Article
Biochemistry & Molecular Biology
Angeliki Valatsou, Panagiotis Theofilis, Spyridon Simantiris, Georgia Vogiatzi, Alexandros Briasoulis, Marios Sagris, Evangelos Oikonomou, Alexios S. Antonopoulos, Alkistis Pantopoulou, Narjes Nasiri-Ansari, Elizabeth Fragopoulou, Despoina Perrea, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: This study suggests that GCSF administration in an atherosclerotic mouse model of hind limb ischemia can lead to decreases in biomarkers associated with endothelial activation and thrombosis.
Article
Dermatology
K. Wolk, T. -C. Brembach, D. Simaite, E. Bartnik, S. Cucinotta, A. Pokrywka, M. L. Irmer, J. Triebus, E. Witte-Haendel, G. Salinas, T. Leeuw, H. -D. Volk, K. Ghoreschi, R. Sabat
Summary: The expression of G-CSF is high in HS skin, especially in inflamed nodules and abscesses. IL-1 and IL-17 induce G-CSF production, and G-CSF blood levels correlate with the severity of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Obstetrics & Gynecology
Mehmet Suhha Bostanci, Ozcan Budak, Huseyin Cakiroglu, Osman Kose, Mehtap Erdogan, Hilal Uslu Yuvaci, Erdem Cokluk
Summary: This study aimed to evaluate the effect of G-CSF protection on IVF results against ischemic and ischemic-reperfusion injury in rat ovaries. The results showed that G-CSF can reduce ovarian damage caused by ischemia and ischemic-reperfusion, and improve the quantity and quality of oocytes.
REPRODUCTIVE SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Shao-Yu Tang, Yi-Chin Lee, Chien-Wei Tseng, Po-Hsun Huang, Ko-Lin Kuo, Der-Cherng Tarng
Summary: This study found that G-CSF can improve angiogenic function in patients with peripheral arterial disease (PAD) associated with chronic kidney disease (CKD) through a hypoxia/IL-10 signaling cascade.
Article
Medicine, General & Internal
Slawomir Lewicki, Monika Lesniak, Agnieszka Sobolewska-Ruta, Aneta Lewicka, Marta Grodzik, Eugeniusz K. Machaj, Marek Saracyn, Jacek Z. Kubiak, Zygmunt Pojda
Summary: Encapsulation of cytokines in liposomes is an efficient method to deliver cytokines to cells at working concentrations without affecting cell morphology or proliferation. This method has great potential and important applications in tissue regeneration and other fields.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Virology
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Huntington Potter, Timothy D. D. Boyd, Kenneth L. L. Tyler
Summary: West Nile virus (WNV) is the main cause of epidemic arboviral encephalitis in the United States. Depleting microglia in WNV-infected mice enhances viral replication and tissue injury, while augmenting microglial activation through GM-CSF administration reduces viral titers and apoptotic activity and increases survival. Stimulation of microglial activation may be a viable therapeutic approach for WNV neuroinvasive disease.
JOURNAL OF VIROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Atsushi Takamatsu, Kotaro Yoshida, Fumihito Toshima, Kazuto Kozaka, Naho Yamamoto, Yoshimichi Sai, Toshifumi Gabata
Summary: This study aims to clarify the incidence and clinicoradiologic characteristics of pegfilgrastim-induced aortitis. The results of the study found that the incidence of pegfilgrastim-induced aortitis may be higher than previously reported and may be more common in patients with esophageal cancer and those who received specific anticancer drugs. Furthermore, CT findings indicated that pegfilgrastim-induced aortitis is often characterized by involvement of the aortic arch and proximal branches.
