Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKα-dependent mechanisms

Protective and Detrimental Roles of p38α MAPK in Different Stages of Nonalcoholic Fatty Liver Disease

(2020) Seonghwan Hwang et al.   HEPATOLOGY

Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study

(2019) Gyongyi Szabo et al.   HEPATOLOGY

Macrophage p38α promotes nutritional steatohepatitis through M1 polarization

(2019) Xiang Zhang et al.   JOURNAL OF HEPATOLOGY

The non-transcriptional activity of IRF3 modulates hepatic immune cell populations in acute-on-chronic ethanol administration in mice

(2019) Carlos Sanz-Garcia et al.   JOURNAL OF HEPATOLOGY

Adipocyte Death Preferentially Induces Liver Injury and Inflammation Through the Activation of Chemokine (C‐C Motif) Receptor 2‐Positive Macrophages and Lipolysis

(2019) Seung‐Jin Kim et al.   HEPATOLOGY

DUSP12 Regulates Hepatic Lipid Metabolism through Inhibition of Lipogenesis and ASK1 Pathways

(2019) Zhen Huang et al.   HEPATOLOGY

Micro RNA ‐223 ameliorates nonalcoholic steatohepatitis and cancer by targeting multiple inflammatory and oncogenic genes in hepatocytes

(2019) Yong He et al.   HEPATOLOGY

Integrated Omics Reveals Tollip as an Aggravator and Therapeutic Target for Hepatic Ischemia‐Reperfusion Injury in Mice

(2019) Zhen‐Zhen Yan et al.   HEPATOLOGY

Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes

(2019) Sangiliyandi Gurunathan et al.   Cells

Hepatocyte TRAF6 Aggravates Hepatic Inflammation and Fibrosis by Promoting Lys6- Linked Polyubiquitination of ASK1

(2019) Yutao Wang et al.   HEPATOLOGY

Diagnosis and Treatment of Alcohol‐Related Liver Diseases: 2019 Practice Guidance from the American Association for the Study of Liver Diseases

(2019) David W. Crabb et al.   HEPATOLOGY

Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity

(2019) Ziguo Song et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA enriched extracellular vesicles

(2019) Wonhyo Seo et al.   JOURNAL OF HEPATOLOGY

Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice

(2018) Xiaojuan Chao et al.   GASTROENTEROLOGY

Cyclophilin D deficiency attenuates mitochondrial perturbation and ameliorates hepatic steatosis

(2018) Xiaolei Wang et al.   HEPATOLOGY

Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles

(2018) Claudia Verderio et al.   JOURNAL OF LIPID RESEARCH

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Microvesicles shed from microglia activated by the P2X7-p38 pathway are involved in neuropathic pain induced by spinal nerve ligation in rats

(2016) Jian Li et al.   Purinergic Signalling

Inhibiting Extracellular Vesicle Release from Human Cardiosphere Derived Cells with Lentiviral Knockdown of nSMase2 Differentially Effects Proliferation and Apoptosis in Cardiomyocytes, Fibroblasts and Endothelial Cells In Vitro

(2016) Jennifer K. Lang et al.   PLoS One

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans

(2015) Ming-Jiang Xu et al.   GASTROENTEROLOGY

Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

(2015) Kiyoshi Itagaki et al.   PLoS One

Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice

(2014) Raul Lazaro et al.   HEPATOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Mouse model of chronic and binge ethanol feeding (the NIAAA model)

(2013) Adeline Bertola et al.   Nature Protocols

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

p38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles

(2009) A. M. CURTIS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

(2008) Atsushi Matsuzawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE