期刊
FEBS LETTERS
卷 588, 期 8, 页码 1193-1204出版社
WILEY
DOI: 10.1016/j.febslet.2014.02.025
关键词
Connexin; Gap junction; Quality control; Membrane transport
资金
- Emory Alcohol and Lung Biology Center [P50-AA013757]
- [R01-HL116958]
- [T32-AA013528]
- [R01-HL058732]
This review is based in part on a roundtable discussion session: Physiological roles for heterotypic/heteromeric channels at the 2013 International Gap Junction Conference (IGJC 2013) in Charleston, South Carolina. It is well recognized that multiple connexins can specifically co- assemble to form mixed gap junction channels with unique properties as a means to regulate intercellular communication. Compatibility determinants for both heteromeric and heterotypic gap junction channel formation have been identified and associated with specific connexin amino acid motifs. Hetero- oligomerization is also a regulated process; differences in connexin quality control and monomer stability are likely to play integral roles to control interactions between compatible connexins. Gap junctions in oligodendrocyte: astrocyte communication and in the cardiovascular system have emerged as key systems where heterotypic and heteromeric channels have unique physiologic roles. There are several methodologies to study heteromeric and heterotypic channels that are best applied to either heterologous expression systems, native tissues or both. There remains a need to use and develop different experimental approaches in order to understand the prevalence and roles for mixed gap junction channels in human physiology. (c) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据