The Bcl-2 family: structures, interactions and targets for drug discovery

BCL2L10 is a predictive factor for resistance to Azacitidine in MDS and AML patients

(2015) Thomas Cluzeau et al.   Oncotarget

Peptides Derived from the Transmembrane Domain of Bcl-2 Proteins as Potential Mitochondrial Priming Tools

(2014) Vicente Andreu-Fernández et al.   ACS Chemical Biology

Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein

(2014) Andrew M. Petros et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity

(2014) R. W. Rooswinkel et al.   BLOOD

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

(2014) Erik Procko et al.   CELL

Human Viral Oncogenesis: A Cancer Hallmarks Analysis

(2014) Enrique A. Mesri et al.   Cell Host & Microbe

APCCdc20 Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction

(2014) Lixin Wan et al.   DEVELOPMENTAL CELL

The Carboxyl-terminal Tail of Noxa Protein Regulates the Stability of Noxa and Mcl-1

(2014) Xiaming Pang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting γ-Herpesvirus 68 Bcl-2-mediated Down-regulation of Autophagy

(2014) Minfei Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coupled Folding and Binding of the Disordered Protein PUMA Does Not Require Particular Residual Structure

(2014) Joseph M. Rogers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L

(2014) S. Campbell et al.   JOURNAL OF VIROLOGY

The BCL-2 database, Act 2: moving beyond dualism to diversity and pleiotropy

(2014) A Aouacheria   Cell Death & Disease

Naturally occurring tumours in the basal metazoan Hydra

(2014) Tomislav Domazet-Lošo et al.   Nature Communications

BCL2DB: database of BCL-2 family members and BH3-only proteins

(2014) V. Rech de Laval et al.   Database-The Journal of Biological Databases and Curation

Genome-Wide Prediction and Validation of Peptides That Bind Human Prosurvival Bcl-2 Proteins

(2014) Joe DeBartolo et al.   PLoS Computational Biology

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Resilience of death: intrinsic disorder in proteins involved in the programmed cell death

(2013) Z Peng et al.   CELL DEATH AND DIFFERENTIATION

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis

(2013) D Westphal et al.   CELL DEATH AND DIFFERENTIATION

A179L, a New Viral Bcl2 Homolog Targeting Beclin 1 Autophagy Related Protein

(2013) B. Hernaez et al.   CURRENT MOLECULAR MEDICINE

Poxviruses and the evolution of host range and virulence

(2013) Sherry L. Haller et al.   INFECTION GENETICS AND EVOLUTION

Evaluation of the BH3-only Protein Puma as a Direct Bak Activator

(2013) Haiming Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly of the Bak Apoptotic Pore

(2013) Stephen Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights of tBid, the Caspase-8-activated Bid, and Its BH3Domain

(2013) Yu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response

(2013) Kristopher A. Sarosiek et al.   MOLECULAR CELL

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct activation of full-length proapoptotic BAK

(2013) Elizaveta S. Leshchiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation

(2013) M. Gerlic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Action of Bcl-2 Family Proteins

(2013) A. Shamas-Din et al.   Cold Spring Harbor Perspectives in Biology

Evolution of the Animal Apoptosis Network

(2013) C. M. Zmasek et al.   Cold Spring Harbor Perspectives in Biology

Structural biology of the Bcl-2 family and its mimicry by viral proteins

(2013) M Kvansakul et al.   Cell Death & Disease

MCMV-mediated Inhibition of the Pro-apoptotic Bak Protein Is Required for Optimal In Vivo Replication

(2013) Peter Fleming et al.   PLoS Pathogens

Crystallization and preliminary X-ray characterization of Epstein–Barr virus BHRF1 in complex with a benzoylurea peptidomimetic

(2012) Sofia Caria et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Molecular Basis for Membrane Pore Formation by Bax Protein Carboxyl Terminus

(2012) Suren A. Tatulian et al.   BIOCHEMISTRY

Transmembrane pore formation by the carboxyl terminus of Bax protein

(2012) Pranav Garg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

(2012) D. Merino et al.   BLOOD

BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax

(2012) F Wilfling et al.   CELL DEATH AND DIFFERENTIATION

The C-terminal helix of Bcl-xL mediates Bax retrotranslocation from the mitochondria

(2012) F Todt et al.   CELL DEATH AND DIFFERENTIATION

A survey of host range genes in poxvirus genomes

(2012) Kirsten A. Bratke et al.   INFECTION GENETICS AND EVOLUTION

Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins

(2012) T. Okamoto et al.   JOURNAL OF VIROLOGY

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

(2012) King Pan Ng et al.   NATURE MEDICINE

Linear motifs: lost in (pre)translation

(2012) Robert J. Weatheritt et al.   TRENDS IN BIOCHEMICAL SCIENCES

Multipolar functions of BCL-2 proteins link energetics to apoptosis

(2012) J. Marie Hardwick et al.   TRENDS IN CELL BIOLOGY

Evolution of Bcl-2 homology motifs: homology versus homoplasy

(2012) Abdel Aouacheria et al.   TRENDS IN CELL BIOLOGY

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist

(2012) G J P Rautureau et al.   Cell Death & Disease

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

(2011) P N Kelly et al.   CELL DEATH AND DIFFERENTIATION

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

(2011) Andreas Strasser et al.   EMBO JOURNAL

Mapping the IκB Kinase β (IKKβ)-binding Interface of the B14 Protein, a Vaccinia Virus Inhibitor of IKKβ-mediated Activation of Nuclear Factor κB

