Article
Pharmacology & Pharmacy
Zhongyan Du, Zhimei Ma, Shanglei Lai, Qinchao Ding, Ziyi Hu, Wenwen Yang, Qianyu Qian, Linwensi Zhu, Xiaobing Dou, Songtao Li
Summary: This study aimed to evaluate the protective effects of Atractylenolide I (AO-I) against acetaminophen (APAP)-induced acute liver injury. The results showed that AO-I treatment significantly reversed APAP-induced liver injury, alleviated oxidative stress and inflammation, and inhibited the activation of TLR4/MAPKs/NF-kappa B pathways. AO-I is a potential therapeutic compound for APAP-induced hepatotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chen Zhang, Xiao Shi, Zhongping Su, Chao Hu, Xianmin Mu, Jinshun Pan, Mengjing Li, Fengmeng Teng, Tao Ling, Ting Zhao, Che Xu, Guozhong Ji, Qiang You
Summary: The study demonstrated that CD36 deficiency ameliorated APAP-induced acute liver injury and inflammatory responses by decreasing JNK activation. CD36 might serve as a new target to reduce acute liver injury.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yuguo Yi, Weigao Zhang, Liang Tao, Qianchao Shao, Qian Xu, Yuxin Chen, Haibing Zhang, Jianfa Zhang, Dan Weng
Summary: This study investigated the role of RIP1 kinase in APAP-induced acute liver injury through genetic or pharmacological inhibition, providing evidence that RIP1 kinase activity plays an important role in the pathogenesis of APAP-induced liver injury. The results demonstrated that RIP1 kinase inactivation significantly attenuated APAP-induced liver injury and mortality, and that Nec-1, a RIP1 kinase inhibitor formulated with PEG400, could efficiently alleviate hepatotoxicity induced by APAP.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Wen Su, Mingji Feng, Yuan Liu, Rong Cao, Yiao Liu, Junyao Tang, Ke Pan, Rongfeng Lan, Zhuo Mao
Summary: Deficiency of ZnT8 in mice alleviates APAP-induced liver injury by inhibiting oxidative stress and promoting hepatocyte proliferation.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Anna Licata, Maria Giovanna Minissale, Simona Stankeviciute, Judith Sanabria-Cabrera, Maria Isabel Lucena, Raul J. Andrade, Piero Luigi Almasio
Summary: N-acetylcysteine (NAC) is an effective therapeutic option for acetaminophen (APAP) overdose, improving hepatotoxicity and reducing mortality. The timing of treatment initiation, within 8 to 24 hours after APAP overdose, is crucial for preventing or minimizing liver damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jae Ho Choi, Sun Woo Jin, Gi Ho Lee, Eun Hee Han, Yong Pil Hwang, Hye Gwang Jeong
Summary: Rutaecarpine shows protective effects against acetaminophen-induced liver toxicity by reducing liver damage indicators, inhibiting inflammatory cytokine expression, and enhancing antioxidant enzyme activity, indicating its great therapeutic potential in treating liver injury.
Article
Gastroenterology & Hepatology
Alexandre Louvet, Line Carolle Ntandja Wandji, Elise Lemaitre, Marion Khaldi, Claire Lafforgue, Florent Artru, Benoit Quesnel, Guillaume Lassailly, Sebastien Dharancy, Philippe Mathurin
Summary: ALI caused by therapeutic doses of APAP is associated with more severe liver injury than overdose, and only occurs in patients with excess drinking and/or fasting.
Article
Immunology
Hao Wu, Chunqing Guo, Zheng Liu, Jinyang Cai, Chong Wang, Huanfa Yi, Arun Sanyal, Puneet Puri, Huiping Zhou, Xiang-Yang Wang
Summary: Drug-associated hepatotoxicity, particularly acetaminophen-induced liver injury (AILI), is a major cause of acute liver failure. This study reveals that serum levels of the pro-inflammatory cytokine interferon (IFN)- γ correlate with disease severity in patients with drug hepatotoxicity. The researchers found that hepatic neutrophils are the primary source of IFN- γ production in response to APAP-injured hepatocytes, and inhibition of IFN- γ effectively reduces hepatotoxicity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Toxicology
Naura Syafira, Andis Graudins, Mark Yarema, Anselm Wong
Summary: The study compared the incidence of acute liver injury in patients receiving acetylcysteine within eight hours of ingestion using the two-bag and three-bag regimens. Results showed that both regimens were effective in reducing the risk of liver injury in patients.
CLINICAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yiwei Zhu, Lin Lei, Xinghui Wang, Linfang Chen, Wei Li, Jinxia Li, Chenchen Zhao, Xiliang Du, Yuxiang Song, Wenwen Gao, Guowen Liu, Xinwei Li
Summary: This study investigates the role of NEDD4-1 in the pathogenesis of acetaminophen-induced liver injury (AILI). The results demonstrate that NEDD4-1 acts as a suppressor of AILI by regulating the degradation of VDAC1.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Gastroenterology & Hepatology
Zhenzhen Sun, Qian Wang, Le Sun, Mengying Wu, Shuzhen Li, Hu Hua, Ying Sun, Tong Ni, Chunlei Zhou, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia
Summary: This study revealed the important role of NEK7 in acetaminophen-induced acute liver injury. Reduced NEK7 exacerbates liver damage and provides protection against APAP-induced injury by regulating the cell cycle progression.
Review
Biochemistry & Molecular Biology
Xiaoyangzi Li, Ruyang Lao, Jiawei Lei, Yuting Chen, Qi Zhou, Ting Wang, Yingpeng Tong
Summary: The liver plays a crucial role in the body's metabolism, synthesis, and detoxification processes, but it is susceptible to damage from various factors. Drug-induced liver injury can be particularly problematic for patients, emphasizing the need for research on new treatment options.
Article
Environmental Sciences
Xiaohan Zhai, Tiantian Dai, Zhongchao Chi, Zirui Zhao, Gaolei Wu, Shilei Yang, Deshi Dong
Summary: This study aimed to investigate the protective effects of naringin against APAP-induced acute hepatotoxicity and the underlying mechanisms. The results showed that naringin alleviates APAP-induced liver injury by activating the CHAC2-Nrf2 pathway. These findings provide new insights into targeted therapies for APAP-induced liver injury by regulating Nrf2.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yi-Ming Chang, Po-Chun Chen, Chien-Peng Hsu, Peng-Fang Ma, Huey-Ling Chen, Shu-Hao Hsu
Summary: The microRNAs miR-192 and miR-194 are abundant in the liver and serve as serum biomarkers of liver injury. This study showed that genetic depletion of miR-194 promoted liver regeneration and protected against APAP-induced injury.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Melissa M. Clemens, Stefanie Kennon-McGill, Joel H. Vazquez, Owen W. Stephens, Erich A. Peterson, Donald J. Johann, Felicia D. Allard, Eric U. Yee, Sandra S. McCullough, Laura P. James, Brian N. Finck, Mitchell R. McGill
Summary: This study demonstrates the beneficial effects of exogenous phosphatidic acid in acetaminophen toxicity by activating IL-6 signaling. However, despite the importance of PA in liver repair, exogenous PA did not alter regeneration.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Pathology
Kevin De Muynck, Bart Vanderborght, Federico F. De Ponti, Eva Gijbels, Sophie Van Welden, Martin Guilliams, Charlotte L. Scott, Alain Beschin, Mathieu Vinken, Sander Lefere, Anja Geerts, Xavier Verhelst, Hans Van Vlierberghe, Lindsey Devisscher
Summary: Primary sclerosing cholangitis (PSC) is a chronic immune-mediated liver disease characterized by bile duct strictures and fibrosis. The role of hepatic macrophages (MFs) in PSC pathogenesis is unclear. This study found that resident Kupffer cells (ResKCs) were depleted during chronic liver injury, while infiltrating monocyte-derived cells (MoKCs) were enriched during the acute phase of PSC. Depletion of KCs did not affect disease outcomes. These findings provide new insights into the heterogeneity of MFs in PSC and suggest that resident and activated KCs do not play a major role in disease progression.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gabriel P. Bacil, Guilherme R. Romualdo, Priscila M. F. D. Piagge, Daniel R. Cardoso, Mathieu Vinken, Bruno Cogliati, Luis F. Barbisan
Summary: This study investigated the hepatic metabolomic profile in a hybrid model of NASH in mice and found that the strain-dependent hepatic metabolomic signature might be linked to the distinct underlying mechanisms of NASH.
Article
Veterinary Sciences
R. D. Mazaro, D. M. . Lorenzetti, M. B. Beckenkamp, T. C. Silva, B. Cogliati, R. A. Fighera
Summary: Lymphoma is a common lymphoproliferative disorder in cats, but cutaneous lymphomas are uncommon. They can be classified as either epitheliotropic or non-epitheliotropic. Epitheliotropic lymphomas are typically T-cell lymphomas with a preference for the epidermis and/or adnexal epithelium. Non-epitheliotropic lymphomas can be either T-cell or B-cell lymphomas and primarily involve the dermis. This study describes a case of multifocal cutaneous anaplastic large T-cell lymphoma in a cat.
ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
(2023)
Review
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, M. A. Cancellieri, H. Chon, M. L. Dagli, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I. Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, M. A. Cancellieri, H. Chon, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I. Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, M. A. Cancellieri, H. Chon, M. L. Dagli, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I. Lee, D. C. Liebler, H. Moustakas, J. Muldoon, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Parviz Azimnasab-Sorkhabi, Maryam Soltani-asl, Tulio Teruo Yoshinaga, Maria Lucia Zaidan Dagli, Cristina de Oliveira Massoco, Jose Roberto Kfoury Junior
Summary: Indoleamine-2,3 dioxygenase is an enzyme that plays a role in the catabolism of tryptophan and has immunosuppressive effects, allowing cancer cells to evade the immune system. Various cytokines and pathways increase the production of indoleamine-2,3 dioxygenase in the tumor microenvironment, leading to anti-tumor immune suppression. Inhibitors have been developed for this enzyme and are being tested in clinical trials. Further research is needed to understand the function of indoleamine-2,3 dioxygenase in the tumor microenvironment.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Felisbina Queiroga, Bruno Cogliati
Review
Oncology
Andrigo Barboza De Nardi, Cristina de Oliveira Massoco Salles Gomes, Carlos Eduardo Fonseca-Alves, Felipe Noleto de Paiva, Lais Calazans Menescal Linhares, Gabriel Joao Unger Carra, Rodrigo dos Santos Horta, Felipe Augusto Ruiz Sueiro, Paulo Cesar Jark, Adriana Tomoko Nishiya, Carmen Helena de Carvalho Vasconcellos, Rodrigo Ubukata, Karen Batschinski, Renata Afonso Sobral, Simone Crestoni Fernandes, Luiz Roberto Biondi, Ricardo De Francisco Strefezzi, Julia Maria Matera, Marcelo Monte Mor Rangel, Denner Santos dos Anjos, Carlos Henrique Maciel Brunner, Renee Laufer-Amorim, Karine Germano Cadrobbi, Juliana Vieira Cirillo, Mauro Caldas Martins, Nazilton de Paula Reis Filho, Diego Fernando Silva Lessa, Roberta Portela, Carolina Scarpa Carneiro, Silvia Regina Ricci Lucas, Heidge Fukumasu, Marcus Antonio Rossi Feliciano, Juliany Gomes Quitzan, Maria Lucia Zaidan Dagli
Summary: Hemangiosarcoma is a malignant tumor that originates in the endothelial cells of blood vessels. It can be classified as non-visceral and visceral types based on the location of origin. This article provides data on the epidemiology, etiology, diagnosis, staging, therapeutic modalities, and prognosis of canine hemangiosarcoma based on a consensus meeting organized by the Brazilian Association of Veterinary Oncology (ABROVET) in September 2022.
Review
Immunology
Neema Ahishakiye Jumapili, Maida Zivalj, Romina Mora Barthelmess, Geert Raes, Timo W. M. De Groof, Nick Devoogdt, Benoit Stijlemans, Cecile Vincke, Jo A. Van Ginderachter
Summary: mAbs have limitations in their distribution and penetration in tumor microenvironment, as well as their ability to reach the brain. Nanobodies, being smaller in size, possess superior abilities in tumor penetration and infiltration into brain tumors. However, the rapid clearance of nanobodies from circulation may affect their suitability for therapy, although their noncovalent binding to albumin can help increase their serum half-life.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Bruno Cogliati, Chittampalli N. Yashaswini, Shuang Wang, Daniela Sia, Scott L. Friedman
Summary: Liver fibrosis is a significant risk factor for liver cancer development and progression. Recent studies have identified specific subpopulations of hepatic stellate cells (HSCs) and cancer-associated fibroblasts (CAFs) that play dual roles in promoting or preventing fibrosis and cancer. Integrative analysis of single-cell transcriptomics and spatial RNA sequencing data has revealed the heterogeneity among these subpopulations and their distinct gene expression signatures and functions. Understanding these roles and pathways will contribute to the development of biomarkers, prognosis assessment, and new therapies for liver cancer prevention and treatment.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eva Gijbels, Kevin De Muynck, Bart Vanderborght, Tim Meese, Filip Van Nieuwerburgh, Aude Vanlander, Frederik Berrevoet, Bart Hendrikx, Anne Hoorens, Hans Van Vlierberghe, Mathieu Vinken, Lindsey Devisscher
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Chemistry, Medicinal
Arthur Lamouroux, Malaury Tournier, Debora Iaculli, Anne Caufriez, Olga M. Rusiecka, Charlotte Martin, Viviane Bes, Laureano E. Carpio, Yana Girardin, Remy Loris, Andreis Tabernilla, Filippo Molica, Rafael Gozalbes, Maria D. Mayan, Mathieu Vinken, Brenda R. Kwak, Steven Ballet
Summary: A series of macrocyclic (stapled) peptidomimetics of 10Panx1 were developed and synthesized, which showed promising potential in inhibiting Panx1 channels and reducing cell adhesion in in vitro experiments.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)