标题
Immunological mechanisms and therapeutic targets of fatty liver diseases
作者
关键词
-
出版物
Cellular & Molecular Immunology
Volume 18, Issue 1, Pages 73-91
出版商
Springer Science and Business Media LLC
发表日期
2020-12-02
DOI
10.1038/s41423-020-00579-3
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Epidemiological feature of NAFLD from 1999 to 2018 in China
- (2020) Jianghua Zhou et al. HEPATOLOGY
- IL-33/ST2 pathway regulates neutrophil migration and predicts outcome in patients with severe alcoholic hepatitis
- (2020) Florent Artru et al. JOURNAL OF HEPATOLOGY
- Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials
- (2020) Stephen A. Harrison et al. JOURNAL OF HEPATOLOGY
- Neutrophils as emerging therapeutic targets
- (2020) Tamás Németh et al. NATURE REVIEWS DRUG DISCOVERY
- Dietary Synbiotic Supplementation Protects Barrier Integrity of Hepatocytes and Liver Sinusoidal Endothelium in a Mouse Model of Chronic-Binge Ethanol Exposure
- (2020) Yingchun Han et al. Nutrients
- Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol‐Related Liver Disease
- (2020) Idania Marrero et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Microbiome
- (2020) Bradley Reuter et al. Clinics in Liver Disease
- Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease
- (2020) Young-Ri Shim et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Inhibition of sphingosine‐1‐phosphate‐induced Th17 cells ameliorates alcoholic steatohepatitis in mice
- (2020) Shenghui Chu et al. HEPATOLOGY
- MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis
- (2020) Xiaoqin Wu et al. JOURNAL OF HEPATOLOGY
- Lytic cell death in metabolic liver disease
- (2020) Jérémie Gautheron et al. JOURNAL OF HEPATOLOGY
- Spatially explicit modeling of metapopulation dynamics of broadcast spawners and stabilizing/destabilizing effects of heterogeneity of quality across local habitats
- (2020) Kazuhiro Bessho et al. JOURNAL OF THEORETICAL BIOLOGY
- What's in a name? Renaming ‘NAFLD’ to ‘MAFLD’
- (2020) Yasser Fouad et al. LIVER INTERNATIONAL
- Deciphering human macrophage development at single-cell resolution
- (2020) Zhilei Bian et al. NATURE
- Liver transplantation in patients with alcohol-related liver disease: current status and future directions
- (2020) Philippe Mathurin et al. Lancet Gastroenterology & Hepatology
- Granulocyte colony stimulating factor: A potential therapeutic rescue in severe alcoholic hepatitis and decompensated cirrhosis
- (2020) Sahaj Rathi et al. Annals of Hepatology
- MR1: a multi-faceted metabolite sensor for T cell activation
- (2020) Hamish EG McWilliam et al. CURRENT OPINION IN IMMUNOLOGY
- IRE1A Stimulates Hepatocyte-derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis
- (2020) Debanjali Dasgupta et al. GASTROENTEROLOGY
- Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis
- (2020) Stephen A. Harrison et al. GASTROENTEROLOGY
- Diagnostic and Prognostic Significance of Complement in Patients with Alcohol‐associated Hepatitis
- (2020) Xiude Fan et al. HEPATOLOGY
- A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder
- (2020) Jasmohan S Bajaj et al. HEPATOLOGY
- Hsd17b13 Deficiency Does not Protect Mice From Obesogenic Diet Injury
- (2020) Yanling Ma et al. HEPATOLOGY
- Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis
- (2020) Sophie Tran et al. IMMUNITY
- Therapeutic modulation of inflammasome pathways
- (2020) Dhruv Chauhan et al. IMMUNOLOGICAL REVIEWS
- Blocking integrin α4β7-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis
- (2020) Ravi P. Rai et al. JOURNAL OF HEPATOLOGY
- Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice
- (2020) Akiko Eguchi et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans
- (2020) Luca Maccioni et al. Gut Microbes
- Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKα-dependent mechanisms
- (2020) Jing Ma et al. JCI Insight
- Design and rationale of a multicenter defeat alcoholic steatohepatitis trial: (DASH) randomized clinical trial to treat alcohol-associated hepatitis
- (2020) Srinivasan Dasarathy et al. Contemporary Clinical Trials
- 4-HNE Immunohistochemistry and Image Analysis for Detection of Lipid Peroxidation in Human Liver Samples Using Vitamin E Treatment in NAFLD as a Proof of Concept
