Non-mitotic functions of polo-like kinases in cancer cells

Peptidomimetic Polo‐Box‐Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor

(2020) Merissa Baxter et al.   ChemMedChem

Identification of PLK1 as a New Therapeutic Target in Mucinous Ovarian Carcinoma

(2020) Roberta Affatato et al.   Cancers

The Prognostic Relevance of the Proliferation Markers Ki-67 and Plk1 in Early-Stage Ovarian Cancer Patients With Serous, Low-Grade Carcinoma Based on mRNA and Protein Expression

(2020) Franz Rödel et al.   Frontiers in Oncology

Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity

(2019) Ellen Watts et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role for polo-like kinase 4 in mediation of cytokinesis

(2019) Michael F. Press et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and Brachytherapy

(2019) Max Fleischmann et al.   Frontiers in Oncology

Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer

(2019) Antonio Giordano et al.   PLoS One

Forkhead box D1 promotes proliferation and suppresses apoptosis via regulating polo-like kinase 2 in colorectal cancer

(2018) Tao Han et al.   BIOMEDICINE & PHARMACOTHERAPY

Co-targeting PLK1 and mTOR induces synergistic inhibitory effects against esophageal squamous cell carcinoma

(2018) Ting-Ting Liu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers

(2018) Masanori Kawakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polo-like kinase 4 mediates epithelial–mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway

(2018) Xiangdong Tian et al.   Cell Death & Disease

PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells

(2018) Monika Raab et al.   Nature Communications

Synthetic lethality in CCNE1-amplified high grade serous ovarian cancer through combined inhibition of polo-like kinase 1 and microtubule dynamics

(2018) Sabrina Noack et al.   Oncotarget

Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number

(2018) Midori Ohta et al.   Cell Reports

Plk2 Loss Commonly Occurs in Colorectal Carcinomas but not Adenomas: Relationship to mTOR Signaling

(2018) Elizabeth M. Matthew et al.   NEOPLASIA

Plk1 overexpression induces chromosomal instability and suppresses tumor development

(2018) Guillermo de Cárcer et al.   Nature Communications

YLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defect

(2018) Qian Lei et al.   Cell Death & Disease

Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity

(2018) Elisa Vitiello et al.   Nature Communications

Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication

(2018) Hongbo Ling et al.   Cell Reports

Centrosome amplification: a suspect in breast cancer and racial disparities

(2017) Angela Ogden et al.   ENDOCRINE-RELATED CANCER

E3 ubiquitin ligases SIAH1/2 regulate hypoxia-inducible factor-1 (HIF-1)-mediated Th17 cell differentiation

(2017) Akiko Matsui-Hasumi et al.   INTERNATIONAL IMMUNOLOGY

CHOP negatively regulates Polo-like kinase 2 expression via recruiting C/EBPα to the upstream-promoter in human osteosarcoma cell line during ER stress

(2017) Tao Shen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mutual regulation between Polo-like kinase 3 and SIAH2 E3 ubiquitin ligase defines a regulatory network that fine-tunes the cellular response to hypoxia and nickel

(2017) Cen Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibiting PLK1 induces autophagy of acute myeloid leukemia cells via mammalian target of rapamycin pathway dephosphorylation

(2017) Yan-Fang Tao et al.   ONCOLOGY REPORTS

A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain

(2017) Simone Treiger Sredni et al.   PEDIATRIC BLOOD & CANCER

Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway

(2017) Xiaoyu Ma et al.   Nature Communications

Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation

(2017) Nikola S. Dzhindzhev et al.   Open Biology

The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis

(2017) Zheng Fu et al.   Cancers

The PLK4–STIL–SAS-6 module at the core of centriole duplication

(2016) Christian Arquint et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Plk2 promotes tumor growth and inhibits apoptosis by targeting Fbxw7/Cyclin E in colorectal cancer

(2016) Baochi Ou et al.   CANCER LETTERS

Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton

(2016) Karineh Kazazian et al.   CANCER RESEARCH

Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8

(2016) Christina Helmke et al.   CELL RESEARCH

CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis

(2016) Sihem Zitouni et al.   CURRENT BIOLOGY

Cytoskeletal architecture and cell motility remain unperturbed in mouse embryonic fibroblasts from Plk3 knockout mice

(2016) Daniel R Michel et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Effect of Hypoxia-regulated Polo-like Kinase 3 (Plk3) on Human Limbal Stem Cell Differentiation

