Article
Biotechnology & Applied Microbiology
Xiaoyue Zhang, Kaixia Zhao, Lan Lan, Na Shi, Hao Nan, Yanan Shi, Xiaodong Xu, Hongying Chen
Summary: By designing gene cassettes to eliminate cell apoptosis, this study successfully increased protein expression efficiency and developed a novel baculovirus vector that could be widely applied in scientific research and pharmaceutical industries.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Endocrinology & Metabolism
Cristina Lamas, Rosa Camara, Carmen Fajardo, Pablo Remon-Ruiz, Betina Biagetti, Fernando Guerrero-Perez, Marta Araujo-Castro, Mireia Mora, Felicia Hanzu, Pedro Iglesias, Rogelio Garcia-Centeno, Alfonso Soto
Summary: In this retrospective study, temozolomide was found to be an effective medical treatment for aggressive pituitary neuroendocrine tumors and pituitary carcinomas, but may sometimes lead to tumor progression. Co-administration with radiotherapy may increase progression-free survival.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tingting Lv, Zirui Zhang, Haoying Yu, Shuyue Ren, Jingrong Wang, Shang Li, Lan Sun
Summary: Tamoxifen has shown promise as a potential combination therapy for pituitary adenomas by inhibiting cell proliferation, promoting apoptosis, reprogramming macrophage phenotype, and inhibiting immune checkpoint expression, ultimately leading to inhibition of tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Pablo Remon-Ruiz, Eva Venegas-Moreno, Elena Dios-Fuentes, Juan Manuel Canelo Moreno, Ignacio Fernandez Pena, Miriam Alonso Garcia, Miguel Angel Japon-Rodriguez, Florinda Roldan, Elena Fajardo, Ariel Kaen, Eugenio Cardenas Ruiz-Valdepenas, David Cano, Alfonso Soto-Moreno
Summary: Imaging and pathology evaluation may not accurately predict the aggressiveness of pituitary tumors, but histological examination can provide useful information. Our case report highlights the importance of suspicion for malignancy in pituitary tumors with aggressive features and the need for multidisciplinary team follow-up to manage potential metastases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanhe Lue, Ronald Swerdloff, Yue Jia, Christina Wang
Summary: The discovery of mitochondrial derived peptides (MDPs) has highlighted the central role of mitochondria in controlling and regulating cell viability and metabolism in the testis. Humanin, the first MDP discovered, plays a key role in protecting male germ cells from apoptosis induced by various stressors.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Review
Oncology
Luigi Albano, Marco Losa, Lina Raffaella Barzaghi, Ajay Niranjan, Zaid Siddiqui, John C. Flickinger, Lawrence Dade Lunsford, Pietro Mortini
Summary: A systematic review and meta-analysis of outcomes of Gamma Knife radiosurgery for pituitary tumors over the past twenty years showed that it is safe and effective, with good tumor control and remission rates for both non-secreting and secreting tumors.
Article
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: Small humanin-like peptide 2 (SHLP2), a mitochondrial-derived peptide, plays a crucial role in energy homeostasis. The study demonstrates that SHLP2 can protect mice from high-fat diet-induced obesity and improve insulin sensitivity. It activates pro-opiomelanocortin (POMC) neurons in the hypothalamus, which suppresses food intake and promotes thermogenesis. The researchers also discover that SHLP2 binds to and activates chemokine receptor 7 (CXCR7).