- (2020) Maren C. Podszun et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis
- (2020) Maren C. Podszun et al. Redox Biology
- Activation of NLRP3 inflammasome in hepatocytes after exposure to cobalt nanoparticles: The role of oxidative stress
- (2020) Sisi Feng et al. TOXICOLOGY IN VITRO
- The role of complement in liver injury, regeneration and transplantation
- (2019) Ebbe Billmann Thorgersen et al. HEPATOLOGY
- Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study
- (2019) Gyongyi Szabo et al. HEPATOLOGY
- A Designer Synbiotic Attenuates Chronic-Binge Ethanol-Induced Gut-Liver Injury in Mice
- (2019) Sanjoy Roychowdhury et al. Nutrients
- Current trials and novel therapeutic targets for alcoholic hepatitis
- (2019) Ashwani K. Singal et al. JOURNAL OF HEPATOLOGY
- Inflammatory pathways in alcoholic steatohepatitis
- (2019) Bin Gao et al. JOURNAL OF HEPATOLOGY
- Microbiome as a therapeutic target in alcohol-related liver disease
- (2019) Shiv K. Sarin et al. JOURNAL OF HEPATOLOGY
- Adipocyte Death Preferentially Induces Liver Injury and Inflammation Through the Activation of Chemokine (C‐C Motif) Receptor 2‐Positive Macrophages and Lipolysis
- (2019) Seung‐Jin Kim et al. HEPATOLOGY
- Neutrophil-to-lymphocyte ratio is independently associated with inflammatory activity and fibrosis grade in nonalcoholic fatty liver disease
- (2019) Tawfik Khoury et al. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
- Intestinal iNKT Cells Migrate to Liver and Contribute to Hepatocyte Apoptosis During Alcoholic Liver Disease
- (2019) Kuei-Chuan Lee et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Novel Role of Macrophage Migration Inhibitory Factor in Upstream Control of the Unfolded Protein Response After Ethanol Feeding in Mice
- (2019) Kyle Lauren Poulsen et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Nonclassical Monocytes in Health and Disease
- (2019) Prakash Babu Narasimhan et al. Annual Review of Immunology
- The immunoregulatory effects of CD8 T-cell–derived perforin on diet-induced nonalcoholic steatohepatitis
- (2019) Tianqi Wang et al. FASEB JOURNAL
- Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis
- (2019) Anissa A. Widjaja et al. GASTROENTEROLOGY
- Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis
- (2019) Oliver Krenkel et al. GUT
- Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP 2E1‐Mediated Oxidative and Nitrative Stress
- (2019) Young‐Eun Cho et al. HEPATOLOGY
- Unexpected Rapid Increase in the Burden of Nonalcoholic Fatty Liver Disease in China From 2008 to 2018: A Systematic Review and Meta‐Analysis
- (2019) Feng Zhou et al. HEPATOLOGY
- HDAC6 Suppresses Let‐7i‐5p to Elicit TSP1/CD47‐mediated Anti‐tumorigenesis and Phagocytosis of Hepatocellular Carcinoma
- (2019) Hee Doo Yang et al. HEPATOLOGY
- Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice
- (2019) Hong Shen et al. JOURNAL OF CLINICAL INVESTIGATION
- Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes
- (2019) Andreea-Manuela Mirea et al. MOLECULAR MEDICINE
- Wolfberry‐Derived Zeaxanthin Dipalmitate Attenuates Ethanol‐Induced Hepatic Damage
- (2019) Hao Gao et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
- (2019) Daniel Lindén et al. Molecular Metabolism
- Specifically Sized Hyaluronan (35 kDa) Prevents Ethanol‐Induced Disruption of Epithelial Tight Junctions Through a layilin‐Dependent Mechanism in Caco‐2 Cells
- (2019) Damien A. Bellos et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Alcohol-induced adipose tissue macrophage phenotype switching is independent of myeloid toll-like receptor 4 expression
- (2019) Melissa A. Fulham et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Intestinal fungal dysbiosis and systemic immune response to fungi in patients with alcoholic hepatitis
- (2019) Sonja Lang et al. HEPATOLOGY
- Obesity in acute alcoholic hepatitis increases morbidity and mortality
- (2019) Richard Parker et al. EBioMedicine
- Emerging Role of Extracellular Vesicles in Liver Diseases
- (2019) Harmeet Malhi AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Integrin β1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH
- (2019) Qianqian Guo et al. JOURNAL OF HEPATOLOGY
- Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development
- (2019) Juliette Mouries et al. JOURNAL OF HEPATOLOGY
- Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis
- (2019) Xuelian Xiong et al. MOLECULAR CELL
- DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation
- (2019) Joel Zindel et al. Annual Review of Pathology-Mechanisms of Disease
- Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism
- (2019) Jin Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease
- (2019) Tatiana Kisseleva et al. Cell Metabolism
- Cholesterol impairs hepatocyte lysosomal function causing M1 polarization of macrophages via exosomal miR-122-5p
- (2019) Zhibo Zhao et al. EXPERIMENTAL CELL RESEARCH
- YAP in Kupffer cells enhances the production of pro‐inflammatory cytokines and promotes the development of non‐alcoholic steatohepatitis
- (2019) Kyoungsub Song et al. HEPATOLOGY
- Genetic variation in HSD17B13 reduces the risk of developing cirrhosis and hepatocellular carcinoma in alcohol misusers
- (2019) Felix Stickel et al. HEPATOLOGY
- An Open Label, Dose Escalation Study To Assess The Safety And Efficacy Of IL‐22 Agonist F‐652 In Patients With Alcoholic Hepatitis
- (2019) Juan P. Arab et al. HEPATOLOGY
- Lipotoxic Hepatocyte‐Derived Exosomal miR‐192‐5p Activates Macrophages via Rictor/Akt/FoxO1 Signaling in NAFLD
- (2019) Xiao‐Lin Liu et al. HEPATOLOGY
- Interleukin‐22 ameliorates neutrophil‐driven nonalcoholic steatohepatitis through multiple targets
- (2019) Seonghwan Hwang et al. HEPATOLOGY
- Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study
- (2019) Stephen A. Harrison et al. JOURNAL OF HEPATOLOGY
- Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
- (2019) Stephen A Harrison et al. LANCET
- Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease
- (2019) Yi Duan et al. NATURE
- Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis
- (2019) Zhou Zhou et al. AMERICAN JOURNAL OF PATHOLOGY
- Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice
- (2019) Boram Seo et al. Cell Host & Microbe
- Cenicriviroc for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis: AURORA Phase 3 study design
- (2019) Quentin M. Anstee et al. Contemporary Clinical Trials
- The Novel Adipokine Gremlin 1 Antagonizes Insulin Action and Is Increased in Type 2 Diabetes and NAFLD/NASH
- (2019) Shahram Hedjazifar et al. DIABETES
- Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting
- (2019) Matias A Avila et al. GUT
- Mitochondrial double‐stranded RNA in exosome promotes interleukin‐17 production through toll‐like receptor 3 in alcoholic liver injury
- (2019) Jun‐Hee Lee et al. HEPATOLOGY
- Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension
- (2019) Guadalupe Garcia-Tsao et al. JOURNAL OF HEPATOLOGY
- A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis
- (2019) Stephen A. Harrison et al. JOURNAL OF HEPATOLOGY
- IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease
- (2019) Hsiao-Yen Ma et al. JOURNAL OF HEPATOLOGY
- Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial
- (2019) Zobair M Younossi et al. LANCET
- Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference
- (2018) Yuri A. Blednov et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- ACG Clinical Guideline: Alcoholic Liver Disease
- (2018) Ashwani K Singal et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Complement Factor D protects mice from ethanol-induced inflammation and liver injury
- (2018) Rebecca L. McCullough et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Interleukin-22 from bench to bedside: a promising drug for epithelial repair
- (2018) Bin Gao et al. Cellular & Molecular Immunology
- Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis
- (2018) Eric J. Lawitz et al. Clinical Gastroenterology and Hepatology
- Cenicriviroc for the treatment of non-alcoholic steatohepatitis and liver fibrosis
- (2018) Frank Tacke EXPERT OPINION ON INVESTIGATIONAL DRUGS
- MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease
- (2018) Abhishek Satishchandran et al. GASTROENTEROLOGY
- Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation
- (2018) Samar H Ibrahim et al. GUT
- Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis
- (2018) Dirk J. van der Windt et al. HEPATOLOGY
- Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients
- (2018) Elena Khanova et al. HEPATOLOGY
- Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90
- (2018) Banishree Saha et al. HEPATOLOGY
- Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis
- (2018) Oliver Krenkel et al. HEPATOLOGY
- IL-1 receptor like 1 protects against alcoholic liver injury by limiting NF-κB activation in hepatic macrophages
- (2018) Meng Wang et al. JOURNAL OF HEPATOLOGY
- Determinants of fibrosis progression and regression in NASH
- (2018) Detlef Schuppan et al. JOURNAL OF HEPATOLOGY
- Lipotoxicity and the gut-liver axis in NASH pathogenesis
- (2018) Fabio Marra et al. JOURNAL OF HEPATOLOGY
- Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use
- (2018) Terence Ndonyi Bukong et al. JOURNAL OF HEPATOLOGY
- Triggering and resolution of inflammation in NASH
- (2018) Susanne Schuster et al. Nature Reviews Gastroenterology & Hepatology
- The gut–liver axis and the intersection with the microbiome
- (2018) Anupriya Tripathi et al. Nature Reviews Gastroenterology & Hepatology
- A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
- (2018) Noura S. Abul-Husn et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Receptor Interacting Protein Kinases in the Liver
- (2018) Lily Dara SEMINARS IN LIVER DISEASE
- Toll-Like Receptor-7 Signaling Promotes Nonalcoholic Steatohepatitis by Inhibiting Regulatory T Cells in Mice
- (2018) Yoon Seok Roh et al. AMERICAN JOURNAL OF PATHOLOGY
- Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release
- (2018) Junjiang Pan et al. CELLULAR IMMUNOLOGY
- Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids
- (2018) Yanhang Gao et al. GUT
- Characteristics of immune response to tumor-associated antigens and immune cell profile in hepatocellular carcinoma patients
- (2018) Yuki Inada et al. HEPATOLOGY
- NLRP3 inflammasome activation in hepatic stellate cells induces murine liver fibrosis
- (2018) Maria Eugenia Inzaugarat et al. HEPATOLOGY
- Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol-induced liver damage, steatosis and inflammation in mice
- (2018) Aditya Ambade et al. HEPATOLOGY
- Pyroptosis versus necroptosis: similarities, differences, and crosstalk
- (2018) Daniel Frank et al. CELL DEATH AND DIFFERENTIATION
- n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review
- (2018) Meng Wang et al. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
- GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease
- (2018) Rohit Loomba et al. GASTROENTEROLOGY
- Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice
- (2018) Xianjun Luo et al. GASTROENTEROLOGY
- Dietary Lipids Differentially Shape NASH Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages
- (2018) Brett McGettigan et al. HEPATOLOGY
- Vitamin E Improves Transplant-free Survival and Hepatic Decompensation among Patients with NASH and Advanced Fibrosis
- (2018) Eduardo Vilar-Gomez et al. HEPATOLOGY
- HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease
- (2018) Yanling Ma et al. HEPATOLOGY
- DAMPs and sterile inflammation in drug hepatotoxicity
- (2018) Runkuan Yang et al. Hepatology International
- STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis
- (2018) Yongsheng Yu et al. JOURNAL OF CLINICAL INVESTIGATION
- Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis
- (2018) Igor Maricic et al. JOURNAL OF IMMUNOLOGY
- Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial
- (2018) Arun Sanyal et al. LANCET
- Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics
- (2018) Stergios A. Polyzos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
- (2018) Taylor K. Soderborg et al. Nature Communications
- Gut-Specific Delivery of T-Helper 17 Cells Reduces Obesity and Insulin Resistance in Mice
- (2017) Chun-Pyo Hong et al. GASTROENTEROLOGY
- Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease
- (2017) Oscar Chávez-Talavera et al. GASTROENTEROLOGY
- Animal Models of Alcoholic Liver Disease: Pathogenesis and Clinical Relevance
- (2017) Bin Gao et al. GENE EXPRESSION
- MAIT cells: a novel therapeutic target for alcoholic liver disease?