Article
Oncology
Chong Wei, Yan Zhang, Wei Wang, Wei Zhang
Summary: Substituting PEG-rhG-CSF for short-acting rhG-CSF in the DA-EPOCH regimen significantly reduces the incidence of febrile neutropenia and related hospitalization, while simplifying management for both patients and healthcare providers.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Neurosciences
Lillian J. Brady, Kirsty R. Erickson, Kelsey E. Lucerne, Aya Osman, Drew D. Kiraly, Erin S. Calipari
Summary: Cocaine use disorder is associated with alterations in immune function and changes in peripheral cytokine expression, impacting responses to drug-related cues and highlighting the critical interaction between the brain and immune system. Upregulation of granulocyte colony-stimulating factor (G-CSF) by cocaine enhances the drug's effects on dopamine terminals through a release-based mechanism, indicating a potential role of immune factors in altering drug responses.
PSYCHOPHARMACOLOGY
(2021)
Article
Oncology
Takeo Fujii, Hasan Rehman, Su Yun Chung, Janice Shen, James Newman, Vernon Wu, Adam Hines, Elham Azimi-Nekoo, Fatima Fayyaz, Meeyoung Lee, George Raptis, Mikala Egeblad, Xinhua Zhu
Summary: The study found that G-CSF use was not associated with an increased risk of brain metastasis in patients with de novo Stage IV breast cancer. However, pulmonary embolism/deep venous thrombosis may be related to brain metastasis. Further research is needed to determine if DVT/PE with or without elevated NETs levels in the blood can predict the development of brain metastasis in these patients.
Article
Immunology
An-ran Xi, Yi-jun Luo, Jin-Tao Guan, Wei-Jie Wang, Zheng-Hao Xu
Summary: This study analyzed the efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in COVID-19 patients. The results showed that GM-CSF antibody treatment can reduce the incidence of invasive mechanical ventilation and have slight but not significant effects on mortality and ventilation improvement. Sensitivity analysis revealed statistically significant results for mortality and ventilation improvement rate when one study was excluded. Furthermore, GM-CSF antibodies did not increase the risks of secondary infection and adverse events.
INFLAMMOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Guang-Yin Shen, Jeong-Hun Shin, Yi-Sun Song, Hyun-Woo Joo, In-Hwa Park, Jin-Hee Seong, Na-Kyoung Shin, A-Hyeon Lee, Young Jong Cho, Yonggu Lee, Young-Hyo Lim, Hyuck Kim, Kyung-Soo Kim
Summary: The study showed that G-CSF can reduce cardiomyocyte apoptosis in diabetic cardiomyopathy by increasing autophagy levels. The anti-apoptotic effect of G-CSF was found to be abrogated by autophagy inhibitors, indicating the significance of autophagy up-regulation in mediating the protective effects of G-CSF.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Oncology
Vincenzo Adamo, Lorenzo Antonuzzo, Marco Danova, Michelino De Laurentiis, Paolo Marchetti, Carmine Pinto, Giovanni Rosti
Summary: This study aims to improve adherence to guideline recommendations for the prevention of febrile neutropenia and to enhance patient care.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Medicine, General & Internal
Yosuke Dotsu, Hiroyuki Yamaguchi, Minoru Fukuda, Takayuki Suyama, Noritaka Honda, Yasuhiro Umeyama, Hirokazu Taniguchi, Hiroshi Gyotoku, Shinnosuke Takemoto, Ryuta Tagawa, Ryosuke Ogata, Hiromi Tomono, Midori Shimada, Hiroaki Senju, Katsumi Nakatomi, Seiji Nagashima, Hiroshi Soda, Hiroaki Ikeda, Kazuto Ashizawa, Hiroshi Mukae
Summary: This study examined the real-world incidence of febrile neutropenia among patients with thoracic malignancies treated with single-agent amrubicin chemotherapy, and found that the incidence rate was 30%. It suggests that prophylactic G-CSF should be administered during practical use of this chemotherapy regimen for patients who have already undergone chemotherapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Chayodom Maneechote, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Chronic inhibition of mitochondrial fission and promotion of fusion have cardioprotective effects in pre-diabetic rats with cardiac ischemia-reperfusion injury, by relieving cardiac mitochondrial dysfunction and dynamic alterations, and reducing myocardial infarction, thereby improving cardiac function.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Review
Cell Biology
Nida Buawangpong, Kanokporn Pinyopornpanish, Natthapat Siri-Angkul, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: TMAO, a gut microbiota metabolite derived from dietary choline and carnitine, has been identified as a potential risk factor of Alzheimer's disease. Through various pathophysiological pathways, TMAO is associated with Alzheimer's disease by causing protein aggregation and activating astrocytes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Surgery
Poon Apichartpiyakul, Krekwit Shinlapawittayatorn, Kittipan Rerkasem, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: This review provides insights into the mechanisms and potential therapeutic interventions for lower limb ischemia-induced IRI, highlighting the need for further clinical studies.