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: Small humanin-like peptide 2 (SHLP2), a mitochondrial-derived peptide, plays an important role in energy homeostasis. In this study, the authors demonstrate that SHLP2 protects male mice from high-fat diet-induced obesity and improves insulin sensitivity. The activation of hypothalamic neurons and the binding of SHLP2 to CXCR7 are involved in the regulation of food intake, energy expenditure, and glucose homeostasis.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
W. Ren, Y. B. Chi, J. L. Sun
Summary: Regulation of S100A4 expression affects proliferation and apoptosis in KLE endometrial cancer cells. High expression of S100A4 promotes cell proliferation, while low expression promotes apoptosis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Ding Nie, Chuzhong Li, Yazhuo Zhang
Summary: This article reviews the relationship between gut microbiota and pituitary neuroendocrine tumors (PitNETs), analyzes the potential effects of the gut-brain axis in this relationship, and presents future research directions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ashley J. Han, Elena V. Varlamov, Maria Fleseriu
Summary: This study characterized the clinical features and natural history of nonfunctioning pituitary microadenomas and found that they are generally benign. It suggests that the initial MRI follow-up interval for these tumors can be extended up to 3 years, unless there are specific concerns.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Jinxiang Huang, Fenglin Zhang, Guohan Hu, Yuan Pan, Wei Sun, Lei Jiang, Peng Wang, Jiting Qiu, Xuehua Ding
Summary: The role of SIRT1 in pituitary tumors was investigated, and it was found that the SIRT1/H3K9ac/PTTG1 axis plays a crucial role in the formation of pituitary tumors. This discovery may provide a new therapeutic strategy for the treatment of pituitary tumors.
Review
Medicine, General & Internal
Roxana-Ioana Dumitriu-Stan, Iulia-Florentina Burcea, Teodor Salmen, Catalina Poiana
Summary: Growth-hormone (GH)- and prolactin (PRL)-secreting PitNETs have multiple histological subtypes, which determine their variable behavior. Proliferation markers alone have limited predictive ability, so we need to identify more accurate prognostic models.
Review
Endocrinology & Metabolism
Chrysoula Boutari, Panagiotis D. Pappas, Theodoros D. Theodoridis, Dimitrios Vavilis
Summary: This article reviews the role of Humanin (HN) in insulin resistance and diabetes treatment, as well as its potential application in age-related diseases such as Alzheimer's disease.
WORLD JOURNAL OF DIABETES
(2022)
Article
Reproductive Biology
Rahul Katiyar, Subrata Kumar Ghosh, M. Karikalan, Abhishek Kumar, Megha Pande, Amare Ishetu Gemeda, Rupali Rautela, S. K. Dhara, S. K. Bhure, Neeraj Srivastava, M. K. Patra, Vikash Chandra, Huidrom Lakshmi Devi, Mahak Singh
Summary: The study found the presence of Humanin in buffalo spermatozoa and seminal plasma for the first time, and concluded that Humanin supplementation improves the freezability and in vitro fertility of buffalo spermatozoa.
Review
Biotechnology & Applied Microbiology
David B. Altshuler, Padma Kadiyala, Felipe J. Nunez, Fernando M. Nunez, Stephen Carney, Mahmoud S. Alghamri, Maria B. Garcia-Fabiani, Antonela S. Asad, Alejandro J. Nicola Candia, Marianela Candolfi, Joerg Lahann, James J. Moon, Anna Schwendeman, Pedro R. Lowenstein, Maria G. Castro
EXPERT OPINION ON BIOLOGICAL THERAPY
(2020)
Article
Multidisciplinary Sciences
Mariela A. Moreno Ayala, Maria Florencia Gottardo, Camila Florencia Zuccato, Matias Luis Pidre, Alejandro Javier Nicola Candia, Antonela Sofia Asad, Mercedes Imsen, Victor Romanowski, Aldo Creton, Marina Isla Larrain, Adriana Seilicovich, Marianela Candolfi
SCIENTIFIC REPORTS
(2020)
Review
Pharmacology & Pharmacy
Antonela S. Asad, Alejandro J. Nicola Candia, Nazareno Gonzalez, Camila F. Zuccato, Adriana Seilicovich, Marianela Candolfi
EXPERT OPINION ON THERAPEUTIC TARGETS
(2020)
Article
Developmental Biology
Carolina Marvaldi, Daniel Martin, Julia G. Conte, Maria Florencia Gottardo, Matias L. Pidre, Mercedes Imsen, Martin Irizarri, Sharron L. Manuel, Francesca E. Duncan, Victor Romanowski, Adriana Seilicovich, Gabriela Jaita
Summary: Humanin (HN) is a short peptide involved in various biological processes such as apoptosis, cell survival, inflammatory response, and stress response. The study found that HN plays a cytoprotective role in granulosa cells in antral follicles and may be involved in folliculogenesis regulation in the ovary. Additionally, HN also acts as a cytoprotective factor in KGN cells, suggesting its potential role in granulosa tumor cell behavior.