- (2017) Bin Gao et al. GUT
- Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice
- (2017) Mitchell Bijnen et al. GUT
- Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD
- (2017) Na Jiao et al. GUT
- Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease
- (2017) Antonio Riva et al. GUT
- Alcohol abstinence in patients surviving an episode of alcoholic hepatitis: Prediction and impact on long-term survival
- (2017) José Altamirano et al. HEPATOLOGY
- Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis
- (2017) Kyle S. McCommis et al. HEPATOLOGY
- MicroRNA 181b-3p and its target importin α5 regulate toll-like receptor 4 signaling in Kupffer cells and liver injury in mice in response to ethanol
- (2017) Paramananda Saikia et al. HEPATOLOGY
- Hepatic mitochondrial DNA/Toll-like receptor 9/MicroRNA-223 forms a negative feedback loop to limit neutrophil overactivation and acetaminophen hepatotoxicity in mice
- (2017) Yong He et al. HEPATOLOGY
- Adipokines and Non-Alcoholic Fatty Liver Disease: Multiple Interactions
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Intestinal fungi contribute to development of alcoholic liver disease
- (2017) An-Ming Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- Prophylactic tributyrin treatment mitigates chronic-binge ethanol-induced intestinal barrier and liver injury
- (2017) Gail A Cresci et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients
- (2017) Veronica Marin et al. JOURNAL OF HEPATOLOGY
- Targeting hepatic macrophages to treat liver diseases
- (2017) Frank Tacke JOURNAL OF HEPATOLOGY
- Murine CD103 + dendritic cells protect against steatosis progression towards steatohepatitis
- (2017) Eva-Carina Heier et al. JOURNAL OF HEPATOLOGY
- Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice
- (2017) Gladys Ferrere et al. JOURNAL OF HEPATOLOGY
- NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
- (2017) Auvro R. Mridha et al. JOURNAL OF HEPATOLOGY
- The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
- (2017) Monica D. Chow et al. MOLECULAR ASPECTS OF MEDICINE
- Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations
- (2017) Richard Parker et al. Nature Reviews Gastroenterology & Hepatology
- Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets
- (2017) Gyongyi Szabo et al. Nature Reviews Gastroenterology & Hepatology
- Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation
- (2017) Diana V. Avila et al. NEUROPHARMACOLOGY
- Deficiency of the Purinergic Receptor 2X7 Attenuates Nonalcoholic Steatohepatitis Induced by High-Fat Diet: Possible Role of the NLRP3 Inflammasome
- (2017) Claudia Blasetti Fantauzzi et al. Oxidative Medicine and Cellular Longevity
- Inflammasomes in Liver Fibrosis
- (2017) Fernando Alegre et al. SEMINARS IN LIVER DISEASE
- Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
- (2017) Jianjin Shi et al. TRENDS IN BIOCHEMICAL SCIENCES
- RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis
- (2017) Yong-Hyun Han et al. Cell Reports
- Avatar-assisted therapy: a proof-of-concept pilot study of a novel technology-based intervention to treat substance use disorders
- (2017) Michael S. Gordon et al. AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
- Evidence Suggesting Absence of Mitochondrial DNA Methylation
- (2017) Mie Mechta et al. Frontiers in Genetics
- Diagnosis and Treatment of Alcoholic Hepatitis: A Systematic Review
- (2016) Ashwani K. Singal et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Hepatocellular autophagy modulates the unfolded protein response and fasting-induced steatosis in mice
- (2016) Wilhelmus J. Kwanten et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus
- (2016) Kenneth Cusi et al. ANNALS OF INTERNAL MEDICINE
- Bile acid receptor agonists INT747 and INT777 decrease oestrogen deficiency-related postmenopausal obesity and hepatic steatosis in mice
- (2016) Monique C. de Oliveira et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma
- (2016) Ana L. Gomes et al. CANCER CELL
- Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation
- (2016) Lirui Wang et al. Cell Host & Microbe
- Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes
- (2016) Petra Hirsova et al. GASTROENTEROLOGY
- Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol
- (2016) Khalidur Rahman et al. GASTROENTEROLOGY
- Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes
- (2016) Laura E. Nagy et al. GASTROENTEROLOGY
- Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening
- (2016) Vlad Ratziu et al. GASTROENTEROLOGY
- Pathogenesis of Nonalcoholic Steatohepatitis
- (2016) Mariana Verdelho Machado et al. GASTROENTEROLOGY
- Myeloid Mixed Lineage Kinase 3 Contributes to Chronic Ethanol-Induced Inflammation and Hepatocyte Injury in Mice
- (2016) Rebecca L. McCullough et al. GENE EXPRESSION
- MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6–p47 phox –oxidative stress pathway in neutrophils
- (2016) Man Li et al. GUT
- Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives
- (2016) Juan P. Arab et al. HEPATOLOGY
- Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9