ANNALS OF VASCULAR SURGERY
(2022)
Review
Pharmacology & Pharmacy
Panat Yanpiset, Chayodom Maneechote, Sirawit Sriwichaiin, Natthaphat Siri-Angkul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Cardiomyocyte death plays a major role in the development of myocardial infarction and myocardial ischemia/reperfusion injury. Pyroptosis, a regulated programmed cell death pathway, has been shown to be involved in these conditions. Activation of gasdermin D (GSDMD) through the canonical or non-canonical pathways is an important step in pyroptosis. Inhibition of GSDMD provides cardioprotection against myocardial infarction and myocardial ischemia/reperfusion injury.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Dentistry, Oral Surgery & Medicine
Savitri Vaseenon, Tanida Srisuwan, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: This study aimed to investigate the effects of lipopolysaccharides (LPS), hydrogen peroxide (H2O2), and their combination on various indicators of human dental pulpal cells. The results showed that H2O2 and the combined agents equally decreased cell proliferation. LPS, H2O2, and the combination decreased mineralization and differentiation while increasing inflammation and apoptosis. Surprisingly, LPS and the combined agents also increased expression of SOD2 and caused an imbalance in mitochondrial dynamics.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Toxicology
Chanisa Thonusin, Wichwara Nawara, Thawatchai Khuanjing, Nanthip Prathumsup, Apiwan Arinno, Benjamin Ongnok, Busarin Arunsak, Sirawit Sriwichaiin, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: This study investigated the changes in blood and cardiac metabolome levels following treatment with doxorubicin and trastuzumab, and their association with cardiac dysfunction and injury. The study found that there were distinct patterns of metabolome alterations between the two treatment groups, and that the constituents of the blood metabolome may serve as non-invasive biomarkers for assessing the severity and prognosis of heart failure induced by these drugs.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Weiwei Zhu, Minxiu Wang, Leiming Jin, Bin Yang, Bin Bai, Rumbidzai Natasha Mutsinze, Wei Zuo, Nipon Chattipakorn, Joo Young Huh, Guang Liang, Yi Wang
Summary: This study discovered a natural compound, licochalcone A, with anti-inflammatory activity. It was found to directly bind to the protein MD2, which regulates the LPS inflammatory signaling pathway, and blocked both TRIF- and MYD88-dependent pathways. In vivo experiments showed that licochalcone A treatment alleviated acute lung injury (ALI) in mice by reducing immunocyte infiltration and suppressing TLR4 pathway activation and inflammatory cytokine production.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Chanon Piamsiri, Chayodom Maneechote, Kewarin Jinawong, Busarin Arunsak, Titikorn Chunchai, Wichwara Nawara, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Myocardial infarction (MI) is a leading cause of death worldwide, and oxidative stress, inflammation, and mitochondrial dysfunction are recognized as possible mechanisms in the development of MI. Different types of programmed cell death (PCDs), including apoptosis, necroptosis, ferroptosis, and pyroptosis, have been associated with different phases of ischemic injury following MI. However, it is still unknown which types of PCDs play the most dominant role in post-MI.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Kwannapas Saengsin, Rekwan Sittiwangkul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Cardiovascular disease is the leading cause of death globally. Molecular hydrogen, which can be administered through various methods, has shown antioxidant, anti-inflammatory, and anti-apoptotic effects, providing protection for the heart.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cell Biology