(2011) Camilla T. O. Benfield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

(2011) Haiming Dai et al.   JOURNAL OF CELL BIOLOGY

Regulation of anti-apoptotic BCL2-proteins by non-canonical interactions: The next step forward or two steps back?

(2011) Levi J. Beverly   JOURNAL OF CELLULAR BIOCHEMISTRY

Characterization of Unique Signature Sequences in the Divergent Maternal Protein Bcl2l10

(2011) Y. Guillemin et al.   MOLECULAR BIOLOGY AND EVOLUTION

The E1B19K Oncoprotein Complexes with Beclin 1 to Regulate Autophagy in Adenovirus-Infected Cells

(2011) Sujan Piya et al.   PLoS One

Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence

(2011) Carlos Maluquer de Motes et al.   PLoS Pathogens

Mitochondrial involvement in cell death of non-mammalian eukaryotes

(2010) Eltyeb Abdelwahid et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa

(2010) Tomislav Domazet-Lošo et al.   BMC BIOLOGY

The molecular cell death machinery in the simple cnidarian Hydra includes an expanded caspase family and pro- and anti-apoptotic Bcl-2 proteins

(2010) Margherita Lasi et al.   CELL RESEARCH

Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX

(2010) Bonsu Ku et al.   CELL RESEARCH

Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis

(2010) Gilles J. P. Rautureau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak

(2010) Han Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccinia Virus Virulence Factor N1L is a Novel Promising Target for Antiviral Therapeutic Intervention

(2010) Anton V. Cheltsov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deerpox Virus Encodes an Inhibitor of Apoptosis That Regulates Bak and Bax

(2010) L. Banadyga et al.   JOURNAL OF VIROLOGY

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

(2010) Wyndham H Wilson et al.   LANCET ONCOLOGY

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

(2010) Michelle L Stewart et al.   Nature Chemical Biology

Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1

(2010) Marc Kvansakul et al.   PLoS Pathogens

BCL2DB: moving ‘helix-bundled’ BCL-2 family members to their database

(2009) Stanislas Valentin Blaineau et al.   APOPTOSIS

Mapping the Interaction of Pro-Apoptotic tBID with Pro-Survival BCL-XL

(2009) Yong Yao et al.   BIOCHEMISTRY

Advances and pitfalls of protein structural alignment

(2009) Hitomi Hasegawa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Vaccinia Virus Protein F1L Is a Caspase-9 Inhibitor

(2009) Dayong Zhai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins

(2009) Delphine Mérino et al.   JOURNAL OF CELL BIOLOGY

Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

(2009) Grant Dewson et al.   MOLECULAR CELL

The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim

(2009) A. L. Desbien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Targeting of Human RNA Helicase DDX3 by Poxvirus Protein K7

(2009) Shun-ichiro Oda et al.   STRUCTURE

An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed in Transformed Cells and Implicated in Burkitt Lymphomagenesis: The Wp/BHRF1 Link

(2009) Gemma L. Kelly et al.   PLoS Pathogens

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

(2008) M Kvansakul et al.   CELL DEATH AND DIFFERENTIATION

Living with death: the evolution of the mitochondrial pathway of apoptosis in animals

(2008) A Oberst et al.   CELL DEATH AND DIFFERENTIATION

Regulation of Bcl-2 Family Proteins by Posttranslational Modifications

(2008) Anthony Letai et al.   CURRENT MOLECULAR MEDICINE

Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1

(2008) Catherine L. Day et al.   JOURNAL OF MOLECULAR BIOLOGY

Poxvirus K7 Protein Adopts a Bcl-2 Fold: Biochemical Mapping of Its Interactions with Human DEAD Box RNA Helicase DDX3

(2008) Arnout P. Kalverda et al.   JOURNAL OF MOLECULAR BIOLOGY

Murine Cytomegalovirus m38.5 Protein Inhibits Bax-Mediated Cell Death

(2008) I. Jurak et al.   JOURNAL OF VIROLOGY

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

(2008) Grant Dewson et al.   MOLECULAR CELL

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE

Bcl-2 family proteins and cancer

(2008) K W Yip et al.   ONCOGENE

Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation

(2008) J. Gsponer et al.   SCIENCE

Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

(2008) Stephen C. Graham et al.   PLoS Pathogens

Viral Control of Mitochondrial Apoptosis

(2008) Lorenzo Galluzzi et al.   PLoS Pathogens

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY