Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation

A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies

(2017) Matthew A. Cottee et al.   Biology Open

CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis

(2016) Sihem Zitouni et al.   CURRENT BIOLOGY

PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space

(2015) Carla A.M. Lopes et al.   DEVELOPMENTAL CELL

Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

(2015) Tyler C. Moyer et al.   JOURNAL OF CELL BIOLOGY

Conserved molecular interactions in centriole-to-centrosome conversion

(2015) Jingyan Fu et al.   NATURE CELL BIOLOGY

Autoinhibition and relief mechanism for Polo-like kinase 4

(2015) Joseph E. Klebba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Centrosome and Its Duplication Cycle

(2015) Jingyan Fu et al.   Cold Spring Harbor Perspectives in Biology

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

(2015) Christian Arquint et al.   eLife

Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation

(2014) Nikola S. Dzhindzhev et al.   CURRENT BIOLOGY

The centrosome duplication cycle in health and disease

(2014) Erich A. Nigg et al.   FEBS LETTERS

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The centriole duplication cycle

(2014) E. N. F rat-Karalar et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Small organelle, big responsibility: the role of centrosomes in development and disease

(2014) P. L. Chavali et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

(2014) Midori Ohta et al.   Nature Communications

The primary cilium

(2014) Andrew M Fry et al.   Organogenesis

Polo-like Kinase 4 Autodestructs by Generating Its Slimb-Binding Phosphodegron

(2013) Joseph E. Klebba et al.   CURRENT BIOLOGY

Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number

(2013) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication

(2013) K. F. Sonnen et al.   JOURNAL OF CELL SCIENCE

Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152

(2013) T.-S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structured illumination of the interface between centriole and peri-centriolar material

(2012) J. Fu et al.   Open Biology

Structural Basis of the 9-Fold Symmetry of Centrioles

(2011) Daiju Kitagawa et al.   CELL

Structures of SAS-6 Suggest Its Organization in Centrioles

(2011) M. van Breugel et al.   SCIENCE

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

(2010) Andrew J. Holland et al.   JOURNAL OF CELL BIOLOGY

Plk4 trans-autophosphorylation regulates centriole number by controlling  TrCP-mediated degradation

(2010) G. Guderian et al.   JOURNAL OF CELL SCIENCE

Asterless is a scaffold for the onset of centriole assembly

(2010) Nikola S. Dzhindzhev et al.   NATURE

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL

The SCFSlimbubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

(2009) Gregory C. Rogers et al.   JOURNAL OF CELL BIOLOGY

The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

(2008) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY