Adipocyte Death Preferentially Induces Liver Injury and Inflammation Through the Activation of Chemokine (C‐C Motif) Receptor 2‐Positive Macrophages and Lipolysis

CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease

(2018) Richard Parker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Take me to the liver: adipose tissue macrophages coordinate hepatic neutrophil recruitment

(2018) Gerard Pernes et al.   GUT

Therapy for steatohepatitis: Do macrophages hold the clue?

(2018) Reben Raeman et al.   HEPATOLOGY

Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment

(2018) Jingying Zhang et al.   HEPATOLOGY

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

(2018) Oliver Krenkel et al.   HEPATOLOGY

SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy

(2018) Daorong Feng et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice

(2017) Mitchell Bijnen et al.   GUT

Inflammation is independent of steatosis in a murine model of steatohepatitis

(2017) Wei Wang et al.   HEPATOLOGY

Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity

(2017) Songtao Li et al.   HEPATOLOGY

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations

(2017) Richard Parker et al.   Nature Reviews Gastroenterology & Hepatology

Cre-inducible human CD59 mediates rapid cell ablation after intermedilysin administration

(2016) Dechun Feng et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease

(2015) Johannie du Plessis et al.   GASTROENTEROLOGY

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

Regulation of adipocyte lipolysis

(2014) Gema Frühbeck et al.   NUTRITION RESEARCH REVIEWS

Fatty Acids - Induced Lipotoxicity and Inflammation

(2012) Stephane Savary et al.   CURRENT DRUG METABOLISM

Increased Death of Adipose Cells, a Path to Release Cell-Free DNA Into Systemic Circulation of Obese Women

(2012) Maricela Haghiac et al.   Obesity

Targeted Deletion of Adipocytes by Apoptosis Leads to Adipose Tissue Recruitment of Alternatively Activated M2 Macrophages

(2011) Pamela Fischer-Posovszky et al.   ENDOCRINOLOGY

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

(2011) Christer Baeck et al.   GUT

Identification of a Cytochrome P4502E1/Bid/C1q-dependent Axis Mediating Inflammation in Adipose Tissue after Chronic Ethanol Feeding to Mice

(2011) Becky M. Sebastian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose Tissue Remodeling under Ischemia: Death of Adipocytes and Activation of Stem/Progenitor Cells

(2010) Hirotaka Suga et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis

(2009) Naim Alkhouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice

(2009) Stephan Wueest et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose tissue remodeling in lipedema: adipocyte death and concurrent regeneration

(2009) Hirotaka Suga et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

(2009) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

(2008) I. Murano et al.   JOURNAL OF LIPID RESEARCH

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

(2008) Harmeet Malhi et al.   SEMINARS IN LIVER DISEASE