(2016) Ling Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

(2016) Marjorie Fournier et al.   Nature Communications

Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy

(2016) Franz Rödel et al.   Oncotarget

Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks

(2016) Corinne Chabalier-Taste et al.   Oncotarget

Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling

(2016) Jianguo Wu et al.   eLife

Optimized Plk1 PBD Inhibitors Based on Poloxin Induce Mitotic Arrest and Apoptosis in Tumor Cells

(2015) Andrej Scharow et al.   ACS Chemical Biology

Drugging Plk1: An attractive approach to inhibit androgen receptor signaling

(2015) Klaus Strebhardt   CELL CYCLE

Identification of Rictor as a Novel Substrate of Polo-like kinase 1

(2015) Tian Shao et al.   CELL CYCLE

PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space

(2015) Carla A.M. Lopes et al.   DEVELOPMENTAL CELL

Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes

(2015) Melpomeni Platani et al.   JOURNAL OF CELL BIOLOGY

Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

(2015) Tyler C. Moyer et al.   JOURNAL OF CELL BIOLOGY

The deregulated promoter methylation of thePolo-like kinasesas a potential biomarker in hematological malignancies

(2015) Alejandra Ward et al.   LEUKEMIA & LYMPHOMA

Polo-like kinase 3 is associated with improved overall survival in cholangiocarcinoma

(2015) Benjamin Juntermanns et al.   LIVER INTERNATIONAL

Cotargeting Polo-Like Kinase 1 and the Wnt/β-Catenin Signaling Pathway in Castration-Resistant Prostate Cancer

(2015) Jie Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Polo-like kinase 3 inhibits osteosarcoma cell proliferation and tumorigenesis via cooperative interaction with p21

(2015) HONGLIN LV et al.   Molecular Medicine Reports

The role of Plk3 in oncogenesis

(2015) C Helmke et al.   ONCOGENE

Autoinhibition and relief mechanism for Polo-like kinase 4

(2015) Joseph E. Klebba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polo-like kinase 2 acting as a promoter in human tumor cells with an abundance of TAp73

(2015) Hai Lu et al.   OncoTargets and Therapy

Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression

(2015) Min Xie et al.   Oncotarget

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

(2015) Christian Arquint et al.   eLife

Downregulation of Plk1 Expression By Receptor-Mediated Uptake of Antisense Oligonucleotide-Loaded Nanoparticles

(2015) Birgit Spänkuch et al.   NEOPLASIA

CAND1 Promotes PLK4-Mediated Centriole Overduplication and Is Frequently Disrupted in Prostate Cancer

(2015) Nina Korzeniewski et al.   NEOPLASIA

Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy

(2014) H. Dohner et al.   BLOOD

Definition of Smad3 Phosphorylation Events That Affect Malignant and Metastatic Behaviors in Breast Cancer Cells

(2014) E. Bae et al.   CANCER RESEARCH

Quantitative chemical proteomics reveals a Plk1 inhibitor-compromised cell death pathway in human cells

(2014) Monika Raab et al.   CELL RESEARCH

Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation

(2014) Nikola S. Dzhindzhev et al.   CURRENT BIOLOGY

Plk2 regulates mitotic spindle orientation and mammary gland development

(2014) E. Villegas et al.   DEVELOPMENT

Current assessment of polo-like kinases as anti-tumor drug targets

(2014) Sandra N Craig et al.   Expert Opinion on Drug Discovery

Thoughts on the current assessment of Polo-like kinase inhibitor drug discovery

(2014) Klaus Strebhardt et al.   Expert Opinion on Drug Discovery

Osmotic Stress-induced Phosphorylation of H2AX by Polo-like Kinase 3 Affects Cell Cycle Progression in Human Corneal Epithelial Cells

(2014) Ling Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PLK1 Inhibition Down-regulates Polycomb Group Protein BMI1 via Modulation of the miR-200c/141 Cluster

(2014) Manjari Dimri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Polo-like Kinase 1 (Plk1) Enhances the Antineoplastic Activity of Metformin in Prostate Cancer

(2014) Chen Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk1 Phosphorylation of PTEN Causes a Tumor-Promoting Metabolic State

(2014) Z. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer

(2014) Kazuya Shinmura et al.   MOLECULAR BIOLOGY REPORTS

Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis

(2014) Yves Matthess et al.   Molecular Oncology

Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1

(2014) Monika Raab et al.   Molecular Oncology

Polo-like kinases: structural variations lead to multiple functions

(2014) Sihem Zitouni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis

(2014) Suk-Youl Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

p53-Dependent and Cell Specific Epigenetic Regulation of the Polo-like kinases under Oxidative Stress