- (2016) Irma Garcia-Martinez et al. JOURNAL OF CLINICAL INVESTIGATION
- Treatment of alcohol use disorders in patients with alcoholic liver disease
- (2016) Giovanni Addolorato et al. JOURNAL OF HEPATOLOGY
- Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease
- (2016) Verena Wieser et al. JOURNAL OF HEPATOLOGY
- Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis
- (2016) Mei Xiang et al. JOURNAL OF HEPATOLOGY
- Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles
- (2016) Vikas K. Verma et al. JOURNAL OF HEPATOLOGY
- The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis
- (2016) Shashi Bala et al. JOURNAL OF HEPATOLOGY
- Glutamine supplementation attenuates ethanol-induced disruption of apical junctional complexes in colonic epithelium and ameliorates gut barrier dysfunction and fatty liver in mice
- (2016) Kamaljit K. Chaudhry et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis
- (2016) Diana V Avila et al. JOURNAL OF PATHOLOGY
- Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study
- (2016) Matthew James Armstrong et al. LANCET
- Differential contribution of complement receptor C5aR in myeloid and non-myeloid cells in chronic ethanol-induced liver injury in mice
- (2016) Rebecca L. McCullough et al. MOLECULAR IMMUNOLOGY
- Signals from the gut microbiota to distant organs in physiology and disease
- (2016) Bjoern O Schroeder et al. NATURE MEDICINE
- Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
- (2016) Giovanni Musso et al. NATURE REVIEWS DRUG DISCOVERY
- Immunology in the liver — from homeostasis to disease
- (2016) Felix Heymann et al. Nature Reviews Gastroenterology & Hepatology
- Hepatic ischemia reperfusion injury: A systematic review of literature and the role of current drugs and biomarkers
- (2016) Marco Cannistrà et al. International Journal of Surgery
- Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury
- (2016) Shaogui Wang et al. Oncotarget
- Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and Inflammation
- (2016) D. T. Reid et al. PLoS One
- CXCL10-Mediates Macrophage, but not Other Innate Immune Cells-Associated Inflammation in Murine Nonalcoholic Steatohepatitis
- (2016) Kyoko Tomita et al. Scientific Reports
- TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration
- (2015) Yoon Seok Roh et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Molecular mechanisms regulating NLRP3 inflammasome activation
- (2015) Eun-Kyeong Jo et al. Cellular & Molecular Immunology
- Gut–Liver Axis in Alcoholic Liver Disease
- (2015) Gyongyi Szabo GASTROENTEROLOGY
- Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease
- (2015) M Llopis et al. GUT
- Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice
- (2015) Igor Maricic et al. HEPATOLOGY
- High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
- (2015) Evaggelia Liaskou et al. HEPATOLOGY
- Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes
- (2015) Samar H. Ibrahim et al. HEPATOLOGY
- Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice
- (2015) Arvin Iracheta-Vellve et al. JOURNAL OF HEPATOLOGY
- Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management
- (2015) Stuart McPherson et al. JOURNAL OF HEPATOLOGY
- TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess
- (2015) Leila Idrissova et al. JOURNAL OF HEPATOLOGY
- Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions
- (2015) Michael Thiele et al. JOURNAL OF IMMUNOLOGY
- Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver
- (2015) Monika Rau et al. JOURNAL OF IMMUNOLOGY
- Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease
- (2015) Jan Petrasek et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
- (2015) Brent A Neuschwander-Tetri et al. LANCET
- Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl4-induced injury
- (2015) Gail A. Cresci et al. MOLECULAR IMMUNOLOGY
- MicroRNAs in Alcoholic Liver Disease
- (2015) Abhishek Satishchandran et al. SEMINARS IN LIVER DISEASE
- Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS
- (2015) Fatemeh Momen-Heravi et al. Scientific Reports
- The Role of Dendritic Cells in Fibrosis Progression in Nonalcoholic Fatty Liver Disease
- (2015) Paloma Almeda-Valdes et al. Biomed Research International
- Granulocyte Colony-Stimulating Factor in Severe Alcoholic Hepatitis: A Randomized Pilot Study
- (2014) Virendra Singh et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Nonalcoholic Fatty Liver Disease, Cardiovascular Risk, and Carotid Inflammation
- (2014) Khalid Al-Rasadi et al. ANGIOLOGY
- Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity
- (2014) Prabhakara R. Nagareddy et al. Cell Metabolism
- Toll-like receptor-4 signalling in the progression of non-alcoholic fatty liver disease induced by high-fat and high-fructose diet in mice
- (2014) Jing Liu et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Bile acids and the gut microbiome
- (2014) Jason M. Ridlon et al. CURRENT OPINION IN GASTROENTEROLOGY
- Adipocyte Cell Death, Fatty Liver Disease and Associated Metabolic Disorders
- (2014) Akiko Eguchi et al. DIGESTIVE DISEASES
- A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis
- (2014) J. Gautheron et al. EMBO Molecular Medicine
- A Histologic Scoring System for Prognosis of Patients With Alcoholic Hepatitis
- (2014) José Altamirano et al. GASTROENTEROLOGY
- Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice
- (2014) Raul Lazaro et al. HEPATOLOGY
- Regulation of the Extrinsic Apoptotic Pathway by MicroRNA-21 in Alcoholic Liver Injury
- (2014) Heather Francis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis
- (2014) Xiang Zhang et al. JOURNAL OF HEPATOLOGY
- Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice
- (2014) Meng Wang et al. JOURNAL OF LEUKOCYTE BIOLOGY
- NLRP3 inflammasome activation is required for fibrosis development in NAFLD
- (2014) Alexander Wree et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Alcohol withdrawal alleviates adipose tissue inflammation in patients with alcoholic liver disease
- (2014) Cosmin S. Voican et al. LIVER INTERNATIONAL
- Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity
- (2014) Sophie Leclercq et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice
- (2014) Yuri A. Blednov et al. Frontiers in Neuroscience
- Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol
- (2013) Irina A. Kirpich et al. ALCOHOL
- Involvement of the mitochondrial permeability transition pore in chronic ethanol-mediated liver injury in mice
- (2013) Adrienne L. King et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice
- (2013) Justin R. Henning et al. HEPATOLOGY
- Alcohol dehydrogenase-specific T-cell responses are associated with alcohol consumption in patients with alcohol-related cirrhosis
- (2013) Fang Lin et al. HEPATOLOGY
- Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: A critical role for E-selectin
- (2013) Adeline Bertola et al. HEPATOLOGY
- Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
- (2013) Jean-Philippe Pradere et al. HEPATOLOGY
- The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease
- (2013) Victoria L. Gadd et al. HEPATOLOGY
- Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance
- (2013) Agnieszka Kaczmarek et al. IMMUNITY
- Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance
- (2013) Mohamed Asrih et al. JOURNAL OF ENDOCRINOLOGY
- NKT-cell subsets: Promoters and protectors in inflammatory liver disease
- (2013) Vipin Kumar JOURNAL OF HEPATOLOGY
- Decoding cell death signals in liver inflammation
- (2013) Catherine Brenner et al. JOURNAL OF HEPATOLOGY
- Altered profile of human gut microbiome is associated with cirrhosis and its complications
- (2013) Jasmohan S. Bajaj et al. JOURNAL OF HEPATOLOGY
- Tim-3/Galectin-9 Regulate the Homeostasis of Hepatic NKT Cells in a Murine Model of Nonalcoholic Fatty Liver Disease
- (2013) Z.-H. Tang et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: IL-25 Elicits Innate Lymphoid Type 2 and Type II NKT Cells That Regulate Obesity in Mice
- (2013) E. Hams et al. JOURNAL OF IMMUNOLOGY
- Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
- (2013) Zhenyu Cai et al. NATURE CELL BIOLOGY
- Immune surveillance by the liver
- (2013) Craig N Jenne et al. NATURE IMMUNOLOGY
- Control of pathogens and pathobionts by the gut microbiota
- (2013) Nobuhiko Kamada et al. NATURE IMMUNOLOGY
- Mouse model of chronic and binge ethanol feeding (the NIAAA model)
- (2013) Adeline Bertola et al. Nature Protocols
- Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis
- (2013) Laura J. Dixon et al. PLoS One
- Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins
- (2013) Jerry R. Colca et al. PLoS One
- Pro-Inflammatory Activated Kupffer Cells by Lipids Induce Hepatic NKT Cells Deficiency through Activation-Induced Cell Death
- (2013) Tongfang Tang et al. PLoS One
- Inhibition of Apoptosis Protects Mice from Ethanol-Mediated Acceleration of Early Markers of CCl4-Induced Fibrosis but not Steatosis or Inflammation
- (2012) Sanjoy Roychowdhury et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury
- (2012) Yuhua Wang et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling
- (2012) Kento Imajo et al. Cell Metabolism
- Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease
- (2012) Hae-Ki Min et al. Cell Metabolism
- Alcohol steatosis and cytotoxicity: The role of cytochrome P4502E1 and autophagy
- (2012) Defeng Wu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Relationship between adipose tissue insulin resistance and liver histology in nonalcoholic steatohepatitis: A pioglitazone versus vitamin E versus placebo for the treatment of nondiabetic patients with nonalcoholic steatohepatitis trial follow-up study
- (2012) Lauren N. Bell et al. HEPATOLOGY
- Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases
- (2012) Shashi Bala et al. HEPATOLOGY
- Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH
- (2012) Lixin Zhu et al. HEPATOLOGY
- Aging promotes the development of diet-induced murine steatohepatitis but not steatosis
- (2012) Luis Fontana et al. HEPATOLOGY
- Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury
- (2012) Sanjoy Roychowdhury et al. HEPATOLOGY
- Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production