Review
Biochemistry & Molecular Biology
Antonela Sofia Asad, Alejandro Javier Nicola Candia, Nazareno Gonzalez, Camila Florencia Zuccato, Adriana Seilicovich, Marianela Candolfi
Summary: Glioblastoma is a challenging disease, and non-viral vectors are considered an effective tool for gene delivery, as they have lower toxicity, high tumor tropism, and the ability to penetrate the blood-brain barrier.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Nazareno Gonzalez, Antonela S. Asad, Jose Gomez Escalante, Jorge A. Pena Agudelo, Alejandro J. Nicola Candia, Matias Garcia Fallit, Adriana Seilicovich, Marianela Candolfi
Summary: The presence of mutated IDH correlates with better prognosis in gliomas, but its role in antitumor immunity and response to immunotherapy is not fully understood. Understanding the relationship between genetic features and the tumor immune microenvironment may help develop appropriate therapeutic strategies. The tumor immune microenvironment differs not only based on IDH mutation status, but also within glioma subtypes, suggesting that specific therapeutic combinations may be beneficial for different subsets of glioma patients.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2021)
Review
Virology
Matias L. Pidre, Paula N. Arrias, Leslie C. Amoros C. Morales, Victor Romanowski
Summary: This article reviews the technological applications of insect-specific enveloped baculoviruses. It summarizes the natural cycle of the virus in larvae and cell culture and how it can be exploited. It discusses various applications of baculovirus-based protein expression systems (BEVS) in the pharmaceutical and biotechnological industry. Finally, it extensively describes different gene therapy strategies based on baculoviruses for the treatment of various diseases.
Article
Oncology
Santiago M. Gomez Bergna, Abril Marchesini, Leslie C. Amoros Morales, Paula N. Arrias, Hernan G. Farina, Victor Romanowski, M. Florencia Gottardo, Matias L. Pidre
Summary: This study investigates the role of BIRC6 in breast cancer, finding that BIRC6 is associated with metastasis and identifies differential expression patterns in apoptotic, proliferation, and metastatic pathways under conditions of high BIRC6 mRNA levels.
JCO CLINICAL CANCER INFORMATICS
(2022)
Article
Virology
Matias Garcia Fallit, Matias L. Pidre, Antonela S. S. Asad, Jorge A. Pena A. Agudelo, Mariana B. B. Vera, Alejandro J. Nicola J. Candia, Sofia B. B. Sagripanti, Melanie Perez Kuper, Leslie C. Amoros C. Morales, Abril Marchesini, Nazareno Gonzalez, Carla M. M. Caruso, Victor Romanowski, Adriana Seilicovich, Guillermo A. A. Videla-Richardson, Flavia A. A. Zanetti, Marianela Candolfi
Summary: We evaluated the potential of baculoviral vectors (BV) for brain cancer gene therapy. BVs efficiently transduced glioma cells and astrocytes without apparent neurotoxicity. These vectors may be valuable for delivering therapeutic genes into the brain since humans do not have pre-existing immunity against BVs.
Article
Oncology
Jorge A. Pena Agudelo, Matias L. Pidre, Matias Garcia Fallit, Melanie Perez Kueper, Camila Zuccato, Alejandro J. Nicola Candia, Abril Marchesini, Mariana B. Vera, Emilio De Simone, Carla Giampaoli, Leslie C. Amoros Morales, Nazareno Gonzalez, Victor Romanowski, Guillermo A. Videla-Richardson, Adriana Seilicovich, Marianela Candolfi
Summary: The mitochondrial-derived peptide, humanin (HN), has been found to increase chemoresistance, migration, and endothelial cell proliferation in glioblastoma (GBM) cells. Inhibiting the HN/FPR2 pathway may improve the response of GBM to standard therapy.
Article
Developmental Biology
J. P. Jaworski, M. Urrutia, E. Dascal, G. Jaita, M. C. Peluffo
MOLECULAR HUMAN REPRODUCTION
(2020)