Prit Kusirisin, Nattayaporn Apaijai, Kajohnsak Noppakun, Srun Kuanprasert, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Contrast-induced acute kidney injury (CI-AKI) is a common type of acute kidney injury in hospitalized patients. However, diagnosing CI-AKI using serum creatinine may not be early enough. This study aimed to investigate the role of circulating mitochondrial dysfunction as a potential early biomarker for detecting CI-AKI. Twenty patients with chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI) were included. Blood and urine samples were collected at different time points after PCI to measure neutrophil gelatinase-associated lipocalin (NGAL) levels and assess oxidative stress, inflammation, mitochondrial function, dynamics, and cell death. The results showed that 40% of patients developed AKI, and plasma NGAL levels increased after 24 hours of receiving contrast media. Cellular and mitochondrial oxidative stress, dysfunction, and decreased fusion occurred 6 hours after contrast media exposure. The subgroup with AKI had higher necroptosis cells and TNF-alpha mRNA expression compared to the subgroup without AKI. In conclusion, circulating mitochondrial dysfunction could serve as an early predictive biomarker for CI-AKI in CKD patients receiving contrast media. These findings provide insights for the development of novel strategies to prevent CI-AKI based on its pathophysiology.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Chanisa Thonusin, Wichwara Nawara, Apiwan Arinno, Thawatchai Khuanjing, Nanthip Prathumsup, Benjamin Ongnok, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Using mass spectrometry-based targeted metabolomics, this study aimed to investigate the patterns of cardiac metabolic reprogramming and energetics in doxorubicin-induced heart failure, as well as the potential effects of melatonin on these processes. The results showed that co-treatment with melatonin could restore cardiac function, glucose and ketone body utilization, and adenosine triphosphate production, while also increasing cardiac fatty acid oxidation, branched-chain amino acid catabolism, and anaplerosis. These findings highlight the potential efficacy of melatonin in cardiac metabolic reprogramming and energetics, suggesting it as an adjunctive treatment for doxorubicin-induced heart failure.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Chayodom Maneechote, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Doxorubicin is an effective chemotherapy drug, but its cardiotoxicity limits its effectiveness. Recent research has shown that excessive mitochondrial fission and impaired fusion contribute to this cardiotoxicity. However, using inhibitors of mitochondrial fission or promoters of fusion can protect the heart against the toxicity of doxorubicin.
Review
Environmental Sciences
Wanitcha Gumtorntip, Nuntana Kasitanon, Worawit Louthrenoo, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: This review summarizes and discusses the association between air pollutants and the development or aggravation of rheumatoid arthritis (RA). The findings suggest that air pollutants can stimulate immunological processes and inflammatory mediators and autoantibodies productions. Furthermore, air pollutants can induce and aggravate RA disease activity. However, discrepancies in the results highlight the need for future studies to elucidate these mechanisms and identify reliable biomarkers for individual susceptibility and disease activity assessment.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Thawatchai Khuanjing, Chayodom Maneechote, Benjamin Ongnok, Nanthip Prathumsap, Apiwan Arinno, Titikorn Chunchai, Busarin Arunsak, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: This study found that donepezil protects against trastuzumab-induced cardiotoxicity by reducing mitochondrial dysfunction, oxidative stress, inflammation, and cardiomyocyte death, leading to improved left ventricular function through activation of muscarinic acetylcholine receptors. This provides a new intervention strategy for treating trastuzumab-induced cardiotoxicity.
MOLECULAR MEDICINE
(2023)
Review
Surgery
Kittitorn Supphapipat, Prangmalee Leurcharusmee, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Air pollution has negative effects on human health, especially for organ transplant patients receiving immunosuppressive treatment. Clinical investigations have shown that air pollution is associated with organ rejection and various diseases.
CLINICAL TRANSPLANTATION
(2023)