(2014) Alejandra Ward et al.   PLoS One

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

(2014) Midori Ohta et al.   Nature Communications

Regulators and Effectors of Siah Ubiquitin Ligases

(2013) Jianfei Qi et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plk1 to centrosomes

(2013) Minhong Shen et al.   CELL RESEARCH

Plk1: unexpected roles in DNA replication

(2013) Ranadip Mandal et al.   CELL RESEARCH

Polo-like Kinase 4 Autodestructs by Generating Its Slimb-Binding Phosphodegron

(2013) Joseph E. Klebba et al.   CURRENT BIOLOGY

Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number

(2013) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly

(2013) Yu-Chih Lin et al.   EMBO JOURNAL

Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication

(2013) K. F. Sonnen et al.   JOURNAL OF CELL SCIENCE

Mammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures

(2013) H. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152

(2013) T.-S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plk1-dependent microtubule dynamics promotes androgen receptor signaling in prostate cancer

(2013) Xianzeng Hou et al.   PROSTATE

SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress

(2013) Takanori Nakamura et al.   Nature Communications

Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop

(2012) Fabio Valenti et al.   CELL CYCLE

Polo-like kinases in AML

(2012) Tobias Berg et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

GCP6 is a substrate of Plk4 and required for centriole duplication

(2012) R. Bahtz et al.   JOURNAL OF CELL SCIENCE

Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4)

(2012) Onur Cizmecioglu et al.   JOURNAL OF CELL SCIENCE

Plk1 and CK2 Act in Concert to Regulate Rad51 during DNA Double Strand Break Repair

(2012) Keiko Yata et al.   MOLECULAR CELL

The Centrosomal Kinase Plk1 Localizes to the Transition Zone of Primary Cilia and Induces Phosphorylation of Nephrocystin-1

(2012) Tamina Seeger-Nukpezah et al.   PLoS One

Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication

(2012) Bing Song et al.   Cell Division

Polo-Box Domain Inhibitor Poloxin Activates the Spindle Assembly Checkpoint and Inhibits Tumor Growth in Vivo

(2011) Juping Yuan et al.   AMERICAN JOURNAL OF PATHOLOGY

Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice

(2011) Alejandra Ward et al.   BMC CANCER

Plk2 regulated centriole duplication is dependent on its localization to the centrosome and a functional polo-box domain

(2011) Onur Cizmecioglu et al.   CELL CYCLE

Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21WAF1/CIP1

(2011) Nina-Naomi Kreis et al.   CELL CYCLE

The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth, and chemosensitivity under hypoxic conditions

(2011) Elizabeth M. Matthew et al.   CELL CYCLE

Biological impact of freezing Plk1 in its inactive conformation in cancer cells

(2011) Sarah Keppner et al.   CELL CYCLE

Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints

(2011) Jianfang Wang et al.   CELLULAR SIGNALLING

Identification of a Polo-like Kinase 4-Dependent Pathway for De Novo Centriole Formation

(2011) Frank Eckerdt et al.   CURRENT BIOLOGY

PLK1 as an oncology target: current status and future potential

(2011) Campbell McInnes et al.   DRUG DISCOVERY TODAY

Upregulation of Polo-like kinase 2 gene expression by GATA-1 acetylation in human osteosarcoma MG-63 cells

(2011) Tao Shen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification

(2011) Christopher W. Brownlee et al.   JOURNAL OF CELL BIOLOGY

Plk5, a Polo Box Domain-Only Protein with Specific Roles in Neuron Differentiation and Glioblastoma Suppression

(2011) G. de Carcer et al.   MOLECULAR AND CELLULAR BIOLOGY

Plk1 Phosphorylation of Orc2 Promotes DNA Replication under Conditions of Stress

(2011) B. Song et al.   MOLECULAR AND CELLULAR BIOLOGY

Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors

(2011) David L. Myer et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication

(2011) Anja Puklowski et al.   NATURE CELL BIOLOGY

CDK11p58 Is Required for Centriole Duplication and Plk4 Recruitment to Mitotic Centrosomes

(2011) Nathalie Franck et al.   PLoS One

Polo-Like Kinase 1 as Predictive Marker and Therapeutic Target for Radiotherapy in Rectal Cancer

(2010) Franz Rödel et al.   AMERICAN JOURNAL OF PATHOLOGY

p53-dependent repression of polo-like kinase-1 (PLK1)

