Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism

The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 43

(2019) Alexandre Maximiliano Trevisan et al.   Acta Cirurgica Brasileira

TRPV4 channels contribute to calcium transients in astrocytes and neurons during peri-infarct depolarizations in a stroke model

(2017) Cordula Rakers et al.   GLIA

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

(2017) Gökhan S. Hotamisligil   IMMUNITY

Role of connexin 43 in different forms of intercellular communication – gap junctions, extracellular vesicles and tunnelling nanotubes

(2017) Teresa M. Ribeiro-Rodrigues et al.   JOURNAL OF CELL SCIENCE

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells

(2017) Jeffrey J. Rodvold et al.   Science Signaling

Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins

(2017) Khanichi N. Charles et al.   Cell Reports

Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells

(2017) Jeffrey J. Rodvold et al.   Science Signaling

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice

(2017) Joost Willebrords et al.   Scientific Reports

Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue

(2017) Sang-Nam Kim et al.   Scientific Reports

Involvement of connexin43 in acetaminophen-induced liver injury

(2016) Michaël Maes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals

(2016) Yi Zhu et al.   Cell Metabolism

Connexins and their channels in inflammation

(2016) Joost Willebrords et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Structure, Regulation and Function of Gap Junctions in Liver

(2015) Joost Willebrords et al.   CELL COMMUNICATION AND ADHESION

S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction

(2015) L. Yang et al.   SCIENCE

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity

(2015) Suneng Fu et al.   Science Translational Medicine

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

(2015) Paul M. Titchenell et al.   Nature Communications

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Mix and match: Investigating heteromeric and heterotypic gap junction channels in model systems and native tissues

(2014) Michael Koval et al.   FEBS LETTERS

Targeting connexin 43 protects against the progression of experimental chronic kidney disease in mice

(2014) Ahmed Abed et al.   KIDNEY INTERNATIONAL

Titration of the gap junction protein Connexin43 reduces atherogenesis

(2014) Sandrine Morel et al.   THROMBOSIS AND HAEMOSTASIS

Elevated Intracellular Ca2+ Signals by Oxidative Stress Activate Connexin 43 Hemichannels in Osteocytes

(2014) Manuel A. Riquelme et al.   Bone Research

Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond

(2014) Catheleyne D'hondt et al.   Frontiers in Physiology

AQP4 KO exacerbating renal dysfunction is mediated by endoplasmic reticulum stress and p66Shc and is attenuated by apocynin and endothelin antagonist CPU0213

(2013) Yu-Si Cheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of connexin 32 in acetaminophen toxicity in a knockout mice model

(2013) Isao Igarashi et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Gap Junction Intercellular Communication Mediated by Connexin43 in Astrocytes Is Essential for Their Resistance to Oxidative Stress

(2013) Hoa T. Le et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure

(2013) Vairappan Balasubramaniyan et al.   JOURNAL OF HEPATOLOGY

The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation

(2013) Kuo Du et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanisms of insulin resistance in obesity

(2013) Jianping Ye   Frontiers of Medicine

Proteomic and metabolomic responses to connexin43 silencing in primary hepatocyte cultures

(2012) Mathieu Vinken et al.   ARCHIVES OF TOXICOLOGY

Connexin 43 phosphorylation and degradation are required for adipogenesis

(2012) Azadeh Yeganeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Gap junction and hemichannel functions in osteocytes

(2012) Alayna E. Loiselle et al.   BONE

Gap-junction-mediated cell-to-cell communication

(2012) Jean-Claude Hervé et al.   CELL AND TISSUE RESEARCH

Functional RNA Interference (RNAi) Screen Identifies System A Neutral Amino Acid Transporter 2 (SNAT2) as a Mediator of Arsenic-induced Endoplasmic Reticulum Stress

(2012) Raymond S. Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gap junctions and non-neoplastic liver disease

(2012) Mathieu Vinken   JOURNAL OF HEPATOLOGY

Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure

(2012) Suraj J Patel et al.   NATURE BIOTECHNOLOGY

Regulatory Effect of Connexin 43 on Basal Ca2+ Signaling in Rat Ventricular Myocytes

(2012) Chen Li et al.   PLoS One

Cell-Extrinsic Effects of Tumor ER Stress Imprint Myeloid Dendritic Cells and Impair CD8+ T Cell Priming

(2012) Navin R. Mahadevan et al.   PLoS One

Protein folding stress in neurodegenerative diseases: a glimpse into the ER

(2011) Soledad Matus et al.   CURRENT OPINION IN CELL BIOLOGY

Human Immunodeficiency Virus Infection of Human Astrocytes Disrupts Blood-Brain Barrier Integrity by a Gap Junction-Dependent Mechanism

(2011) E. A. Eugenin et al.   JOURNAL OF NEUROSCIENCE

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Connexins: Key Mediators of Endocrine Function

(2011) Domenico Bosco et al.   PHYSIOLOGICAL REVIEWS

Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells

(2011) N. R. Mahadevan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis

(2010) Ira Tabas   CIRCULATION RESEARCH

Cell-Cell Propagation of NF-κB Transcription Factor and MAP Kinase Activation Amplifies Innate Immunity against Bacterial Infection

(2010) Christoph Alexander Kasper et al.   IMMUNITY

Morphological and molecular pathology of CCL4-induced hepatic fibrosis in connexin43-deficient mice

(2010) Bruno Cogliati et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Blockade of Connexin 43 Hemichannels Reduces Neointima Formation After Vascular Injury by Inhibiting Proliferation and Phenotypic Modulation of Smooth Muscle Cells

(2009) MingBao Song et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The Origins of Multicellularity and the Early History of the Genetic Toolkit For Animal Development

(2008) Antonis Rokas   Annual Review of Genetics

Cross-Talk Between Pulmonary Injury, Oxidant Stress, and Gap Junctional Communication

(2008) Latoya N. Johnson et al.   ANTIOXIDANTS & REDOX SIGNALING