- (2012) Lydia Lynch et al. IMMUNITY
- Activation of Natural Killer T Cells Promotes M2 Macrophage Polarization in Adipose Tissue and Improves Systemic Glucose Tolerance via Interleukin-4 (IL-4)/STAT6 Protein Signaling Axis in Obesity
- (2012) Yewei Ji et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production
- (2012) Annie-Carole Tosello-Trampont et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice
- (2012) Jan Petrasek et al. JOURNAL OF CLINICAL INVESTIGATION
- The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
- (2012) Mitchell R. McGill et al. JOURNAL OF CLINICAL INVESTIGATION
- Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up
- (2012) Shira Zelber-Sagi et al. JOURNAL OF HEPATOLOGY
- Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA
- (2012) M. W. Julian et al. JOURNAL OF IMMUNOLOGY
- Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease
- (2012) Geoffrey Porez et al. JOURNAL OF LIPID RESEARCH
- Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis
- (2012) Laura J Dixon et al. LABORATORY INVESTIGATION
- Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
- (2012) Saswata Talukdar et al. NATURE MEDICINE
- Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice
- (2012) L. Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease
- (2012) Alexandra K. Leamy et al. PROGRESS IN LIPID RESEARCH
- Ethanol-Induced Oxidative Stress via the CYP2E1 Pathway Disrupts Adiponectin Secretion from Adipocytes
- (2011) Hui Tang et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Lactobacillus rhamnosus GG Treatment Potentiates Intestinal Hypoxia-Inducible Factor, Promotes Intestinal Integrity and Ameliorates Alcohol-Induced Liver Injury
- (2011) Yuhua Wang et al. AMERICAN JOURNAL OF PATHOLOGY
- Regulation and function of IL-17A- and IL-22-producing γδ T cells
- (2011) Kristin J. Ness-Schwickerath et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
- (2011) Bin Gao et al. GASTROENTEROLOGY
- Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
- (2011) Christer Baeck et al. GUT
- Identification of a Cytochrome P4502E1/Bid/C1q-dependent Axis Mediating Inflammation in Adipose Tissue after Chronic Ethanol Feeding to Mice
- (2011) Becky M. Sebastian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease
- (2011) Naim Alkhouri et al. LIVER INTERNATIONAL
- The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
- (2011) Mohamed El-Behi et al. NATURE IMMUNOLOGY
- Mice Lacking NKT Cells but with a Complete Complement of CD8+ T-Cells Are Not Protected against the Metabolic Abnormalities of Diet-Induced Obesity
- (2011) Benjamin S. Mantell et al. PLoS One
- Impact of CD1d Deficiency on Metabolism
- (2011) Maya E. Kotas et al. PLoS One
- Complement and Alcoholic Liver Disease: Role of C1q in the Pathogenesis of Ethanol-Induced Liver Injury in Mice
- (2010) Jessica I. Cohen et al. GASTROENTEROLOGY
- Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice
- (2010) Kouichi Miura et al. GASTROENTEROLOGY
- Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data
- (2010) P. Mathurin et al. GUT
- Enteric dysbiosis associated with a mouse model of alcoholic liver disease
- (2010) Arthur W. Yan et al. HEPATOLOGY
- The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
- (2010) Yaron Rotman et al. HEPATOLOGY
- Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease
- (2010) Shashi Bala et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Harmful effect of adipose tissue on liver lesions in patients with alcoholic liver disease
- (2010) Sylvie Naveau et al. JOURNAL OF HEPATOLOGY
- Circulating mitochondrial DAMPs cause inflammatory responses to injury
- (2010) Qin Zhang et al. NATURE
- Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
- (2010) Arun J. Sanyal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Type of alcoholic beverage and incidence of overweight/obesity in a Mediterranean cohort: The SUN project
- (2010) Carmen Sayon-Orea et al. NUTRITION
- Inflammasome-mediated regulation of hepatic stellate cells
- (2009) Azuma Watanabe et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Kupffer cell activation is a causal factor for hepatic insulin resistance
- (2009) Nicolas Lanthier et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance
- (2009) W. Huang et al. DIABETES
- Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis
- (2009) Amalia Gastaldelli et al. HEPATOLOGY
- Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis
- (2009) Michael Kremer et al. HEPATOLOGY
- The Extrapancreatic Effects of Glucagon-Like Peptide-1 and Related Peptides
- (2009) Rania Abu-Hamdah et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Signalling pathways in alcohol-induced liver inflammation
- (2009) Pranoti Mandrekar et al. JOURNAL OF HEPATOLOGY
- CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
- (2009) Satoshi Nishimura et al. NATURE MEDICINE
- The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88
- (2008) Istvan Hritz et al. HEPATOLOGY
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
- (2008) Stefano Romeo et al. NATURE GENETICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started