(2010) Lynsey McKenzie et al.   CELL CYCLE

Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore–microtubule attachments

(2010) Hongchang Li et al.   EMBO JOURNAL

Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery

(2010) X Shawn Liu et al.   EMBO REPORTS

Regulation of PTEN Stability and Activity by Plk3

(2010) Dazhong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk3 Functions as an Essential Component of the Hypoxia Regulatory Pathway by Direct Phosphorylation of HIF-1α

(2010) Dazhong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome

(2010) Onur Cizmecioglu et al.   JOURNAL OF CELL BIOLOGY

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

(2010) Andrew J. Holland et al.   JOURNAL OF CELL BIOLOGY

Stepwise evolution of the centriole-assembly pathway

(2010) Z. Carvalho-Santos et al.   JOURNAL OF CELL SCIENCE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus

(2010) Zdenek Andrysik et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation by polo-like kinase 1 induces the tumor-suppressing activity of FADD

(2010) M-S Jang et al.   ONCOGENE

Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polo-like kinase 4: the odd one out of the family

(2010) James E Sillibourne et al.   Cell Division

Development of high-throughput assays based on fluorescence polarization for inhibitors of the polo-box domains of polo-like kinases 2 and 3

(2009) Wolfgang Reindl et al.   ANALYTICAL BIOCHEMISTRY

Gene expression patterns in heterozygous Plk4 murine embryonic fibroblasts

(2009) Alan Morettin et al.   BMC GENOMICS

A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis

(2009) Wolfgang Reindl et al.   CHEMBIOCHEM

Polo Kinase and Separase Regulate the Mitotic Licensing of Centriole Duplication in Human Cells

(2009) Meng-Fu Bryan Tsou et al.   DEVELOPMENTAL CELL

The SCFSlimbubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

(2009) Gregory C. Rogers et al.   JOURNAL OF CELL BIOLOGY

Uptake of plasmid-loaded nanoparticles in breast cancer cells and effect on Plk1 expression

(2009) Isabel Steinhauser et al.   JOURNAL OF DRUG TARGETING

Polo-Like Kinase 1 Depletion Induces DNA Damage in Early S Prior to Caspase Activation

(2009) H. Yim et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophosphorylation of Polo-like Kinase 4 and Its Role in Centriole Duplication

(2009) James E. Sillibourne et al.   MOLECULAR BIOLOGY OF THE CELL

The Ubiquitin Ligase Siah2 and the Hypoxia Response

(2009) K. Nakayama et al.   MOLECULAR CANCER RESEARCH

Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance

(2009) E. A. Perez   MOLECULAR CANCER THERAPEUTICS

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Castration resistance of prostate cancer cells caused by castration-induced oxidative stress through Twist1 and androgen receptor overexpression

(2009) M Shiota et al.   ONCOGENE

Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay

(2009) Jung-Eun Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase 1

(2008) Wolfgang Reindl et al.   ANALYTICAL BIOCHEMISTRY

Effect of trastuzumab-modified antisense oligonucleotide-loaded human serum albumin nanoparticles prepared by heat denaturation

(2008) Isabel M. Steinhauser et al.   BIOMATERIALS

Polo-like Kinase 3 Functions as a Tumor Suppressor and Is a Negative Regulator of Hypoxia-Inducible Factor-1  under Hypoxic Conditions

(2008) Y. Yang et al.   CANCER RESEARCH

Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions

(2008) Wolfgang Reindl et al.   CHEMISTRY & BIOLOGY

The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

(2008) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

Combinatorial Application of Nucleic Acid-Based Agents Targeting Protein Kinases for Cancer Treatment

(2008) B. Spankuch et al.   CURRENT PHARMACEUTICAL DESIGN

Activation of Polo-like Kinase 3 by Hypoxic Stresses

(2008) Ling Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk3 Interacts with and Specifically Phosphorylates VRK1 in Ser342, a Downstream Target in a Pathway That Induces Golgi Fragmentation

(2008) I. Lopez-Sanchez et al.   MOLECULAR AND CELLULAR BIOLOGY

Plk1 depletion in nontransformed diploid cells activates the DNA-damage checkpoint

(2008) M Lei et al.   ONCOGENE

The PTEN–PI3K pathway: of feedbacks and cross-talks

(2008) A Carracedo et al.   ONCOGENE

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations

(2008) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing

(2008) Z.-Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA