGY
- The Protective Effect of Humanin Derivative AGA(C8R)-HNG17 Against Acetaminophen-Induced Liver Injury in Mice
- (2018) David Meridor et al. International Journal of Peptide Research and Therapeutics
- The Neurovascular Protective Effect of S14G-Humanin in a Murine MCAO Model and Brain Endothelial Cells
- (2018) Tao Peng et al. IUBMB LIFE
- Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2
- (2018) Xiaohui Wang et al. MOLECULAR IMMUNOLOGY
- Glycaemic variability in diabetes: clinical and therapeutic implications
- (2018) Antonio Ceriello et al. Lancet Diabetes & Endocrinology
- Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases
- (2018) Camila Florencia Zuccato et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease
- (2018) Farzaneh G. Tahrir et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Optical tools for understanding the complexity of β-cell signalling and insulin release
- (2018) James A. Frank et al. Nature Reviews Endocrinology
- Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases
- (2018) Junying Yuan et al. NATURE REVIEWS NEUROSCIENCE
- Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family
- (2018) Aruo Nan et al. Advanced Science
- Colivelin Ameliorates Impairments in Cognitive Behaviors and Synaptic Plasticity in APP/PS1 Transgenic Mice
- (2017) Meina Wu et al. JOURNAL OF ALZHEIMERS DISEASE
- Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity
- (2017) Margherita Romeo et al. JOURNAL OF ALZHEIMERS DISEASE
- Mitochondrially derived peptides as novel regulators of metabolism
- (2017) Su-Jeong Kim et al. JOURNAL OF PHYSIOLOGY-LONDON
- Humanin inhibits apoptosis in pituitary tumor cells through several signaling pathways including NF-κB activation
- (2017) María Florencia Gottardo et al. Journal of Cell Communication and Signaling
- How to unleash mitochondrial apoptotic blockades to kill cancers?
- (2017) Jing Deng Acta Pharmaceutica Sinica B
- The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity
- (2017) Alan K. Okada et al. Scientific Reports
- Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers
- (2016) Laura J. Cobb et al. Aging-US
- Humanin exerts cardioprotection against cardiac ischemia/reperfusion injury through attenuation of mitochondrial dysfunction
- (2016) Savitree Thummasorn et al. Cardiovascular Therapeutics
- Potential Roles of Humanin on Apoptosis in the Heart
- (2016) Savitree T. Charununtakorn et al. Cardiovascular Therapeutics
- MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism
- (2016) Changhan Lee et al. FREE RADICAL BIOLOGY AND MEDICINE
- Humanin: Functional Interfaces with IGF-I
- (2016) J. Xiao et al. GROWTH HORMONE & IGF RESEARCH
- [Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats
- (2016) Li Yuan et al. Neuroscience Bulletin
- The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus
- (2016) Su-Jeong Kim et al. Oncotarget
- TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death
- (2016) Jürgen Fritsch et al. Oncotarget
- The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs
- (2015) Yue Jia et al. APOPTOSIS
- The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice
- (2015) YanHe Lue et al. ENDOCRINOLOGY
- Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production
- (2015) Vladislava Paharkova et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Unknown
- (2015) Aviv Cohen et al. MOLECULAR MEDICINE
- Immunotherapeutic Approaches for Alzheimer’s Disease
- (2015) Thomas Wisniewski et al. NEURON
- Role of apoptosis in pathogenesis and treatment of bone-related diseases
- (2015) Samaneh Mollazadeh et al. Journal of Orthopaedic Surgery and Research
- Humanin protects against chemotherapy-induced stage-specific male germ cell apoptosis in rats
- (2015) P. Surampudi et al. Andrology
- Reperfusion injury and reactive oxygen species: The evolution of a concept
- (2015) D. Neil Granger et al. Redox Biology
- The Bcl-2 family: structures, interactions and targets for drug discovery
- (2014) Marc Kvansakul et al. APOPTOSIS
- A dual role for the anti-apoptotic Bcl-2 protein in cancer: Mitochondria versus endoplasmic reticulum
- (2014) Haidar Akl et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells
- (2014) Ying Xie et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Protective Role of Humanin on Bortezomib-Induced Bone Growth Impairment in Anticancer Treatment
- (2014) Emma Eriksson et al. JNCI-Journal of the National Cancer Institute
- New Role for the Mitochondrial Peptide Humanin: Protective Agent Against Chemotherapy-Induced Side Effects
- (2014) P. Cohen JNCI-Journal of the National Cancer Institute
- Apollon/Bruce is upregulated by Humanin
- (2014) Yuichi Hashimoto et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties
- (2014) Barbara Zapała et al. Pharmacological Reports
- Antiapoptotic Factor Humanin Is Expressed in Normal and Tumoral Pituitary Cells and Protects Them from TNF-α-Induced Apoptosis
- (2014) María Florencia Gottardo et al. PLoS One
- Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats
- (2014) Gao-Shang Chai et al. Neuroscience Bulletin
- Genome expression analysis by suppression subtractive hybridization identified overexpression of Humanin, a target gene in gastric cancer chemoresistance
- (2014) Negar Mottaghi-Dastjerdi et al. DARU-Journal of Pharmaceutical Sciences
- Humanin and Age-Related Diseases: A New Link?
- (2014) Zhenwei Gong et al. Frontiers in Endocrinology
- Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell
- (2013) Regina Kuliawat et al. FASEB JOURNAL
- Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
- (2013) Peter E. Czabotar et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Humanin: a harbinger of mitochondrial-derived peptides?
- (2013) Changhan Lee et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer’s disease models via the heterotrimeric Humanin receptor
- (2013) Y Hashimoto et al. Cell Death & Disease
- The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis
- (2013) Y. Jia et al. Andrology
- Circulating humanin levels are associated with preserved coronary endothelial function
- (2012) R. J. Widmer et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- The emerging role of the mitochondrial-derived peptide humanin in stress resistance
- (2012) Kelvin Yen et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Interaction structure of the complex between neuroprotective factor humanin and Alzheimer's β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling
- (2012) Madalina Maftei et al. JOURNAL OF PEPTIDE SCIENCE
- Granulocyte-colony stimulating factor attenuates mitochondrial dysfunction induced by oxidative stress in cardiac mitochondria
- (2011) Savitree Thummasorn et al. MITOCHONDRION
- Immunolocalization of humanin in human sperm and testis
- (2010) Elena Moretti et al. FERTILITY AND STERILITY
- Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer’s disease rescue factor Humanin
- (2009) Yuichi Hashimoto et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Opposing Roles of Insulin-Like Growth Factor Binding Protein 3 and Humanin in the Regulation of Testicular Germ Cell Apoptosis
- (2009) YanHe Lue et al. ENDOCRINOLOGY
- Evidence for potential functionality of nuclearly-encoded humanin isoforms
- (2009) Marek Bodzioch et al. GENOMICS
- The neurosurvival factor Humanin inhibits β-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice
- (2009) Phuong T. Hoang et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Humanin and the Receptors for Humanin
- (2009) Masaaki Matsuoka et al. MOLECULAR NEUROBIOLOGY
- Humanin: A Novel Central Regulator of Peripheral Insulin Action
- (2009) Radhika H. Muzumdar et al. PLoS One
- Levonorgestrel Enhances Spermatogenesis Suppression by Testosterone with Greater Alteration in Testicular Gene Expression in Men1
- (2008) YanHe Lue et al. BIOLOGY OF REPRODUCTION
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More